Idiopathic adolescent scoliosis

Common Name(s)

Idiopathic adolescent scoliosis

Adolescent idiopathic scoliosis is an abnormal curvature of the spine that appears in late childhood or adolescence. Instead of growing straight, the spine develops a side-to-side curvature, usually in an elongated "s" or "C" shape, and the bones of the spine become slightly twisted or rotated. In many cases, the abnormal spinal curve is stable; however, in some children, the curve becomes more severe over time (progressive). For unknown reasons, severe and progressive curves occur more frequently in girls than in boys. The cause of adolescent idiopathic scoliosis is unknown. It is likely that there are both genetic and environmental factors involved. Treatment may include observation, bracing and/or surgery.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Idiopathic adolescent scoliosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Idiopathic adolescent scoliosis" returned 225 free, full-text research articles on human participants. First 3 results:

Transforming growth factor-beta (TGF- β) signaling in paravertebral muscles in juvenile and adolescent idiopathic scoliosis.
 

Author(s): Roman Nowak, Magdalena Kwiecien, Magdalena Tkacz, Urszula Mazurek

Journal: Biomed Res Int. 2014 ;2014():594287.

 

Most researchers agree that idiopathic scoliosis (IS) is a multifactorial disease influenced by complex genetic and environmental factors. The onset of the spinal deformity that determines the natural course of the disease, usually occurs in the juvenile or adolescent period. Transforming ...

Last Updated: 14 Oct 2014

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Abnormal response of the proliferation and differentiation of growth plate chondrocytes to melatonin in adolescent idiopathic scoliosis.
 

Author(s): William Wei-Jun Wang, Gene Chi-Wai Man, Jack Ho Wong, Tzi-Bun Ng, Kwong-Man Lee, Bobby Kin-Wah Ng, Hiu-Yan Yeung, Yong Qiu, Jack Chun-Yiu Cheng

Journal:

 

Abnormalities in the melatonin signaling pathway and the involvement of melatonin receptor MT2 have been reported in patients with adolescent idiopathic scoliosis (AIS). Whether these abnormalities were involved in the systemic abnormal skeletal growth in AIS during the peripubertal ...

Last Updated: 26 Sep 2014

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The effectiveness of combined bracing and exercise in adolescent idiopathic scoliosis based on SRS and SOSORT criteria: a prospective study.
 

Author(s): Stefano Negrini, Sabrina Donzelli, Monia Lusini, Salvatore Minnella, Fabio Zaina

Journal:

 

Recently an RCT confirmed brace efficacy in adolescent idiopathic scoliosis (AIS) patients. Previously, a Cochrane review suggested also producing studies according to the Scoliosis Research Society (SRS) criteria on the effectiveness of bracing for AIS. Even if the SRS criteria propose ...

Last Updated: 13 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Idiopathic adolescent scoliosis" returned 26 free, full-text review articles on human participants. First 3 results:

[Perceived self-image in adolescent idiopathic scoliosis: an integrative review of the literature].
 

Author(s): Maria Isabel Bonilla Carrasco, Maria Carmen Solano Ruiz

Journal: Rev Esc Enferm USP. 2014 Aug;48(4):748-58.

 

To learn about the experiences of adolescents diagnosed with idiopathic scoliosis.

Last Updated: 23 Oct 2014

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A review of pinealectomy-induced melatonin-deficient animal models for the study of etiopathogenesis of adolescent idiopathic scoliosis.
 

Author(s): Gene Chi Wai Man, Man Gene Chi Wai, William Wei Jun Wang, Wang William Wei Jun, Annie Po Yee Yim, Yim Annie Po Yee, Jack Ho Wong, Wong Jack Ho, Tzi Bun Ng, Ng Tzi Bun, Tsz Ping Lam, Lam Tsz Ping, Simon Kwong Man Lee, Lee Simon Kwong Man, Bobby Kin Wah Ng, Ng Bobby Kin Wah, Chi Chiu Wang, Wang Chi Chiu, Yong Qiu, Qiu Yong, Chun Yiu Cheng, Cheng Jack Chun Yiu

Journal:

 

Adolescent idiopathic scoliosis (AIS) is a common orthopedic disorder of unknown etiology and pathogenesis. Melatonin and melatonin pathway dysfunction has been widely suspected to play an important role in the pathogenesis. Many different types of animal models have been developed ...

Last Updated: 20 Sep 2014

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How 'idiopathic' is adolescent idiopathic scoliosis? A systematic review on associated abnormalities.
 

Author(s): Tom P C Schlösser, Geert J M G van der Heijden, Anne L Versteeg, René M Castelein

Journal:

 

Despite more than a century of dedicated research, the etiology and pathogenesis of adolescent idiopathic scoliosis (AIS) remain unclear. By definition, 'idiopathic' implies an unknown cause. Nevertheless, many abnormalities concomitant to AIS have been described, often with the suggestion ...

Last Updated: 13 May 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis
 

Status: Not yet recruiting

Condition Summary: Adolescent Idiopathic Scoliosis

 

Last Updated: 8 Jun 2015

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Last Updated: 26 Nov 2014

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Safety and Effectiveness Evaluation of the Minimal Invasive Deformity Correction (MID-C) System in Adolescent Idiopathic Scoliosis (AIS)
 

Status: Not yet recruiting

Condition Summary: Adolescent Idiopathic Scoliosis (AIS)

 

Last Updated: 13 Jan 2015

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