Hypereosinophilic syndromes

Common Name(s)

Hypereosinophilic syndromes, Hypereosinophilic syndrome

Hypereosinophilic syndrome is a group of rare blood disorders characterized by increased levels of eosinophils (a type of white blood cell that plays a role in the human immune system) persisting for more than six months. The signs and symptoms are due to involvement of several internal organs and there is usually no evidence of parasites, allergy, or other known causes of an elevated eosinophil count. This condition largely occurs in males, typically at middle age. It usually presents with fever, weight loss, fatigue, and rash. An enlarged liver and spleen and liver is often present. The lungs, kidneys, heart, and nervous system can also be affected.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypereosinophilic syndromes" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypereosinophilic syndromes" returned 5 free, full-text research articles on human participants. First 3 results:

Long-term safety of mepolizumab for the treatment of hypereosinophilic syndromes.
 

Author(s): Florence E Roufosse, Jean-Emmanuel Kahn, Gerald J Gleich, Lawrence B Schwartz, Anish D Singh, Lanny J Rosenwasser, Judah A Denburg, Johannes Ring, Marc E Rothenberg, Javed Sheikh, Ann E Haig, Stephen A Mallett, Deborah N Templeton, Hector G Ortega, Amy D Klion

Journal: J. Allergy Clin. Immunol.. 2013 Feb;131(2):461-7.e1-5.

 

Hypereosinophilic syndromes (HESs) are chronic disorders that require long-term therapy to suppress eosinophilia and clinical manifestations. Corticosteroids are usually effective, yet many patients become corticosteroid refractory or develop corticosteroid toxicity. Mepolizumab, ...

Last Updated: 4 Feb 2013

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Lung involvement in hypereosinophilic syndromes.
 

Author(s): Megan M Dulohery, Rajesh R Patel, Frank Schneider, Jay H Ryu

Journal: Respir Med. 2011 Jan;105(1):114-21.

 

Hypereosinophilic syndromes (HES) are a heterogeneous group of conditions that are characterized by tissue-associated eosinophilic inflammation and peripheral eosinophilia. Although clinical and radiologic features associated with most forms of eosinophilic lung diseases are relatively ...

Last Updated: 14 Dec 2010

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Recent advances in the diagnosis and treatment of hypereosinophilic syndromes.
 

Author(s): Amy D Klion

Journal: Hematology Am Soc Hematol Educ Program. 2005 ;():209-14.

 

Hypereosinophilic syndromes (HES) are a heterogeneous group of disorders characterized by marked peripheral blood and tissue eosinophilia resulting in end organ damage. Recent advances in molecular biology and immunology have led to the identification of a number of distinct subtypes ...

Last Updated: 23 Nov 2005

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypereosinophilic syndromes" returned 7 free, full-text review articles on human participants. First 3 results:

Therapeutic approaches to patients with hypereosinophilic syndromes.
 

Author(s): Hans-Uwe Simon, Amy Klion

Journal: Semin. Hematol.. 2012 Apr;49(2):160-70.

 

Hypereosinophilic syndromes (HES) are a heterogeneous group of disorders that range from asymptomatic eosinophilia > 1,500/mL to aggressive disease complicated by life-threatening end organ involvement, including endomyocardial fibrosis and thromboembolism. To complicate matters further, ...

Last Updated: 27 Mar 2012

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Diagnostic and therapeutic management in patients with hypereosinophilic syndromes.
 

Author(s): Grzegorz Helbig, Sławomira Kyrcz-Krzemień

Journal: Pol. Arch. Med. Wewn.. ;121(1-2):44-52.

 

The hypereosinophilic syndromes (HES) are rare disorders characterized by sustained, nonreactive hypereosinophilia with eosinophilia-associated organ damage/dysfunction. The most frequent clinical manifestations include skin abnormalities, cardiac failure, and neurological deficits, ...

Last Updated: 24 Feb 2011

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Novel therapies for hypereosinophilic syndromes.
 

Author(s): S A Antoniu

Journal: Neth J Med. 2010 Aug;68(1):304-10.

 

Conventional therapies (corticosteroids, cytotoxic agents or interferon-a) or newer compounds such imatinib are used specifically in subsets of hypereosinophilic syndromes (HES). However other therapies are still needed in this condition.

Last Updated: 26 Aug 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of STI571 in the Treatment of Patients With Idiopathic Hypereosinophilic Syndrome (HES) and Eosinophilic Leukemias
 

Status: Recruiting

Condition Summary: Hypereosinophilic Syndrome; Chronic Eosinophilic Leukemia (CEL); Myeloproliferative Disorders

 

Last Updated: 14 Sep 2009

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Compassionate Use of Mepolizumab in Subjects With Hypereosinophilic Syndrome (HES)
 

Status: Recruiting

Condition Summary: Hypereosinophilic Syndrome

 

Last Updated: 28 Aug 2014

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Imatinib Mesylate to Treat Myeloproliferative Hypereosinophilic Syndrome
 

Status: Recruiting

Condition Summary: Hypereosinophilic Syndrome

 

Last Updated: 17 Jun 2014

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