Keratoacanthoma

Common Name(s)

Keratoacanthoma, Muir-Torre Syndrome

Muir-Torre syndrome is an autosomal dominant skin condition of genetic origin, characterized by tumors of the sebaceous gland or keratoacanthoma that are associated with visceral malignant diseases (cancers of the internal organs). The cutaneous characteristics of Muir-Torre syndrome are sebaceous adenoma, sebaceous epithelioma, sebaceous carcinoma, or multiple keratoacanthomas, whereas visceral malignant diseases include colorectal, endometrial, urological, and upper gastrointestinal tumors. Men are affected twice as often as women. Muir-Torre syndrome is associated with hereditary non-polyposis colon cancer (HNPCC), an autosomal dominant cancer genetic syndrome. Sebaceous neoplasms associated with Muir-Torre syndrome exhibit microsatellite instability (MSI), as do other HNPCC-related cancers.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoacanthoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Keratoacanthoma" returned 45 free, full-text research articles on human participants. First 3 results:

[Giant keratoacanthoma of the eyelid].
 

Author(s): Zouheir Hafidi, Rajae Daoudi

Journal:

 

Last Updated: 5 Feb 2014

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Malignancies with skin lesions mimicking keratoacanthoma.
 

Author(s): Ryan R Riahi, Philip R Cohen

Journal:

 

A variety of tumors mimicking keratoacanthoma have been described. Herein we categorize metastases of visceral malignancies that can present with the appearance of a keratoacanthoma.

Last Updated: 9 Dec 2013

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Keratoacanthoma in the inferior lip of an immunosuppressed patient. A case report.
 

Author(s): Cassiano Lima Chaiben, Joslei Carlos Bohn, Adriano Kuczynski, Francisca Berenice Dias Gil, Antonio Adilson Soares de Lima

Journal: Stomatologija. 2013 ;15(2):61-4.

 

Keratoacanthoma is a lesion typical crater, symmetrical, rounded, rapid growth with high potential for self-involution. The lesions may be multiple, disseminated and associated with some syndromes. The etiology of keratoacanthoma is not known, but it is often observed in patients ...

Last Updated: 16 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Keratoacanthoma" returned 3 free, full-text review articles on human participants. First 3 results:

[Role of the pathologist in the diagnosis of palpebral keratoacanthoma: case report and literature review].
 

Author(s): A Harmouch, M C Chefchaouni, M Maher, S Sefiani

Journal: J Fr Ophtalmol. 2012 Dec;35(10):816.e1-3.

 

We report the case of a keratoacanthoma of the lower lid in a 14-year-old girl posing diagnostic difficulty with differentiating the lesion from a verrucous squamous cell carcinoma on histologic examination of an incisional biopsy. It was only upon complete excision of the tumor that ...

Last Updated: 11 Dec 2012

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Keratoacanthoma of the inferior lip: review and report of case with spontaneous regression.
 

Author(s): Lara Maria A Ramos, Sérgio V Cardoso, Adriano M Loyola, Marcus A Rocha, Antônio Francisco Durighetto-Júnior

Journal: J Appl Oral Sci. ;17(3):262-5.

 

Keratoacanthoma (KA) is a self-limited benign epithelial proliferative lesion that eventually presents with very similar clinical features to squamous cell carcinoma. Many KA appear in the vermilion border of the lips and therefore dental professionals must be familiar of the disease. ...

Last Updated: 25 May 2009

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The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma.
 

Author(s): R T Prehn

Journal: Cancer Res.. 1996 Mar;56(5):937-940.

 

Partial regression in cutaneous malignant melanoma has been reported by a number of observers, albeit not all, to be associated with a relatively poor prognosis; in contrast, a keratoacanthoma, which eventually regresses, does not metastasize. The Hammond effect could explain the ...

Last Updated: 15 Jul 1996

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.