Keratoacanthoma

Common Name(s)

Keratoacanthoma, Muir-Torre Syndrome

Muir-Torre syndrome is an autosomal dominant skin condition of genetic origin, characterized by tumors of the sebaceous gland or keratoacanthoma that are associated with visceral malignant diseases (cancers of the internal organs). The cutaneous characteristics of Muir-Torre syndrome are sebaceous adenoma, sebaceous epithelioma, sebaceous carcinoma, or multiple keratoacanthomas, whereas visceral malignant diseases include colorectal, endometrial, urological, and upper gastrointestinal tumors. Men are affected twice as often as women. Muir-Torre syndrome is associated with hereditary non-polyposis colon cancer (HNPCC), an autosomal dominant cancer genetic syndrome. Sebaceous neoplasms associated with Muir-Torre syndrome exhibit microsatellite instability (MSI), as do other HNPCC-related cancers.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoacanthoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Keratoacanthoma" returned 43 free, full-text research articles on human participants. First 3 results:

Cutaneous angiosarcoma of the scalp mimicking a keratoacanthoma.
 

Author(s): Yan Ling Kong, Suyien Nisha Subash Chandran, Seng Geok Nicholas Goh, See Ket Ng

Journal:

 

Cutaneous angiosarcoma (CA) has a wide range of clinical presentations. In this case report, we discuss a 78-year-old gentleman, who presented with a keratoacanthoma-like scalp lesion that turned out histologically to be a cutaneous angiosarcoma. A brief overview of CA, including ...

Last Updated: 9 Sep 2013

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Comparison of immunosuppressive and immunomodulatory cells in keratoacanthoma and cutaneous squamous cell carcinoma.
 

Author(s): Yumi Kambayashi, Taku Fujimura, Setsuya Aiba

Journal: Acta Derm. Venereol.. 2013 Nov;93(6):663-8.

 

An imbalance of immunosuppressive and immunomodulatory cells plays an important role in inhibiting the anti-tumour immune response in a tumour-bearing host. Among such cells, regulatory T cells (Tregs), together with immunosuppressive macrophages, such as CD163+ M2 macrophages, play ...

Last Updated: 23 Oct 2013

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Keratoacanthoma centrifugam marginatum: an atypical presentation.
 

Author(s): N Rani, P Kumar, J D Patil, S S Choudhary

Journal: J Postgrad Med. ;59(1):58-60.

 

Keratoacanthoma centrifugam marginatum (KCM) is a rare variant of keratoacanthoma characterized by a progressive peripheral growth with concomitant central healing. We report a case of a 50-year-old female who presented with multiple, veracious non-tender papules coalescing to form ...

Last Updated: 25 Mar 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Keratoacanthoma" returned 3 free, full-text review articles on human participants. First 3 results:

[Role of the pathologist in the diagnosis of palpebral keratoacanthoma: case report and literature review].
 

Author(s): A Harmouch, M C Chefchaouni, M Maher, S Sefiani

Journal: J Fr Ophtalmol. 2012 Dec;35(10):816.e1-3.

 

We report the case of a keratoacanthoma of the lower lid in a 14-year-old girl posing diagnostic difficulty with differentiating the lesion from a verrucous squamous cell carcinoma on histologic examination of an incisional biopsy. It was only upon complete excision of the tumor that ...

Last Updated: 11 Dec 2012

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Keratoacanthoma of the inferior lip: review and report of case with spontaneous regression.
 

Author(s): Lara Maria A Ramos, Sérgio V Cardoso, Adriano M Loyola, Marcus A Rocha, Antônio Francisco Durighetto-Júnior

Journal: J Appl Oral Sci. ;17(3):262-5.

 

Keratoacanthoma (KA) is a self-limited benign epithelial proliferative lesion that eventually presents with very similar clinical features to squamous cell carcinoma. Many KA appear in the vermilion border of the lips and therefore dental professionals must be familiar of the disease. ...

Last Updated: 25 May 2009

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The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma.
 

Author(s): R T Prehn

Journal: Cancer Res.. 1996 Mar;56(5):937-940.

 

Partial regression in cutaneous malignant melanoma has been reported by a number of observers, albeit not all, to be associated with a relatively poor prognosis; in contrast, a keratoacanthoma, which eventually regresses, does not metastasize. The Hammond effect could explain the ...

Last Updated: 15 Jul 1996

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.