Hypopituitarism

Common Name(s)

Hypopituitarism

Hypopituitarism occurs when the body has low levels of certain hormones made by the pituitary gland.  The pituitary gland normally makes several hormones (including growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, follicle stimulating hormone and luteinizing hormone, vasopressin, and oxytocin).  These hormones are important for directing body growth and development, and for regulating blood pressure and metabolism.  Symptoms of this condition vary and depend on which hormones are affected.  Treatment depends on the cause of this condition; once the cause is corrected, medication (hormone replacement therapy) must be taken to provide the body with the normal amount of hormones.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypopituitarism" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypopituitarism" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypopituitarism" returned 231 free, full-text research articles on human participants. First 3 results:

Cholesteatoma in the Sellar Region Presenting as Hypopituitarism and Diabetes Insipidus.
 

Author(s): Xiangyi Kong, Huanwen Wu, Wenbin Ma, Yongning Li, Bing Xing, Yanguo Kong, Renzhi Wang

Journal: Medicine (Baltimore). 2016 Mar;95(10):e2938.

 

Clinically significant sellar cysts unrelated to pituitary adenomas are uncommon. Intracranial cholesteatomas are also rare and are most common in the middle ear and mastoid region. We report an even rarer case of cholesteatoma in the sellar region-a challenging diagnosis guided by ...

Last Updated: 11 Mar 2016

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Oculomotor Paralysis, Postorbital Pain, and Hypopituitarism as First Presentations of Metastatic Gastric Cancer in the Pituitary Flourished by Internal Carotid Aneurysm: A Case Report.
 

Author(s): Chuanwei Yang, Hongqiang Zhang, Shiqiang Zhang, Ling Liu, Binbin Ma, Jiacheng Lou, Xiaorui Sun, Bo Zhang

Journal: Medicine (Baltimore). 2015 Dec;94(50):e2317.

 

Metastatic gastric cancer in the pituitary (MGCP) is rare. Few are known on the clinical and radiological characteristics of MGCP. To date, the coexistence of metastatic pituitary tumors and intracranial aneurysms has not been reported in literatures. We present a case of MGCP with ...

Last Updated: 19 Dec 2015

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The modulation of corticosteroid metabolism by hydrocortisone therapy in patients with hypopituitarism increases tissue glucocorticoid exposure.
 

Author(s): Mark Sherlock, Lucy Ann Behan, Mark J Hannon, Aurora Aragon Alonso, Christopher J Thompson, Robert D Murray, Nicola Crabtree, Beverly A Hughes, Wiebke Arlt, Amar Agha, Andrew A Toogood, Paul M Stewart

Journal: Eur. J. Endocrinol.. 2015 Nov;173(5):583-93.

 

Patients with hypopituitarism have increased morbidity and mortality. There is ongoing debate about the optimum glucocorticoid (GC) replacement therapy.

Last Updated: 29 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypopituitarism" returned 25 free, full-text review articles on human participants. First 3 results:

Role of GLI2 in hypopituitarism phenotype.
 

Author(s): Ivo J P Arnhold, Marcela M Fran├ža, Luciani R Carvalho, Berenice B Mendonca, Alexander A L Jorge

Journal: J. Mol. Endocrinol.. 2015 Jun;54(3):R141-50.

 

GLI2 is a zinc-finger transcription factor involved in the Sonic Hedgehog pathway. Gli2 mutant mice have hypoplastic anterior and absent posterior pituitary glands. We reviewed the literature for patients with hypopituitarism and alterations in GLI2. Twenty-five patients (16 families) ...

Last Updated: 22 May 2015

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Acute hypopituitarism complicating Russell's viper envenomation: case series and systematic review.
 

Author(s): S Rajagopala, M M Thabah, K K Ariga, M Gopalakrishnan

Journal: QJM. 2015 Sep;108(9):719-28.

 

Chronic hypopituitarism following Russell viper envenomation (RVE) is a rare but well-recognized syndrome. The clinical features, associations, management and outcomes of RVE associated-acute hypopituitarism (AHP) are not well described.

Last Updated: 31 Aug 2015

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Hypopituitarism after subarachnoid haemorrhage, do we know enough?
 

Author(s): Ladbon Khajeh, Karin Blijdorp, Sebastian Jcmm Neggers, Gerard M Ribbers, Diederik Wj Dippel, Fop van Kooten

Journal:

 

Fatigue, slowness, apathy and decrease in level of activity are common long-term complaints after a subarachnoid haemorrhage (SAH). They resemble the symptoms frequently found in patients with endocrine dysfunction. Pituitary dysfunction may be the result of SAH or its complications. ...

Last Updated: 27 Apr 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Influence of Different Hydrocortisone Replacement Doses on the Partitioning and Flexibility of Ectopic Lipids in Patients With Corticotropic Hypopituitarism
 

Status: Recruiting

Condition Summary: Hypopituitarism; Hydrocortisone; Lipids; Fatty Acids, Nonesterified; Insulin Sensitivity

 

Last Updated: 19 Aug 2015

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Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients
 

Status: Recruiting

Condition Summary: Hypopituitarism; Hypogonadism; Thyroid Dysfunction; Bone Diseases, Metabolic

 

Last Updated: 5 Nov 2016

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Pubertal Induction in Individuals With Hypogonadism
 

Status: Not yet recruiting

Condition Summary: Primary Amenorrhoea; Hypothalamic Amenorrhoea; Hypogonadotrophic Hypogonadism; Hypopituitarism; Turner's Syndrome; Primary Ovarian Insufficiency

 

Last Updated: 15 Aug 2016

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