Hypopituitarism

Common Name(s)

Hypopituitarism

Hypopituitarism occurs when the body has low levels of certain hormones made by the pituitary gland.  The pituitary gland normally makes several hormones (including growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, follicle stimulating hormone and luteinizing hormone, vasopressin, and oxytocin).  These hormones are important for directing body growth and development, and for regulating blood pressure and metabolism.  Symptoms of this condition vary and depend on which hormones are affected.  Treatment depends on the cause of this condition; once the cause is corrected, medication (hormone replacement therapy) must be taken to provide the body with the normal amount of hormones.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypopituitarism" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypopituitarism" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypopituitarism" returned 176 free, full-text research articles on human participants. First 3 results:

Hypopituitarism possibly due to lymphocytic hypophysitis in a patient with type 1 diabetes.
 

Author(s): Keiichiro Matoba, Sumie Mitsuishi, Satoshi Hayashida, Hiroyuki Yamazaki

Journal: Intern. Med.. 2014 ;53(17):1961-4.

 

Hypopituitarism often develops insidiously, and undiagnosed hypopituitarism can influence the glycemic profile of patients with type 1 diabetes. We herein report the case of a 49-year-old man with type 1 diabetes and Hashimoto's thyroiditis who experienced an unexplained improvement ...

Last Updated: 1 Sep 2014

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Association between l-thyroxine treatment, GH deficiency, and radiological vertebral fractures in patients with adult-onset hypopituitarism.
 

Author(s): G Mazziotti, M Mormando, A Cristiano, A Bianchi, T Porcelli, A Giampietro, F Maffezzoni, V Serra, L De Marinis, A Giustina

Journal: Eur. J. Endocrinol.. 2014 Jun;170(6):893-9.

 

In this study, we aimed at evaluating the association between radiological vertebral fractures and levo-thyroxine (l-T4) replacement doses in adult patients with hypopituitarism.

Last Updated: 19 May 2014

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Hypopituitarism in a neonate with hyperbilirubinemia and decreased level of consciousness: a case report study.
 

Author(s): Hadi Mousavi, Salar Bakhtiyari

Journal: Acta Med Iran. 2014 ;52(1):82-4.

 

Decreased level of consciousness in neonates may result from different etiologies, including rare metabolic and hormonal disorder due to anterior pituitary insufficiency. In this case report, a five-day-old newborn boy was referred to the neonatal intensive care unit of Mustafa Khomeini ...

Last Updated: 24 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypopituitarism" returned 22 free, full-text review articles on human participants. First 3 results:

The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature.
 

Author(s): Hironori Bando, Genzo Iguchi, Hidenori Fukuoka, Masaaki Taniguchi, Masaaki Yamamoto, Ryusaku Matsumoto, Kentaro Suda, Hitoshi Nishizawa, Michiko Takahashi, Eiji Kohmura, Yutaka Takahashi

Journal:

 

The prevalence and clinical characteristics of IgG4-related hypophysitis remain unclear due to the limited number of case reports. Therefore, in this study, we screened consecutive outpatients with hypopituitarism and/or diabetes insipidus (DI) to estimate its prevalence.

Last Updated: 23 Dec 2013

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GH therapy and cancer risk in hypopituitarism: what we know from human studies.
 

Author(s): Sandra Pekic, Vera Popovic

Journal:

 

It has been difficult to identify factors that affect the risk of cancer, but we know that people are at higher risk as they get older, or if they have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood. Early ...

Last Updated: 2 Oct 2013

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Pituitary stem cell update and potential implications for treating hypopituitarism.
 

Author(s): Frederic Castinetti, Shannon W Davis, Thierry Brue, Sally A Camper

Journal: Endocr. Rev.. 2011 Aug;32(4):453-71.

 

Stem cells have been identified in organs with both low and high cell turnover rates. They are characterized by the expression of key marker genes for undifferentiated cells, the ability to self-renew, and the ability to regenerate tissue after cell loss. Several recent reports present ...

Last Updated: 8 Aug 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Influence of Different Hydrocortisone Replacement Doses on the Partitioning and Flexibility of Ectopic Lipids in Patients With Corticotropic Hypopituitarism
 

Status: Recruiting

Condition Summary: Hypopituitarism; Hydrocortisone; Lipids; Fatty Acids, Nonesterified; Insulin Sensitivity

 

Last Updated: 4 Feb 2015

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Hormone Deficiency After Brain Injury During Combat
 

Status: Not yet recruiting

Condition Summary: Traumatic Brain Injury; Hypopituitarism

 

Last Updated: 14 Aug 2012

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Pituitary Functions After Traumatic Brain Injury (TBI) and/or Subarachnoid Hemorrhage (SAH)
 

Status: Recruiting

Condition Summary: Traumatic Brain Injury; Subarachnoid Hemorrhage; Hypopituitarism

 

Last Updated: 27 Sep 2007

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