Hypoparathyroidism

Common Name(s)

Hypoparathyroidism

Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). It may be caused by injury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, DiGeorge syndrome, and type I polyglandular autoimmune syndrome. The goal of treatment is to restore the calcium and mineral balance in the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoparathyroidism" for support, advocacy or research.

Logo
Hypoparathyroidism UK

Working to improve the lives of people with hypoparathyroidism and other parathyroid conditions.

Last Updated: 1 Apr 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoparathyroidism" for support, advocacy or research.

Logo
Hypoparathyroidism UK

Working to improve the lives of people with hypoparathyroidism and other parathyroid conditions.

http://www.hpth.org.uk

Last Updated: 1 Apr 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypoparathyroidism" returned 218 free, full-text research articles on human participants. First 3 results:

Pharmacokinetics and pharmacodynamics of subcutaneous recombinant parathyroid hormone (1-84) in patients with hypoparathyroidism: an open-label, single-dose, phase I study.
 

Author(s): Bart L Clarke, Jolene Kay Berg, John Fox, Jane A Cyran, Hjalmar Lagast

Journal: Clin Ther. 2014 May;36(5):722-36.

 

Impaired mineral homeostasis affecting calcium, phosphate, and magnesium is a result of parathyroid hormone (PTH) deficiency in hypoparathyroidism. The current standard of treatment with active vitamin D and oral calcium does not control levels of these major minerals. Recombinant ...

Last Updated: 23 May 2014

Go To URL
Permanent hypoparathyroidism after completion total thyroidectomy as a second surgery: How do we avoid it?
 

Author(s): Yasuhiro Ito, Minoru Kihara, Kaoru Kobayashi, Akihiro Miya, Akira Miyauchi

Journal: Endocr. J.. 2014 ;61(4):403-8.

 

A permanent hypoparathyroidism is a problematic complication of total thyroidectomy. In this study, we investigated its incidence and how to avoid it at the time of completion total thyroidectomy after hemithyroidectomy. Eight of the 154 patients who underwent completion total thyroidectomy ...

Last Updated: 5 May 2014

Go To URL
Genetic and clinical characteristics of korean patients with isolated hypoparathyroidism: from the Korean hypopara registry study.
 

Author(s): So Young Park, Young Sil Eom, Byoungho Choi, Hyon-Seung Yi, Seung-Hee Yu, Kiyoung Lee, Hyun-Seok Jin, Yoon-Sok Chung, Tae Sik Jung, Sihoon Lee

Journal: J. Korean Med. Sci.. 2013 Oct;28(10):1489-95.

 

Isolated hypoparathyroidism (IH) shows heterogeneous phenotypes and can be caused by defects in a variety of genes. The goal of our study was to determine the clinical features and to analyze gene mutations in a large cohort of Korean patients with sporadic or familial IH. We recruited ...

Last Updated: 17 Oct 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypoparathyroidism" returned 13 free, full-text review articles on human participants. First 3 results:

Use of parathyroid hormone in hypoparathyroidism.
 

Author(s): N E Cusano, M R Rubin, D Irani, J Sliney, J P Bilezikian

Journal: J. Endocrinol. Invest.. 2013 Dec;36(11):1121-7.

 

Hypoparathyroidism is a disorder characterized by hypocalcemia, deficient PTH, and abnormal bone remodeling. Standard treatment of hypoparathyroidism consists of oral calcium and vitamin D supplementation. However, maintaining serum calcium levels can be a challenge. In addition, ...

Last Updated: 21 Jan 2014

Go To URL
Pure red cell aplasia as a presenting feature in systemic lupus erythematosus and association with thymoma, hypothyroidism and hypoparathyroidism: a case report and literature review.
 

Author(s): Sasan Fallahi, Mahmoud Akbarian, Shahriar Dabiri

Journal: Iran J Allergy Asthma Immunol. 2014 Apr;13(2):138-43.

 

This paper presents a 54-year-old female with lupus whom severe anaemia due to pure red cell aplasia (PRCA) was the first manifestation. There was seven years interval between PRCA onset and diagnosis of lupus. Thymectomy due to thymoma had been carried out six years before but anaemia ...

Last Updated: 16 Dec 2013

Go To URL
Mini-review: new therapeutic options in hypoparathyroidism.
 

Author(s): Natalie E Cusano, Mishaela R Rubin, James Sliney, John P Bilezikian

Journal: Endocrine. 2012 Jun;41(3):410-4.

 

Hypoparathyroidism is a disorder characterized by hypocalcemia and low or absent parathyroid hormone (PTH). While standard treatment of hypoparathyroidism consists of oral calcium and vitamin D supplementation, maintaining serum calcium levels can be a challenge, and concerns exist ...

Last Updated: 4 May 2012

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of PTH Replacement on Bone in Hypoparathyroidism
 

Status: Recruiting

Condition Summary: Hypoparathyroidism; DiGeorge Syndrome

 

Last Updated: 22 May 2014

Go to URL
PARADIGHM A Natural History Registry for Patients With Chronic Hypoparathyroidism
 

Status: Recruiting

Condition Summary: Chronic Hypoparathyroidism

 

Last Updated: 9 Feb 2015

Go to URL

Last Updated: 19 Mar 2013

Go to URL