Kawasaki Disease

Common Name(s)

Kawasaki Disease, Acute febrile mucocutaneous lymph node syndrome, Kawasaki syndrome

Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a serious condition that is characterized by the inflammation of the blood vessels in the body. The condition typically affects children under the age of five, primarily those of Asian and Pacific Island descent. However, the disease can also develop in individuals of different ages and ethnicities.

Symptoms of this condition generally come in stages. The early symptoms may include a high fever lasting more than five days, blood shot eyes, red cracked lips, swollen strawberry red colored tongue, and rashes on the chest and genital area. Later symptoms may include peeling of the skin on the hands and feet, joint pain, abdominal pain, diarrhea, and vomiting.

At this time, there is not an exact test to determine if someone is experiencing Kawasaki disease. After taking a health history, in addition to other tests to exclude other conditions, a doctor can make a formal diagnosis. Unfortunately, the official cause for this condition is unknown. The disease itself is usually manageable, but without treatment can cause very serious heart conditions for the affected individual. Therefore, if you or someone you know is experiencing the symptoms of Kawasaki disease, speak to your doctor immediately to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kawasaki Disease" returned 801 free, full-text research articles on human participants. First 3 results:

Male-specific association of the FCGR2A His167Arg polymorphism with Kawasaki disease.
 

Author(s): Young-Chang Kwon, Jae-Jung Kim, Sin Weon Yun, Jeong Jin Yu, Kyung Lim Yoon, Kyung-Yil Lee, Hong-Ryang Kil, Gi Beom Kim, Myung-Ki Han, Min Seob Song, Hyoung Doo Lee, Kee-Soo Ha, Sejung Sohn, Ryota Ebata, Hiromichi Hamada, Hiroyuki Suzuki, Kaoru Ito, Yoshihiro Onouchi, Young Mi Hong, Gi Young Jang, Jong-Keuk Lee,

Journal:

 

Kawasaki disease (KD) is an acute systemic vasculitis that can potentially cause coronary artery aneurysms in some children. KD occurs approximately 1.5 times more frequently in males than in females. To identify sex-specific genetic variants that are involved in KD pathogenesis in ...

Last Updated: 8 Sep 2017

Go To URL
Effective therapy with infliximab for clinically mild encephalitis/encephalopathy with a reversible splenial lesion in an infant with Kawasaki disease.
 

Author(s): Yoshie Kurokawa, Hiroshi Masuda, Tohru Kobayashi, Hiroshi Ono, Hitoshi Kato, Ken-Ichi Imadome, Jun Abe, Yuichi Abe, Shuichi Ito, Akira Ishiguro

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2017 ;40(3):190-195.

 

Kawasaki disease (KD) is a systemic vasculitis in infants. In KD, encephalopathy is rarely (0.1%) associated, however, clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) has previously been reported in some pediatric patients. Here, we report on a ...

Last Updated: 27 Jul 2017

Go To URL
Correlation between elevated platelet count and immunoglobulin levels in the early convalescent stage of Kawasaki disease.
 

Author(s): Ji-Whan Han, Jin-Hee Oh, Jung-Woo Rhim, Kyung-Yil Lee

Journal: Medicine (Baltimore). 2017 Jul;96(29):e7583.

 

Kawasaki disease (KD) may be an acute systemic immune-mediated disease which occurs after infection of unknown KD pathogen(s). The aim of this study is to evaluate the changes in platelet count and immunoglobulin (Ig) levels (IgG, IgM, IgA, and IgE) during hospitalization.Forty-three ...

Last Updated: 20 Jul 2017

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kawasaki Disease" returned 62 free, full-text review articles on human participants. First 3 results:

Anemia in Kawasaki Disease: Hepcidin as a Potential Biomarker.
 

Author(s): Ying-Hsien Huang, Ho-Chang Kuo

Journal:

 

Kawasaki disease (KD) is an autoimmune-like disease and acute childhood vasculitis syndrome that affects various systems but has unknown etiology. In addition to the standard diagnostic criteria, anemia is among the most common clinical features of KD patients and is thought to have ...

Last Updated: 18 Apr 2017

Go To URL
Pathogenetic determinants in Kawasaki disease: the haematological point of view.
 

Author(s): Domenico Del Principe, Donatella Pietraforte, Lucrezia Gambardella, Alessandra Marchesi, Isabella Tarissi de Jacobis, Alberto Villani, Walter Malorni, Elisabetta Straface

Journal: J. Cell. Mol. Med.. 2017 Apr;21(4):632-639.

 

Kawasaki disease is a multisystemic vasculitis that can result in coronary artery lesions. It predominantly affects young children and is characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and non-suppurative ...

Last Updated: 7 Jan 2017

Go To URL
[Research advances in association between vitamin D and Kawasaki disease and related mechanisms of action].
 

Author(s): Xue Yang, Xiang-Yu Dong

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Dec;18(12):1319-1323.

 

Vitamin D is an important steroid hormone, which has a wide biological effect and is the protective factor against cardiovascular disease and other diseases. At present, the etiology and pathogenesis of Kawasaki disease (KD) remain unknown, but recent studies have shown that vitamin ...

Last Updated: 15 Dec 2016

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 25 Oct 2016

Go to URL
Anakinra in Infants and Children With Coronary Artery Abnormalities in Acute Kawasaki Disease
 

Status: Recruiting

Condition Summary: Kawasaki Disease

 

Last Updated: 24 Oct 2017

Go to URL

Last Updated: 3 Nov 2016

Go to URL