Hypospadias

Common Name(s)

Hypospadias

Hypospadias is a birth defect in which the urethra (the tube that drains urine from the bladder) is abnormally located on the underside of the penis instead of at the tip. It is typically diagnosed at birth, but less severe hypospadius can potentially go overlooked. Hypospadias is caused by an inbalance of hormones required for normal development of the urethra. Treatment involves surgery to reposition the urethra, most commonly resulting in normal appearance and function of the penis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypospadias" for support, advocacy or research.

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Hypospadias Epispadias Association

The Hypospadias and Epispadias Association, Inc. (HEA) is an organization founded in the year 2000 for the support and education of people born with hypospadias or epispadias and their families, loved ones, and medical care givers.

Last Updated: 25 Mar 2013

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Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

Last Updated: 8 Nov 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypospadias" for support, advocacy or research.

Logo
Hypospadias Epispadias Association

The Hypospadias and Epispadias Association, Inc. (HEA) is an organization founded in the year 2000 for the support and education of people born with hypospadias or epispadias and their families, loved ones, and medical care givers.

http://www.HEAinfo.org

Last Updated: 25 Mar 2013

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Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

http://www.PullthruNetwork.org

Last Updated: 8 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypospadias" returned 148 free, full-text research articles on human participants. First 3 results:

A wet dressing for hypospadias surgery.
 

Author(s): Ana Gabriela Santos Martins, Salvador Vilar Correia Lima, Luiz Alberto Pereira de Araújo, Fábio de Oliveira Vilar, Niedson Thiago Pereira Cavalcante

Journal: Int Braz J Urol. ;39(3):408-13.

 

One of the main problems faced by surgeons involved in male genitalia surgeries, in particular in children with hypospadias, is the type of dressing and its use during the post-operatory period.

Last Updated: 15 Jul 2013

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Hypospadias and maternal intake of phytoestrogens.
 

Author(s): Suzan L Carmichael, Mary E Cogswell, Chen Ma, Amparo Gonzalez-Feliciano, Richard S Olney, Adolfo Correa, Gary M Shaw,

Journal: Am. J. Epidemiol.. 2013 Aug;178(3):434-40.

 

Experimental data indicate that gestational exposures to estrogenic compounds impact risk of hypospadias. We examined whether risk of hypospadias (i.e., a congenital malformation in which the opening of the penile urethra occurs on the ventral side of the penis) was associated with ...

Last Updated: 31 Jul 2013

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Hypospadias and genes related to genital tubercle and early urethral development.
 

Author(s): Suzan L Carmichael, Chen Ma, Shweta Choudhry, Edward J Lammer, John S Witte, Gary M Shaw

Journal: J. Urol.. 2013 Nov;190(5):1884-92.

 

We determined whether variants in genes associated with genital tubercle (the anlage for the penis) and early urethral development were associated with hypospadias in humans.

Last Updated: 14 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypospadias" returned 14 free, full-text review articles on human participants. First 3 results:

Environmental and genetic contributors to hypospadias: a review of the epidemiologic evidence.
 

Author(s): Suzan L Carmichael, Gary M Shaw, Edward J Lammer

Journal: Birth Defects Res. Part A Clin. Mol. Teratol.. 2012 Jul;94(7):499-510.

 

This review evaluates current knowledge related to trends in the prevalence of hypospadias, the association of hypospadias with endocrine-disrupting exposures, and the potential contribution of genetic susceptibility to its etiology. The review focuses on epidemiologic evidence. Increasing ...

Last Updated: 10 Jul 2012

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Aetiology of hypospadias: a systematic review of genes and environment.
 

Author(s): L F M van der Zanden, I A L M van Rooij, W F J Feitz, B Franke, N V A M Knoers, N Roeleveld

Journal: Hum. Reprod. Update. ;18(3):260-83.

 

Hypospadias is a common congenital malformation of the male external genitalia. Most cases have an unknown aetiology, which is probably a mix of monogenic and multifactorial forms, implicating both genes and environmental factors. This review summarizes current knowledge about the ...

Last Updated: 17 Apr 2012

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Proximal hypospadias.
 

Author(s): Kate H Kraft, Aseem R Shukla, Douglas A Canning

Journal:

 

Hypospadias results from abnormal development of the penis that leaves the urethral meatus proximal to its normal glanular position. Meatal position may be located anywhere along the penile shaft, but more severe forms of hypospadias may have a urethral meatus located at the scrotum ...

Last Updated: 25 Apr 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prophylactic Antibiotics or Placebo After Hypospadias Repair
 

Status: Recruiting

Condition Summary: Hypospadias

 

Last Updated: 18 Sep 2014

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Last Updated: 17 Jun 2014

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Hemostasis During Hypospadias Surgery
 

Status: Recruiting

Condition Summary: Hypospadias Repair

 

Last Updated: 15 Oct 2014

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