Hypopituitarism

Common Name(s)

Hypopituitarism

Hypopituitarism occurs when the body has low levels of certain hormones made by the pituitary gland.  The pituitary gland normally makes several hormones (including growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, follicle stimulating hormone and luteinizing hormone, vasopressin, and oxytocin).  These hormones are important for directing body growth and development, and for regulating blood pressure and metabolism.  Symptoms of this condition vary and depend on which hormones are affected.  Treatment depends on the cause of this condition; once the cause is corrected, medication (hormone replacement therapy) must be taken to provide the body with the normal amount of hormones.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypopituitarism" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypopituitarism" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypopituitarism" returned 230 free, full-text research articles on human participants. First 3 results:

Oculomotor Paralysis, Postorbital Pain, and Hypopituitarism as First Presentations of Metastatic Gastric Cancer in the Pituitary Flourished by Internal Carotid Aneurysm: A Case Report.
 

Author(s): Chuanwei Yang, Hongqiang Zhang, Shiqiang Zhang, Ling Liu, Binbin Ma, Jiacheng Lou, Xiaorui Sun, Bo Zhang

Journal: Medicine (Baltimore). 2015 Dec;94(50):e2317.

 

Metastatic gastric cancer in the pituitary (MGCP) is rare. Few are known on the clinical and radiological characteristics of MGCP. To date, the coexistence of metastatic pituitary tumors and intracranial aneurysms has not been reported in literatures. We present a case of MGCP with ...

Last Updated: 19 Dec 2015

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Hypopituitarism as consequence of late neonatal infection by Group B streptococcus: a case report.
 

Author(s): Amanda Santana Ferreira, Ana Lourdes Lima Araújo Fernandes, Guilherme Guaragna-Filho

Journal:

 

Hypopituitarism is a condition characterized by dysfunction of the pituitary gland hormone production. The insults of the perinatal period, which includes the late infection by Group B Streptococcus, consists in a rare etiology of this condition. We present the case of a 39-days-old ...

Last Updated: 10 Jul 2015

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Reversible hypopituitarism with pituitary tuberculoma.
 

Author(s): Keiji Tanimoto, Ayumi Imbe, Kanako Shishikura, Hisashi Imbe, Tetsuya Hiraiwa, Tomo Miyata, Naokado Ikeda, Toshihiko Kuroiwa, Jungo Terasaki, Toshiaki Hanafusa

Journal: Intern. Med.. 2015 ;54(10):1247-51.

 

A 50-year-old woman presented with a headache and nausea. A sellar and suprasellar mass was detected on MRI; the tumor was heterogeneously enhanced with gadolinium, and the pituitary stalk was slightly thickened. Laboratory tests revealed severe growth hormone, luteinizing hormone, ...

Last Updated: 19 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypopituitarism" returned 25 free, full-text review articles on human participants. First 3 results:

Role of GLI2 in hypopituitarism phenotype.
 

Author(s): Ivo J P Arnhold, Marcela M França, Luciani R Carvalho, Berenice B Mendonca, Alexander A L Jorge

Journal: J. Mol. Endocrinol.. 2015 Jun;54(3):R141-50.

 

GLI2 is a zinc-finger transcription factor involved in the Sonic Hedgehog pathway. Gli2 mutant mice have hypoplastic anterior and absent posterior pituitary glands. We reviewed the literature for patients with hypopituitarism and alterations in GLI2. Twenty-five patients (16 families) ...

Last Updated: 22 May 2015

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Hypopituitarism after subarachnoid haemorrhage, do we know enough?
 

Author(s): Ladbon Khajeh, Karin Blijdorp, Sebastian Jcmm Neggers, Gerard M Ribbers, Diederik Wj Dippel, Fop van Kooten

Journal:

 

Fatigue, slowness, apathy and decrease in level of activity are common long-term complaints after a subarachnoid haemorrhage (SAH). They resemble the symptoms frequently found in patients with endocrine dysfunction. Pituitary dysfunction may be the result of SAH or its complications. ...

Last Updated: 27 Apr 2015

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The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature.
 

Author(s): Hironori Bando, Genzo Iguchi, Hidenori Fukuoka, Masaaki Taniguchi, Masaaki Yamamoto, Ryusaku Matsumoto, Kentaro Suda, Hitoshi Nishizawa, Michiko Takahashi, Eiji Kohmura, Yutaka Takahashi

Journal:

 

The prevalence and clinical characteristics of IgG4-related hypophysitis remain unclear due to the limited number of case reports. Therefore, in this study, we screened consecutive outpatients with hypopituitarism and/or diabetes insipidus (DI) to estimate its prevalence.

Last Updated: 23 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Influence of Different Hydrocortisone Replacement Doses on the Partitioning and Flexibility of Ectopic Lipids in Patients With Corticotropic Hypopituitarism
 

Status: Recruiting

Condition Summary: Hypopituitarism; Hydrocortisone; Lipids; Fatty Acids, Nonesterified; Insulin Sensitivity

 

Last Updated: 19 Aug 2015

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Hormone Deficiency After Brain Injury During Combat
 

Status: Not yet recruiting

Condition Summary: Traumatic Brain Injury; Hypopituitarism

 

Last Updated: 14 Aug 2012

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Pituitary Functions After Traumatic Brain Injury (TBI) and/or Subarachnoid Hemorrhage (SAH)
 

Status: Recruiting

Condition Summary: Traumatic Brain Injury; Subarachnoid Hemorrhage; Hypopituitarism

 

Last Updated: 27 Sep 2007

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