Iron Overload

Common Name(s)

Iron Overload

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Iron Overload" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Iron Overload" returned 324 free, full-text research articles on human participants. First 3 results:

Korean guideline for iron chelation therapy in transfusion-induced iron overload.
 

Author(s): Jun Ho Jang, Je-Hwan Lee, Sung-Soo Yoon, Deog-Yeon Jo, Hyeoung-Joon Kim, Jooseop Chung, Jong Wook Lee,

Journal: J. Korean Med. Sci.. 2013 Nov;28(11):1563-72.

 

Many Korean patients with transfusion-induced iron overload experience serious clinical sequelae, including organ damage, and require lifelong chelation therapy. However, due to a lack of compliance and/or unavailability of an appropriate chelator, most patients have not been treated ...

Last Updated: 22 Nov 2013

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High expression of APAF-1 elevates erythroid apoptosis in iron overload myelodysplastic syndrome.
 

Author(s): Shucheng Gu, Youshan Zhao, Juan Guo, Feng Xu, Chengming Fei, Xi Zhang, Chao Xiao, Chunkang Chang, Xiao Li

Journal: Tumour Biol.. 2014 Mar;35(3):2211-8.

 

Apoptotic protease-activating factor 1 (APAF-1) is a central component of the intrinsic pathway of apoptosis. Our study aims at searching the role of APAF-1 in iron overload myelodysplastic syndrome (MDS). Erythroid apoptosis rate, mRNA expression levels of APAF-1, and caspase-9 activity ...

Last Updated: 27 Mar 2014

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Right and left ventricular function and myocardial scarring in adult patients with sickle cell disease: a comprehensive magnetic resonance assessment of hepatic and myocardial iron overload.
 

Author(s): Flávia P Junqueira, Juliano L Fernandes, Guilherme M Cunha, Tadeu T A Kubo, Claudio M A O Lima, Daniel B P Lima, Marly Uellendhal, Sidney R Sales, Carolina A S Cunha, Viviani L R de Pessoa, Clarisse L C Lobo, Edson Marchiori

Journal:

 

Patients with Sickle cell disease (SCD) who receive regular transfusions are at risk for developing cardiac toxicity from iron overload. The aim of this study was to assess right and left cardiac volumes and function, late gadolinium enhancement (LGE) and iron deposits in patients ...

Last Updated: 15 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Iron Overload" returned 68 free, full-text review articles on human participants. First 3 results:

Consequences and management of iron overload in sickle cell disease.
 

Author(s): John Porter, Maciej Garbowski

Journal: Hematology Am Soc Hematol Educ Program. 2013 ;2013():447-56.

 

The aims of this review are to highlight the mechanisms and consequences of iron distribution that are most relevant to transfused sickle cell disease (SCD) patients and to address the particular challenges in the monitoring and treatment of iron overload. In contrast to many inherited ...

Last Updated: 9 Dec 2013

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MicroRNAs and liver cancer associated with iron overload: therapeutic targets unravelled.
 

Author(s): Catherine M Greene, Robert B Varley, Matthew W Lawless

Journal: World J. Gastroenterol.. 2013 Aug;19(32):5212-26.

 

Primary liver cancer is a global disease that is on the increase. Hepatocellular carcinoma (HCC) accounts for most primary liver cancers and has a notably low survival rate, largely attributable to late diagnosis, resistance to treatment, tumour recurrence and metastasis. MicroRNAs ...

Last Updated: 28 Aug 2013

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[Hemochromatosis: one form of iron-overload diseases].
 

Author(s): Ferenc Szalay

Journal: Orv Hetil. 2013 Jul;154(29):1156-64.

 

Iron-overload diseases are typically insidious, causing progressive and irreversible organ injury before clinical symptoms develop. Some iron-overload diseases as HFE-associated hemochromatosis and beta-thalassemia are quite common, whereas others are very rare. Early diagnosis is ...

Last Updated: 15 Jul 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of Phlebotomy on Insulin Sensitivity in Insulin Resistance-associated Hepatic Iron Overload Patients
 

Status: Recruiting

Condition Summary: Insulin Resistance; Iron Overload

 

Last Updated: 3 Jun 2014

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Amlodipine in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major
 

Status: Recruiting

Condition Summary: Thalassemia; Iron Overload

 

Last Updated: 25 Aug 2011

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High-Tc Susceptometer to Monitor Transfusional Iron Overload
 

Status: Recruiting

Condition Summary: Transfusional Iron Overload; Thalassemia Major; Sickle Cell Disease; Myelodysplastic Syndromes; Aplastic Anemia

 

Last Updated: 26 Feb 2014

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