Inflammatory breast cancer

Common Name(s)

Inflammatory breast cancer, Breast cancer, inflammatory

Inflammatory breast cancer is a rare and rapidly developing cancer that affects the breasts. This form of breast cancer can cause rapid changes in the appearance of the breast over the course of several weeks, including enlargement of the breast, discoloration (red, purple, pink, or bruised appearance), dimpling or ridges on the skin of the affected breast (similar to an orange peel), and flatting or turning inward of the nipple. Symptoms can also include breast tenderness, pain or aching, enlarged lymph nodes under the arm, as well as a thickness and heaviness to the breast. In some cases, there may be an unusual warmth in the affected breast.

The exact cause of inflammatory breast cancer is unknown. Like all forms of cancer, inflammatory breast cancer starts with a mutation (change) within the DNA of a cell within the breast. Because of this genetic change, this abnormal cell then grows and divides faster than it should, causing a blockage of the vessels that filter and transport fluids away from breast tissue (lymphatic vessels). This blockage and buildup of fluid causes the red and swollen appearance of the breast. Risk factors for inflammatory breast cancer include gender (woman are diagnosed with inflammatory breast cancer more than men), ethnicity (black women have a higher risk), weight (obesity increases the risk of cancer), and age (the older you are, the higher your risk for inflammatory breast cancer).

A doctor can diagnose inflammatory breast cancer by performing a physical exam, collecting images of the breast (using a mammogram (breast X-ray) or breast ultrasound), and removing a sample of tissue for testing (biopsy). Treatment of inflammatory breast cancer can include chemotherapy (chemical treatment), surgery, radiation therapy, and hormone therapy. It is important to talk to your doctor if you or someone you know has been diagnosed with inflammatory breast cancer to determine the best treatment plan.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory breast cancer" for support, advocacy or research.

Inflammatory Breast Cancer Research Foundation

Our mission is to assist scientists and researchers in their quest to determine the definitive causes of inflammatory breast cancer. The Inflammatory Breast Cancer Research Foundation seeks to assist them in their work so effective and meaningful detection and diagnosis, prevention and treatment can be pursued and achieved.

Last Updated: 29 Apr 2014

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

Last Updated: 21 May 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Kommah Seray Inflammatory Breast Cancer Foundation

To raise awareness of Inflammatory Breast Cancer and meet the immediate needs of active cancer patients by providing assistance and support. Additionally, the foundation will work toward educating medical professionals and the community at large on how to detect Inflammatory Breast Cancer.

Last Updated: 26 Mar 2013

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory breast cancer" for support, advocacy or research.

Inflammatory Breast Cancer Research Foundation

Our mission is to assist scientists and researchers in their quest to determine the definitive causes of inflammatory breast cancer. The Inflammatory Breast Cancer Research Foundation seeks to assist them in their work so effective and meaningful detection and diagnosis, prevention and treatment can be pursued and achieved.

http://www.ibcresearch.org

Last Updated: 29 Apr 2014

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Bay Area Cancer Connections

We support people touched by breast and ovarian cancer by providing comprehensive, personalized services in an atmosphere of warmth and compassion.

http://www.bcconnections.org

Last Updated: 21 May 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Kommah Seray Inflammatory Breast Cancer Foundation

To raise awareness of Inflammatory Breast Cancer and meet the immediate needs of active cancer patients by providing assistance and support. Additionally, the foundation will work toward educating medical professionals and the community at large on how to detect Inflammatory Breast Cancer.

http://www.ksibcf.org

Last Updated: 26 Mar 2013

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory breast cancer" returned 298 free, full-text research articles on human participants. First 3 results:

Reliability of medical records in diagnosing inflammatory breast cancer in Egypt.
 

