Hypoparathyroidism

Common Name(s)

Hypoparathyroidism

Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). It may be caused by injury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, DiGeorge syndrome, and type I polyglandular autoimmune syndrome. The goal of treatment is to restore the calcium and mineral balance in the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoparathyroidism" for support, advocacy or research.

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Hypoparathyroidism UK

Working to improve the lives of people with hypoparathyroidism and other parathyroid conditions.

Last Updated: 1 Apr 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoparathyroidism" for support, advocacy or research.

Logo
Hypoparathyroidism UK

Working to improve the lives of people with hypoparathyroidism and other parathyroid conditions.

http://www.hpth.org.uk

Last Updated: 1 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypoparathyroidism" returned 222 free, full-text research articles on human participants. First 3 results:

Mood disorder as a manifestation of primary hypoparathyroidism: a case report.
 

Author(s): Regis G Rosa, Alcina J S Barros, Antonio R B de Lima, William Lorenzi, Rafael R Da Rosa, Karine D Zambonato, Gustavo V Alves

Journal:

 

Primary hypoparathyroidism is a rare condition caused by parathyroid hormone deficiency and characterized by hypocalcemia. The clinical manifestations of primary hypoparathyroidism include tetany, seizures, paresthesias, dementia, and parkinsonism. Psychiatric manifestations such ...

Last Updated: 11 Oct 2014

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Total thyroidectomy is associated with increased prevalence of permanent hypoparathyroidism.
 

Author(s): Ireneusz Nawrot, Aneta Pragacz, Krzysztof Pragacz, Wiesław Grzesiuk, Marcin Barczyński

Journal:

 

Thyroid disorders are very common in adults. Despite advances in conservative management, surgery remains a treatment modality of choice in many cases. The mortality and morbidity of thyroidectomy are low, but long-term postoperative hypoparathyroidism (HPT) remains a prominent complication ...

Last Updated: 19 Sep 2014

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Relationship between hypoparathyroidism and the number of parathyroid glands preserved during thyroidectomy.
 

Author(s): Chang Myeon Song, Joo Hwan Jung, Yong Bae Ji, Hyun Jung Min, You Hern Ahn, Kyung Tae

Journal:

 

The relationship between the number of parathyroid glands preserved and hypoparathyroidism is not well understood. We sought to determine the number of parathyroid glands that need to be preserved to prevent hypoparathyroidism.

Last Updated: 22 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypoparathyroidism" returned 14 free, full-text review articles on human participants. First 3 results:

Bone disease in hypoparathyroidism.
 

Author(s): Bart L Clarke

Journal: Arq Bras Endocrinol Metabol. 2014 Jul;58(5):545-52.

 

Hypoparathyroidism is a rare disorder that may be acquired or inherited. Postsurgical hypoparathyroidism is responsible for the majority of acquired hypoparathyroidism. Bone disease occurs in hypoparathyroidism due to markedly reduced bone remodeling due to the absence or low levels ...

Last Updated: 29 Aug 2014

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Use of parathyroid hormone in hypoparathyroidism.
 

Author(s): N E Cusano, M R Rubin, D Irani, J Sliney, J P Bilezikian

Journal: J. Endocrinol. Invest.. 2013 Dec;36(11):1121-7.

 

Hypoparathyroidism is a disorder characterized by hypocalcemia, deficient PTH, and abnormal bone remodeling. Standard treatment of hypoparathyroidism consists of oral calcium and vitamin D supplementation. However, maintaining serum calcium levels can be a challenge. In addition, ...

Last Updated: 21 Jan 2014

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Pure red cell aplasia as a presenting feature in systemic lupus erythematosus and association with thymoma, hypothyroidism and hypoparathyroidism: a case report and literature review.
 

Author(s): Sasan Fallahi, Mahmoud Akbarian, Shahriar Dabiri

Journal: Iran J Allergy Asthma Immunol. 2014 Apr;13(2):138-43.

 

This paper presents a 54-year-old female with lupus whom severe anaemia due to pure red cell aplasia (PRCA) was the first manifestation. There was seven years interval between PRCA onset and diagnosis of lupus. Thymectomy due to thymoma had been carried out six years before but anaemia ...

Last Updated: 16 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of PTH Replacement on Bone in Hypoparathyroidism
 

Status: Recruiting

Condition Summary: Hypoparathyroidism; DiGeorge Syndrome

 

Last Updated: 21 Apr 2015

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PARADIGHM A Natural History Registry for Patients With Chronic Hypoparathyroidism
 

Status: Recruiting

Condition Summary: Chronic Hypoparathyroidism

 

Last Updated: 19 May 2015

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Vitamin D Levels and Postoperative Hypocalcemia After Total Thyroidectomy
 

Status: Recruiting

Condition Summary: Hypocalcemia; Hypoparathyroidism; Vitamin D Deficiency; Thyroidectomy

 

Last Updated: 24 Dec 2009

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