Postural orthostatic tachycardia syndrome

Common Name(s)

Postural orthostatic tachycardia syndrome, Hypovolemic postural tachycardia syndrome

Postural orthostatic tachycardia syndrome (POTS) describes a group of symptoms that are commonly seen together. For people with POTS, going from a position of lying on their back (supine position) to sitting up causes an increased heart rate (tachycardia). The person’s blood pressure often does not change, but when it does it can be either lower or higher than normal. POTS may make it difficult for one to do day to day tasks and thus can affect quality of life.

People with POTS have a rapid heart rate when sitting up or standing. Other symptoms may include fainting, migraines, fatigue, and blotchy purplish skin while standing (blood pooling). Anyone can develop POTS, but it is more common in women under 50. Although the symptoms are similar to those of panic and anxiety disorders, POTS is not a mental health condition. Its underlying causes are many, including certain genetic conditions (e.g. Ehlers-Danlos syndrome, mitochondrial disease), diabetes, hepatitis C, pregnancy, multiple sclerosis, vitamin deficiencies, anemia, certain infections (e.g. mononucleosis, Epstein Barr virus, & Lyme disease), autoimmune disorders (e.g. Lupus, Sjorgren’s syndrome, & sarcoidosis) and more.

A tilt table test, which monitors heart rate as the table goes from a flat to upright position, is used to diagnose POTS. Other tests will be performed to determine the underlying cause. Treatment may include certain dietary changes and medications, but again is dependent on the underlying cause. Long term outlook is also dependent on the underlying cause and the severity of symptoms. Research is ongoing, so talk to your doctor about the most current treatment options. If your diagnosis includes a genetic condition, talk to a genetic counselor to learn more information about genetic testing and the condition. Support groups are also good resources of information and can help connect you with others living with POTS.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Postural orthostatic tachycardia syndrome" for support, advocacy or research.

Ehlers-Danlos Support UK

EDS UK was set up in 1987 to support, advise and inform those living with Ehlers-Danlos Syndrome. We aim to help them live a full, active and positive life. Over 25 years later, we remain the only UK based charity that exclusively represents and supports people with all types of EDS. We run regular events and conferences to bring our community together, and produce literature and merchandise to increase understanding and improve management of the condition. We have over 30 support groups around the country to provide our members with a local peer support network and we hope to expand this

Last Updated: 17 Aug 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Postural orthostatic tachycardia syndrome" for support, advocacy or research.

Ehlers-Danlos Support UK

EDS UK was set up in 1987 to support, advise and inform those living with Ehlers-Danlos Syndrome. We aim to help them live a full, active and positive life. Over 25 years later, we remain the only UK based charity that exclusively represents and supports people with all types of EDS. We run regular events and conferences to bring our community together, and produce literature and merchandise to increase understanding and improve management of the condition. We have over 30 support groups around the country to provide our members with a local peer support network and we hope to expand this

http://www.ehlers-danlos.org

Last Updated: 17 Aug 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Postural orthostatic tachycardia syndrome" returned 49 free, full-text research articles on human participants. First 3 results:

Orthostatic Intolerance and Postural Orthostatic Tachycardia Syndrome in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome, Hypermobility Type: Neurovegetative Dysregulation or Autonomic Failure?
 

Author(s): Claudia Celletti, Filippo Camerota, Marco Castori, Federica Censi, Laura Gioffrè, Giovanni Calcagnini, Stefano Strano

Journal: Biomed Res Int. 2017 ;2017():9161865.

 

Background. Joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type (JHS/EDS-HT), is a hereditary connective tissue disorder mainly characterized by generalized joint hypermobility, skin texture abnormalities, and visceral and vascular dysfunctions, also comprising ...

Last Updated: 13 Mar 2017

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Orthostatic intolerance symptoms are associated with depression and diminished quality of life in patients with postural tachycardia syndrome.
 

Author(s): Jangsup Moon, Do-Yong Kim, Jung-Ick Byun, Jun-Sang Sunwoo, Jung-Ah Lim, Tae-Joon Kim, Jung-Won Shin, Woo-Jin Lee, Han Sang Lee, Jin-Sun Jun, Kyung-Il Park, Keun-Hwa Jung, Soon-Tae Lee, Ki-Young Jung, Kon Chu, Sang Kun Lee

Journal:

 

Patients with postural tachycardia syndrome often appear depressive and report diminished quality of life (QOL). In the current study, we first evaluated if the maximal heart rate (HR) increment after standing is associated with the clinical symptoms in patients with excessive orthostatic ...

Last Updated: 12 Oct 2016

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Postural orthostatic tachycardia syndrome is associated with platelet storage pool deficiency.
 

Author(s): William T Gunning, Beverly L Karabin, Thomas M Blomquist, Blair P Grubb

Journal: Medicine (Baltimore). 2016 Sep;95(37):e4849.

 

Mechanisms have been postulated to explain postural orthostatic tachycardia syndrome (POTS), however, the etiology of this often debilitating disorder remains unknown. We conducted a retrospective case-control study of 181 POTS patients who exhibited/reported bleeding symptoms for ...

Last Updated: 16 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Postural orthostatic tachycardia syndrome" returned 4 free, full-text review articles on human participants. First 3 results:

Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance.
 

Author(s): Emily M Garland, Jorge E Celedonio, Satish R Raj

Journal: Curr Neurol Neurosci Rep. 2015 Sep;15(9):60.

 

Postural tachycardia syndrome (POTS) is a form of chronic orthostatic intolerance for which the hallmark physiological trait is an excessive increase in heart rate with assumption of upright posture. The orthostatic tachycardia occurs in the absence of orthostatic hypotension and ...

Last Updated: 22 Jul 2015

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Exercise in the postural orthostatic tachycardia syndrome.
 

Author(s): Qi Fu, Benjamin D Levine

Journal: Auton Neurosci. 2015 Mar;188():86-9.

 

Patients with the Postural Orthostatic Tachycardia Syndrome (POTS) have orthostatic intolerance, as well as exercise intolerance. Peak oxygen uptake (VO2peak) is generally lower in these patients compared with healthy sedentary individuals, suggesting a lower physical fitness level. ...

Last Updated: 20 Feb 2015

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Postural orthostatic tachycardia syndrome.
 

Author(s): A K Agarwal, R Garg, A Ritch, P Sarkar

Journal: Postgrad Med J. 2007 Jul;83(981):478-80.

 

Postural orthostatic tachycardia syndrome (POTS) is an autonomic disturbance which has become better understood in recent years. It is now thought to encompass a group of disorders that have similar clinical features, such as orthostatic intolerance, but individual distinguishing ...

Last Updated: 10 Jul 2007

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of Ivabradine on Patients With Postural Orthostatic Tachycardia Syndrome
 

Status: Recruiting

Condition Summary: Postural Orthostatic Tachycardia Syndrome

 

Last Updated: 20 Jun 2017

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Iron Sucrose in Adolescents With Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS)
 

Status: Recruiting

Condition Summary: Postural Orthostatic Tachycardia Syndrome

 

Last Updated: 15 Sep 2016

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Transdermal Vagal Stimulation for POTS
 

Status: Recruiting

Condition Summary: Postural Orthostatic Tachycardia Syndrome

 

Last Updated: 13 Jan 2017

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