Hypoplastic left heart syndrome

Common Name(s)

Hypoplastic left heart syndrome

Hypoplastic left heart syndrome (HLHS) is a problem with the heartÕs structure that is present at birth (congenital). It occurs when parts of the left side of the heart (mitral valve, left ventricle, aortic valve, and aorta) do not develop completely. The underdeveloped left side of the heart is unable to provide enough blood flow to the body, which decreases the oxygen-rich blood supply. Babies with HLHS might look normal at birth, but will develop symptoms of HLHS within a few days. These symptoms might include: poor feeding, problems breathing, pounding heart, weak pulse, and ashen or bluish skin color. The cause of HLHs is presently unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoplastic left heart syndrome" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

Last Updated: 15 Mar 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoplastic left heart syndrome" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypoplastic left heart syndrome" returned 159 free, full-text research articles on human participants. First 3 results:

Survival of Children With Hypoplastic Left Heart Syndrome.
 

Author(s): Csaba Siffel, Tiffany Riehle-Colarusso, Matthew E Oster, Adolfo Correa

Journal: Pediatrics. 2015 Oct;136(4):e864-70.

 

To examine the survival of infants with hypoplastic left heart syndrome (HLHS) and potential influence of demographic and clinical characteristics on survival using population-based data.

Last Updated: 2 Oct 2015

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Stem cells on a new stage: Treatment of hypoplastic left heart syndrome.
 

Author(s): Sunjay Kaushal, Brody Wehman

Journal: J. Thorac. Cardiovasc. Surg.. 2015 Nov;150(5):1209-11.

 

Last Updated: 7 Nov 2015

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Distention of the Immature Left Ventricle Triggers Development of Endocardial Fibroelastosis: An Animal Model of Endocardial Fibroelastosis Introducing Morphopathological Features of Evolving Fetal Hypoplastic Left Heart Syndrome.
 

Author(s): Shogo Shimada, Christian Robles, Ben M W Illigens, Alejandra M Casar Berazaluce, Pedro J del Nido, Ingeborg Friehs

Journal: Biomed Res Int. 2015 ;2015():462469.

 

Endocardial fibroelastosis (EFE), characterized by a diffuse endocardial thickening through collagen and elastin fibers, develops in the human fetal heart restricting growth of the left ventricle (LV). Recent advances in fetal imaging indicate that EFE development is directly associated ...

Last Updated: 11 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypoplastic left heart syndrome" returned 12 free, full-text review articles on human participants. First 3 results:

Oseltamivir-warfarin interaction in hypoplastic left heart syndrome: case report and review.
 

Author(s): Jonathan Wagner, Susan M Abdel-Rahman

Journal: Pediatrics. 2015 May;135(5):e1333-6.

 

An 8-year-old boy with hypoplastic left heart syndrome with a previous history of thrombosis within the inferior vena cava receiving stable warfarin dosing for anticoagulation was diagnosed with influenza B. He was subsequently placed on oseltamivir therapy according to the Centers ...

Last Updated: 2 May 2015

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Improvements in survival and neurodevelopmental outcomes in surgical treatment of hypoplastic left heart syndrome: a meta-analytic review.
 

Author(s): Joseph J Sistino, Heather Shaw Bonilha

Journal: J Extra Corpor Technol. 2012 Dec;44(4):216-23.

 

The purpose of this study was to analyze the changes over the past two decades in hospital survival and neurodevelopmental outcomes after surgical treatment for hypoplastic left heart syndrome. The hypothesis for this study is that increasing hospital survival following the Stage ...

Last Updated: 27 Feb 2013

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Nutrition algorithms for infants with hypoplastic left heart syndrome; birth through the first interstage period.
 

Author(s): Julie Slicker, David A Hehir, Megan Horsley, Jessica Monczka, Kenan W Stern, Brandis Roman, Elena C Ocampo, Liz Flanagan, Erin Keenan, Linda M Lambert, Denise Davis, Marcy Lamonica, Nancy Rollison, Haleh Heydarian, Jeffrey B Anderson,

Journal: Congenit Heart Dis. ;8(2):89-102.

 

Failure to thrive is common in infants with hypoplastic left heart syndrome and its variants and those with poor growth may be at risk for worse surgical and neurodevelopmental outcomes. The etiology of growth failure in this population is multifactorial and complex, but may be impacted ...

Last Updated: 4 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome
 

Status: Recruiting

Condition Summary: Aortic Stenosis; Hypoplastic Left Heart Syndrome

 

Last Updated: 1 Dec 2015

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A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Palliation
 

Status: Recruiting

Condition Summary: Hypoplastic Left Heart Syndrome

 

Last Updated: 11 Mar 2016

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Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome
 

Status: Recruiting

Condition Summary: Hypoplastic Left Heart Syndrome

 

Last Updated: 11 Mar 2016

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