Kawasaki Disease

Common Name(s)

Kawasaki Disease, Acute febrile mucocutaneous lymph node syndrome, Kawasaki syndrome

Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a serious condition that is characterized by the inflammation of the blood vessels in the body. The condition typically affects children under the age of five, primarily those of Asian and Pacific Island descent. However, the disease can also develop in individuals of different ages and ethnicities.

Symptoms of this condition generally come in stages. The early symptoms may include a high fever lasting more than five days, blood shot eyes, red cracked lips, swollen strawberry red colored tongue, and rashes on the chest and genital area. Later symptoms may include peeling of the skin on the hands and feet, joint pain, abdominal pain, diarrhea, and vomiting.

At this time, there is not an exact test to determine if someone is experiencing Kawasaki disease. After taking a health history, in addition to other tests to exclude other conditions, a doctor can make a formal diagnosis. Unfortunately, the official cause for this condition is unknown. The disease itself is usually manageable, but without treatment can cause very serious heart conditions for the affected individual. Therefore, if you or someone you know is experiencing the symptoms of Kawasaki disease, speak to your doctor immediately to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kawasaki Disease" returned 749 free, full-text research articles on human participants. First 3 results:

Correlation between elevated platelet count and immunoglobulin levels in the early convalescent stage of Kawasaki disease.
 

Author(s): Ji-Whan Han, Jin-Hee Oh, Jung-Woo Rhim, Kyung-Yil Lee

Journal: Medicine (Baltimore). 2017 Jul;96(29):e7583.

 

Kawasaki disease (KD) may be an acute systemic immune-mediated disease which occurs after infection of unknown KD pathogen(s). The aim of this study is to evaluate the changes in platelet count and immunoglobulin (Ig) levels (IgG, IgM, IgA, and IgE) during hospitalization.Forty-three ...

Last Updated: 20 Jul 2017

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A comparison of the predictive validity of the combination of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and other risk scoring systems for intravenous immunoglobulin (ivig)-resistance in Kawasaki disease.
 

Author(s): Seiichiro Takeshita, Takashi Kanai, Yoichi Kawamura, Yusuke Yoshida, Shigeaki Nonoyama

Journal:

 

We recently reported that the combination of the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) is a novel and useful predictor of intravenous immunoglobulin (IVIG)-resistance in Kawasaki disease (KD). In the present study, to evaluate the effectiveness ...

Last Updated: 25 May 2017

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A plasma mir-125a-5p as a novel biomarker for Kawasaki disease and induces apoptosis in HUVECs.
 

Author(s): Zhuoying Li, Jie Jiang, Lang Tian, Xin Li, Jia Chen, Shentang Li, Chunyun Li, Zuocheng Yang

Journal:

 

Kawasaki disease (KD) is a childhood systemic vasculitis that exhibits a specific preference for the coronary arteries. The aetiology remains unknown and there are no especially diagnostic tests. microRNAs (miRNAs) are 18 to 23 nucleotides non-coding RNAs that are negative regulator ...

Last Updated: 3 May 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kawasaki Disease" returned 58 free, full-text review articles on human participants. First 3 results:

Anemia in Kawasaki Disease: Hepcidin as a Potential Biomarker.
 

Author(s): Ying-Hsien Huang, Ho-Chang Kuo

Journal:

 

Kawasaki disease (KD) is an autoimmune-like disease and acute childhood vasculitis syndrome that affects various systems but has unknown etiology. In addition to the standard diagnostic criteria, anemia is among the most common clinical features of KD patients and is thought to have ...

Last Updated: 18 Apr 2017

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Pathogenetic determinants in Kawasaki disease: the haematological point of view.
 

Author(s): Domenico Del Principe, Donatella Pietraforte, Lucrezia Gambardella, Alessandra Marchesi, Isabella Tarissi de Jacobis, Alberto Villani, Walter Malorni, Elisabetta Straface

Journal: J. Cell. Mol. Med.. 2017 Apr;21(4):632-639.

 

Kawasaki disease is a multisystemic vasculitis that can result in coronary artery lesions. It predominantly affects young children and is characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and non-suppurative ...

Last Updated: 7 Jan 2017

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Kawasaki Disease.
 

Author(s): Jane W Newburger, Masato Takahashi, Jane C Burns

Journal: J. Am. Coll. Cardiol.. 2016 Apr;67(14):1738-49.

 

Kawasaki disease is an acute, self-limited vasculitis of unknown etiology that occurs predominantly in infants and children. If not treated early with high-dose intravenous immunoglobulin, 1 in 5 children develop coronary artery aneurysms; this risk is reduced 5-fold if intravenous ...

Last Updated: 8 Apr 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 25 Oct 2016

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Anakinra in Infants and Children With Coronary Artery Abnormalities in Acute Kawasaki Disease
 

Status: Recruiting

Condition Summary: Kawasaki Disease

 

Last Updated: 11 May 2016

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Last Updated: 3 Nov 2016

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