Hypoplastic left heart syndrome

Common Name(s)

Hypoplastic left heart syndrome

Hypoplastic left heart syndrome (HLHS) is a problem with the heartÕs structure that is present at birth (congenital). It occurs when parts of the left side of the heart (mitral valve, left ventricle, aortic valve, and aorta) do not develop completely. The underdeveloped left side of the heart is unable to provide enough blood flow to the body, which decreases the oxygen-rich blood supply. Babies with HLHS might look normal at birth, but will develop symptoms of HLHS within a few days. These symptoms might include: poor feeding, problems breathing, pounding heart, weak pulse, and ashen or bluish skin color. The cause of HLHs is presently unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoplastic left heart syndrome" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

Last Updated: 15 Mar 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoplastic left heart syndrome" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypoplastic left heart syndrome" returned 224 free, full-text research articles on human participants. First 3 results:

Mortality-related resource utilization in the inpatient care of hypoplastic left heart syndrome.
 

Author(s): David A Danford, Quentin Karels, Aparna Kulkarni, Aysha Hussain, Yunbin Xiao, Shelby Kutty

Journal:

 

Quantifying resource utilization in the inpatient care of congenital heart diease is clinically relevant. Our purpose is to measure the investment of inpatient care resources to achieve survival in hypoplastic left heart syndrome (HLHS), and to determine how much of that investment ...

Last Updated: 23 Oct 2015

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Frequent Dilatation of the Descending Aorta in Children With Hypoplastic Left Heart Syndrome Relates to Decreased Aortic Arch Elasticity.
 

Author(s): Inga Voges, Michael Jerosch-Herold, Philip Wegner, Christopher Hart, Dominik Gabbert, Abdullah Al Bulushi, Gunther Fischer, Ana Cristina Andrade, Hoang Minh Pham, Ines Kristo, Hans-Heiner Kramer, Carsten Rickers

Journal:

 

Patients with hypoplastic left heart syndrome after a Norwood operation show dilatation and reduced distensibility of the reconstructed proximal aorta. Cardiac magnetic resonance imaging (CMR) and angiographic examinations indicate that the native descending aorta (DAo) is also dilated, ...

Last Updated: 6 Oct 2015

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Survival of Children With Hypoplastic Left Heart Syndrome.
 

Author(s): Csaba Siffel, Tiffany Riehle-Colarusso, Matthew E Oster, Adolfo Correa

Journal: Pediatrics. 2015 Oct;136(4):e864-70.

 

To examine the survival of infants with hypoplastic left heart syndrome (HLHS) and potential influence of demographic and clinical characteristics on survival using population-based data.

Last Updated: 2 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypoplastic left heart syndrome" returned 13 free, full-text review articles on human participants. First 3 results:

Oseltamivir-warfarin interaction in hypoplastic left heart syndrome: case report and review.
 

Author(s): Jonathan Wagner, Susan M Abdel-Rahman

Journal: Pediatrics. 2015 May;135(5):e1333-6.

 

An 8-year-old boy with hypoplastic left heart syndrome with a previous history of thrombosis within the inferior vena cava receiving stable warfarin dosing for anticoagulation was diagnosed with influenza B. He was subsequently placed on oseltamivir therapy according to the Centers ...

Last Updated: 2 May 2015

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Improvements in survival and neurodevelopmental outcomes in surgical treatment of hypoplastic left heart syndrome: a meta-analytic review.
 

Author(s): Joseph J Sistino, Heather Shaw Bonilha

Journal: J Extra Corpor Technol. 2012 Dec;44(4):216-23.

 

The purpose of this study was to analyze the changes over the past two decades in hospital survival and neurodevelopmental outcomes after surgical treatment for hypoplastic left heart syndrome. The hypothesis for this study is that increasing hospital survival following the Stage ...

Last Updated: 27 Feb 2013

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Nutrition algorithms for infants with hypoplastic left heart syndrome; birth through the first interstage period.
 

Author(s): Julie Slicker, David A Hehir, Megan Horsley, Jessica Monczka, Kenan W Stern, Brandis Roman, Elena C Ocampo, Liz Flanagan, Erin Keenan, Linda M Lambert, Denise Davis, Marcy Lamonica, Nancy Rollison, Haleh Heydarian, Jeffrey B Anderson,

Journal: Congenit Heart Dis. ;8(2):89-102.

 

Failure to thrive is common in infants with hypoplastic left heart syndrome and its variants and those with poor growth may be at risk for worse surgical and neurodevelopmental outcomes. The etiology of growth failure in this population is multifactorial and complex, but may be impacted ...

Last Updated: 4 Apr 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome
 

Status: Recruiting

Condition Summary: Aortic Stenosis; Hypoplastic Left Heart Syndrome

 

Last Updated: 1 Dec 2015

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A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Palliation
 

Status: Recruiting

Condition Summary: Hypoplastic Left Heart Syndrome

 

Last Updated: 11 Mar 2016

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Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome
 

Status: Recruiting

Condition Summary: Hypoplastic Left Heart Syndrome

 

Last Updated: 11 Mar 2016

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