Iron Overload

Common Name(s)

Iron Overload

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Iron Overload" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Iron Overload" returned 354 free, full-text research articles on human participants. First 3 results:

Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload.
 

Author(s): Yesim Aydinok, Antonis Kattamis, M Domenica Cappellini, Amal El-Beshlawy, Raffaella Origa, Mohsen Elalfy, Yurdanur Kilinç, Silverio Perrotta, Zeynep Karakas, Vip Viprakasit, Dany Habr, Niculae Constantinovici, Junwu Shen, John B Porter,

Journal: Blood. 2015 Jun;125(25):3868-77.

 

Deferasirox (DFX) monotherapy is effective for reducing myocardial and liver iron concentrations (LIC), although some patients may require intensive chelation for a limited duration. HYPERION, an open-label single-arm prospective phase 2 study, evaluated combination DFX-deferoxamine ...

Last Updated: 19 Jun 2015

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R2* relaxometry for the quantification of hepatic iron overload: biopsy-based calibration and comparison with the literature.
 

Author(s): B Henninger, H Zoller, S Rauch, A Finkenstedt, M Schocke, W Jaschke, C Kremser

Journal: Rofo. 2015 Jun;187(6):472-9.

 

We compared the calibration of hepatic iron based on R2* relaxometry and liver biopsy with similar studies that have already been published to investigate the transferability of published calibration curves.

Last Updated: 28 May 2015

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Effect of deferoxamine therapy on insulin resistance in end-stage renal disease patients with iron overload.
 

Author(s): Alsayed Ahmed Alnahal, Magdy Tahan, Aymen Fathy, Tamer Fathy

Journal: Saudi J Kidney Dis Transpl. 2014 Jul;25(4):808-13.

 

Cardiovascular diseases are a common cause of morbidity and mortality in subjects on regular hemodialysis. Insulin resistance is associated with increased cardiovascular diseases. Elevated serum ferritin is linked to insulin resistance. The aim of this work is to study the effect ...

Last Updated: 27 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Iron Overload" returned 71 free, full-text review articles on human participants. First 3 results:

Use of magnetic resonance imaging to monitor iron overload.
 

Author(s): John C Wood

Journal: Hematol. Oncol. Clin. North Am.. 2014 Aug;28(4):747-64, vii.

 

Treatment of iron overload requires robust estimates of total-body iron burden and its response to iron chelation therapy. Compliance with chelation therapy varies considerably among patients, and individual reporting is notoriously unreliable. Even with perfect compliance, intersubject ...

Last Updated: 28 Jul 2014

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Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome.
 

Author(s): Niraj Shenoy, Nishanth Vallumsetla, Eliezer Rachmilewitz, Amit Verma, Yelena Ginzburg

Journal: Blood. 2014 Aug;124(6):873-81.

 

Myelodysplastic syndromes (MDSs) are a group of heterogeneous clonal bone marrow disorders characterized by ineffective hematopoiesis, peripheral blood cytopenias, and potential for malignant transformation. Lower/intermediate-risk MDSs are associated with longer survival and high ...

Last Updated: 8 Aug 2014

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Role of iron overload-induced macrophage apoptosis in the pathogenesis of peritoneal endometriosis.
 

Author(s): Leila Pirdel, Manijeh Pirdel

Journal: Reproduction. 2014 Jun;147(6):R199-207.

 

This article presents an overview of the involvement of iron overload-induced nitric oxide (NO) overproduction in apoptosis of peritoneal macrophages of women with endometriosis. We have postulated that the peritoneal iron overload originated from retrograde menstruation or bleeding ...

Last Updated: 23 May 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of Phlebotomy on Insulin Sensitivity in Insulin Resistance-associated Hepatic Iron Overload Patients
 

Status: Recruiting

Condition Summary: Insulin Resistance; Iron Overload

 

Last Updated: 26 May 2015

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High-Tc Susceptometer to Monitor Transfusional Iron Overload
 

Status: Recruiting

Condition Summary: Transfusional Iron Overload; Thalassemia Major; Sickle Cell Disease; Myelodysplastic Syndromes; Aplastic Anemia

 

Last Updated: 3 Jun 2015

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Estimation of Myocardial Iron Overload by 3 Tesla MRI in HFE Hereditary Haemochromatosis
 

Status: Recruiting

Condition Summary: Myocardial Iron Overload; HFE-Associated Hereditary Hemochromatosis

 

Last Updated: 20 Aug 2015

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