Ichthyosis

Common Name(s)

Ichthyosis

Ichthyosis is an umbrella term used to describe the many forms of inherited skin disorders in which dead skin cells accumulate in thick, dry scales on your skin's surface. Types of ichthyoses are classified by their appearance and their genetic cause. Ichthyosis vulgaris, accounts for 95% of all ichthyosis cases. Sometimes, mild cases of ichthyosis go undiagnosed because they're mistaken for extremely dry skin. Also, sometimes, other skin diseases, such as the allergic skin condition eczema, are associated with ichthyosis. Exposure to sunlight may improve or worsen the condition. In some cases, excess dead skin sheds much better from wet tanned skin after bathing or a swim, although the dry skin might be preferable to the damaging effects of sun exposure.

There is no cure for ichthyosis. The main goal of treatment is to moisturize and exfoliate. This helps prevent dryness, scaling, cracking and build-up of skin.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ichthyosis" for support, advocacy or research.

Foundation for Ichthyosis and Related Skin Types, Inc.

The Foundation's mission is to educate, inspire, and connect those touched by ichthyosis and related disorders through emotional support, information, advocacy and research funding for better treatments and eventual cures.

Last Updated: 15 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ichthyosis" for support, advocacy or research.

Foundation for Ichthyosis and Related Skin Types, Inc.

The Foundation's mission is to educate, inspire, and connect those touched by ichthyosis and related disorders through emotional support, information, advocacy and research funding for better treatments and eventual cures.

http://www.firstskinfoundation.org

Last Updated: 15 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ichthyosis" returned 304 free, full-text research articles on human participants. First 3 results:

[Identification of gene mutation and prenatal diagnosis in a family with X-linked ichthyosis].
 

Author(s): Ji-Wei Huang, Ning Tang, Wu-Gao Li, Zhe-Tao Li, Shi-Qiang Luo, Jing-Wen Li, Jun Huang, Ti-Zhen Yan

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Nov;18(11):1136-1140.

 

X-linked ichthyosis (XLI) is a metabolic disease with steroid sulfatase deficiency and often occurs at birth or shortly after birth. The encoding gene of steroid sulfatase, STS, is located on the short arm of the X chromosome, and STS deletion or mutation can lead to the development ...

Last Updated: 7 Nov 2016

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Extensive Post-zygotic Mosaicism of KRT1 or KRT10 Mutation Mimicking Classical Epider-molytic Ichthyosis.
 

Author(s): Maella Severino-Freire, Nathalie Jonca, Melanie Pichery, Emilie Tournier, Nicolas Chassaing, Juliette Mazereeuw-Hautier

Journal: Acta Derm. Venereol.. 2017 Mar;97(3):387-388.

 

is missing (short communication).

Last Updated: 10 Oct 2016

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Lamellar ichthyosis-like eruption associated with ponatinib.
 

Author(s): Özge Mine Örenay, Funda Tamer, Evren Sarıfakıoğlu, Umran Yıldırım

Journal: Acta Dermatovenerol Alp Pannonica Adriat. 2016 Sep;25(3):59-60.

 

Last Updated: 3 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ichthyosis" returned 18 free, full-text review articles on human participants. First 3 results:

From Hyperactive Connexin26 Hemichannels to Impairments in Epidermal Calcium Gradient and Permeability Barrier in the Keratitis-Ichthyosis-Deafness Syndrome.
 

Author(s): Isaac E García, Felicitas Bosen, Paula Mujica, Amaury Pupo, Carolina Flores-Muñoz, Oscar Jara, Carlos González, Klaus Willecke, Agustín D Martínez

Journal: J. Invest. Dermatol.. 2016 Mar;136(3):574-83.

 

The keratitis-ichthyosis-deafness (KID) syndrome is characterized by corneal, skin, and hearing abnormalities. KID has been linked to heterozygous dominant missense mutations in the GJB2 and GJB6 genes, encoding connexin26 and 30, respectively. In vitro evidence indicates that KID ...

Last Updated: 23 Feb 2016

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Ichthyosis with confetti: clinics, molecular genetics and management.
 

Author(s): Liliana Guerra, Andrea Diociaiuti, May El Hachem, Daniele Castiglia, Giovanna Zambruno

Journal:

 

Ichthyosis with confetti (IWC) is an autosomal dominant congenital ichthyosis also known as ichthyosis variegata or congenital reticular ichthyosiform erythroderma. It manifests at birth with generalized ichthyosiform erythroderma or with a collodion baby picture. The erythrodermic ...

Last Updated: 19 Sep 2015

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Annular epidermolytic ichthyosis: a rare phenotypic variant of bullous congenital ichthyosiform erythroderma.
 

Author(s): Aditi Jha, Jitender Taneja, V Ramesh, Avninder Singh

Journal: Indian J Dermatol Venereol Leprol. ;81(2):194-7.

 

Last Updated: 10 Mar 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 1 Sep 2016

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A Safety and Tolerability Study of Topical PAT-001 in Congenital Ichthyosis
 

Status: Recruiting

Condition Summary: Congenital Ichthyosis

 

Last Updated: 17 Jan 2017

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The Efficacy and Safety of Secukinumab in Patients With Ichthyoses
 

Status: Recruiting

Condition Summary: Ichthyosis; Autosomal Recessive Congenital Ichthyosis; Lamellar Ichthyosis; Congenital Ichthyosiform Erythroderma; Epidermolytic Ichthyosis; Netherton Syndrome

 

Last Updated: 31 Jan 2017

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