Hypertrophic Cardiomyopathy

Common Name(s)

Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a disease in which the walls of the heart muscle become abnormally thick. When the walls of the heart are thick it makes it difficult to pump blood. HCM can affect men and women of any age. HCM often goes undiagnosed because people often have few symptoms. Some may experience symptoms such as shortness of breath, chest pain, fainting, dizziness, fatigue, heart murmur or sensation of a racing heart beat. A physician can typically diagnose HCM using a heart function test called an echocardiogram. Additional tests, such as a treadmill stress test, may be needed. Medication and certain medical procedures can help manage symptoms and prevent sudden cardiac death. People with HCM often lead normal lives with no significant problems.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypertrophic Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

Last Updated: 11 Apr 2016

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Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

Last Updated: 20 Jul 2015

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Hypertrophic Cardiomyopathy Association

Our mission is to provide support, advocacy and education to patients, and their family members, the medical community and the public about Hypertrophic Cardiomyopathy.

Last Updated: 6 May 2013

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Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypertrophic Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

https://www.barthsyndrome.org

Last Updated: 11 Apr 2016

View Details
Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

http://www.childrenscardiomyopathy.org

Last Updated: 20 Jul 2015

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Hypertrophic Cardiomyopathy Association

Our mission is to provide support, advocacy and education to patients, and their family members, the medical community and the public about Hypertrophic Cardiomyopathy.

http://www.4hcm.org

Last Updated: 6 May 2013

View Details
Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

View Details

 

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General Resources

Barth Syndrome Professional Healthcare Brochure

Important information regarding diagnosis and treatment of Barth syndrome.

Updated 12 Apr 2014

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How to Diagnose

How to diagnose Barth syndrome

Updated 14 Jan 2015

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Overview of Barth syndrome

Overview of Barth syndrome

Updated 14 Jan 2015

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Barath Syndrome Journal

Newsletter published twice a year.

Updated 15 Mar 2016

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypertrophic Cardiomyopathy" returned 1974 free, full-text research articles on human participants. First 3 results:

Genetic anticipation in a special form of hypertrophic cardiomyopathy with sudden cardiac death in a family with 74 members across 5 generations.
 

Author(s): Xiying Guo, Chaomei Fan, Yanping Wang, Miao Wang, Chi Cai, Yinjian Yang, Shihua Zhao, Fujian Duan, Yishi Li

Journal: Medicine (Baltimore). 2017 Mar;96(11):e6249.

 

Hypertrophic cardiomyopathy (HCM) is the most common heritable heart disease. The genetic anticipation of HCM and its associated etiology, sudden cardiac death (SCD), remains unclear. The aim of this study was to investigate the mechanism underlying the genetic anticipation of HCM ...

Last Updated: 15 Mar 2017

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Stress cardiomyopathy in a patient with hypertrophic cardiomyopathy and myocardial bridging.
 

Author(s): Miguel Benavides, Juan M Vinardell, Ivan Arenas, Orlando Santana

Journal:

 

Stress cardiomyopathy is an acquired cardiomyopathy of unknown aetiology. It usually occurs in women over the age of 70 who have experienced physical or emotional stress. It is most commonly characterised by a transient, left ventricular systolic dysfunction in the apical portion ...

Last Updated: 23 Feb 2017

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Prognostic Significance of Non-Dilated Left Ventricular Size and Mitral Regurgitation in Patients With Dilated Phase of Hypertrophic Cardiomyopathy.
 

Author(s): Toru Kubo, Yuichi Baba, Takayoshi Hirota, Katsutoshi Tanioka, Naohito Yamasaki, Yoshinori L Doi, Hiroaki Kitaoka

Journal: Int Heart J. 2017 Feb;58(1):63-68.

 

Although a subtype of hypertrophic cardiomyopathy (HCM), dilated phase of HCM (D-HCM) characterized by left ventricular (LV) systolic dysfunction, has been reported to have a poor prognosis, some patients with D-HCM survive for a relatively long period. The degree of LV dilatation ...

Last Updated: 12 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypertrophic Cardiomyopathy" returned 154 free, full-text review articles on human participants. First 3 results:

Positron-emission tomography myocardial blood flow quantification in hypertrophic cardiomyopathy.
 

Author(s): Roberto Sciagrà

Journal: Q J Nucl Med Mol Imaging. 2016 Dec;60(4):354-61.

 

In the setting of hypertrophic cardiomyopathy (HCM), ischemia plays a possibly under-evaluated role. In particular, a large body of evidence indicates that structural and functional abnormalities in the coronary microcirculation contribute to myocardial ischemia and are key elements ...

Last Updated: 29 Sep 2016

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Echocardiographic diagnosis of the different phenotypes of hypertrophic cardiomyopathy.
 

Author(s): Vito Maurizio Parato, Valeria Antoncecchi, Fabiola Sozzi, Stefania Marazia, Annapaola Zito, Maria Maiello, Pasquale Palmiero,

Journal:

 

Hypertrophic Cardiomyopathy (HCM) is an inherited cardiovascular disorder of great genetic heterogeneity and has a prevalence of 0.1 - 0.2 % in the general population. Several hundred mutations in more than 27 genes, most of which encode sarcomeric structures, are associated with ...

Last Updated: 13 Aug 2016

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Obstructive Form of Hypertrophic Cardiomyopathy-Left Ventricular Outflow Tract Gradient: Novel Methods of Provocation, Monitoring of Biomarkers, and Recent Advances in the Treatment.
 

Author(s): Pawel Petkow Dimitrow, Renata Rajtar-Salwa

Journal: Biomed Res Int. 2016 ;2016():1575130.

 

Dynamic (latent or/and labile) obstruction of left ventricular outflow (LVOT) was recognized from the earliest clinical descriptions of hypertrophic cardiomyopathy (HCM) and has proved to be a complex phenomenon, as well as arguably the most audible ("visible") pathophysiological ...

Last Updated: 1 Jun 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

French Hypertrophic Cardiomyopathy Observatory
 

Status: Recruiting

Condition Summary: Hypertrophic Cardiomyopathy

 

Last Updated: 12 Feb 2015

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Assessment of Wall Thickness in Hypertrophic Cardiomyopathy
 

Status: Recruiting

Condition Summary: Hypertrophic Cardiomyopathy

 

Last Updated: 26 Sep 2016

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Efficacy, Safety, and Tolerability of Perhexiline in Subjects With Hypertrophic Cardiomyopathy and Heart Failure
 

Status: Not yet recruiting

Condition Summary: Hypertrophic Cardiomyopathy

 

Last Updated: 29 Apr 2015

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