Intervertebral disc disease

Common Name(s)

Intervertebral disc disease, Intervertebral disc disorder

Intervertebral disc disease (IDD) is a common musculoskeletal condition that primarily affects the back. It is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. Both environmental and genetic factors are thought to predispose an individual to developing the condition. Treatment for IDD may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intervertebral disc disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Intervertebral disc disease" returned 12 free, full-text research articles on human participants. First 3 results:

The biological basis of degenerative disc disease: proteomic and biomechanical analysis of the canine intervertebral disc.
 

Author(s): William Mark Erwin, Leroi DeSouza, Martha Funabashi, Greg Kawchuk, Muhammad Zia Karim, Sarah Kim, Stefanie Mӓdler, Ajay Matta, Xiaomei Wang, K Arne Mehrkens

Journal:

 

In the present study, we sought to quantify and contrast the secretome and biomechanical properties of the non-chondrodystrophic (NCD) and chondrodystrophic (CD) canine intervertebral disc (IVD) nucleus pulposus (NP).

Last Updated: 5 Sep 2015

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Analysis of trace element in intervertebral disc by Atomic Absorption Spectrometry techniques in degenerative disc disease in the Polish population.
 

Author(s): Andrzej Nowakowski, Łukasz Kubaszewski, Marcin Frankowski, Magdalena Wilk-Frańczuk, Anetta Zioła-Frankowska, Roża Czabak-Garbacz, Jacek Kaczmarczyk, Robert Gasik

Journal: Ann Agric Environ Med. 2015 ;22(2):362-7.

 

Although trace elements are regarded crucial and their content has been determined in number of tissue there are only few papers addressing this problem in intervertebral disc in humans. Most of the trace elements are important substrates of enzymes influencing metabolism and senescence ...

Last Updated: 22 Jun 2015

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Screening of genes related with intervertebral disc disease by dynamic differential interaction network analysis.
 

Author(s): K Jiang, Y Li, G-Y Cao, D Liu, D-F Liao, K Gong, Q-Y Xie, Z-H Ma, X-M Pan

Journal: Eur Rev Med Pharmacol Sci. 2013 Dec;17(23):3186-91.

 

Gene expression profiles for intervertebral disc (IVD) cells treated with different osmolarities were compared to identify key genes associated with intervertebral disc diseases.

Last Updated: 16 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Intervertebral disc disease" returned 3 free, full-text review articles on human participants. First 3 results:

Future perspectives of cell-based therapy for intervertebral disc disease.
 

Author(s): Daisuke Sakai

Journal: Eur Spine J. 2008 Dec;17 Suppl 4():452-8.

 

Intervertebral disc degeneration is a primary cause of low back pain and has a high societal cost. Research on cell-based therapies for intervertebral disc disease is emerging, along with the interest in biological therapy to treat disc disease without reducing the mobility of the ...

Last Updated: 26 Nov 2008

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Advances in susceptibility genetics of intervertebral degenerative disc disease.
 

Author(s): Yin'gang Zhang, Zhengming Sun, Jiangtao Liu, Xiong Guo

Journal:

 

The traditional view that the etiology of lumbar disc herniation is primarily due to age, gender, occupation, smoking and exposure to vehicular vibration dominated much of the last century. Recent research indicates that heredity may be largely responsible for the degeneration as ...

Last Updated: 10 Sep 2008

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New knowledge of intervertebral disc disease.
 

Author(s): J Ball

Journal: J Clin Pathol Suppl (R Coll Pathol). 1978 ;12():200-4.

 

Last Updated: 13 Mar 1979

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine
 

Status: Recruiting

Condition Summary: Intervertebral Disc Disease; Intervertebral Disc Degeneration; Spondylosis; Spondylolisthesis; Spinal Stenosis

 

Last Updated: 5 Oct 2015

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A Study of SI-6603 in Patients With Lumbar Disc Herniation
 

Status: Recruiting

Condition Summary: Intervertebral Disc Disease; Lumbar Disc Disease

 

Last Updated: 7 Jan 2016

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A Prospective Study of NuCel® in Cervical Spine Fusion
 

Status: Recruiting

Condition Summary: Spondylosis; Spinal Stenosis; Spondylolisthesis; Intervertebral Disc Disease; Intervertebral Disc Degeneration

 

Last Updated: 5 Oct 2015

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