Amyloidosis AA

Common Name(s)

Amyloidosis AA

Amyloidosis is a group of diseases in which a protein, called amyloid, builds up in the body's organs and tissues. Amyloidosis AA is also referred to as Secondary amyloidosis or Inflammatory amyloidosis. This disease is caused by a long-lasting infection or inflammatory disease such as rheumatoid arthritis, familial Mediterranean fever, or osteomyelitis. Infection or inflammation in the body causes an increased amount of a specific protein called serum amyloid A (SAA) protein. In this disease, part of the SAA protein forms deposits called "amyloid fibrils". These desposits occur in the space around the cells of certain tissues of the body. Amyloidosis AA usually begins as a disease in the kidneys, but other organs can be affected such as the liver and spleen. Medical or surgical treatment of the underlying infection or inflammatory disease can slow down or stop the progression of this condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyloidosis AA" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Amyloidosis AA" returned 77 free, full-text research articles on human participants. First 3 results:

AA Amyloidosis and IgG4-Related Disease.
 

Author(s): Faiz Karim, Marian Clahsen-van Groningen, Jan A M van Laar

Journal: N. Engl. J. Med.. 2017 02;376(6):599-600.

 

Last Updated: 8 Feb 2017

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AA-negative and Kappa-positive Amyloidosis in a Patient with Rheumatoid Arthritis.
 

Author(s): Toshiharu Ueno, Keiichi Sumida, Junichi Hoshino, Tatsuya Suwabe, Koki Mise, Ryo Hazue, Noriko Hayami, Rikako Hiramatsu, Masahiro Kawada, Aya Imafuku, Eiko Hasegawa, Naoki Sawa, Kenmei Takaichi, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Aya Nishida, Yoshifumi Ubara

Journal: Intern. Med.. 2016 ;55(17):2491-5.

 

A 57-year-old Japanese woman with a 5-year history of rheumatoid arthritis (RA) was admitted to our hospital for an evaluation of nephrotic range proteinuria (4.8 g/day). A renal biopsy led to the diagnosis of amyloidosis according to strong positivity for Congo red staining and the ...

Last Updated: 1 Sep 2016

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Mutational Spectrum of the MEFV Gene in AA Amyloidosis Associated With Familial Mediterranean Fever.
 

Author(s): Ayse Feyda Nursal, Akin Tekcan, Suheyla Uzun Kaya, Ercan Turkmen, Serbulent Yigit

Journal: Iran J Kidney Dis. 2016 May;10(3):107-12.

 

Familial Mediterranean fever (FMF) is a recessively inherited disease which is characterized by recurrent episodic fever, abdominal pain, and polyserositis. It is caused by mutations in the MEFV gene, encoding the pyrin protein. The most important complication of FMF is secondary ...

Last Updated: 26 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Amyloidosis AA" returned 7 free, full-text review articles on human participants. First 3 results:

AA amyloidosis: basic knowledge, unmet needs and future treatments.
 

Author(s): Laura Obici, Giampaolo Merlini

Journal:

 

Systemic AA amyloidosis is a long-term complication of several chronic inflammatory disorders, including rheumatoid arthritis, ankylosing spondylitis, autoinflammatory syndromes, Crohn's disease, malignancies and conditions predisposing to recurrent infections. Organ damage results ...

Last Updated: 1 Jun 2012

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Recent insights into the pathogenesis of type AA amyloidosis.
 

Author(s): J C H van der Hilst

Journal:

 

The amyloidoses are a group of life-threatening diseases in which fibrils made of misfolded proteins are deposited in organs and tissues. The fibrils are stable, insoluble aggregates of precursor proteins that have adopted an antiparallel beta-sheet structure. In type AA, or reactive, ...

Last Updated: 15 Mar 2011

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Susceptibility to AA amyloidosis in rheumatic diseases: a critical overview.
 

Author(s): Laura Obici, Sara Raimondi, Francesca Lavatelli, Vittorio Bellotti, Giampaolo Merlini

Journal: Arthritis Rheum.. 2009 Oct;61(10):1435-40.

 

Last Updated: 14 Oct 2009

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.