Hypoparathyroidism

Common Name(s)

Hypoparathyroidism

Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). It may be caused by injury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, DiGeorge syndrome, and type I polyglandular autoimmune syndrome. The goal of treatment is to restore the calcium and mineral balance in the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoparathyroidism" for support, advocacy or research.

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Hypoparathyroidism UK

Working to improve the lives of people with hypoparathyroidism and other parathyroid conditions.

Last Updated: 1 Apr 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoparathyroidism" for support, advocacy or research.

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Hypoparathyroidism UK

Working to improve the lives of people with hypoparathyroidism and other parathyroid conditions.

http://www.hpth.org.uk

Last Updated: 1 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypoparathyroidism" returned 293 free, full-text research articles on human participants. First 3 results:

[Fahr syndrome secondary to primary hypoparathyroidism: about a case].
 

Author(s): Fatima El Boukhrissi, Ghizlane Zoulati, Issam En-Nafaa, Hassan Ouleghzal, Sara Derrou, Soumaya Safi, Youssef Bamou, Lhoussine Balouch

Journal:

 

Fahr syndrome is a rare anatomo-clinic disease whose most common cause is primary or postoperative hypoparathyroidism. It is characterized by bilateral and symmetrical intracerebral calcifications located in the central gray nuclei, most often associated with phosphocalcium metabolism ...

Last Updated: 28 Apr 2017

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Idiopathic hypoparathyroidism with extensive intracranial calcification in children: First report from Saudi Arabia.
 

Author(s): Naglaa M Kamal, Hamed A Alghamdi, Abdulrahman A Halabi, Ayman A Bakkar, Ali Algarni, Abdullah Alharbi, Abdulla A Alharthi, Rawan A Alharbi, Laila M Sherief

Journal: Medicine (Baltimore). 2017 Apr;96(16):e6347.

 

Pediatric idiopathic hypoparathyroidism with extensive intracranial calcifications outside the basal ganglia (BG) is extremely rare with less than 10 cases worldwide.

Last Updated: 19 Apr 2017

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Clinical Auditory Phenotypes Associated with GATA3 Gene Mutations in Familial Hypoparathyroidism-deafness-renal Dysplasia Syndrome.
 

Author(s): Li Wang, Qiong-Fen Lin, Hong-Yang Wang, Jing Guan, Lan Lan, Lin-Yi Xie, Lan Yu, Ju Yang, Cui Zhao, Jin-Long Liang, Han-Lin Zhou, Huan-Ming Yang, Wen-Ping Xiong, Qiu-Jing Zhang, Da-Yong Wang, Qiu-Ju Wang

Journal: Chin. Med. J.. 2017 Mar;130(6):703-709.

 

Hypoparathyroidism-deafness-renal dysplasia (HDR) syndrome is an autosomal dominant disorder primarily caused by haploinsufficiency of GATA binding protein 3 (GATA3) gene mutations, and hearing loss is the most frequent phenotypic feature. This study aimed at identifying the causative ...

Last Updated: 17 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypoparathyroidism" returned 16 free, full-text review articles on human participants. First 3 results:

Epidemiology and Diagnosis of Hypoparathyroidism.
 

Author(s): Bart L Clarke, Edward M Brown, Michael T Collins, Harald Jüppner, Peter Lakatos, Michael A Levine, Michael M Mannstadt, John P Bilezikian, Anatoly F Romanischen, Rajesh V Thakker

Journal: J. Clin. Endocrinol. Metab.. 2016 Jun;101(6):2284-99.

 

Hypoparathyroidism is a disorder characterized by hypocalcemia due to insufficient secretion of PTH. Pseudohypoparathyroidism is a less common disorder due to target organ resistance to PTH. This report summarizes the results of the findings and recommendations of the Working Group ...

Last Updated: 3 Jun 2016

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Management of Hypoparathyroidism: Present and Future.
 

Author(s): John P Bilezikian, Maria Luisa Brandi, Natalie E Cusano, Michael Mannstadt, Lars Rejnmark, René Rizzoli, Mishaela R Rubin, Karen K Winer, Uri A Liberman, John T Potts

Journal: J. Clin. Endocrinol. Metab.. 2016 Jun;101(6):2313-24.

 

Conventional management of hypoparathyroidism has focused upon maintaining the serum calcium with oral calcium and active vitamin D, often requiring high doses and giving rise to concerns about long-term consequences including renal and brain calcifications. Replacement therapy with ...

Last Updated: 3 Jun 2016

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Bone disease in hypoparathyroidism.
 

Author(s): Bart L Clarke

Journal: Arq Bras Endocrinol Metabol. 2014 Jul;58(5):545-52.

 

Hypoparathyroidism is a rare disorder that may be acquired or inherited. Postsurgical hypoparathyroidism is responsible for the majority of acquired hypoparathyroidism. Bone disease occurs in hypoparathyroidism due to markedly reduced bone remodeling due to the absence or low levels ...

Last Updated: 29 Aug 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Survey on Epidemiology of Hypoparathyroidism in France
 

Status: Recruiting

Condition Summary: Hypoparathyroidism

 

Last Updated: 17 Jul 2016

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Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy
 

Status: Recruiting

Condition Summary: Transient Hypoparathyroidism

 

Last Updated: 4 Apr 2016

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PARADIGHM A Natural History Registry for Patients With Chronic Hypoparathyroidism
 

Status: Recruiting

Condition Summary: Chronic Hypoparathyroidism

 

Last Updated: 24 May 2017

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