Hypertrophic Cardiomyopathy

Common Name(s)

Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a disease in which the walls of the heart muscle become abnormally thick. When the walls of the heart are thick it makes it difficult to pump blood. HCM can affect men and women of any age. HCM often goes undiagnosed because people often have few symptoms. Some may experience symptoms such as shortness of breath, chest pain, fainting, dizziness, fatigue, heart murmur or sensation of a racing heart beat. A physician can typically diagnose HCM using a heart function test called an echocardiogram. Additional tests, such as a treadmill stress test, may be needed. Medication and certain medical procedures can help manage symptoms and prevent sudden cardiac death. People with HCM often lead normal lives with no significant problems.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypertrophic Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

Last Updated: 11 Apr 2016

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Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

Last Updated: 20 Jul 2015

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Hypertrophic Cardiomyopathy Association

Our mission is to provide support, advocacy and education to patients, and their family members, the medical community and the public about Hypertrophic Cardiomyopathy.

Last Updated: 6 May 2013

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Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypertrophic Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

https://www.barthsyndrome.org

Last Updated: 11 Apr 2016

View Details
Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

http://www.childrenscardiomyopathy.org

Last Updated: 20 Jul 2015

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Hypertrophic Cardiomyopathy Association

Our mission is to provide support, advocacy and education to patients, and their family members, the medical community and the public about Hypertrophic Cardiomyopathy.

http://www.4hcm.org

Last Updated: 6 May 2013

View Details
Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

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General Support Organizations

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General Resources

Barth Syndrome Professional Healthcare Brochure

Important information regarding diagnosis and treatment of Barth syndrome.

Updated 12 Apr 2014

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How to Diagnose

How to diagnose Barth syndrome

Updated 14 Jan 2015

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Overview of Barth syndrome

Overview of Barth syndrome

Updated 14 Jan 2015

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Barath Syndrome Journal

Newsletter published twice a year.

Updated 15 Mar 2016

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypertrophic Cardiomyopathy" returned 1943 free, full-text research articles on human participants. First 3 results:

Approaching the facts between genetic mutation and clinical practice of hypertrophic cardiomyopathy: A case report with RAF1 770C>T mutant.
 

Author(s): Xiaoqin Wang, Kaiyu Zhou, Yimin Hua, Yifei Li

Journal: Medicine (Baltimore). 2016 Sep;95(37):e4815.

 

Hypertrophic cardiomyopathy (HCM) is one of the most common cardiomyopathies, which induces sudden cardiac death. Several mutants have been identified among HCM cases.

Last Updated: 16 Sep 2016

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Capnocytophaga ochracea-related Bacterium Bacteremia in a Hypertrophic Cardiomyopathy Patient without Neutropenia.
 

Author(s): Shimpei Ito, Hideharu Hagiya, Keigo Kimura, Isao Nishi, Hisao Yoshida, Hidetaka Kioka, Tomohito Ohtani, Osamu Yamaguchi, Kazuaki Tanabe, Kazunori Tomono, Yasushi Sakata

Journal: Intern. Med.. ;55(18):2731-5.

 

Gram-negative fusiform rods were detected in a blood culture obtained from a 63-year-old man who had been hospitalized for a long duration for severe heart failure. Although the organism could not be identified using a conventional method, it was finally identified as a bacterium ...

Last Updated: 16 Sep 2016

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Familial hypertrophic obstructive cardiomyopathy with the GLA E66Q mutation and zebra body.
 

Author(s): Masayoshi Oikawa, Nobuo Sakamoto, Atsushi Kobayashi, Satoshi Suzuki, Akiomi Yoshihisa, Takayoshi Yamaki, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-Ichi Saitoh, Yuichirou Kiko, Hajime Nakano, Takeharu Hayashi, Akinori Kimura, Yasuchika Takeishi

Journal:

 

Fabry disease is caused by mutations in the α-galactosidase A (GLA) gene, which is located in X-chromosome coding for the lysosomal enzyme of GLA. Among many gene mutations, E66Q mutation is under discussion for its pathogenicity because there is no clinical report showing pathological ...

Last Updated: 10 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypertrophic Cardiomyopathy" returned 149 free, full-text review articles on human participants. First 3 results:

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin.
 

Author(s): James A Spudich, Tural Aksel, Sadie R Bartholomew, Suman Nag, Masataka Kawana, Elizabeth Choe Yu, Saswata S Sarkar, Jongmin Sung, Ruth F Sommese, Shirley Sutton, Carol Cho, Arjun S Adhikari, Rebecca Taylor, Chao Liu, Darshan Trivedi, Kathleen M Ruppel

Journal: J. Exp. Biol.. 2016 Jan;219(Pt 2):161-7.

 

Hypertrophic cardiomyopathy is the most frequently occurring inherited cardiovascular disease, with a prevalence of more than one in 500 individuals worldwide. Genetically acquired dilated cardiomyopathy is a related disease that is less prevalent. Both are caused by mutations in ...

Last Updated: 21 Jan 2016

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Application of Genetic Testing in Hypertrophic Cardiomyopathy for Preclinical Disease Detection.
 

Author(s): Jodie Ingles, Charlotte Burns, Alexandra Barratt, Christopher Semsarian

Journal: Circ Cardiovasc Genet. 2015 Dec;8(6):852-9.

 

Last Updated: 16 Dec 2015

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Last Updated: 1 Dec 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

French Hypertrophic Cardiomyopathy Observatory
 

Status: Recruiting

Condition Summary: Hypertrophic Cardiomyopathy

 

Last Updated: 12 Feb 2015

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Assessment of Wall Thickness in Hypertrophic Cardiomyopathy
 

Status: Recruiting

Condition Summary: Hypertrophic Cardiomyopathy

 

Last Updated: 26 Sep 2016

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Efficacy, Safety, and Tolerability of Perhexiline in Subjects With Hypertrophic Cardiomyopathy and Heart Failure
 

Status: Not yet recruiting

Condition Summary: Hypertrophic Cardiomyopathy

 

Last Updated: 29 Apr 2015

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