Ambiguous genitalia

Common Name(s)

Ambiguous genitalia

Ambiguous genitalia is a rare condition where a baby is born with genitalia (sexual organs) that are not clearly male or female. About 1 in 4,500 babies is born with ambiguous genitalia, which is usually diagnosed by a doctor at birth. With ambiguous genitalia, the baby's sexual organs may not be fully developed and the baby may have characteristics of both sexes, or the internal sexual organs might not match the external sexual organs. Ambiguous genitalia may be caused by abnormal amounts of hormones (important chemicals) during development. The steps for managing ambiguous genitalia depend on the family's choice, but it is important to have genetic testing to determine whether or not the condition is caused by mutations to certain genes or missing or extra chromosomes. In some cases, surgery to correct ambiguous genitalia or hormone medication may be used, but these options are not for everyone. Most children with ambiguous genitalia are otherwise completely healthy. Talk with your baby's doctor as well as genetic and other specialists to determine the best care plan for your child. Connecting with other families affected by ambigous genitalia may also be helpful.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ambiguous genitalia" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ambiguous genitalia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ambiguous genitalia" returned 27 free, full-text research articles on human participants. First 3 results:

Macrosomia and ambiguous genitalia: a long overdue answer to the citizens of Frusino.
 

Author(s): Vasiliki Vasileiou, Anastasia K Armeni, Apostolos L Pierris, Neoklis A Georgopoulos

Journal: Hormones (Athens). ;11(2):215-21.

 

In the literature of the Roman Era, a case of macrosomia and genital ambiguity in a newborn is described. Textual evidence concerning this case of androgynism and its symbolism is provided in the present study. Medical interpretation of such cases covers the entire spectrum of differential ...

Last Updated: 17 Jul 2012

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RE: Ambiguous genitalia: two decades of experience.
 

Author(s): Mahmood D Al-Mendalawi

Journal: Ann Saudi Med. ;31(5):549-50.

 

Last Updated: 13 Sep 2011

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Ambiguous genitalia: two decades of experience.
 

Author(s): Nasir A M Al-Jurayyan

Journal: Ann Saudi Med. ;31(3):284-8.

 

Ambiguous genitalia is a complex, medical and social emergency. The aim of this study is to present our experience over two decades, focusing on the pattern and clinical presentation.

Last Updated: 30 May 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ambiguous genitalia" returned 3 free, full-text review articles on human participants. First 3 results:

[Children born with ambiguous genitalia].
 

Author(s): Trond H Diseth

Journal: Tidsskr. Nor. Laegeforen.. 2008 Feb;128(5):576-80.

 

For 10 - 12 children born with ambiguous genitalia in Norway annually, the sex cannot be decided directly after birth. The condition is now termed "Disorders of Sex Development" (DSD). Severely undervirilised chromosomal and gonadal boys (46,XY DSD) represent the greatest challenge; ...

Last Updated: 3 Mar 2008

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Anogenital malformation with ambiguous genitalia as part of the OEIS complex.
 

Author(s): I Witters, J Deprest, C Van Hole, M Hanssens, H Devlieger, J P Fryns

Journal: Ultrasound Obstet Gynecol. 2004 Dec;24(7):797-8.

 

Last Updated: 13 Dec 2004

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Surgical management of ambiguous genitalia.
 

Author(s): L Rangecroft,

Journal: Arch. Dis. Child.. 2003 Sep;88(9):799-801.

 

The surgical management of children born with ambiguous genitalia has always been difficult, subject to evolving attitudes and techniques, and at times controversial. Standard protocols have stressed the need for early diagnosis, gender assignment, and appropriate surgery in infancy.(1) ...

Last Updated: 25 Aug 2003

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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