Iridocorneal endothelial syndrome

Common Name(s)

Iridocorneal endothelial syndrome

Iridocorneal endothelial (ICE) syndrome describes a group of eye diseases that are characterized by three main features:   Visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye)  Swelling of the cornea, and  The development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly)

ICE syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. The condition is actually a grouping of three closely linked conditions: Cogan-Reese syndrome; Chandler's syndrome; and essential (progressive) iris atrophy. The cause of ICE syndrome is unknown. While there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling.  

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Iridocorneal endothelial syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Iridocorneal endothelial syndrome" returned 16 free, full-text research articles on human participants. First 3 results:

Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects.
 

Author(s): Premanand Chandran, Harsha L Rao, Anil K Mandal, Nikhil S Choudhari, Chandra S Garudadri, Sirisha Senthil

Journal:

 

To report the demographic profile, clinical features, and prevalence of glaucoma and its management in patients with Iridocorneal endothelial (ICE) syndrome.

Last Updated: 10 Mar 2017

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Cystoid macular edema associated with iridocorneal endothelial syndrome: a case report.
 

Author(s): Keita Suzuki, Tadashi Mizuguchi, Yui Seno, Atsuhiro Tanikawa, Masayuki Horiguchi

Journal:

 

Iridocorneal endothelial (ICE) syndrome occurs mainly in young and middle-aged women and typically presents as a unilateral disease characterized by abnormalities of the iris and corneal endothelium. While the ICE syndrome is known to be associated with glaucoma and bullous keratopathy, ...

Last Updated: 2 Sep 2016

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Intracameral injection of tissue plasminogen activator to treat severe postoperative fibrinous reaction in iridocorneal endothelial syndrome.
 

Author(s): Bryan K Hong, Brian A Francis

Journal:

 

Iridocorneal endothelial (ICE) syndrome is a primary endothelial abnormality that can cause a spectrum of iris changes, corneal edema, and glaucoma. Glaucoma secondary to ICE is difficult to manage because of the inflammatory reaction and fibrosis it can cause. We present a case of ...

Last Updated: 10 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Iridocorneal endothelial syndrome" returned 1 free, full-text review articles on human participants. First 3 results:

Diagnosis and Management of Iridocorneal Endothelial Syndrome.
 

Author(s): Marta Sacchetti, Flavio Mantelli, Marco Marenco, Ilaria Macchi, Oriella Ambrosio, Paolo Rama

Journal: Biomed Res Int. 2015 ;2015():763093.

 

The iridocorneal endothelial (ICE) syndrome is a rare ocular disorder that includes a group of conditions characterized by structural and proliferative abnormalities of the corneal endothelium, the anterior chamber angle, and the iris. Common clinical features include corneal edema, ...

Last Updated: 9 Oct 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Zhongshan Iridocorneal Endothelial Syndrome Study (ICEs)
 

Status: Recruiting

Condition Summary: Glaucoma

 

Last Updated: 18 Sep 2017

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Study of Endothelial Keratoplasty Outcomes
 

Status: Recruiting

Condition Summary: Fuchs' Endothelial Corneal Dystrophy; Bullous Keratopathy; Iridocorneal Endothelial Syndrome; Posterior Polymorphous Dystrophy

 

Last Updated: 9 Aug 2017

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