Iron Overload

Common Name(s)

Iron Overload

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Iron Overload" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Iron Overload" returned 432 free, full-text research articles on human participants. First 3 results:

Proteomic Profiling of Iron Overload-Induced Human Hepatic Cells Reveals Activation of TLR2-Mediated Inflammatory Response.
 

Author(s): Xiang Li, Shiwei Li, Mize Lu, Guohua Yang, Yunfeng Shen, Xin Zhou

Journal:

 

Hepatic iron overload is common in patients who have undergone hematopoietic cell transplantation (HCT) and may predispose to peri- and post-HCT toxicity. To better reveal more molecules that might be involved in iron overload-induced liver injury, we utilized proteomics to investigate ...

Last Updated: 22 Mar 2016

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Study of gonadal hormones in Egyptian female children with sickle cell anemia in correlation with iron overload: Single center study.
 

Author(s): Adel A Hagag, Mohamed S El-Farargy, Shaymaa Elrefaey, Amany M Abo El-enein

Journal: Hematol Oncol Stem Cell Ther. 2016 Mar;9(1):1-7.

 

Sickle cell disease is a hereditary hemoglobinopathy characterized by abnormal hemoglobin production, hemolytic anemia, and intermittent occlusion of small blood vessels, leading to tissue ischemia, chronic organ damage, and organ dysfunction including endocrine organs. The aim of ...

Last Updated: 21 Mar 2016

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Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy.
 

Author(s): Subhash K Das, Wang Wang, Pavel Zhabyeyev, Ratnadeep Basu, Brent McLean, Dong Fan, Nirmal Parajuli, Jessica DesAulniers, Vaibhav B Patel, Roger J Hajjar, Jason R B Dyck, Zamaneh Kassiri, Gavin Y Oudit

Journal:

 

Iron-overload cardiomyopathy is a prevalent cause of heart failure on a world-wide basis and is a major cause of mortality and morbidity in patients with secondary iron-overload and genetic hemochromatosis. We investigated the therapeutic effects of resveratrol in acquired and genetic ...

Last Updated: 7 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Iron Overload" returned 76 free, full-text review articles on human participants. First 3 results:

Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology.
 

Author(s): Christina N Kontoghiorghe, Annita Kolnagou, George J Kontoghiorghes

Journal:

 

Iron chelating drugs are primarily and widely used in the treatment of transfusional iron overload in thalassaemia and similar conditions. Recent in vivo and clinical studies have also shown that chelators, and in particular deferiprone, can be used effectively in many conditions ...

Last Updated: 27 Nov 2015

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Use of magnetic resonance imaging to monitor iron overload.
 

Author(s): John C Wood

Journal: Hematol. Oncol. Clin. North Am.. 2014 Aug;28(4):747-64, vii.

 

Treatment of iron overload requires robust estimates of total-body iron burden and its response to iron chelation therapy. Compliance with chelation therapy varies considerably among patients, and individual reporting is notoriously unreliable. Even with perfect compliance, intersubject ...

Last Updated: 28 Jul 2014

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The impact of chelation therapy on survival in transfusional iron overload: a meta-analysis of myelodysplastic syndrome.
 

Author(s): Arch G Mainous, Rebecca J Tanner, Mary M Hulihan, Mirna Amaya, Thomas D Coates

Journal: Br. J. Haematol.. 2014 Dec;167(5):720-3.

 

Last Updated: 14 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Estimation of Myocardial Iron Overload by 3 Tesla MRI in HFE Hereditary Haemochromatosis
 

Status: Recruiting

Condition Summary: Myocardial Iron Overload; HFE-Associated Hereditary Hemochromatosis

 

Last Updated: 11 Jul 2016

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Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia Patients
 

Status: Recruiting

Condition Summary: Beta-Thalassemia; Iron Overload

 

Last Updated: 24 Oct 2016

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Effect of Deferiprone on Oxidative-Stress and Iron-Overload in Low Risk Transfusion-Dependent MDS Patients
 

Status: Recruiting

Condition Summary: Myelodysplastic Syndrome With Low-grade Lesions; Iron Overload Due to Repeated Red Blood Cell Transfusions

 

Last Updated: 13 Apr 2016

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