Iron Overload

Common Name(s)

Iron Overload

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Iron Overload" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Iron Overload" returned 348 free, full-text research articles on human participants. First 3 results:

Effect of deferoxamine therapy on insulin resistance in end-stage renal disease patients with iron overload.
 

Author(s): Alsayed Ahmed Alnahal, Magdy Tahan, Aymen Fathy, Tamer Fathy

Journal: Saudi J Kidney Dis Transpl. 2014 Jul;25(4):808-13.

 

Cardiovascular diseases are a common cause of morbidity and mortality in subjects on regular hemodialysis. Insulin resistance is associated with increased cardiovascular diseases. Elevated serum ferritin is linked to insulin resistance. The aim of this work is to study the effect ...

Last Updated: 27 Jun 2014

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Endogenous siderophore 2,5-dihydroxybenzoic acid deficiency promotes anemia and splenic iron overload in mice.
 

Author(s): Zhuoming Liu, Alieta Ciocea, L Devireddy

Journal: Mol. Cell. Biol.. 2014 Jul;34(13):2533-46.

 

Eukaryotes produce a siderophore-like molecule via a remarkably conserved biosynthetic pathway. 3-OH butyrate dehydrogenase (BDH2), a member of the short-chain dehydrogenase (SDR) family of reductases, catalyzes a rate-limiting step in the biogenesis of the mammalian siderophore 2,5-dihydroxybenzoic ...

Last Updated: 3 Jun 2014

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Iron overload is rare in patients homozygous for the H63D mutation.
 

Author(s): Melissa Kelley, Nikhil Joshi, Yagang Xie, Mark Borgaonkar

Journal: Can J Gastroenterol Hepatol. 2014 Apr;28(4):198-202.

 

Previous research has suggested that the H63D HFE mutation is associated with elevated iron indexes. However, the true penetrance of this mutation remains unclear.

Last Updated: 14 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Iron Overload" returned 68 free, full-text review articles on human participants. First 3 results:

Role of iron overload-induced macrophage apoptosis in the pathogenesis of peritoneal endometriosis.
 

Author(s): Leila Pirdel, Manijeh Pirdel

Journal: Reproduction. 2014 Jun;147(6):R199-207.

 

This article presents an overview of the involvement of iron overload-induced nitric oxide (NO) overproduction in apoptosis of peritoneal macrophages of women with endometriosis. We have postulated that the peritoneal iron overload originated from retrograde menstruation or bleeding ...

Last Updated: 23 May 2014

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Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches.
 

Author(s): Paul J Schmidt, Mark D Fleming

Journal: Hematol. Oncol. Clin. North Am.. 2014 Apr;28(2):387-401.

 

In this article, the authors discuss new approaches to treating iron overload diseases using hepcidin mimetics or by modulating endogenous hepcidin expression. In particular, the authors discuss lipid nanoparticle encapsulated siRNA and antisense oligonucleotide-mediated inhibition ...

Last Updated: 4 Mar 2014

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Prooxidant mechanisms in iron overload cardiomyopathy.
 

Author(s): Ching-Feng Cheng, Wei-Shiung Lian

Journal: Biomed Res Int. 2013 ;2013():740573.

 

Iron overload cardiomyopathy (IOC), defined as the presence of systolic or diastolic cardiac dysfunction secondary to increased deposition of iron, is emerging as an important cause of heart failure due to the increased incidence of this disorder seen in thalassemic patients and in ...

Last Updated: 18 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of Phlebotomy on Insulin Sensitivity in Insulin Resistance-associated Hepatic Iron Overload Patients
 

Status: Recruiting

Condition Summary: Insulin Resistance; Iron Overload

 

Last Updated: 3 Jun 2014

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High-Tc Susceptometer to Monitor Transfusional Iron Overload
 

Status: Recruiting

Condition Summary: Transfusional Iron Overload; Thalassemia Major; Sickle Cell Disease; Myelodysplastic Syndromes; Aplastic Anemia

 

Last Updated: 11 Feb 2015

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Estimation of Myocardial Iron Overload by 3 Tesla MRI in HFE Hereditary Haemochromatosis
 

Status: Recruiting

Condition Summary: Myocardial Iron Overload; HFE-Associated Hereditary Hemochromatosis

 

Last Updated: 17 Feb 2015

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