Hypercholesterolemia

Common Name(s)

Hypercholesterolemia, High cholesterol

Hypercholesterolemia, or high cholesterol, is a condition in which there are high levels of cholesterol in the blood. Cholesterol is a thick, fat-like substance. It is made by our body, mainly in the liver, but we also get cholesterol from some of the foods we eat, such as egg yolks, meat, poultry, fish, and dairy products. The body needs cholesterol, but too much may cause health problems. Too much cholesterol may stick to the sides of arteries (the blood vessels which carry oxygen rich blood to every part of our body). As more cholesterol builds up, a mass of cholesterol and other substances that circulate in our blood form plaques or clumps on the wall of the artery. As the plaque builds, the arteries become narrow and stiff (also known as atherosclerosis). Decreased flow of oxygen to the heart may cause angina (chest pain) or a heart attack. Decreased oxygen flow to the legs may cause leg pain or peripheral artery disease. Sometimes a plaque ruptures, and the blood clot that forms to stop the bleeding blocks the artery completely leading to a heart attack or stroke, depending on the artery affected.

There are often no symptoms in the early stages of high cholesterol. The best way to find out if you have high cholesterol is to have a lipid panel/lipid profile blood test. Risk factors associated with high cholesterol include: family history of high cholesterol or heart disease, smoking, diabetes, high blood pressure, obesity, poor diet, and lack of exercise. Certain types of hypercholesterolemia may run in families. Treatment to lower cholesterol levels may include exercise, eating food low in cholesterol, and medication. Sometimes surgery may be needed. Early diagnosis and treatment have been shown to improve the health of individuals affected by hypercholesterolemia. Talk with your doctor about the latest treatments to decide which options are the best for you. Support groups are also good sources of information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypercholesterolemia" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypercholesterolemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypercholesterolemia" returned 914 free, full-text research articles on human participants. First 3 results:

Homozygous familial hypercholesterolemia.
 

Author(s): M K Alicezah, R Razali, T Rahman, B P Hoh, N H Suhana, S Muid, H M Nawawi, M Koshy

Journal: Malays J Pathol. 2014 Aug;36(2):131-7.

 

We report a rare case of homozygous familial hypercholesterolemia (HoFH), a 22-year-old Malay woman who presented initially with minor soft tissue injury due to a cycling accident. She was then incidentally found to have severe xanthelasma and hypercholesterolemia (serum TC 15.3 mmol/L ...

Last Updated: 8 Sep 2014

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Whole-exome sequencing in an extended family with myocardial infarction unmasks familial hypercholesterolemia.
 

Author(s): Ingrid Brænne, Benedikt Reiz, Anja Medack, Mariana Kleinecke, Marcus Fischer, Salih Tuna, Christian Hengstenberg, Panos Deloukas, Jeanette Erdmann, Heribert Schunkert,

Journal:

 

Familial hypercholesterolemia (FH) is an autosomal-dominant disease leading to markedly elevated low-density lipoprotein (LDL) cholesterol levels and increased risk for premature myocardial infarction (MI). Mutation carriers display variable LDL cholesterol levels, which may obscure ...

Last Updated: 4 Sep 2014

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Plant sterols-enriched diet decreases small, dense LDL-cholesterol levels in children with hypercholesterolemia: a prospective study.
 

Author(s): Anastasia Garoufi, Styliani Vorre, Alexandra Soldatou, Charalampos Tsentidis, Lydia Kossiva, Antonios Drakatos, Antonios Marmarinos, Dimitrios Gourgiotis

Journal:

 

Small dense low density lipoprotein-cholesterol (sdLDL-C) molecules are more atherogenic compared with large buoyant ones. Phytosterols-enriched diets are effective in decreasing total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) concentrations in hyperlipidemic ...

Last Updated: 4 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypercholesterolemia" returned 57 free, full-text review articles on human participants. First 3 results:

Canadian Cardiovascular Society position statement on familial hypercholesterolemia.
 

Author(s): , Jacques Genest, Robert A Hegele, Jean Bergeron, James Brophy, Andre Carpentier, Patrick Couture, Jean Davignon, Robert Dufour, Jiri Frohlich, Daniel Gaudet, Milan Gupta, Preetha Krisnamoorthy, John Mancini, Brian McCrindle, Paolo Raggi, Isabelle Ruel, Julie St-Pierre

Journal: Can J Cardiol. 2014 Dec;30(12):1471-81.

 

Familial hypercholesterolemia (FH) is the most common genetic disorder causing premature cardiovascular disease and death. Heterozygous FH conservatively affects approximately 1:500 Canadians, and the more serious homozygous form affects approximately 1:1,000,000 Canadians, although ...

Last Updated: 5 Dec 2014

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Inhibition of hepatic microsomal triglyceride transfer protein - a novel therapeutic option for treatment of homozygous familial hypercholesterolemia.
 

Author(s): Alpo Vuorio, Matti J Tikkanen, Petri T Kovanen

Journal:

 

Familial hypercholesterolemia (FH) is an autosomal dominant disease caused by mutations in the low-density lipoprotein (LDL)-receptor gene (LDLR). Patients with homozygous FH (hoFH) have inherited a mutated LDLR gene from both parents, and therefore all their LDL-receptors are incapable ...

Last Updated: 22 May 2014

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Managing hypercholesterolemia and preventing cardiovascular events in elderly and younger Chinese adults: focus on rosuvastatin.
 

Author(s): Zhen Wang, Junbo Ge

Journal: Clin Interv Aging. 2014 ;9():1-8.

 

Coronary heart disease (CHD) is the leading cause of death worldwide. The efficacy and safety of statins in primary and secondary prevention of CHD is confirmed in several large studies, and rosuvastatin is the latest statin on market. We review the published literature on rosuvastatin ...

Last Updated: 19 Dec 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Familial Hypercholesterolemia Canada / Hypercholesterolemie Familiale Canada
 

Status: Recruiting

Condition Summary: Familial Hypercholesterolemia; Lipid Disorder

 

Last Updated: 20 Jun 2014

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Study of Awareness and Detection of Familial Hypercholesterolemia
 

Status: Recruiting

Condition Summary: Hypercholesterolemia

 

Last Updated: 18 Dec 2014

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Safety Study of AEM-28 to Treat Refractory Hypercholesterolemia
 

Status: Recruiting

Condition Summary: Hypercholesterolemia; Hyperlipoproteinemia Type II

 

Last Updated: 1 Apr 2014

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