Hypopituitarism

Common Name(s)

Hypopituitarism

Hypopituitarism occurs when the body has low levels of certain hormones made by the pituitary gland.  The pituitary gland normally makes several hormones (including growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, follicle stimulating hormone and luteinizing hormone, vasopressin, and oxytocin).  These hormones are important for directing body growth and development, and for regulating blood pressure and metabolism.  Symptoms of this condition vary and depend on which hormones are affected.  Treatment depends on the cause of this condition; once the cause is corrected, medication (hormone replacement therapy) must be taken to provide the body with the normal amount of hormones.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypopituitarism" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypopituitarism" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypopituitarism" returned 226 free, full-text research articles on human participants. First 3 results:

Successful Pregnancies and Deliveries in a Patient With Evolving Hypopituitarism due to Pituitary Stalk Transection Syndrome: Role of Growth Hormone Replacement.
 

Author(s): Miyako Yoshizawa, Yasuhiko Ieki, Eisuke Takazakura, Kaori Fukuta, Takao Hidaka, Takanobu Wakasugi, Akira Shimatsu

Journal: Intern. Med.. 2017 ;56(5):527-530.

 

We herein report a 31-year-old Japanese woman with evolving hypopituitarism due to pituitary stalk transection syndrome. She had a history of short stature treated with growth hormone (GH) in childhood and had hypothyroidism and primary amenorrhea at 20 years old. Levothyroxine replacement ...

Last Updated: 2 Mar 2017

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Hypopituitarism Presenting as Adrenal Insufficiency and Hypothyroidism in a Patient with Wilson's Disease: a Case Report.
 

Author(s): Hae Won Lee, Jin Du Kang, Chang Woo Yeo, Sung Woon Yoon, Kwang Jae Lee, Mun Ki Choi

Journal: J. Korean Med. Sci.. 2016 Aug;31(8):1345-8.

 

Wilson's disease typically presents symptoms associated with liver damage or neuropsychiatric disturbances, while endocrinologic abnormalities are rare. We report an unprecedented case of hypopituitarism in a patient with Wilson's disease. A 40-year-old woman presented with depression, ...

Last Updated: 1 Aug 2016

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Intraparenchymal infiltration of Rathke's cleft cysts manifesting as severe neurological deficits and hypopituitarism: 2 case reports.
 

Author(s): Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

Journal:

 

Rathke's cleft cysts generally remain asymptomatic throughout life, but a few patients may suffer severe neurological and/or endocrinological deficits. The symptoms include visual disturbances caused by compression of the optic chiasm, and severe endocrinological deficits caused by ...

Last Updated: 20 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypopituitarism" returned 27 free, full-text review articles on human participants. First 3 results:

DIAGNOSIS OF ENDOCRINE DISEASE: Expanding the cause of hypopituitarism.
 

Author(s): Sandra Pekic, Vera Popovic

Journal: Eur. J. Endocrinol.. 2017 Jun;176(6):R269-R282.

 

Hypopituitarism is defined as one or more pituitary hormone deficits due to a lesion in the hypothalamic-pituitary region. By far, the most common cause of hypopituitarism associated with a sellar mass is a pituitary adenoma. A high index of suspicion is required for diagnosing hypopituitarism ...

Last Updated: 4 Mar 2017

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Four-year follow-up of a Wilson disease pedigree complicated with epilepsy and hypopituitarism: Case report with a literature review.
 

Author(s): Qi-Jie Zhang, Liu-Qing Xu, Chong Wang, Wei Hu, Ning Wang, Wan-Jin Chen

Journal: Medicine (Baltimore). 2016 Dec;95(49):e5331.

 

Wilson's disease (WD) is an autosomal recessive inherited disorder of copper metabolism with excellent prognosis if treated timely. However, WD is usually prone to neglect and misdiagnosis at an early stage. We reported a rare WD pedigree, and the clinical features, laboratory tests, ...

Last Updated: 8 Dec 2016

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How should we interrogate the hypothalamic-pituitary-adrenal axis in patients with suspected hypopituitarism?
 

Author(s): Aoife Garrahy, Amar Agha

Journal:

 

Hypopituitarism is deficiency of one or more pituitary hormones, of which adrenocorticotrophic hormone (ACTH) deficiency is the most serious and potentially life-threatening. It may occur in isolation or, more commonly as part of more widespread pituitary failure. Diagnosis requires ...

Last Updated: 18 Jun 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients
 

Status: Recruiting

Condition Summary: Hypopituitarism; Hypogonadism; Thyroid Dysfunction; Bone Diseases, Metabolic

 

Last Updated: 18 Oct 2017

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Pubertal Induction in Individuals With Hypogonadism
 

Status: Not yet recruiting

Condition Summary: Primary Amenorrhoea; Hypothalamic Amenorrhoea; Hypogonadotrophic Hypogonadism; Hypopituitarism; Turner's Syndrome; Primary Ovarian Insufficiency

 

Last Updated: 15 Aug 2016

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Lipolytic Effects of GH in Hypopituitary Patients in Vivo
 

Status: Recruiting

Condition Summary: Hypopituitarism; Insulin Resistance; Endocrine System Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Pituitary Diseases; Brain Diseases

 

Last Updated: 20 May 2016

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