Inflammatory breast cancer

Common Name(s)

Inflammatory breast cancer, Cancer, Breast - Inflammatory

Inflammatory breast cancer is a rare but very aggressive type of breast cancer in which the cancer cells block the lymph vessels in the skin of the breast. This type of breast cancer is called “inflammatory” because the breast often looks swollen and red, or “inflamed.”  There may be no abnormality on amammogram beyond skin thickening, and a lump in the breast may not be felt.  It is crucial to identify the warning signs and clinical symptoms of IBC because a prompt diagnosis and early management can signficantly improve the outcome.  With the advent of multimodality treatments including primary systemic chemotherapy, surgery, and radiation therapy, approximately one-third of individuals diagnosed with IBC will become long-term survivors.    Like other types of breast cancer, IBC can occur in men, but usually at an older age than in women. Some studies have shown an association between family history of breast cancer and IBC, but more studies are needed to draw firm conclusions.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory breast cancer" for support, advocacy or research.

Inflammatory Breast Cancer Research Foundation

Our mission is to assist scientists and researchers in their quest to determine the definitive causes of inflammatory breast cancer. The Inflammatory Breast Cancer Research Foundation seeks to assist them in their work so effective and meaningful detection and diagnosis, prevention and treatment can be pursued and achieved.

Last Updated: 29 Apr 2014

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Breast Cancer Connections

We support people touched by breast or ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 22 Apr 2014

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Kommah Seray Inflammatory Breast Cancer Foundation

To raise awareness of Inflammatory Breast Cancer and meet the immediate needs of active cancer patients by providing assistance and support. Additionally, the foundation will work toward educating medical professionals and the community at large on how to detect Inflammatory Breast Cancer.

Last Updated: 26 Mar 2013

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory breast cancer" for support, advocacy or research.

Inflammatory Breast Cancer Research Foundation

Our mission is to assist scientists and researchers in their quest to determine the definitive causes of inflammatory breast cancer. The Inflammatory Breast Cancer Research Foundation seeks to assist them in their work so effective and meaningful detection and diagnosis, prevention and treatment can be pursued and achieved.

http://www.ibcresearch.org

Last Updated: 29 Apr 2014

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Breast Cancer Connections

We support people touched by breast or ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 22 Apr 2014

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Kommah Seray Inflammatory Breast Cancer Foundation

To raise awareness of Inflammatory Breast Cancer and meet the immediate needs of active cancer patients by providing assistance and support. Additionally, the foundation will work toward educating medical professionals and the community at large on how to detect Inflammatory Breast Cancer.

http://www.ksibcf.org

Last Updated: 26 Mar 2013

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory breast cancer" returned 195 free, full-text research articles on human participants. First 3 results:

Epigallocatechin-3-gallate inhibits stem-like inflammatory breast cancer cells.
 

Author(s): Nora D Mineva, K Eric Paulson, Stephen P Naber, Amy S Yee, Gail E Sonenshein

Journal:

 

Inflammatory Breast Cancer (IBC) is a highly aggressive form of cancer characterized by high rates of proliferation, lymphangiogenesis and metastasis, and an overall poor survival. As regular green tea consumption has been associated with improved prognosis of breast cancer patients, ...

Last Updated: 16 Sep 2013

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Statin use in primary inflammatory breast cancer: a cohort study.
 

Author(s): T M Brewer, H Masuda, D D Liu, Y Shen, P Liu, T Iwamoto, K Kai, C M Barnett, W A Woodward, J M Reuben, P Yang, G N Hortobagyi, N T Ueno

Journal: Br. J. Cancer. 2013 Jul;109(2):318-24.

 

Some studies have suggested that statins, which have cholesterol-lowering and anti-inflammatory properties, may have antitumor effects. Effects of statins on inflammatory breast cancer (IBC) have never been studied.

Last Updated: 24 Jul 2013

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Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells.
 

Author(s): Namita Chatterjee, Wei-Lin Winnie Wang, Tucker Conklin, Sridar Chittur, Martin Tenniswood

Journal: Cancer Biol. Ther.. 2013 Jul;14(7):658-71.

 

To develop new therapies for inflammatory breast cancer (IBC) we have compared the effects of two hydroxamic acid-based histone deacetylase (HDAC) inhibitors, CG-1521 and Trichostatin A (TSA) on the biology of two IBC cell lines: SUM149PT and SUM190PT. CG-1521 and TSA induce dose ...

Last Updated: 2 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory breast cancer" returned 21 free, full-text review articles on human participants. First 3 results:

Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review.
 

Author(s): Michael Retsky, Romano Demicheli, William J M Hrushesky, Patrice Forget, Marc De Kock, Isaac Gukas, Rick A Rogers, Michael Baum, Vikas Sukhatme, Jayant S Vaidya

Journal: Curr. Med. Chem.. 2013 ;20(33):4163-76.

 

To explain a bimodal pattern of hazard of relapse among early stage breast cancer patients identified in multiple databases, we proposed that late relapses result from steady stochastic progressions from single dormant malignant cells to avascular micrometastases and then on to growing ...

Last Updated: 24 Sep 2013

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Inflammatory breast cancer: what we know and what we need to learn.
 

Author(s): Hideko Yamauchi, Wendy A Woodward, Vicente Valero, Ricardo H Alvarez, Anthony Lucci, Thomas A Buchholz, Takayuki Iwamoto, Savitri Krishnamurthy, Wei Yang, James M Reuben, Gabriel N Hortobágyi, Naoto T Ueno

Journal: Oncologist. 2012 ;17(7):891-9.

 

We review the current status of multidisciplinary care for patients with inflammatory breast cancer (IBC) and discuss what further research is needed to advance the care of patients with this disease.

Last Updated: 19 Jul 2012

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Inflammatory breast cancer: the disease, the biology, the treatment.
 

Author(s): Fredika M Robertson, Melissa Bondy, Wei Yang, Hideko Yamauchi, Shannon Wiggins, Samira Kamrudin, Savitri Krishnamurthy, Huong Le-Petross, Luc Bidaut, Audrey N Player, Sanford H Barsky, Wendy A Woodward, Thomas Buchholz, Anthony Lucci, Naoto T Ueno, Naoto Ueno, Massimo Cristofanilli

Journal: CA Cancer J Clin. ;60(6):351-75.

 

Inflammatory breast cancer (IBC) is a rare and aggressive form of invasive breast cancer accounting for 2.5% of all breast cancer cases. It is characterized by rapid progression, local and distant metastases, younger age of onset, and lower overall survival compared with other breast ...

Last Updated: 15 Nov 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy and Safety of Bevacizumab in the Neodjuvant Treatment of Inflammatory Breast Cancer
 

Status: Recruiting

Condition Summary: Inflammatory Breast Cancer

 

Last Updated: 14 Jun 2013

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Case-Control Study of Inflammatory Breast Cancer in North Africa
 

Status: Recruiting

Condition Summary: Inflammatory Breast Cancer

 

Last Updated: 14 Mar 2014

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Romidepsin and Abraxane in Treating Patients With Metastatic Inflammatory Breast Cancer
 

Status: Recruiting

Condition Summary: HER2-negative Breast Cancer; Inflammatory Breast Cancer; Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer

 

Last Updated: 24 Apr 2014

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