Kaposiform hemangioendothelioma

Common Name(s)

Kaposiform hemangioendothelioma

A Kaposiform hemangioendothelioma (KHE) is a very rare non-cancerous (benign) vascular tumor (affecting the blood vessels) that occurs in children and resembles a birthmark. Most birthmarks go away on their own or cause no medical problems. This type of tumor however requires monitoring and treatment since it involves the vascular system. Signs and symptoms may include: a growing spot (lesion) on the skin, a lesion that swells and becomes painful, and decreased motion in the area around the lesion. KHE tumors are often associated with a more serious condition called Kasabach-Merritt phenomenon. Kasabach-Merritt phenomenon is when blood clots begin to form throughout the body potentially causing organ damage, a loss of platelets (thrombocytopenia) which causes excessive bleeding, and anemia (low levels of iron in the blood). KHE tumors can be diagnosed using MRI tests, ultrasounds, CT scans, blood tests, and by examining the tumor’s cellular appearance. KHE tumors are treatable and medications can be used to treat this kind of tumor. If they are ineffective, additional treatment may be required such as chemotherapy, radiation therapy, or surgery to remove the tumor. Because of the complexity of treatment, multiple specialists may be involved in the care of a KHE tumor.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kaposiform hemangioendothelioma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kaposiform hemangioendothelioma" returned 15 free, full-text research articles on human participants. First 3 results:

Recurrent multifocal cutaneous Kaposiform hemangioendothelioma: A rare vascular tumor of infancy and childhood.
 

Author(s): Bhagyalakshmi Atla, P V Sudhakar, Nagarjun Rao, Uma Prasad

Journal: Indian J Pathol Microbiol. ;59(3):392-4.

 

Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor of childhood although cases occurring in adulthood are also described. The features overlap with juvenile capillary hemangioma and Kaposi sarcoma. We report a rare case of recurrent, multifocal (nose and ...

Last Updated: 11 Aug 2016

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Abdominal Kaposiform Hemangioendothelioma Associated With Lymphangiomatosis Involving Mesentery and Ileum: A Case Report of MRI, CT, and 18F-FDG PET/CT Findings.
 

Author(s): Aisheng Dong, Ling Zhang, Yang Wang, Tianlin He, Changjing Zuo

Journal: Medicine (Baltimore). 2016 Feb;95(6):e2806.

 

Kaposiform hemangioendothelioma (KH) is a rare vascular tumor of intermediate malignancy that occurs mainly in the childhood. Adult patients with KH are rare. Imaging findings of KH have rarely been reported before. We present magnetic resonance imaging (MRI), computed tomography ...

Last Updated: 13 Feb 2016

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Clinicopathological features of Kaposiform hemangioendothelioma.
 

Author(s): Qiuyu Liu, Lili Jiang, Danting Wu, Yunzhen Kan, Fangfang Fu, Dongyi Zhang, Yubin Gong, Ying Wang, Changxian Dong, Lingfei Kong

Journal:

 

Kaposiform hemangioendothelioma (KHE), an intermediate tumor of endothelial origin in childhood, is often associated with Kasabach-Merritt phenomenon (KMP). In this study, 22 cases of KHE were immunochemically studied for CD31, CD34, ERG, smooth muscle actin (SMA), D240, GLUT1 and ...

Last Updated: 1 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kaposiform hemangioendothelioma" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors
 

Status: Recruiting

Condition Summary: Kaposiform Hemangioendothelioma (KHE); Kasabach-Merritt Syndrome; Tufted Angioma

 

Last Updated: 13 Oct 2016

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Identification of Biomarkers for Patients With Vascular Anomalies
 

Status: Recruiting

Condition Summary: Vascular Anomaly; Generalized Lymphatic Anomaly; Kaposiform Hemangioendothelioma; Kaposiform Lymphangiomatosis; Gorham-Stout Disease

 

Last Updated: 26 Apr 2017

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Lymphatic Anomalies Registry
 

Status: Recruiting

Condition Summary: Lymphatic Malformation; Generalized Lymphatic Anomaly (GLA); Central Conducting Lymphatic Anomaly; CLOVES Syndrome; Gorham-Stout Disease ("Disappearing Bone Disease"); Blue Rubber Bleb Nevus Syndrome; Kaposiform Lymphangiomatosis; Kaposiform Hemangioendothelioma/Tufted Angioma; Klippel-Trenaunay Syndrome; Lymphangiomatosis

 

Last Updated: 26 Jul 2016

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