Hypertrophic Cardiomyopathy

Common Name(s)

Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a disease in which the walls of the heart muscle become abnormally thick. When the walls of the heart are thick it makes it difficult to pump blood. HCM can affect men and women of any age. HCM often goes undiagnosed because people often have few symptoms. Some may experience symptoms such as shortness of breath, chest pain, fainting, dizziness, fatigue, heart murmur or sensation of a racing heart beat. A physician can typically diagnose HCM using a heart function test called an echocardiogram. Additional tests, such as a treadmill stress test, may be needed. Medication and certain medical procedures can help manage symptoms and prevent sudden cardiac death. People with HCM often lead normal lives with no significant problems.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypertrophic Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

Last Updated: 12 Apr 2014

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Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

Last Updated: 20 May 2014

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Hypertrophic Cardiomyopathy Association

Our mission is to provide support, advocacy and education to patients, and their family members, the medical community and the public about Hypertrophic Cardiomyopathy.

Last Updated: 6 May 2013

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Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 30 Oct 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypertrophic Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

http://www.barthsyndrome.org

Last Updated: 12 Apr 2014

View Details
Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

http://www.childrenscardiomyopathy.org

Last Updated: 20 May 2014

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Hypertrophic Cardiomyopathy Association

Our mission is to provide support, advocacy and education to patients, and their family members, the medical community and the public about Hypertrophic Cardiomyopathy.

http://www.4hcm.org

Last Updated: 6 May 2013

View Details
Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 30 Oct 2012

View Details

 

General Support Organizations

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General Resources

2012 Conference Program

Barth Syndrome Foundation 2012 Conference Program

Updated 2 Nov 2012

Open Doc
Barth Syndrome Professional Healthcare Brochure

Important information regarding diagnosis and treatment of Barth syndrome.

Updated 12 Apr 2014

Open Doc
 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypertrophic Cardiomyopathy" returned 1682 free, full-text research articles on human participants. First 3 results:

Diverse geometric changes related to dynamic left ventricular outflow tract obstruction without overt hypertrophic cardiomyopathy.
 

Author(s): Jung-Joon Cha, Hyemoon Chung, Young Won Yoon, Ji Hyun Yoon, Jong-Youn Kim, Pil-Ki Min, Byoung-Kwon Lee, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Eui-Young Choi

Journal:

 

Dynamic left ventricular (LV) outflow tract (LVOT) obstruction (DLVOTO) is not infrequently observed in older individuals without overt hypertrophic cardiomyopathy (HCM). We sought to investigate associated geometric changes and then evaluate their clinical characteristics.

Last Updated: 9 Jul 2014

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Rapid molecular genetic diagnosis of hypertrophic cardiomyopathy by semiconductor sequencing.
 

Author(s): Zongzhe Li, Jin Huang, Jinzhao Zhao, Chen Chen, Hong Wang, Hu Ding, Dao Wu Wang, Dao Wen Wang

Journal:

 

Rapidly determining the complex genetic basis of Hypertrophic cardiomyopathy (HCM) is vital to better understanding and optimally managing this common polygenetic cardiovascular disease.

Last Updated: 27 Jun 2014

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A novel and practical cardiovascular magnetic resonance method to quantify mitral annular excursion and recoil applied to hypertrophic cardiomyopathy.
 

Author(s): Shahryar G Saba, Sohae Chung, Sharath Bhagavatula, Robert Donnino, Monvadi B Srichai, Muhamed Saric, Stuart D Katz, Leon Axel

Journal:

 

We have developed a novel and practical cardiovascular magnetic resonance (CMR) technique to evaluate left ventricular (LV) mitral annular motion by tracking the atrioventricular junction (AVJ). To test AVJ motion analysis as a metric for LV function, we compared AVJ motion variables ...

Last Updated: 4 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypertrophic Cardiomyopathy" returned 137 free, full-text review articles on human participants. First 3 results:

Hypertrophic cardiomyopathy: how do mutations lead to disease?
 

Author(s): JĂșlia Daher Carneiro Marsiglia, Alexandre Costa Pereira

Journal: Arq. Bras. Cardiol.. 2014 Mar;102(3):295-304.

 

Hypertrophic cardiomyopathy (HCM) is the most common monogenic genetic cardiac disease, with an estimated prevalence of 1:500 in the general population. Clinically, HCM is characterized by hypertrophy of the left ventricle (LV) walls, especially the septum, usually asymmetric, in ...

Last Updated: 9 Apr 2014

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Hypertrophic and dilated cardiomyopathy: four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseases.
 

Author(s): James A Spudich

Journal: Biophys. J.. 2014 Mar;106(6):1236-49.

 

With the advent of technologies to obtain the complete sequence of the human genome in a cost-effective manner, this decade and those to come will see an exponential increase in our understanding of the underlying genetics that lead to human disease. And where we have a deep understanding ...

Last Updated: 24 Mar 2014

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The influence of Angiotensin converting enzyme and angiotensinogen gene polymorphisms on hypertrophic cardiomyopathy.
 

Author(s): Rong Luo, Xiaoping Li, Yuequn Wang, Yongqing Li, Yun Deng, Yongqi Wan, Zhigang Jiang, Wei Hua, Xiushan Wu

Journal:

 

Some studies have reported that angiotensin converting enzyme (ACE) and angiotensinogen (AGT) genes have been associated with hypertrophic cardiomyopathy (HCM). However, there have been inconsonant results among different studies. To clarify the influence of ACE and AGT on HCM, a ...

Last Updated: 8 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

French Hypertrophic Cardiomyopathy Observatory
 

Status: Recruiting

Condition Summary: Hypertrophic Cardiomyopathy

 

Last Updated: 8 Jul 2014

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Effect of GS-6615 on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy
 

Status: Not yet recruiting

Condition Summary: Hypertrophic Cardiomyopathy

 

Last Updated: 11 Nov 2014

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Assessment of Wall Thickness in Hypertrophic Cardiomyopathy
 

Status: Not yet recruiting

Condition Summary: Hypertrophic Cardiomyopathy

 

Last Updated: 5 Sep 2014

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