Ichthyosis

Common Name(s)

Ichthyosis

Ichthyosis is an umbrella term used to describe the many forms of inherited skin disorders in which dead skin cells accumulate in thick, dry scales on your skin's surface. Types of ichthyoses are classified by their appearance and their genetic cause. Ichthyosis vulgaris, accounts for 95% of all ichthyosis cases. Sometimes, mild cases of ichthyosis go undiagnosed because they're mistaken for extremely dry skin. Also, sometimes, other skin diseases, such as the allergic skin condition eczema, are associated with ichthyosis. Exposure to sunlight may improve or worsen the condition. In some cases, excess dead skin sheds much better from wet tanned skin after bathing or a swim, although the dry skin might be preferable to the damaging effects of sun exposure.

There is no cure for ichthyosis. The main goal of treatment is to moisturize and exfoliate. This helps prevent dryness, scaling, cracking and build-up of skin.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ichthyosis" for support, advocacy or research.

Foundation for Ichthyosis and Related Skin Types, Inc.

The Foundation's mission is to educate, inspire, and connect those touched by ichthyosis and related disorders through emotional support, information, advocacy and research funding for better treatments and eventual cures.

Last Updated: 15 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ichthyosis" for support, advocacy or research.

Foundation for Ichthyosis and Related Skin Types, Inc.

The Foundation's mission is to educate, inspire, and connect those touched by ichthyosis and related disorders through emotional support, information, advocacy and research funding for better treatments and eventual cures.

http://www.firstskinfoundation.org

Last Updated: 15 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ichthyosis" returned 237 free, full-text research articles on human participants. First 3 results:

Frequent somatic reversion of KRT1 mutations in ichthyosis with confetti.
 

Author(s): Keith A Choate, Yin Lu, Jing Zhou, Peter M Elias, Samir Zaidi, Amy S Paller, Anita Farhi, Carol Nelson-Williams, Debra Crumrine, Leonard M Milstone, Richard P Lifton

Journal: J. Clin. Invest.. 2015 Apr;125(4):1703-7.

 

Widespread reversion of genetic disease is rare; however, such events are particularly evident in some skin disorders in which normal clones develop on a background of affected skin. We previously demonstrated that mutations in keratin 10 (KRT10) cause ichthyosis with confetti (IWC), ...

Last Updated: 2 Apr 2015

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A novel mutation in the transglutaminase-1 gene in an autosomal recessive congenital ichthyosis patient.
 

Author(s): D Vaigundan, Neha V Kalmankar, J Krishnappa, N Yellappa Gowda, A V M Kutty, Patnam R Krishnaswamy

Journal: Biomed Res Int. 2014 ;2014():706827.

 

Structure-function implication on a novel homozygous Trp250/Gly mutation of transglutaminase-1 (TGM1) observed in a patient of autosomal recessive congenital ichthyosis is invoked from a bioinformatics analysis. Structural consequences of this mutation are hypothesized in comparison ...

Last Updated: 2 Sep 2014

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X-linked ichthyosis.
 

Author(s): Anirban Das, Vivek Mishra

Journal: Indian Pediatr. 2014 Aug;51(8):678.

 

Last Updated: 18 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ichthyosis" returned 14 free, full-text review articles on human participants. First 3 results:

Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis.
 

Author(s): Peter M Elias, Mary L Williams, Eung-Ho Choi, Kenneth R Feingold

Journal: Biochim. Biophys. Acta. 2014 Mar;1841(3):353-61.

 

X-linked ichthyosis is a relatively common syndromic form of ichthyosis most often due to deletions in the gene encoding the microsomal enzyme, steroid sulfatase, located on the short area of the X chromosome. Syndromic features are mild or unapparent unless contiguous genes are affected. ...

Last Updated: 25 Feb 2014

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Detection of the STS gene in a family with X-linked recessive ichthyosis.
 

Author(s): Na Wang, Kun An, Hong Liu, Xi'an Fu, Gongqi Yu, Yongxiang Yu, Hongqing Tian, Furen Zhang

Journal: Indian J Dermatol Venereol Leprol. ;79(2):268.

 

Last Updated: 27 Feb 2013

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Ichthyosis in the newborn.
 

Author(s): Brittany G Craiglow

Journal: Semin. Perinatol.. 2013 Feb;37(1):26-31.

 

The ichthyoses encompass a variety of genetic disorders marked by abnormal epidermal differentiation. The neonatal period is critical for patients with ichthyosis because of the risk for significant associated morbidity and mortality, with the majority of complications arising as ...

Last Updated: 19 Feb 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous
 

Status: Not yet recruiting

Condition Summary: Lamellar Ichthyosis

 

Last Updated: 15 Oct 2010

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Studies of Skin Microbes in Healthy People and in People With Skin Conditions
 

Status: Recruiting

Condition Summary: Atopic Dermatitis; Eczema; Ichthyosis Vulgaris

 

Last Updated: 3 Jun 2015

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A Study of Topical NS2 Cream to Treat Ichthyosis in Sjögren-Larsson Syndrome (SLS)
 

Status: Recruiting

Condition Summary: Sjögren-Larsson Syndrome

 

Last Updated: 10 Jul 2015

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