Intervertebral disc disease

Common Name(s)

Intervertebral disc disease, Intervertebral disc disorder

Intervertebral disc disease (IDD) is a common musculoskeletal condition that primarily affects the back. It is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. Both environmental and genetic factors are thought to predispose an individual to developing the condition. Treatment for IDD may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion.
 

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intervertebral disc disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Intervertebral disc disease" returned 9 free, full-text research articles on human participants. First 3 results:

Screening of genes related with intervertebral disc disease by dynamic differential interaction network analysis.
 

Author(s): K Jiang, Y Li, G-Y Cao, D Liu, D-F Liao, K Gong, Q-Y Xie, Z-H Ma, X-M Pan

Journal: Eur Rev Med Pharmacol Sci. 2013 Dec;17(23):3186-91.

 

Gene expression profiles for intervertebral disc (IVD) cells treated with different osmolarities were compared to identify key genes associated with intervertebral disc diseases.

Last Updated: 16 Dec 2013

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MRI assessment of lumbar intervertebral disc degeneration with lumbar degenerative disease using the Pfirrmann grading systems.
 

Author(s): Li-Peng Yu, Wen-Wu Qian, Guo-Yong Yin, Yong-Xin Ren, Zhi-Yi Hu

Journal: PLoS ONE. 2012 ;7(12):e48074.

 

To evaluate by MRI intervertebral disc degeneration in patients with lumbar degenerative disease using the Pfirrmann grading system and to determine whether Modic changes correlated with the Pfirrmann grades and modified Pfirrmann grades of disc degeneration.

Last Updated: 3 Jan 2013

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Heparanase isoform expression and extracellular matrix remodeling in intervertebral disc degenerative disease.
 

Author(s): Luciano Miller Reis Rodrigues, Thérèse Rachell Theodoro, Leandro Luongo Matos, Ana Maria Mader, Carlo Milani, Maria Aparecida da Silva Pinhal

Journal: Clinics (Sao Paulo). 2011 ;66(5):903-9.

 

To determine the molecules involved in extracellular matrix remodeling and to identify and quantify heparanase isoforms present in herniated and degenerative discs.

Last Updated: 26 Jul 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Intervertebral disc disease" returned 3 free, full-text review articles on human participants. First 3 results:

Future perspectives of cell-based therapy for intervertebral disc disease.
 

Author(s): Daisuke Sakai

Journal: Eur Spine J. 2008 Dec;17 Suppl 4():452-8.

 

Intervertebral disc degeneration is a primary cause of low back pain and has a high societal cost. Research on cell-based therapies for intervertebral disc disease is emerging, along with the interest in biological therapy to treat disc disease without reducing the mobility of the ...

Last Updated: 26 Nov 2008

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Advances in susceptibility genetics of intervertebral degenerative disc disease.
 

Author(s): Yin'gang Zhang, Zhengming Sun, Jiangtao Liu, Xiong Guo

Journal:

 

The traditional view that the etiology of lumbar disc herniation is primarily due to age, gender, occupation, smoking and exposure to vehicular vibration dominated much of the last century. Recent research indicates that heredity may be largely responsible for the degeneration as ...

Last Updated: 10 Sep 2008

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New knowledge of intervertebral disc disease.
 

Author(s): J Ball

Journal: J Clin Pathol Suppl (R Coll Pathol). 1978 ;12():200-4.

 

Last Updated: 13 Mar 1979

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine
 

Status: Recruiting

Condition Summary: Intervertebral Disc Disease; Intervertebral Disc Degeneration; Spondylosis; Spondylolisthesis; Spinal Stenosis

 

Last Updated: 27 Dec 2013

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A Study of SI-6603 in Patients With Lumbar Disc Herniation
 

Status: Recruiting

Condition Summary: Intervertebral Disc Disease; Lumbar Disc Disease

 

Last Updated: 22 Jul 2014

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Electroacupuncture for Sciatica Due to Intervertebral Disc Displacement
 

Status: Recruiting

Condition Summary: Sciatica Due to Intervertebral Disc Disorder

 

Last Updated: 13 Mar 2014

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