Intestinal pseudo-obstruction

Common Name(s)

Intestinal pseudo-obstruction

Intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. Signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. It may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality. The condition is sometimes inherited (in an X-linked recessive or autosomal dominant manner) and may be caused by mutations in the FLNA gene; it may also be acquired after certain illnesses. The goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intestinal pseudo-obstruction" for support, advocacy or research.

G-PACT

G-PACT is dedicated to increasing awareness of gastroparesis (GP), chronic intestinal pseudo obstruction (CIP), and colonic inertia (CI) among medical professionals, patients, and the general population. We are working towards finding a cure and/or better treatment options for people dealing with DTP. We provide educational resources, multiple support programs, patient advocacy programs, and other aid as needed to help patients cope and to provide hope to everyone afflicted with the condition.

Last Updated: 28 Apr 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intestinal pseudo-obstruction" for support, advocacy or research.

G-PACT

G-PACT is dedicated to increasing awareness of gastroparesis (GP), chronic intestinal pseudo obstruction (CIP), and colonic inertia (CI) among medical professionals, patients, and the general population. We are working towards finding a cure and/or better treatment options for people dealing with DTP. We provide educational resources, multiple support programs, patient advocacy programs, and other aid as needed to help patients cope and to provide hope to everyone afflicted with the condition.

http://www.g-pact.org

Last Updated: 28 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Intestinal pseudo-obstruction" returned 76 free, full-text research articles on human participants. First 3 results:

Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction.
 

Author(s): Ming Fu, Solange Landreville, Olga A Agapova, Luke A Wiley, Michael Shoykhet, J William Harbour, Robert O Heuckeroth

Journal: J. Clin. Invest.. 2013 Dec;123(12):5152-64.

 

The retinoblastoma 1 (RB1) tumor suppressor is a critical regulator of cell cycle progression and development. To investigate the role of RB1 in neural crest-derived melanocytes, we bred mice with a floxed Rb1 allele with mice expressing Cre from the tyrosinase (Tyr) promoter. TyrCre+;Rb1fl/fl ...

Last Updated: 2 Dec 2013

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Epidemiology and clinical experience of chronic intestinal pseudo-obstruction in Japan: a nationwide epidemiologic survey.
 

Author(s): Hiroshi Iida, Hidenori Ohkubo, Masahiko Inamori, Atsushi Nakajima, Hajime Sato

Journal: J Epidemiol. 2013 ;23(4):288-94.

 

We estimated the prevalence and incidence of chronic intestinal pseudo-obstruction (CIPO) in Japan, investigated the patterns of hospital visits among those with CIPO, and examined present knowledge of CIPO among medical professionals.

Last Updated: 8 Jul 2013

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Intestinal amyloidosis with intractable diarrhea and intestinal pseudo-obstruction.
 

Author(s): Yeon-Joo Kim, Hyun-Soo Kim, Seon-Young Park, Sang-Woo Park, Yoo-Duk Choi, Chang-Hwan Park, Sung-Kyu Choi, Jong-Sun Rew

Journal: Korean J Gastroenterol. 2012 Sep;60(3):172-6.

 

We report herein a case of intestinal amyloidosis with grave prognosis that caused intractable diarrhea and intestinal pseudo-obstruction, alternately in spite of intensive conservative treatment. A 44-year-old woman was admitted for fever, diarrhea, and crampy abdominal pain which ...

Last Updated: 28 Sep 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Intestinal pseudo-obstruction" returned 10 free, full-text review articles on human participants. First 3 results:

Chronic intestinal pseudo-obstruction.
 

Author(s): Alexandra Antonucci, Lucia Fronzoni, Laura Cogliandro, Rosanna-F Cogliandro, Carla Caputo, Roberto De Giorgio, Francesca Pallotti, Giovanni Barbara, Roberto Corinaldesi, Vincenzo Stanghellini

Journal: World J. Gastroenterol.. 2008 May;14(19):2953-61.

 

Chronic intestinal pseudo-obstruction (CIPO) is a severe digestive syndrome characterized by derangement of gut propulsive motility which resembles mechanical obstruction, in the absence of any obstructive process. Although uncommon in clinical practice, this syndrome represents one ...

Last Updated: 21 May 2008

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Severe delayed complication after percutaneous endoscopic colostomy for chronic intestinal pseudo-obstruction: a case report and review of the literature.
 

Author(s): David Bertolini, Philippe De Saussure, Michael Chilcott, Marc Girardin, Jean-Marc Dumonceau

Journal: World J. Gastroenterol.. 2007 Apr;13(15):2255-7.

 

Percutaneous endoscopic colostomy (PEC) is increasingly proposed as an alternative to surgery to treat various disorders, including acute colonic pseudo-obstruction, chronic intestinal pseudo-obstruction and relapsing sigmoid volvulus. We report on a severe complication that occurred ...

Last Updated: 30 Apr 2007

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[Chronic intestinal pseudo-obstruction].
 

Author(s): M T Muñoz, J A Solís Herruzo

Journal: Rev Esp Enferm Dig. 2007 Feb;99(2):100-11.

 

Chronic intestinal pseudo-obstruction (CIPO) is a syndrome characterized by the presence of recurrent episodes of clinical intestinal obstruction in the absence of obstructive lesions. Although this syndrome is rare, it causes a high morbidity. It is caused by a disturbance of the ...

Last Updated: 9 Apr 2007

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.