Ichthyosis

Common Name(s)

Ichthyosis

Ichthyosis is an umbrella term used to describe the many forms of inherited skin disorders in which dead skin cells accumulate in thick, dry scales on your skin's surface. Types of ichthyoses are classified by their appearance and their genetic cause. Ichthyosis vulgaris, accounts for 95% of all ichthyosis cases. Sometimes, mild cases of ichthyosis go undiagnosed because they're mistaken for extremely dry skin. Also, sometimes, other skin diseases, such as the allergic skin condition eczema, are associated with ichthyosis. Exposure to sunlight may improve or worsen the condition. In some cases, excess dead skin sheds much better from wet tanned skin after bathing or a swim, although the dry skin might be preferable to the damaging effects of sun exposure.

There is no cure for ichthyosis. The main goal of treatment is to moisturize and exfoliate. This helps prevent dryness, scaling, cracking and build-up of skin.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ichthyosis" for support, advocacy or research.

Foundation for Ichthyosis and Related Skin Types, Inc.

The Foundation's mission is to educate, inspire, and connect those touched by ichthyosis and related disorders through emotional support, information, advocacy and research funding for better treatments and eventual cures.

Last Updated: 14 Jan 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ichthyosis" for support, advocacy or research.

Foundation for Ichthyosis and Related Skin Types, Inc.

The Foundation's mission is to educate, inspire, and connect those touched by ichthyosis and related disorders through emotional support, information, advocacy and research funding for better treatments and eventual cures.

http://www.firstskinfoundation.org

Last Updated: 14 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ichthyosis" returned 215 free, full-text research articles on human participants. First 3 results:

A case of harlequin ichthyosis treated with isotretinoin.
 

Author(s): Laura M Chang, Melissa Reyes

Journal:

 

Harlequin ichthyosis is a rare congenital ichthyosis classified under the category of Autosomal Recessive Congenital Ichthyoses, which also include lamellar ichthyosis and congenital ichthyosiform erythroderma. It is caused by functional null mutations in the ABCA12 gene, a keratinocyte ...

Last Updated: 11 Mar 2014

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Prevalence of inherited ichthyosis in France: a study using capture-recapture method.
 

Author(s): Isabelle Dreyfus, Cécile Chouquet, Khaled Ezzedine, Sophie Henner, Christine Chiavérini, Aude Maza, Sandrine Pascal, Lauriane Rodriguez, Pierre Vabres, Ludovic Martin, Stéphanie Mallet, Sébastien Barbarot, Jérôme Dupuis, Juliette Mazereeuw-Hautier

Journal:

 

Inherited ichthyoses represent a group of rare skin disorders characterized by scaling, hyperkeratosis and inconstant erythema, involving most of the tegument. Epidemiology remains poorly described. This study aims to evaluate the prevalence of inherited ichthyosis (excluding very ...

Last Updated: 9 Jan 2014

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Mosaic epidermolytic ichthyosis--case report.
 

Author(s): Marcela Sena Teixeira Mendes, Samara Silva Kouzak, Thaissa Araújo Aquino, Gustavo Henrique Soares Takano, Antonio de Padua Lima

Journal: An Bras Dermatol. ;88(6 Suppl 1):116-9.

 

Epidermolytic ichthyosis is a rare autosomal dominant disease that manifests at birth with fragile blisters and erosions that evolve into hyperkeratotic lesions associated or not with erythroderma. When the disease is associated with a mutation in cytokeratin 1, it may be related ...

Last Updated: 18 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ichthyosis" returned 13 free, full-text review articles on human participants. First 3 results:

Detection of the STS gene in a family with X-linked recessive ichthyosis.
 

Author(s): Na Wang, Kun An, Hong Liu, Xi'an Fu, Gongqi Yu, Yongxiang Yu, Hongqing Tian, Furen Zhang

Journal: Indian J Dermatol Venereol Leprol. ;79(2):268.

 

Last Updated: 27 Feb 2013

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Ichthyosis in the newborn.
 

Author(s): Brittany G Craiglow

Journal: Semin. Perinatol.. 2013 Feb;37(1):26-31.

 

The ichthyoses encompass a variety of genetic disorders marked by abnormal epidermal differentiation. The neonatal period is critical for patients with ichthyosis because of the risk for significant associated morbidity and mortality, with the majority of complications arising as ...

Last Updated: 19 Feb 2013

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[X-chromosome-linked ichthyosis associated to epilepsy, hyperactivity, autism and mental retardation, due to the Xp22.31 microdeletion].
 

Author(s): M Carmen Carrascosa-Romero, Javier Suela, Blanca Alfaro-Ponce, Antonio J Cepillo-Boluda

Journal: Rev Neurol. 2012 Feb;54(4):241-8.

 

X-chromosome-linked ichthyosis is caused by mutation or deletion of the STS gene associated with a deficiency of the enzyme steroid sulphatase, located in the distal part of the short arm of the X chromosome (Xp22.3-pter), close to the pseudo-autosomal region. Depending on its size, ...

Last Updated: 8 Feb 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous
 

Status: Not yet recruiting

Condition Summary: Lamellar Ichthyosis

 

Last Updated: 15 Oct 2010

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Studies of Skin Microbes in Healthy People and in People With Skin Conditions
 

Status: Recruiting

Condition Summary: Atopic Dermatitis; Eczema; Ichthyosis Vulgaris

 

Last Updated: 11 Nov 2014

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Sjogren-Larsson Syndrome: Natural History, Clinical Variation and Evaluation of Biochemical Markers
 

Status: Recruiting

Condition Summary: Sjogren-Larsson Syndrome (SLS)

 

Last Updated: 29 Oct 2013

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