Hypospadias

Common Name(s)

Hypospadias

Hypospadias is a birth defect in which the urethra (the tube that drains urine from the bladder) is abnormally located on the underside of the penis instead of at the tip. It is typically diagnosed at birth, but less severe hypospadius can potentially go overlooked. Hypospadias is caused by an inbalance of hormones required for normal development of the urethra. Treatment involves surgery to reposition the urethra, most commonly resulting in normal appearance and function of the penis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypospadias" for support, advocacy or research.

AIS-DSD Support Group

The AIS-DSD Support Group is a compassionate community of individuals, families and allies collaborating to promote better lives and informed decision-making through advancement of knowledge so no one will face a diagnosis alone.

Last Updated: 12 Jan 2015

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Hypospadias Epispadias Association

The Hypospadias and Epispadias Association, Inc. (HEA) is an organization founded in the year 2000 for the support and education of people born with hypospadias or epispadias and their families, loved ones, and medical care givers.

Last Updated: 25 Mar 2013

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Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

Last Updated: 8 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypospadias" for support, advocacy or research.

AIS-DSD Support Group

The AIS-DSD Support Group is a compassionate community of individuals, families and allies collaborating to promote better lives and informed decision-making through advancement of knowledge so no one will face a diagnosis alone.

http://www.aisdsd.org

Last Updated: 12 Jan 2015

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Hypospadias Epispadias Association

The Hypospadias and Epispadias Association, Inc. (HEA) is an organization founded in the year 2000 for the support and education of people born with hypospadias or epispadias and their families, loved ones, and medical care givers.

http://www.HEAinfo.org

Last Updated: 25 Mar 2013

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Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

http://www.PullthruNetwork.org

Last Updated: 8 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypospadias" returned 274 free, full-text research articles on human participants. First 3 results:

Outcomes of Patients with Glanular Hypospadias or Dorsal Hood Deformity with Mild Chordee Ttreated by Modified Firlit's Technique.
 

Author(s): Farshid Alizadeh, Shekoufeh Shirani

Journal:

 

To assess the success and complication rates of glanular hypospadias or dorsal hood deformity surgery,using a modified Firlit's technique without glanuloplasty.

Last Updated: 8 Dec 2016

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The Ideal Use of Catheters in Hypospadias Repair: An Experimental Study.
 

Author(s): Haci Polat, Umut Gulacti

Journal:

 

To find answers to some catheter-related questions in hypospadias repair such as which type of catheter should be used, with which catheter balloon inflation volume, and when should the catheter be removed from the urethra? As catheter use and post-op retention time varies among surgeons ...

Last Updated: 13 Oct 2016

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[Effect of epidermal growth factor and testosterone on androgen receptor activation in urethral plate fibroblasts in hypospadias].
 

Author(s): Junshan Lin, Cheng Xie, Ruiqing Chen, Dumiao Li

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 May;41(5):507-12.

 

To investigate androgen receptor (AR) expression and the effect of epidermal growth factor (EGF) and testosterone on AR expression level.


Last Updated: 9 Jun 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypospadias" returned 23 free, full-text review articles on human participants. First 3 results:

Diethylstilbestrol-induced mouse hypospadias: "window of susceptibility".
 

Author(s): Adriane Watkins Sinclair, Mei Cao, Laurence Baskin, Gerald R Cunha

Journal: Differentiation. ;91(1-3):1-18.

 

This review presents published and novel results that define the programming window for diethylstilbestrol (DES)-induced abnormal development of the mouse penis. These data indicate that DES has its greatest effect during the period of most intense penile morphogenesis, namely postnatal ...

Last Updated: 22 Mar 2016

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The Genetic and Environmental Factors Underlying Hypospadias.
 

Author(s): Aurore Bouty, Katie L Ayers, Andrew Pask, Yves Heloury, Andrew H Sinclair

Journal: Sex Dev. 2015 ;9(5):239-59.

 

Hypospadias results from a failure of urethral closure in the male phallus and affects 1 in 200-300 boys. It is thought to be due to a combination of genetic and environmental factors. The development of the penis progresses in 2 stages: an initial hormone-independent phase and a ...

Last Updated: 30 Jan 2016

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Current understanding of hypospadias: relevance of animal models.
 

Author(s): Gerald R Cunha, Adriane Sinclair, Gail Risbridger, John Hutson, Laurence S Baskin

Journal: Nat Rev Urol. 2015 May;12(5):271-80.

 

Hypospadias is a congenital abnormality of the penile urethra with an incidence of approximately 1:200-1:300 male births, which has doubled over the past three decades. The aetiology of the overwhelming majority of hypospadias remains unknown but appears to be a combination of genetic ...

Last Updated: 12 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prophylactic Antibiotics or Placebo After Hypospadias Repair
 

Status: Recruiting

Condition Summary: Hypospadias

 

Last Updated: 4 Aug 2016

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Last Updated: 30 Aug 2016

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Caudal vs Local Anesthesia in Hypospadias
 

Status: Recruiting

Condition Summary: Hypospadias

 

Last Updated: 14 Oct 2016

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