Amyloidosis AA

Common Name(s)

Amyloidosis AA

Amyloidosis is a group of diseases in which a protein, called amyloid, builds up in the body's organs and tissues. Amyloidosis AA is also referred to as Secondary amyloidosis or Inflammatory amyloidosis. This disease is caused by a long-lasting infection or inflammatory disease such as rheumatoid arthritis, familial Mediterranean fever, or osteomyelitis. Infection or inflammation in the body causes an increased amount of a specific protein called serum amyloid A (SAA) protein. In this disease, part of the SAA protein forms deposits called "amyloid fibrils". These desposits occur in the space around the cells of certain tissues of the body. Amyloidosis AA usually begins as a disease in the kidneys, but other organs can be affected such as the liver and spleen. Medical or surgical treatment of the underlying infection or inflammatory disease can slow down or stop the progression of this condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyloidosis AA" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Amyloidosis AA" returned 93 free, full-text research articles on human participants. First 3 results:

Tocilizumab for AA Amyloidosis after Treatment of Multicentric Castleman Disease with Steroids, Chemotherapy and Rituximab for Over 20 Years.
 

Author(s): Takashi Iijima, Junichi Hoshino, Tatsuya Suwabe, Keiichi Sumida, Koki Mise, Masahiro Kawada, Toshiharu Ueno, Satoshi Hamanoue, Noriko Hayami, Rikako Hiramatsu, Naoki Sawa, Kenmei Takaichi, Yoshifumi Ubara

Journal: Intern. Med.. 2015 ;54(24):3215-9.

 

We herein report the long-term outcome (30 years) of a human immunodeticiency virus- and human herpesvirus 8-negative Japanese man who was diagnosed to have multicentric Castleman disease (MCD) of the plasmacytic type after investigation of generalized lymphadenopathy at 34 of age ...

Last Updated: 15 Dec 2015

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Tocilizumab in the treatment of patients with AA amyloidosis secondary to familial Mediterranean fever.
 

Author(s): Sedat Yilmaz, Muhammet Cinar, Ismail Simsek, Hakan Erdem, Salih Pay

Journal: Rheumatology (Oxford). 2015 Mar;54(3):564-5.

 

Last Updated: 20 Feb 2015

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Colchicine use in isolated renal AA amyloidosis.
 

Author(s): Carlos F Meneses, César A Egües, Miren Uriarte, Joaquín Belzunegui, Marta Rezola

Journal: Reumatol Clin. ;11(4):242-3.

 

We present the case of a 45-year-old woman, with two-year history of chronic renal insufficiency and proteinuria. A kidney biopsy showed the presence of AA amyloidosis (positive Congo red staining and immunohistochemistry). There was no evidence of amyloid deposits in other organs ...

Last Updated: 23 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Amyloidosis AA" returned 8 free, full-text review articles on human participants. First 3 results:

AA amyloidosis: basic knowledge, unmet needs and future treatments.
 

Author(s): Laura Obici, Giampaolo Merlini

Journal:

 

Systemic AA amyloidosis is a long-term complication of several chronic inflammatory disorders, including rheumatoid arthritis, ankylosing spondylitis, autoinflammatory syndromes, Crohn's disease, malignancies and conditions predisposing to recurrent infections. Organ damage results ...

Last Updated: 1 Jun 2012

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Recent insights into the pathogenesis of type AA amyloidosis.
 

Author(s): J C H van der Hilst

Journal:

 

The amyloidoses are a group of life-threatening diseases in which fibrils made of misfolded proteins are deposited in organs and tissues. The fibrils are stable, insoluble aggregates of precursor proteins that have adopted an antiparallel beta-sheet structure. In type AA, or reactive, ...

Last Updated: 15 Mar 2011

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Susceptibility to AA amyloidosis in rheumatic diseases: a critical overview.
 

Author(s): Laura Obici, Sara Raimondi, Francesca Lavatelli, Vittorio Bellotti, Giampaolo Merlini

Journal: Arthritis Rheum.. 2009 Oct;61(10):1435-40.

 

Last Updated: 14 Oct 2009

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Progression of Renal Amyloidosis of FMF and Relation to Serum SAA Level
 

Status: Not yet recruiting

Condition Summary: Observational

 

Last Updated: 16 Aug 2010

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