Hypothalamic dysfunction

Common Name(s)

Hypothalamic dysfunction

Hypothalamic dysfunction refers to a condition in which the hypothalamus is not working properly. The hypothalamus produces hormones that control body temperature, hunger, moods, release of hormones from many glands such as the pituitary gland, sex drive, sleep, and thirst. The signs and symptoms patients have vary depending on the hormones missing. A number of different causes including anorexia, bleeding, genetic disorder, tumors, and more have been linked to hypothalamic dysfunction. Treatment depends on the cause of the hypothalamic dysfunction.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypothalamic dysfunction" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypothalamic dysfunction" returned 28 free, full-text research articles on human participants. First 3 results:

Evaluation of the hypothalamic-pituitary-adrenal axis and its relationship with central respiratory dysfunction in children with Prader-Willi syndrome.
 

Author(s): Veronique Beauloye, K Dhondt, W Buysse, A Nyakasane, F Zech, J De Schepper, S Van Aken, K De Waele, M Craen, I Gies, I Francois, D Beckers, A Desloovere, G Francois, M Cools

Journal:

 

Children with Prader-Willi Syndrome (PWS) have been considered at risk for central adrenal insufficiency (CAI). Hypothalamic dysregulation has been proposed as a common mechanism underlying both stress-induced CAI and central respiratory dysfunction during sleep.

Last Updated: 2 Sep 2015

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Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD): exome sequencing of trios, monozygotic twins and tumours.
 

Author(s): Sarah F Barclay, Casey M Rand, Lauren A Borch, Lisa Nguyen, Paul A Gray, William T Gibson, Richard J A Wilson, Paul M K Gordon, Zaw Aung, Elizabeth M Berry-Kravis, Diego Ize-Ludlow, Debra E Weese-Mayer, N Torben Bech-Hansen

Journal:

 

Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) is thought to be a genetic disease caused by de novo mutations, though causative mutations have yet to be identified. We searched for de novo coding mutations among a carefully-diagnosed ...

Last Updated: 25 Aug 2015

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Hypothalamic-pituitary-adrenal axis dysfunction and illness progression in bipolar disorder.
 

Author(s): Gabriel Rodrigo Fries, Mirela Paiva Vasconcelos-Moreno, Carolina Gubert, Bárbara Tietböhl Martins Quadros dos Santos, Juliana Sartori, Bárbara Eisele, Pamela Ferrari, Adam Fijtman, Joëlle Rüegg, Nils Christian Gassen, Flávio Kapczinski, Theo Rein, Márcia Kauer-Sant'Anna

Journal:

 

Impaired stress resilience and a dysfunctional hypothalamic-pituitary-adrenal (HPA) axis are suggested to play key roles in the pathophysiology of illness progression in bipolar disorder (BD), but the mechanisms leading to this dysfunction have never been elucidated. This study aimed ...

Last Updated: 15 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypothalamic dysfunction" returned 5 free, full-text review articles on human participants. First 3 results:

[Hypothalamic dysfunction in obesity].
 

Author(s): Simone van de Sande-Lee, Licio A Velloso

Journal: Arq Bras Endocrinol Metabol. 2012 Aug;56(6):341-50.

 

Obesity, defined as abnormal or excessive fat accumulation that may impair life quality, is one of the major public health problems worldwide. It results from an imbalance between food intake and energy expenditure. The control of energy balance in animals and humans is performed ...

Last Updated: 19 Sep 2012

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Rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dysregulation (ROHHAD): a case with additional features and review of the literature.
 

Author(s): H B Chew, L H Ngu, W T Keng

Journal:

 

A rare syndrome of rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dysregulation (ROHHAD) has been recently described. We report the first patient with this syndrome in Southeast Asia and review reported cases to date. Our patient was good health with ...

Last Updated: 20 Jun 2012

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[Childhood maltreatment and adult psychopathology: pathways to hypothalamic-pituitary-adrenal axis dysfunction].
 

Author(s): Marcelo F Mello, Alvaro A Faria, Andrea F Mello, Linda L Carpenter, Audrey R Tyrka, Lawrence H Price

Journal: Rev Bras Psiquiatr. 2009 Oct;31 Suppl 2():S41-8.

 

The aim of this paper was to examine the relationship between childhood maltreatment and adult psychopathology, as reflected in hypothalamic-pituitary-adrenal axis dysfunction.

Last Updated: 7 Dec 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Reproductive Hormones During Sustained Administration of Kisspeptin
 

Status: Recruiting

Condition Summary: Fertility Disorders; Hypothalamic Dysfunction

 

Last Updated: 27 Oct 2015

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Last Updated: 17 May 2016

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Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients
 

Status: Recruiting

Condition Summary: Hypopituitarism; Hypogonadism; Thyroid Dysfunction; Bone Diseases, Metabolic

 

Last Updated: 18 Sep 2015

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