Inflammatory breast cancer

Common Name(s)

Inflammatory breast cancer, Breast cancer, inflammatory

Inflammatory breast cancer is a rare and rapidly developing cancer that affects the breasts. This form of breast cancer can cause rapid changes in the appearance of the breast over the course of several weeks, including enlargement of the breast, discoloration (red, purple, pink, or bruised appearance), dimpling or ridges on the skin of the affected breast (similar to an orange peel), and flatting or turning inward of the nipple. Symptoms can also include breast tenderness, pain or aching, enlarged lymph nodes under the arm, as well as a thickness and heaviness to the breast. In some cases, there may be an unusual warmth in the affected breast.

The exact cause of inflammatory breast cancer is unknown. Like all forms of cancer, inflammatory breast cancer starts with a mutation (change) within the DNA of a cell within the breast. Because of this genetic change, this abnormal cell then grows and divides faster than it should, causing a blockage of the vessels that filter and transport fluids away from breast tissue (lymphatic vessels). This blockage and buildup of fluid causes the red and swollen appearance of the breast. Risk factors for inflammatory breast cancer include gender (woman are diagnosed with inflammatory breast cancer more than men), ethnicity (black women have a higher risk), weight (obesity increases the risk of cancer), and age (the older you are, the higher your risk for inflammatory breast cancer).

A doctor can diagnose inflammatory breast cancer by performing a physical exam, collecting images of the breast (using a mammogram (breast X-ray) or breast ultrasound), and removing a sample of tissue for testing (biopsy). Treatment of inflammatory breast cancer can include chemotherapy (chemical treatment), surgery, radiation therapy, and hormone therapy. It is important to talk to your doctor if you or someone you know has been diagnosed with inflammatory breast cancer to determine the best treatment plan.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory breast cancer" for support, advocacy or research.

Inflammatory Breast Cancer Research Foundation

Our mission is to assist scientists and researchers in their quest to determine the definitive causes of inflammatory breast cancer. The Inflammatory Breast Cancer Research Foundation seeks to assist them in their work so effective and meaningful detection and diagnosis, prevention and treatment can be pursued and achieved.

Last Updated: 29 Apr 2014

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 21 May 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Kommah Seray Inflammatory Breast Cancer Foundation

To raise awareness of Inflammatory Breast Cancer and meet the immediate needs of active cancer patients by providing assistance and support. Additionally, the foundation will work toward educating medical professionals and the community at large on how to detect Inflammatory Breast Cancer.

Last Updated: 26 Mar 2013

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory breast cancer" for support, advocacy or research.

Inflammatory Breast Cancer Research Foundation

Our mission is to assist scientists and researchers in their quest to determine the definitive causes of inflammatory breast cancer. The Inflammatory Breast Cancer Research Foundation seeks to assist them in their work so effective and meaningful detection and diagnosis, prevention and treatment can be pursued and achieved.

http://www.ibcresearch.org

Last Updated: 29 Apr 2014

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 21 May 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Kommah Seray Inflammatory Breast Cancer Foundation

To raise awareness of Inflammatory Breast Cancer and meet the immediate needs of active cancer patients by providing assistance and support. Additionally, the foundation will work toward educating medical professionals and the community at large on how to detect Inflammatory Breast Cancer.

http://www.ksibcf.org

Last Updated: 26 Mar 2013

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory breast cancer" returned 251 free, full-text research articles on human participants. First 3 results:

Inflammatory breast cancer: time to standardise diagnosis assessment and management, and for the joining of forces to facilitate effective research.
 

Author(s): D Rea, A Francis, A M Hanby, V Speirs, E Rakha, A Shaaban, S Chan, S Vinnicombe, I O Ellis, S G Martin, L J Jones, F Berditchevski,

Journal: Br. J. Cancer. 2015 Apr;112(9):1613-5.

 

Last Updated: 29 Apr 2015

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Genetic polymorphisms in inflammatory response genes and their associations with breast cancer risk.
 