Author(s): Lynne Le, Catherine Schairer, Ahmed Hablas, Jane Meza, Shinobu Watanabe-Galloway, Mohamed Ramadan, Sofia D Merajver, Ibrahim A Seifeldin, Amr S Soliman

Journal:

 

Inflammatory breast cancer (IBC) is a rare, aggressive breast cancer diagnosed clinically by the presence of diffuse erythema, peau d'orange, and edema that arise quickly in the affected breast. This study evaluated the validity of medical records in Gharbiah, Egypt in identifying ...

Last Updated: 17 Mar 2017

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Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine.
 

Author(s): Gerald Goh, Ramona Schmid, Kelly Guiver, Wichit Arpornwirat, Imjai Chitapanarux, Vinod Ganju, Seock-Ah Im, Sung-Bae Kim, Arunee Dechaphunkul, Jedzada Maneechavakajorn, Neil Spector, Thomas Yau, Mehdi Afrit, Slim Ben Ahmed, Stephen R Johnston, Neil Gibson, Martina Uttenreuther-Fischer, Javier Herrero, Charles Swanton

Journal:

 

Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer associated with HER2 amplification, with high risk of metastasis and an estimated median survival of 2.9 y. We performed an open-label, single-arm phase II clinical trial (ClinicalTrials.gov NCT01325428) ...

Last Updated: 6 Dec 2016

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[Inflammatory breast cancer].
 

Author(s): Sami Aziz Brahm, Fatima Zahra Ziani

Journal:

 

Last Updated: 12 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory breast cancer" returned 26 free, full-text review articles on human participants. First 3 results:

Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer.
 

Author(s): Nicholas J Brady, Pavlina Chuntova, Kathryn L Schwertfeger

Journal: Mediators Inflamm.. 2016 ;2016():4549676.

 

Macrophages are critical mediators of inflammation and important regulators of developmental processes. As a key phagocytic cell type, macrophages evolved as part of the innate immune system to engulf and process cell debris and pathogens. Macrophages produce factors that act directly ...

Last Updated: 17 Feb 2016

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n-3 polyunsaturated fatty acids and mechanisms to mitigate inflammatory paracrine signaling in obesity-associated breast cancer.
 

Author(s): Jennifer M Monk, Harmony F Turk, Danyelle M Liddle, Anna A De Boer, Krista A Power, David W L Ma, Lindsay E Robinson

Journal:

 

Globally, the prevalence of obesity is increasing which subsequently increases the risk of the development of obesity-related chronic diseases. Low-grade chronic inflammation and dysregulated adipose tissue inflammatory mediator/adipokine secretion are well-established in obesity, ...

Last Updated: 1 Nov 2014

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Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review.
 

Author(s): Michael Retsky, Romano Demicheli, William J M Hrushesky, Patrice Forget, Marc De Kock, Isaac Gukas, Rick A Rogers, Michael Baum, Vikas Sukhatme, Jayant S Vaidya

Journal: Curr. Med. Chem.. 2013 ;20(33):4163-76.

 

To explain a bimodal pattern of hazard of relapse among early stage breast cancer patients identified in multiple databases, we proposed that late relapses result from steady stochastic progressions from single dormant malignant cells to avascular micrometastases and then on to growing ...

Last Updated: 24 Sep 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Case-Control Study of Inflammatory Breast Cancer in North Africa
 

Status: Recruiting

Condition Summary: Inflammatory Breast Cancer

 

Last Updated: 20 Apr 2017

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Study Of Ruxolitinib (INCB018424) With Preoperative Chemotherapy For Triple Negative Inflammatory Breast Cancer
 

Status: Recruiting

Condition Summary: Inflammatory Breast Cancer (IBC)

 

Last Updated: 27 Apr 2017

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A Phase 2 Study of Eribulin Followed by AC as Preoperative Therapy for HER2-negative Inflammatory Breast Cancer
 

Status: Recruiting

Condition Summary: Inflammatory Breast Cancer; Human Epidermal Growth Factor 2 Negative Carcinoma of Breast

 

Last Updated: 18 Nov 2016

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