Hypokalemic periodic paralysis

Common Name(s)

Hypokalemic periodic paralysis

Hypokalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness typically beginning in childhood or adolescence. Most often, these episodes involve a temporary inability to move muscles in the arms and legs. The duration and frequency of the episodes may vary. Hypokalemic periodic paralysis is caused by mutations in the CACNA1S and SCN4A genes which are inherited in an autosomal dominant fashion. A small percentage of people with the characteristic features of hypokalemic periodic paralysis do not have identified mutations in these genes. In these cases, the cause of the condition is unknown.  Paralytic crises can be treated with oral or IV potassium. Other management includes prevention of crises and support of specific symptoms.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypokalemic periodic paralysis" for support, advocacy or research.

Periodic Paralysis Association

To provide convenient access to science-based information to help better understand and manage the periodic paralyses. To stimulate interaction between the periodic paralysis community and various professional disciplines that may be able to bring light to this complex and often misunderstood collection of disorders. To provide the tools and a forum for open discussion of the diverse issues associated with these disorders. To promote an increasing level of awareness of these disorders, leading to increased research, improved management guidelines, improved diagnostic protocols, and ultimately, their prevention and cure

Last Updated: 23 Jun 2015

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Periodic Paralysis International

Our Mission statement is to disseminate timely, medically accurate and useful information, to provide supportive services, and to encourage research which enhances the quality of life for people with the skeletal muscle ion channelopathies classified as the periodic paralyses.

Last Updated: 12 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypokalemic periodic paralysis" for support, advocacy or research.

Periodic Paralysis Association

To provide convenient access to science-based information to help better understand and manage the periodic paralyses. To stimulate interaction between the periodic paralysis community and various professional disciplines that may be able to bring light to this complex and often misunderstood collection of disorders. To provide the tools and a forum for open discussion of the diverse issues associated with these disorders. To promote an increasing level of awareness of these disorders, leading to increased research, improved management guidelines, improved diagnostic protocols, and ultimately, their prevention and cure

http://www.periodicparalysis.org

Last Updated: 23 Jun 2015

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Periodic Paralysis International

Our Mission statement is to disseminate timely, medically accurate and useful information, to provide supportive services, and to encourage research which enhances the quality of life for people with the skeletal muscle ion channelopathies classified as the periodic paralyses.

http://hkpp.org

Last Updated: 12 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypokalemic periodic paralysis" returned 47 free, full-text research articles on human participants. First 3 results:

[Thyrotoxic hypokalemic periodic paralysis in patients of African descent].
 

Author(s): Morgana Lima e Maia, Paula Grasiele Carvalho Trevisam, Marcos Minicucci, Glaucia M F S Mazeto, Paula S Azevedo

Journal: Arq Bras Endocrinol Metabol. 2014 Oct;58(7):779-81.

 

Thyrotoxic hypokalemic periodic paralysis (THPP) is an endocrine emergency marked by recurrent attacks of muscle weakness associated with hypokalemia and thyrotoxicosis. Asiatic male patients are most often affected. On the other hand, African descents rarely present this disease. ...

Last Updated: 6 Nov 2014

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Disrupted coupling of gating charge displacement to Na+ current activation for DIIS4 mutations in hypokalemic periodic paralysis.
 

Author(s): Wentao Mi, Volodymyr Rybalchenko, Stephen C Cannon

Journal: J. Gen. Physiol.. 2014 Aug;144(2):137-45.

 

Missense mutations at arginine residues in the S4 voltage-sensor domains of NaV1.4 are an established cause of hypokalemic periodic paralysis, an inherited disorder of skeletal muscle involving recurrent episodes of weakness in conjunction with low serum K(+). Expression studies in ...

Last Updated: 29 Jul 2014

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Possible brugada phenocopy induced by hypokalemia in a patient with congenital hypokalemic periodic paralysis.
 

Author(s): Daniel D Anselm, Natalia Rodriguez Genaro, Adrian Baranchuk

Journal: Arq. Bras. Cardiol.. 2014 Jan;102(1):104.

 

Last Updated: 21 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypokalemic periodic paralysis" returned 3 free, full-text review articles on human participants. First 3 results:

Extracellular potassium homeostasis: insights from hypokalemic periodic paralysis.
 

Author(s): Chih-Jen Cheng, Elizabeth Kuo, Chou-Long Huang

Journal: Semin. Nephrol.. 2013 May;33(3):237-47.

 

Extracellular potassium makes up only about 2% of the total body's potassium store. The majority of the body potassium is distributed in the intracellular space, of which about 80% is in skeletal muscle. Movement of potassium in and out of skeletal muscle thus plays a pivotal role ...

Last Updated: 19 Aug 2013

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[Thyrotoxic hypokalemic periodic paralysis, an endocrine emergency: clinical and genetic features in 25 patients].
 

Author(s): Magnus R Dias da Silva, Maria Izabel Chiamolera, Teresa S Kasamatsu, Janete M Cerutti, Rui M B Maciel

Journal: Arq Bras Endocrinol Metabol. 2004 Feb;48(1):196-215.

 

Thyrotoxic hypokalemic periodic paralysis (THPP) is a medical emergency characterized by acute attacks of weakness, hypokalemia, and thyrotoxicosis that resolve with the treatment of hyperthyroidism. Attacks are transient, self-limited, associated with hypokalemia and resemble those ...

Last Updated: 21 Dec 2004

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Skeletal muscle sodium current is reduced in hypokalemic periodic paralysis.
 

Author(s): R L Ruff

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2000 Aug;97(18):9832-3.

 

Last Updated: 5 Oct 2000

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.