Iron Overload

Common Name(s)

Iron Overload

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Iron Overload" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Iron Overload" returned 398 free, full-text research articles on human participants. First 3 results:

Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload.
 

Author(s): Yesim Aydinok, Antonis Kattamis, M Domenica Cappellini, Amal El-Beshlawy, Raffaella Origa, Mohsen Elalfy, Yurdanur Kilinç, Silverio Perrotta, Zeynep Karakas, Vip Viprakasit, Dany Habr, Niculae Constantinovici, Junwu Shen, John B Porter,

Journal: Blood. 2015 Jun;125(25):3868-77.

 

Deferasirox (DFX) monotherapy is effective for reducing myocardial and liver iron concentrations (LIC), although some patients may require intensive chelation for a limited duration. HYPERION, an open-label single-arm prospective phase 2 study, evaluated combination DFX-deferoxamine ...

Last Updated: 19 Jun 2015

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R2* relaxometry for the quantification of hepatic iron overload: biopsy-based calibration and comparison with the literature.
 

Author(s): B Henninger, H Zoller, S Rauch, A Finkenstedt, M Schocke, W Jaschke, C Kremser

Journal: Rofo. 2015 Jun;187(6):472-9.

 

We compared the calibration of hepatic iron based on R2* relaxometry and liver biopsy with similar studies that have already been published to investigate the transferability of published calibration curves.

Last Updated: 28 May 2015

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Serum ferritin is a biomarker for liver mortality in the Hemochromatosis and Iron Overload Screening Study.
 

Author(s): Paul C Adams, James C Barton, Helen Guo, David Alter, Mark Speechley

Journal: Ann Hepatol. ;14(3):348-53.

 

We identified no reports of long-term follow-up of participants in hemochromatosis screening programs. We evaluated causes of death and survival in non-C282Y homozygous Canadian participants in the primary care-based hemochromatosis and iron overload screening (HEIRS) study.

Last Updated: 13 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Iron Overload" returned 81 free, full-text review articles on human participants. First 3 results:

Iron age: novel targets for iron overload.
 

Author(s): Carla Casu, Stefano Rivella

Journal: Hematology Am Soc Hematol Educ Program. 2014 Dec;2014(1):216-21.

 

Excess iron deposition in vital organs is the main cause of morbidity and mortality in patients affected by β-thalassemia and hereditary hemochromatosis. In both disorders, inappropriately low levels of the liver hormone hepcidin are responsible for the increased iron absorption, ...

Last Updated: 20 Feb 2015

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Guidelines for quantifying iron overload.
 

Author(s): John C Wood

Journal: Hematology Am Soc Hematol Educ Program. 2014 Dec;2014(1):210-5.

 

Both primary and secondary iron overload are increasingly prevalent in the United States because of immigration from the Far East, increasing transfusion therapy in sickle cell disease, and improved survivorship of hematologic malignancies. This chapter describes the use of historical ...

Last Updated: 20 Feb 2015

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Iron clad: iron homeostasis and the diagnosis of hereditary iron overload.
 

Author(s): Matthew M Heeney

Journal: Hematology Am Soc Hematol Educ Program. 2014 Dec;2014(1):202-9.

 

Iron is an ubiquitous metal of vital importance to the normal physiologic processes of many organisms. Over the last 2 decades, the discovery of mutations in genes leading to hereditary disorders of iron overload, iron deficiency, and iron maldistribution have accelerated our understanding ...

Last Updated: 20 Feb 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of Phlebotomy on Insulin Sensitivity in Insulin Resistance-associated Hepatic Iron Overload Patients
 

Status: Recruiting

Condition Summary: Insulin Resistance; Iron Overload

 

Last Updated: 26 May 2015

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High-Tc Susceptometer to Monitor Transfusional Iron Overload
 

Status: Recruiting

Condition Summary: Transfusional Iron Overload; Thalassemia Major; Sickle Cell Disease; Myelodysplastic Syndromes; Aplastic Anemia

 

Last Updated: 23 Nov 2015

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Estimation of Myocardial Iron Overload by 3 Tesla MRI in HFE Hereditary Haemochromatosis
 

Status: Recruiting

Condition Summary: Myocardial Iron Overload; HFE-Associated Hereditary Hemochromatosis

 

Last Updated: 20 Aug 2015

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