Infective endocarditis

Common Name(s)

Infective endocarditis

Infective endocarditis is an infection of the heart lining, heart valves, or blood vessels. The infection is usually caused by bacteria (bacterial endocarditis) but in some rare cases can be caused by fungus (fungal endocarditis). The risk of endocarditis is greater in individuals with heart conditions that prevent blood from moving correctly through the heart, such as those with congenital heart defects, damaged heart valves, or an implanted heart device. Those who have HIV/AIDS or IV drug users are also at increased risk for developing infective endocarditis.

Symptoms of infective endocarditis include fever, chills, fatigue, and achiness. Later symptoms include coughing, shortness of breath, weight loss, muscle and joint pain, a heart murmur, and small spots of blood under the skin or fingernails. The symptoms of infective endocarditis will typically become more severe over time as the bacteria or fungi continues to grow. It is important to seek treatment if you experience these symptoms. If untreated, endocarditis can be fatal.

Infective endocarditis can often be diagnosed using a physical examination, an ultrasound of the heart (echocardiogram), testing of heart rhythm with an EKG, blood cultures to test for bacteria, and an X-ray of the chest. Treatment usually includes IV antibiotics. Good dental hygiene is an important preventative measure, as bacteria from the mouth are likely to enter the bloodstream and can then grow in the heart. Check with your doctor if you think you may be at risk for endocarditis, and you may be given antibiotics to take before a dental procedure. If you have been diagnosed with infective endocarditis, talk to your doctor about the most current treatment options.

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Condition Specific Organizations

Following organizations serve the condition "Infective endocarditis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Infective endocarditis" returned 1013 free, full-text research articles on human participants. First 3 results:

[Microbiological approach to a possible infective endocarditis case caused by Aggregatibacter actinomycetemcomitans].
 

Author(s): Şaban Gürcan, Selahattin Ünlü, Figen Kuloğlu, Aynur Karadenizli, Mert Ahmet Kuşkucu

Journal: Mikrobiyol Bul. 2016 Apr;50(2):315-21.

 

Aggregatibacter (Actinobacillus) actinomycetemcomitans, a small, gram-negative coccobacillus that grows slow and fastidious, is generally colonized in the oral cavity. It is a rarely seen bacterium because of the difficulty of isolation but it can be a causative agent for dental infections ...

Last Updated: 14 May 2016

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Advantages and Limitations of Direct PCR Amplification of Bacterial 16S-rDNA from Resected Heart Tissue or Swabs Followed by Direct Sequencing for Diagnosing Infective Endocarditis: A Retrospective Analysis in the Routine Clinical Setting.
 

Author(s): Daniela Maneg, Janina Sponsel, Iris Müller, Benedikt Lohr, John Penders, Katharina Madlener, Klaus-Peter Hunfeld

Journal: Biomed Res Int. 2016 ;2016():7923874.

 

Infective endocarditis (IE) is a life-threatening disease that is associated with high morbidity and mortality. Its long-term prognosis strongly depends on a timely and optimized antibiotic treatment. Therefore, identification of the causative pathogen is crucial and currently based ...

Last Updated: 25 Apr 2016

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Validated Risk Score for Predicting 6-Month Mortality in Infective Endocarditis.
 

Author(s): Lawrence P Park, Vivian H Chu, Gail Peterson, Athanasios Skoutelis, Tatjana Lejko-Zupa, Emilio Bouza, Pierre Tattevin, Gilbert Habib, Ren Tan, Javier Gonzalez, Javier Altclas, Jameela Edathodu, Claudio Querido Fortes, Rinaldo Focaccia Siciliano, Orathai Pachirat, Souha Kanj, Andrew Wang,

Journal:

 

Host factors and complications have been associated with higher mortality in infective endocarditis (IE). We sought to develop and validate a model of clinical characteristics to predict 6-month mortality in IE.

Last Updated: 19 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Infective endocarditis" returned 108 free, full-text review articles on human participants. First 3 results:

Development and evaluation of a novel fast broad-range 16S ribosomal DNA PCR and sequencing assay for diagnosis of bacterial infective endocarditis: multi-year experience in a large Canadian healthcare zone and a literature review.
 

Author(s): Robert J H Miller, Barbara Chow, Dylan Pillai, Deirdre Church

Journal:

 

The study aimed to explore the sensitivity and specificity of a novel fast 16S rDNA PCR and sequencing assay for the improved diagnosis of infective endocarditis (IE) in patients with suspected native or prosthetic heart valve (HV) infection over a multi-year period at our cardiovascular center.

Last Updated: 12 Apr 2016

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Optimal timing for early surgery in infective endocarditis: a meta-analysis.
 

Author(s): Fuxiang Liang, Bing Song, Ruisheng Liu, Liu Yang, Hanbo Tang, Yuanming Li

Journal: Interact Cardiovasc Thorac Surg. 2016 Mar;22(3):336-45.

 

To systematically review early surgery and the optimal timing of surgery in patients with infective endocarditis (IE), a search for foreign and domestic articles on cohort studies about the association between early surgery and infective endocarditis published from inception to January ...

Last Updated: 13 Feb 2016

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Value of brain MRI in infective endocarditis: a narrative literature review.
 

Author(s): J Champey, P Pavese, H Bouvaist, A Kastler, A Krainik, P Francois

Journal: Eur. J. Clin. Microbiol. Infect. Dis.. 2016 Feb;35(2):159-68.

 

The nervous system is frequently involved in patients with infective endocarditis (IE). A systematic review of the literature was realized in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). This study sought to systematically evaluate ...

Last Updated: 25 Jan 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Beta-lactam Pharmacokinetics in Patients With Infective Endocarditis
 

Status: Recruiting

Condition Summary: Infective Endocarditis

 

Last Updated: 17 Jun 2015

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Last Updated: 19 Oct 2016

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Infective Endocarditis in the Elderly
 

Status: Recruiting

Condition Summary: Infective Endocarditis

 

Last Updated: 21 Sep 2016

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