Hypoparathyroidism

Common Name(s)

Hypoparathyroidism

Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). It may be caused by injury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, DiGeorge syndrome, and type I polyglandular autoimmune syndrome. The goal of treatment is to restore the calcium and mineral balance in the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoparathyroidism" for support, advocacy or research.

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Hypoparathyroidism UK

Working to improve the lives of people with hypoparathyroidism and other parathyroid conditions.

Last Updated: 1 Apr 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoparathyroidism" for support, advocacy or research.

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Hypoparathyroidism UK

Working to improve the lives of people with hypoparathyroidism and other parathyroid conditions.

http://www.hpth.org.uk

Last Updated: 1 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypoparathyroidism" returned 219 free, full-text research articles on human participants. First 3 results:

Genetic and clinical characteristics of korean patients with isolated hypoparathyroidism: from the Korean hypopara registry study.
 

Author(s): So Young Park, Young Sil Eom, Byoungho Choi, Hyon-Seung Yi, Seung-Hee Yu, Kiyoung Lee, Hyun-Seok Jin, Yoon-Sok Chung, Tae Sik Jung, Sihoon Lee

Journal: J. Korean Med. Sci.. 2013 Oct;28(10):1489-95.

 

Isolated hypoparathyroidism (IH) shows heterogeneous phenotypes and can be caused by defects in a variety of genes. The goal of our study was to determine the clinical features and to analyze gene mutations in a large cohort of Korean patients with sporadic or familial IH. We recruited ...

Last Updated: 17 Oct 2013

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Prolonged hypocalcaemia after pamidronate infusion in Riedel's thyroiditis associated hypoparathyroidism.
 

Author(s): D Boumans, P A M de Vries, N E T Rikken, G D Laverman

Journal: Neth J Med. 2013 Oct;71(8):442-3.

 

Last Updated: 15 Oct 2013

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Recovery of parathyroid hormone secretion and function in postoperative hypoparathyroidism: a case series.
 

Author(s): Natalie E Cusano, Laura Anderson, Mishaela R Rubin, Barbara C Silva, Aline G Costa, Dinaz Irani, James Sliney, John P Bilezikian

Journal: J. Clin. Endocrinol. Metab.. 2013 Nov;98(11):4285-90.

 

Transient and permanent postoperative hypoparathyroidism are recognized complications of neck surgery. Postoperative hypoparathyroidism is usually considered permanent when it persists for 6 months; in rare cases, recovery of hypoparathyroidism through 1 year has been described. Recovery ...

Last Updated: 6 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypoparathyroidism" returned 11 free, full-text review articles on human participants. First 3 results:

Mini-review: new therapeutic options in hypoparathyroidism.
 

Author(s): Natalie E Cusano, Mishaela R Rubin, James Sliney, John P Bilezikian

Journal: Endocrine. 2012 Jun;41(3):410-4.

 

Hypoparathyroidism is a disorder characterized by hypocalcemia and low or absent parathyroid hormone (PTH). While standard treatment of hypoparathyroidism consists of oral calcium and vitamin D supplementation, maintaining serum calcium levels can be a challenge, and concerns exist ...

Last Updated: 4 May 2012

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Anti-parathyroid and anti-calcium sensing receptor antibodies in autoimmune hypoparathyroidism.
 

Author(s): Edward M Brown

Journal: Endocrinol. Metab. Clin. North Am.. 2009 Jun;38(2):437-45, x.

 

The parathyroid glands are an infrequent target for autoimmunity, the exception being autoimmune polyglandular syndrome type 1, in which autoimmune hypoparathyroidism is the rule. Antibodies that are directed against the parathyroid cell surface calcium-sensing receptor (CaSR) have ...

Last Updated: 30 Mar 2009

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Hypoparathyroidism and pseudohypoparathyroidism.
 

Author(s): Sergio S Maeda, Erika M Fortes, Ulisses M Oliveira, Victoria C Z Borba, Marise Lazaretti-Castro

Journal: Arq Bras Endocrinol Metabol. 2006 Aug;50(4):664-73.

 

The principal function of the parathyroid hormone (PTH) is maintenance of calcium plasmatic levels, withdrawing the calcium from bone tissue, reabsorbing it from the glomerular filtrate, and indirectly increasing its intestinal absorption by stimulating active vitamin D (calcitriol) ...

Last Updated: 22 Nov 2006

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of PTH Replacement on Bone in Hypoparathyroidism
 

Status: Recruiting

Condition Summary: Hypoparathyroidism; DiGeorge Syndrome

 

Last Updated: 22 May 2014

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PARADIGHM A Natural History Registry for Patients With Chronic Hypoparathyroidism
 

Status: Recruiting

Condition Summary: Chronic Hypoparathyroidism

 

Last Updated: 3 Nov 2014

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A Pilot Study to Assess the Safety and Efficacy of Oral PTH (1-34) in the Treatment of Hypoparathyroidism
 

Status: Not yet recruiting

Condition Summary: Hypoparathyroidism

 

Last Updated: 28 May 2014

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