Intervertebral disc disease

Common Name(s)

Intervertebral disc disease, Intervertebral disc disorder

Intervertebral disc disease (IDD) is a common musculoskeletal condition that primarily affects the back. It is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. Both environmental and genetic factors are thought to predispose an individual to developing the condition. Treatment for IDD may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Intervertebral disc disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Intervertebral disc disease" returned 15 free, full-text research articles on human participants. First 3 results:

Complex Regional Pain Syndrome Caused by Lumbar Herniated Intervertebral Disc Disease.
 

Author(s): Se Hee Kim, Sang Sik Choi, Mi Kyung Lee, Jung Eun Kin

Journal: Pain Physician. 2016 Jul;19(6):E901-4.

 

Most cases of complex regional pain syndrome (CRPS) occur after some inciting injury. There are a few cases of CRPS after an operation for disc disease. CRPS from a mild herniated intervertebral disc (HIVD) without surgical intervention is even rarer than CRPS after an operation for ...

Last Updated: 26 Jul 2016

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Evaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Disease.
 

Author(s): Adem Bozkurt Aras, Mustafa Guven, Naci Balak, Erdoğan Ayan, Suheyla Bozkurt Uyar, Ilhan Elmaci

Journal: Turk Neurosurg. 2016 ;26(2):274-9.

 

The intervertebral disc starts to degenerate when a human being begins to stand and learn to walk. It is known that many extrinsic, intrinsic and genetic factors play a role in disc degeneration. In this study, we examined whether the matrix metalloproteinase 11 might be associated ...

Last Updated: 9 Mar 2016

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The biological basis of degenerative disc disease: proteomic and biomechanical analysis of the canine intervertebral disc.
 

Author(s): William Mark Erwin, Leroi DeSouza, Martha Funabashi, Greg Kawchuk, Muhammad Zia Karim, Sarah Kim, Stefanie Mӓdler, Ajay Matta, Xiaomei Wang, K Arne Mehrkens

Journal:

 

In the present study, we sought to quantify and contrast the secretome and biomechanical properties of the non-chondrodystrophic (NCD) and chondrodystrophic (CD) canine intervertebral disc (IVD) nucleus pulposus (NP).

Last Updated: 5 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Intervertebral disc disease" returned 3 free, full-text review articles on human participants. First 3 results:

Future perspectives of cell-based therapy for intervertebral disc disease.
 

Author(s): Daisuke Sakai

Journal: Eur Spine J. 2008 Dec;17 Suppl 4():452-8.

 

Intervertebral disc degeneration is a primary cause of low back pain and has a high societal cost. Research on cell-based therapies for intervertebral disc disease is emerging, along with the interest in biological therapy to treat disc disease without reducing the mobility of the ...

Last Updated: 26 Nov 2008

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Advances in susceptibility genetics of intervertebral degenerative disc disease.
 

Author(s): Yin'gang Zhang, Zhengming Sun, Jiangtao Liu, Xiong Guo

Journal:

 

The traditional view that the etiology of lumbar disc herniation is primarily due to age, gender, occupation, smoking and exposure to vehicular vibration dominated much of the last century. Recent research indicates that heredity may be largely responsible for the degeneration as ...

Last Updated: 10 Sep 2008

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New knowledge of intervertebral disc disease.
 

Author(s): J Ball

Journal: J Clin Pathol Suppl (R Coll Pathol). 1978 ;12():200-4.

 

Last Updated: 13 Mar 1979

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Triadyme-C, a Polycrystalline Diamond Compact Cervical Disc Replacement (cTDR)
 

Status: Recruiting

Condition Summary: Intervertebral Disc Disorder Cervical

 

Last Updated: 14 Aug 2017

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Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine
 

Status: Recruiting

Condition Summary: Intervertebral Disc Disease; Intervertebral Disc Degeneration; Spondylosis; Spondylolisthesis; Spinal Stenosis

 

Last Updated: 14 Sep 2017

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Validation of the STarT Back Screening Tool in the Military
 

Status: Recruiting

Condition Summary: Low Back Pain; Lumbago; Radiculopathy; Intervertebral Disc Disorder

 

Last Updated: 20 Apr 2017

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