Intestinal pseudo-obstruction

Common Name(s)

Intestinal pseudo-obstruction

Intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. Signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. It may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality. The condition is sometimes inherited (in an X-linked recessive or autosomal dominant manner) and may be caused by mutations in the FLNA gene; it may also be acquired after certain illnesses. The goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intestinal pseudo-obstruction" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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G-PACT

G-PACT is dedicated to increasing awareness of gastroparesis (GP), chronic intestinal pseudo obstruction (CIP), and colonic inertia (CI) among medical professionals, patients, and the general population. We are working towards finding a cure and/or better treatment options for people dealing with DTP. We provide educational resources, multiple support programs, patient advocacy programs, and other aid as needed to help patients cope and to provide hope to everyone afflicted with the condition.

Last Updated: 28 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intestinal pseudo-obstruction" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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G-PACT

G-PACT is dedicated to increasing awareness of gastroparesis (GP), chronic intestinal pseudo obstruction (CIP), and colonic inertia (CI) among medical professionals, patients, and the general population. We are working towards finding a cure and/or better treatment options for people dealing with DTP. We provide educational resources, multiple support programs, patient advocacy programs, and other aid as needed to help patients cope and to provide hope to everyone afflicted with the condition.

http://www.g-pact.org

Last Updated: 28 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Intestinal pseudo-obstruction" returned 95 free, full-text research articles on human participants. First 3 results:

Intestinal pseudo-obstruction in patients with systemic sclerosis: an analysis of the Nationwide Inpatient Sample.
 

Author(s): Antonia Valenzuela, Shufeng Li, Laren Becker, Nielsen Fernandez-Becker, Dinesh Khanna, Linda Nguyen, Lorinda Chung

Journal: Rheumatology (Oxford). 2016 Apr;55(4):654-8.

 

Intestinal pseudo-obstruction is a rare gastrointestinal complication in patients with SSc without large studies examining its prevalence or outcomes. We aimed to compare outcomes in SSc patients with intestinal pseudo-obstruction to patients with intestinal pseudo-obstruction secondary ...

Last Updated: 18 Mar 2016

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Clinical analysis of 61 systemic lupus erythematosus patients with intestinal pseudo-obstruction and/or ureterohydronephrosis: a retrospective observational study.
 

Author(s): Na Xu, Jiuliang Zhao, Jinjing Liu, Di Wu, Lidan Zhao, Qian Wang, Yong Hou, Mengtao Li, Wen Zhang, Xuejun Zeng, Weigang Fang, Xiaoming Huang, Xuan Zhang, Xinping Tian, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang

Journal: Medicine (Baltimore). 2015 Jan;94(4):e419.

 

The objective of this article is to investigate the clinical features of intestinal pseudo-obstruction (IPO) and/or ureterohydronephrosis in systemic lupus erythematosus (SLE). Sixty-one SLE patients with IPO and/or ureterohydronephrosis were analyzed retrospectively. A total of 183 ...

Last Updated: 30 Jan 2015

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Mutations in RAD21 disrupt regulation of APOB in patients with chronic intestinal pseudo-obstruction.
 

Author(s): Elena Bonora, Francesca Bianco, Lina Cordeddu, Michael Bamshad, Ludmila Francescatto, Dustin Dowless, Vincenzo Stanghellini, Rosanna F Cogliandro, Greger Lindberg, Zeynel Mungan, Kivanc Cefle, Tayfun Ozcelik, Sukru Palanduz, Sukru Ozturk, Asuman Gedikbasi, Alessandra Gori, Tommaso Pippucci, Claudio Graziano, Umberto Volta, Giacomo Caio, Giovanni Barbara, Mauro D'Amato, Marco Seri, Nicholas Katsanis, Giovanni Romeo, Roberto De Giorgio

Journal: Gastroenterology. 2015 Apr;148(4):771-782.e11.

 

Chronic intestinal pseudo-obstruction (CIPO) is characterized by severe intestinal dysmotility that mimics a mechanical subocclusion with no evidence of gut obstruction. We searched for genetic variants associated with CIPO to increase our understanding of its pathogenesis and to ...

Last Updated: 25 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Intestinal pseudo-obstruction" returned 14 free, full-text review articles on human participants. First 3 results:

Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review.
 

Author(s): Napat Angkathunyakul, Suporn Treepongkaruna, Sani Molagool, Nichanan Ruangwattanapaisarn

Journal: World J. Gastroenterol.. 2015 Jun;21(22):7059-64.

 

Visceral myopathy is one of the causes of chronic intestinal pseudo-obstruction. Most cases pathologically reveal degenerative changes of myocytes or muscularis propia atrophy and fibrosis. Abnormal layering of muscularis propria is extremely rare. We report a case of a 9-mo-old Thai ...

Last Updated: 16 Jun 2015

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Intestinal pseudo-obstruction in systemic lupus erythematosus: a case report and review of the literature.
 

Author(s): Jian-lin Wang, Gang Liu, Tong Liu, Jiang-peng Wei

Journal: Medicine (Baltimore). 2014 Dec;93(29):e248.

 

Intestinal pseudo-obstruction (IPO) is a rare but dangerous complication of systemic lupus erythematosus (SLE) when the patient has no other manifestations except gastrointestinal symptoms. We performed 1 patient with a 2-month history of recurrent vomiting and abdominal distension. ...

Last Updated: 30 Dec 2014

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Intestinal pseudo-obstruction as a complication of paragangliomas: case report and literature review.
 

Author(s): T E Osinga, M N Kerstens, M M van der Klauw, J J Koornstra, B H R Wolffenbuttel, T P Links, A N A van der Horst-Schrivers

Journal: Neth J Med. 2013 Dec;71(10):512-7.

 

Intestinal pseudo-obstruction is a rare and relatively unknown complication of phaeochromocytoma÷ paraganglioma (PCC÷PGL). Its pathophysiology can be explained by the hypersecretion of catecholamines, which may reduce the peristaltic activity of the gastrointestinal tract. Clinically, ...

Last Updated: 7 Jan 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy and Safety of Fecal Microbiota Transplantation for Chronic Intestinal Pseudo-obstruction
 

Status: Recruiting

Condition Summary: Chronic Intestinal Pseudo Obstruction

 

Last Updated: 6 Apr 2016

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Last Updated: 4 Jan 2012

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Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure Patients
 

Status: Not yet recruiting

Condition Summary: Short Bowel Syndrome

 

Last Updated: 25 Sep 2015

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