Hypereosinophilic syndromes

Common Name(s)

Hypereosinophilic syndromes, Hypereosinophilic syndrome

Hypereosinophilic syndrome (HES) is a condition in which there is an abnormally high number of a certain type of white blood cell called eosinophils. Eosinophils, like all white blood cells, are involved in the immune system. In HES, the number of eosinophils circulating in the blood remains high for a period of over 6 months with no apparent cause. This elevation in eosinophils can affect many organs, such as the heart, nervous system, bone marrow, spleen, or skin.

Symptoms of HES include cardiomyopathy, skin lesions, difficulty breathing, weakness, and numbness. About half of people with HES will also have anemia, or a low number of red blood cells circulating in the blood. This syndrome mostly affects people between the ages of 20 and 50. HES can be caused by certain gene mutations, although in most cases the cause is unknown.

A doctor may use blood tests, bone marrow tests, and imaging tests to rule out other conditions when diagnosing HES. Treatment usually involves medications, such as steroid hormones, and can rarely require surgery. Talk to your doctor about the most current treatment options and which options may be right for you. Support groups can also be a good source of information and encouragement.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypereosinophilic syndromes" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypereosinophilic syndromes" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypereosinophilic syndromes" returned 4 free, full-text research articles on human participants. First 3 results:

Long-term safety of mepolizumab for the treatment of hypereosinophilic syndromes.
 

Author(s): Florence E Roufosse, Jean-Emmanuel Kahn, Gerald J Gleich, Lawrence B Schwartz, Anish D Singh, Lanny J Rosenwasser, Judah A Denburg, Johannes Ring, Marc E Rothenberg, Javed Sheikh, Ann E Haig, Stephen A Mallett, Deborah N Templeton, Hector G Ortega, Amy D Klion

Journal: J. Allergy Clin. Immunol.. 2013 Feb;131(2):461-7.e1-5.

 

Hypereosinophilic syndromes (HESs) are chronic disorders that require long-term therapy to suppress eosinophilia and clinical manifestations. Corticosteroids are usually effective, yet many patients become corticosteroid refractory or develop corticosteroid toxicity. Mepolizumab, ...

Last Updated: 4 Feb 2013

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Lung involvement in hypereosinophilic syndromes.
 

Author(s): Megan M Dulohery, Rajesh R Patel, Frank Schneider, Jay H Ryu

Journal: Respir Med. 2011 Jan;105(1):114-21.

 

Hypereosinophilic syndromes (HES) are a heterogeneous group of conditions that are characterized by tissue-associated eosinophilic inflammation and peripheral eosinophilia. Although clinical and radiologic features associated with most forms of eosinophilic lung diseases are relatively ...

Last Updated: 14 Dec 2010

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Immunophenotypic evaluation of circulating T-cell clones in hypereosinophilic syndromes with or without abnormal CD3 and CD4 lymphocytes.
 

Author(s): Renato Bassan, Giovanni Locatelli, Gianmaria Borleri, Anna Salvi, Tiziano Barbui

Journal: Haematologica. 2004 Feb;89(2):238-9.

 

Last Updated: 8 Mar 2004

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypereosinophilic syndromes" returned 8 free, full-text review articles on human participants. First 3 results:

Therapeutic approaches to patients with hypereosinophilic syndromes.
 

Author(s): Hans-Uwe Simon, Amy Klion

Journal: Semin. Hematol.. 2012 Apr;49(2):160-70.

 

Hypereosinophilic syndromes (HES) are a heterogeneous group of disorders that range from asymptomatic eosinophilia > 1,500/mL to aggressive disease complicated by life-threatening end organ involvement, including endomyocardial fibrosis and thromboembolism. To complicate matters further, ...

Last Updated: 27 Mar 2012

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Diagnostic and therapeutic management in patients with hypereosinophilic syndromes.
 

Author(s): Grzegorz Helbig, Sławomira Kyrcz-Krzemień

Journal: Pol. Arch. Med. Wewn.. ;121(1-2):44-52.

 

The hypereosinophilic syndromes (HES) are rare disorders characterized by sustained, nonreactive hypereosinophilia with eosinophilia-associated organ damage/dysfunction. The most frequent clinical manifestations include skin abnormalities, cardiac failure, and neurological deficits, ...

Last Updated: 24 Feb 2011

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Novel therapies for hypereosinophilic syndromes.
 

Author(s): S A Antoniu

Journal: Neth J Med. 2010 Aug;68(1):304-10.

 

Conventional therapies (corticosteroids, cytotoxic agents or interferon-a) or newer compounds such imatinib are used specifically in subsets of hypereosinophilic syndromes (HES). However other therapies are still needed in this condition.

Last Updated: 26 Aug 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Imatinib Mesylate to Treat Myeloproliferative Hypereosinophilic Syndrome
 

Status: Recruiting

Condition Summary: Hypereosinophilic Syndrome

 

Last Updated: 23 Apr 2016

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Compassionate Use of Mepolizumab in Subjects With Hypereosinophilic Syndrome (HES)
 

Status: Recruiting

Condition Summary: Hypereosinophilic Syndrome

 

Last Updated: 5 Jul 2016

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Study of STI571 in the Treatment of Patients With Idiopathic Hypereosinophilic Syndrome (HES) and Eosinophilic Leukemias
 

Status: Recruiting

Condition Summary: Hypereosinophilic Syndrome; Chronic Eosinophilic Leukemia (CEL); Myeloproliferative Disorders

 

Last Updated: 14 Sep 2009

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