Hypospadias

Common Name(s)

Hypospadias

Hypospadias is a birth defect in which the urethra (the tube that drains urine from the bladder) is abnormally located on the underside of the penis instead of at the tip. It is typically diagnosed at birth, but less severe hypospadius can potentially go overlooked. Hypospadias is caused by an inbalance of hormones required for normal development of the urethra. Treatment involves surgery to reposition the urethra, most commonly resulting in normal appearance and function of the penis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypospadias" for support, advocacy or research.

AIS-DSD Support Group

The AIS-DSD Support Group is a compassionate community of individuals, families and allies collaborating to promote better lives and informed decision-making through advancement of knowledge so no one will face a diagnosis alone.

Last Updated: 12 Jan 2015

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Hypospadias Epispadias Association

The Hypospadias and Epispadias Association, Inc. (HEA) is an organization founded in the year 2000 for the support and education of people born with hypospadias or epispadias and their families, loved ones, and medical care givers.

Last Updated: 25 Mar 2013

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Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

Last Updated: 8 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypospadias" for support, advocacy or research.

AIS-DSD Support Group

The AIS-DSD Support Group is a compassionate community of individuals, families and allies collaborating to promote better lives and informed decision-making through advancement of knowledge so no one will face a diagnosis alone.

http://www.aisdsd.org

Last Updated: 12 Jan 2015

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Hypospadias Epispadias Association

The Hypospadias and Epispadias Association, Inc. (HEA) is an organization founded in the year 2000 for the support and education of people born with hypospadias or epispadias and their families, loved ones, and medical care givers.

http://www.HEAinfo.org

Last Updated: 25 Mar 2013

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Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

http://www.PullthruNetwork.org

Last Updated: 8 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypospadias" returned 291 free, full-text research articles on human participants. First 3 results:

Comparison of lingual mucosa and buccal mucosa grafts used in inlay urethroplasty in failed hypospadias of pre-pubertal boys in a Chinese group.
 

Author(s): Jin Hongyong, Chen Shuzhu, Wu Min, Ye Weijing, Liu Yidong

Journal:

 

The purpose of this study was to compare the outcomes of the buccal mucosa and lingual mucosa used in children who received multiple failed hypospadias surgeries.

Last Updated: 31 Dec 1969

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Psychosocial outcomes in adult men born with hypospadias: A register-based study.
 

Author(s): Anna Skarin Nordenvall, Christina Norrby, Agnieszka Butwicka, Louise Frisén, Anna Nordenström, Catarina Almqvist, Agneta Nordenskjöld

Journal:

 

In this nationwide matched cohort study, we have investigated whether being born with hypospadias affect subsequent psychosocial outcomes in adulthood. We analyzed prospectively collected data from national Swedish registers. Data on the diagnoses were collected from the National ...

Last Updated: 31 Dec 1969

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Our experience of proximal hypospadias repair using the Cloutier-Bracka technique at the Gynaeco-Obstetric and Paediatric Hospital, Yaounde-Cameroon.
 

Author(s): Mouafo Tambo Faustin Felicien, A S Nwaha Makon, C Kamadjou, G Fossi, C Le Coultre, O G Andze, M A Sosso, P Y Mure

Journal: Afr J Paediatr Surg. ;13(4):193-195.

 

In parts of Africa, routine circumcision is practised and sometimes even on children with hypospadias. The lack of preputial foreskin renders urethroplasty more difficult and often requires to use of a mucosal graft as described by Bracka.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypospadias" returned 25 free, full-text review articles on human participants. First 3 results:

Hypospadias, all there is to know.
 

Author(s): H J R van der Horst, L L de Wall

Journal: Eur. J. Pediatr.. 2017 Apr;176(4):435-441.

 

Hypospadias is one of the most common congenital anomalies in men. The condition is typically characterized by proximal displacement of the urethral opening, penile curvature, and a ventrally deficient hooded foreskin. In about 70%, the urethral meatus is located distally on the penile ...

Last Updated: 31 Dec 1969

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Impact of preoperative hormonal stimulation on postoperative complication rates after hypospadias repair: a meta-analysis.
 

Author(s): Min Chao, Yin Zhang, Chaozhao Liang

Journal: Minerva Urol Nefrol. 2017 Jun;69(3):253-261.

 

To improve the surgical outcome of hypospadias repair surgery, preoperative hormonal stimulation (PHS) has been proposed. We conducted a meta-analysis to evaluate the impact of preoperative hormonal stimulation (PHS) treatment on complication rates following hypospadias repair surgery.

Last Updated: 31 Dec 1969

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Diethylstilbestrol-induced mouse hypospadias: "window of susceptibility".
 

Author(s): Adriane Watkins Sinclair, Mei Cao, Laurence Baskin, Gerald R Cunha

Journal: Differentiation. ;91(1-3):1-18.

 

This review presents published and novel results that define the programming window for diethylstilbestrol (DES)-induced abnormal development of the mouse penis. These data indicate that DES has its greatest effect during the period of most intense penile morphogenesis, namely postnatal ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prophylactic Antibiotics or Placebo After Hypospadias Repair
 

Status: Recruiting

Condition Summary: Hypospadias

 

Last Updated: 4 Aug 2016

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Last Updated: 8 Nov 2017

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Caudal vs Local Anesthesia in Hypospadias
 

Status: Recruiting

Condition Summary: Hypospadias

 

Last Updated: 28 Aug 2017

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