Juvenile dermatomyositis

Common Name(s)

Juvenile dermatomyositis

Juvenile dermatomyositis has some similarities to adult dermatomyositis and polymyositis. It typically affects children ages 2 to 15 years, with symptoms that include weakness of the muscles close to the trunk of the body, inflammation, edema, muscle pain, fatigue, skin rashes, abdominal pain, fever, and contractures. Children with juvenile dermatomyositis may have difficulty swallowing and breathing, and the heart may also be affected.  About 20 to 30 percent of children with juvenile dermatomyositis develop calcium deposits in the soft tissue. Affected children may not show higher than normal levels of the muscle enzyme creatine kinase in their blood but have higher than normal levels of other muscle enzymes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Juvenile dermatomyositis" for support, advocacy or research.

Isabella's Aviary Alliance, LLC

Isabella’s Aviary Alliance, LLC actively demonstrates, through Isabella’s passionate and loving care in breeding and raising baby parrots for other special needs children, the possibility for two hearts—bird and child—coming together and connecting in a way which infinitely brightens the lives of both.

Last Updated: 2 Aug 2013

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The Myositis Association

The mission of the Myositis Association is to: - Provide support to myositis patients and their families - Provide connections between the Medical Advisory Board and the general medical and patient communities - Increase funding to support myositis research

Last Updated: 14 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Juvenile dermatomyositis" for support, advocacy or research.

Isabella's Aviary Alliance, LLC

Isabella’s Aviary Alliance, LLC actively demonstrates, through Isabella’s passionate and loving care in breeding and raising baby parrots for other special needs children, the possibility for two hearts—bird and child—coming together and connecting in a way which infinitely brightens the lives of both.

http://www.isabellasaviary.com

Last Updated: 2 Aug 2013

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The Myositis Association

The mission of the Myositis Association is to: - Provide support to myositis patients and their families - Provide connections between the Medical Advisory Board and the general medical and patient communities - Increase funding to support myositis research

http://www.myositis.org

Last Updated: 14 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Juvenile dermatomyositis" returned 184 free, full-text research articles on human participants. First 3 results:

In juvenile dermatomyositis, heart rate variability is reduced, and associated with both cardiac dysfunction and markers of inflammation: a cross-sectional study median 13.5 years after symptom onset.
 

Author(s): Zoltan Barth, Birgit Nomeland Witczak, Thomas Schwartz, Knut Gjesdal, Berit Flatø, Akos Koller, Helga Sanner, Ivar Sjaastad

Journal: Rheumatology (Oxford). 2016 Mar;55(3):535-43.

 

Low heart rate variability (HRV) is a well-established predictor of cardiac death. The aim of this study was to investigate arrhythmias and HRV in patients with JDM, and associations between HRV and inflammatory markers, echocardiographic measurements and disease parameters.

Last Updated: 10 Feb 2016

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Vasculopathy-related clinical and pathological features are associated with severe juvenile dermatomyositis.
 

Author(s): Cyril Gitiaux, Marie De Antonio, Jessie Aouizerate, Romain K Gherardi, Thomas Guilbert, Christine Barnerias, Christine Bodemer, Karine Brochard-Payet, Pierre Quartier, Lucile Musset, Bénédicte Chazaud, Isabelle Desguerre, Brigitte Bader-Meunier

Journal: Rheumatology (Oxford). 2016 Mar;55(3):470-9.

 

Outcome of JDM is highly heterogeneous. Our objective was to determine clinical and muscle biopsy features associated with poor outcome and response to treatment.

Last Updated: 10 Feb 2016

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Development of an internationally agreed minimal dataset for juvenile dermatomyositis (JDM) for clinical and research use.
 

Author(s): Liza J McCann, Jamie J Kirkham, Lucy R Wedderburn, Clarissa Pilkington, Adam M Huber, Angelo Ravelli, Duncan Appelbe, Paula R Williamson, Michael W Beresford

Journal:

 

Juvenile dermatomyositis (JDM) is a rare autoimmune inflammatory disorder associated with significant morbidity and mortality. International collaboration is necessary to better understand the pathogenesis of the disease, response to treatment and long-term outcome. To aid international ...

Last Updated: 18 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Juvenile dermatomyositis" returned 11 free, full-text review articles on human participants. First 3 results:

Adult and juvenile dermatomyositis: are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms?
 

Author(s): Sarah L Tansley, Neil J McHugh, Lucy R Wedderburn

Journal:

 

Adult and juvenile dermatomyositis share the hallmark features of pathognomic skin rash and muscle inflammation, but are heterogeneous disorders with a range of additional disease features and complications. The frequency of important clinical features such as calcinosis, interstitial ...

Last Updated: 1 Aug 2014

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Type I interferon pathway in adult and juvenile dermatomyositis.
 

Author(s): Emily C Baechler, Hatice Bilgic, Ann M Reed

Journal: Arthritis Res. Ther.. 2011 ;13(6):249.

 

Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating ...

Last Updated: 28 Mar 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Five-year Actively Controlled Clinical Trial in New Onset Juvenile Dermatomyositis
 

Status: Recruiting

Condition Summary: Juvenile Dermatomyositis

 

Last Updated: 16 Feb 2011

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Creatine Supplementation in Pediatric Rheumatology
 

Status: Recruiting

Condition Summary: Juvenile Systemic Lupus Erythematosus; Juvenile Dermatomyositis

 

Last Updated: 12 Jan 2012

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Compassionate Use Protocol for the Treatment of Autoinflammatory Syndromes
 

Status: Available

Condition Summary: Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy and Elevated Temperature (CANDLE); Juvenile Dermatomyositis (JDM); Stimulator of Interferon Genes (STING)-Associated Vasculopathy With Onset During Infancy (SAVI)

 

Last Updated: 8 Mar 2016

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