Hypercholesterolemia

Common Name(s)

Hypercholesterolemia, High cholesterol

Hypercholesterolemia, also known as high cholesterol, is a condition in which there are high levels of cholesterol in the blood. Cholesterol is a thick, fat-like substance which is produced in the body but we also get from foods such as egg yolks, meat, poultry, fish, and dairy products. The body needs cholesterol, but too much can cause health problems. Too much cholesterol in the blood forms clumps (plaques) which can stick to the sides of blood vessel walls, especially arteries which carry oxygen rich blood to the heart (coronary arteries) and brain. The plaque builds on the vessel walls and causes the arteries to become narrow and stiff. This can mean not enough oxygen will get to the heart, causing chest pain (angina) or a heart attack. Sometimes the blood vessels to the brain become too narrow or clogged causing a stroke. Pieces of the plaque may break lose causing a blood clot and completely block an artery. There are usually no symptoms in the early stages of high cholesterol. The best way to find out if you have high cholesterol is to have a blood test called a lipid panel or profile. Risk factors for having high cholesterol levels include a family history of high cholesterol or heart disease, smoking, diabetes, high blood pressure, obesity, poor diet, and lack of exercise. Certain types of hypercholesterolemia may be run in families (see Familial hypercholesterolemia). Treatment to lower cholesterol levels may include exercise, eating healthier food low in cholesterol, and medication. If certain blood vessels are already too narrow, surgery may be needed. Early diagnosis and treatment have been shown to improve the health of individuals affected by hypercholesterolemia. Talk with your doctor to about the latest treatments to decide which options are the best for you. Support groups are also good sources of information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypercholesterolemia" for support, advocacy or research.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypercholesterolemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypercholesterolemia" returned 902 free, full-text research articles on human participants. First 3 results:

Homozygous familial hypercholesterolemia.
 

Author(s): M K Alicezah, R Razali, T Rahman, B P Hoh, N H Suhana, S Muid, H M Nawawi, M Koshy

Journal: Malays J Pathol. 2014 Aug;36(2):131-7.

 

We report a rare case of homozygous familial hypercholesterolemia (HoFH), a 22-year-old Malay woman who presented initially with minor soft tissue injury due to a cycling accident. She was then incidentally found to have severe xanthelasma and hypercholesterolemia (serum TC 15.3 mmol/L ...

Last Updated: 8 Sep 2014

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A genetic variant in the LDLR promoter is responsible for part of the LDL-cholesterol variability in primary hypercholesterolemia.
 

Author(s): Isabel De Castro-Orós, Javier Pérez-López, Rocio Mateo-Gallego, Soraya Rebollar, Marta Ledesma, Montserrat León, Montserrat Cofán, Jose A Casasnovas, Emilio Ros, Jose C Rodríguez-Rey, Fernando Civeira, Miguel Pocoví

Journal:

 

GWAS have consistently revealed that LDLR locus variability influences LDL-cholesterol in general population. Severe LDLR mutations are responsible for familial hypercholesterolemia (FH). However, most primary hypercholesterolemias are polygenic diseases. Although Cis-regulatory regions ...

Last Updated: 18 Apr 2014

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Hypercholesterolemia and risk of incident psoriasis and psoriatic arthritis in US women.
 

Author(s): Shaowei Wu, Wen-Qing Li, Jiali Han, Qi Sun, Abrar A Qureshi

Journal: Arthritis Rheumatol. 2014 Feb;66(2):304-10.

 

Psoriasis is a systemic inflammatory disorder associated with an increased risk of cardiovascular disease. Hypercholesterolemia is a major risk factor for cardiovascular disease, and patients with psoriasis or psoriatic arthritis (PsA) have been shown to have elevated cholesterol ...

Last Updated: 7 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypercholesterolemia" returned 58 free, full-text review articles on human participants. First 3 results:

Inhibition of hepatic microsomal triglyceride transfer protein - a novel therapeutic option for treatment of homozygous familial hypercholesterolemia.
 

Author(s): Alpo Vuorio, Matti J Tikkanen, Petri T Kovanen

Journal:

 

Familial hypercholesterolemia (FH) is an autosomal dominant disease caused by mutations in the low-density lipoprotein (LDL)-receptor gene (LDLR). Patients with homozygous FH (hoFH) have inherited a mutated LDLR gene from both parents, and therefore all their LDL-receptors are incapable ...

Last Updated: 22 May 2014

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Managing hypercholesterolemia and preventing cardiovascular events in elderly and younger Chinese adults: focus on rosuvastatin.
 

Author(s): Zhen Wang, Junbo Ge

Journal: Clin Interv Aging. 2014 ;9():1-8.

 

Coronary heart disease (CHD) is the leading cause of death worldwide. The efficacy and safety of statins in primary and secondary prevention of CHD is confirmed in several large studies, and rosuvastatin is the latest statin on market. We review the published literature on rosuvastatin ...

Last Updated: 19 Dec 2013

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Management of familial hypercholesterolemia: a review of the recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia.
 

Author(s): Jennifer G Robinson

Journal: J Manag Care Pharm. 2013 Mar;19(2):139-49.

 

Familial hypercholesterolemia (FH) is a genetic disorder of lipid metabolism that is characterized by a significant elevation in levels of low-density lipoprotein cholesterol (LDL-C), and patients are at very high risk for premature coronary heart disease (CHD). The etiology of FH ...

Last Updated: 6 Mar 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Awareness and Detection of Familial Hypercholesterolemia
 

Status: Recruiting

Condition Summary: Hypercholesterolemia

 

Last Updated: 8 Oct 2013

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Familial Hypercholesterolemia Canada / Hypercholesterolemie Familiale Canada
 

Status: Recruiting

Condition Summary: Familial Hypercholesterolemia; Lipid Disorder

 

Last Updated: 20 Jun 2014

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Safety Study of AEM-28 to Treat Refractory Hypercholesterolemia
 

Status: Recruiting

Condition Summary: Hypercholesterolemia; Hyperlipoproteinemia Type II

 

Last Updated: 1 Apr 2014

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