Author(s): Zhi Wang, Qiu-Lian Liu, Wu Sun, Chun-Jing Yang, Lei Tang, Xian Zhang, Xiao-Ming Zhong

Journal: Croat. Med. J.. 2014 Dec;55(6):638-46.

 

To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-949C>T (rs2233406), IL-8 c.-352A>T (rs4073), IL-10 c.-854T>C (rs1800871), TNF c.-418G>A (rs361525), and TNF c.-488G>A (rs1800629) polymorphisms with breast cancer risk in an East Chinese population.

Last Updated: 6 Jan 2015

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Lack of prognostic value of human epidermal growth factor-like receptor 2 status in inflammatory breast cancer (IBC): a meta-analysis.
 

Author(s): Xiu-Juan Li, Quan-Bin Zha, Xin-Yu Xu, Lei Xia, Zhe Zhang, Zhao-Jun Ren, Jin-Hai Tang

Journal: Asian Pac. J. Cancer Prev.. 2014 ;15(22):9615-9.

 

Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer which is more likely to be her-2/ neu amplified. While the her-2/neu status has been utilised to predict prognosis, the published data are inconsistent. The present meta-analysis was conducted to determine ...

Last Updated: 18 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory breast cancer" returned 26 free, full-text review articles on human participants. First 3 results:

n-3 polyunsaturated fatty acids and mechanisms to mitigate inflammatory paracrine signaling in obesity-associated breast cancer.
 

Author(s): Jennifer M Monk, Harmony F Turk, Danyelle M Liddle, Anna A De Boer, Krista A Power, David W L Ma, Lindsay E Robinson

Journal:

 

Globally, the prevalence of obesity is increasing which subsequently increases the risk of the development of obesity-related chronic diseases. Low-grade chronic inflammation and dysregulated adipose tissue inflammatory mediator/adipokine secretion are well-established in obesity, ...

Last Updated: 1 Nov 2014

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Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review.
 

Author(s): Michael Retsky, Romano Demicheli, William J M Hrushesky, Patrice Forget, Marc De Kock, Isaac Gukas, Rick A Rogers, Michael Baum, Vikas Sukhatme, Jayant S Vaidya

Journal: Curr. Med. Chem.. 2013 ;20(33):4163-76.

 

To explain a bimodal pattern of hazard of relapse among early stage breast cancer patients identified in multiple databases, we proposed that late relapses result from steady stochastic progressions from single dormant malignant cells to avascular micrometastases and then on to growing ...

Last Updated: 24 Sep 2013

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Inflammatory breast cancer: what we know and what we need to learn.
 

Author(s): Hideko Yamauchi, Wendy A Woodward, Vicente Valero, Ricardo H Alvarez, Anthony Lucci, Thomas A Buchholz, Takayuki Iwamoto, Savitri Krishnamurthy, Wei Yang, James M Reuben, Gabriel N Hortobágyi, Naoto T Ueno

Journal: Oncologist. 2012 ;17(7):891-9.

 

We review the current status of multidisciplinary care for patients with inflammatory breast cancer (IBC) and discuss what further research is needed to advance the care of patients with this disease.

Last Updated: 19 Jul 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy and Safety of Bevacizumab in the Neodjuvant Treatment of Inflammatory Breast Cancer
 

Status: Recruiting

Condition Summary: Inflammatory Breast Cancer

 

Last Updated: 14 Jun 2013

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Romidepsin and Abraxane in Treating Patients With Metastatic Inflammatory Breast Cancer
 

Status: Recruiting

Condition Summary: HER2-negative Breast Cancer; Inflammatory Breast Cancer; Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer

 

Last Updated: 17 Jun 2015

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Case-Control Study of Inflammatory Breast Cancer in North Africa
 

Status: Recruiting

Condition Summary: Inflammatory Breast Cancer

 

Last Updated: 11 Dec 2014

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