High cholesterol

Common Name(s)

High cholesterol, Hypercholesterolemia

High cholesterol, or hypercholesterolemia, is a condition in which there are high levels of cholesterol in the blood. Cholesterol is a thick, fat-like substance made by our body, mainly in the liver. We also get cholesterol from some of the foods we eat, such as egg yolks, meat, poultry, fish, and dairy products. Our bodies needs cholesterol, but too much may cause health problems. Too much cholesterol may stick to the sides of arteries (the blood vessels which carry oxygen rich blood to every part of our body). As more cholesterol builds up, a mass of cholesterol and other substances that circulate in our blood form plaques or clumps on the wall of the artery. As the plaque builds, the arteries become narrow and stiff (also known as atherosclerosis). Decreased flow of oxygen to the heart may cause angina (chest pain) or a heart attack. Decreased oxygen flow to the legs may cause leg pain or peripheral artery disease. Sometimes a plaque ruptures, and the blood clot that forms to stop the bleeding blocks the artery completely leading to a heart attack or stroke, depending on the artery affected.

There are often no symptoms in the early stages of high cholesterol. The best way to find out if you have high cholesterol is to have a lipid panel/lipid profile blood test. Risk factors associated with high cholesterol include: family history of high cholesterol or heart disease, smoking, diabetes, high blood pressure, obesity, poor diet, and lack of exercise. Certain types of high cholesterol may run in families. Treatment to lower cholesterol levels may include exercise, eating food low in cholesterol, and medication. Sometimes surgery may be needed. Early diagnosis and treatment have been shown to improve the health of individuals affected by high cholesterol. Talk with your doctor about the latest treatments to decide which options are the best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "High cholesterol" for support, advocacy or research.

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Familial Hypercholesterolemia (FH) Foundation

The FH Foundation is a patient-centered nonprofit organization dedicated to education, advocacy, and research of Familial Hypercholesterolemia (FH). Our mission is to raise awareness and save lives by increasing the rate of early diagnosis and encouraging proactive treatment. If left untreated, FH leads to aggressive and premature heart disease in women, men and children of all racial and ethnic backgrounds.

Last Updated: 1 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "High cholesterol" for support, advocacy or research.

Logo
Familial Hypercholesterolemia (FH) Foundation

The FH Foundation is a patient-centered nonprofit organization dedicated to education, advocacy, and research of Familial Hypercholesterolemia (FH). Our mission is to raise awareness and save lives by increasing the rate of early diagnosis and encouraging proactive treatment. If left untreated, FH leads to aggressive and premature heart disease in women, men and children of all racial and ethnic backgrounds.

http://www.thefhfoundation.org

Last Updated: 1 Jun 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "High cholesterol" returned 952 free, full-text research articles on human participants. First 3 results:

Apolipoprotein B is not superior to non-high-density lipoprotein cholesterol for dyslipidemic classification of glycated hemoglobin-defined diabetic patients.
 

Author(s): Junhui Xie, Shuhong Hu

Journal: Medicine (Baltimore). 2018 Oct;97(42):e12896.

 

Low-density lipoprotein (LDL) cholesterol (LDL-C) always underestimates the true cholesterol burden in diabetic patients. We aimed to explore the impact of the inclusion of apolipoprotein B (apoB) or non-high-density lipoprotein (HDL) cholesterol (non-HDL-C), which are alternative ...

Last Updated: 31 Dec 1969

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High-density lipoprotein cholesterol, apolipoprotein E and atherogenic index of plasma are associated with risk of chronic kidney disease.
 

Author(s): Jasmina Smajić, Sabaheta Hasić, Senija Rašić

Journal: Med Glas (Zenica). 2018 Aug;15(2):115-121.

 

Aim To investigate the association of parameters of lipid profile and estimated glomerular filtration rate (eGFR) p<60 ml/min/1.73m2 calculated by the Modification of Diet in Renal Disease (MDRD) in non-dialysis kidney patients. Methods The observational, case-control study enrolled ...

Last Updated: 31 Dec 1969

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Association between circulating full-length angiopoietin-like protein 8 and non-high-density lipoprotein cholesterol levels in Chinese non-diabetic individuals: a cross-sectional study.
 

Author(s): Song Yang, Xiaolu Jiao, Xiaoguang Huo, Miaomiao Zhu, Yi Wang, Xiangnan Fang, Yunyun Yang, Weidong Yue, Yanwen Qin

Journal:

 

Angiopoietin-like protein 8 (ANGPTL8) is a novel hormone involved in the regulation of lipid metabolism and glucose homeostasis. There are inconsistent results regarding the association between ANGPTL8 and lipids in humans. We aimed to investigate the associations between ANGPTL8 ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "High cholesterol" returned 55 free, full-text review articles on human participants. First 3 results:

High-density lipoprotein (HDL) cholesterol - more complicated than we think?
 

Author(s): Katarzyna Nessler, Adam Windak, Rafał Grzybczak, Michał Bohdan Nessler, Aleksander Siniarski, Grzegorz Gajos

Journal: Ann Agric Environ Med. 2018 Sep;25(3):517-526.

 

There are some clinical situations where a high level of HDL cholesterol (HDL-C) may be unfavourable. In these situations, HDL-C may undergo some changes, and even if its quantity is within the reference range, its quality is no longer the same.

Last Updated: 31 Dec 1969

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High-density lipoprotein-cholesterol functionality and metabolic syndrome: Protocol for review and meta-analysis.
 

Author(s): Leonardo Roever, Elmiro Santos Resende, Angélica Lemos Debs Diniz, Nilson Penha-Silva, João Lucas O'Connell, Paulo Fernando Silva Gomes, Hugo Ribeiro Zanetti, Anaisa Silva Roerver-Borges, Fernando César Veloso, Fernanda Rodrigues de Souza, Poliana Rodrigues Alves Duarte, Thiago Montes Fidale, Antonio Casella-Filho, Paulo Magno Martins Dourado, Antonio Carlos Palandri Chagas, Sadeq Ali-Hasan-Al-Saegh, Paulo Eduardo Ocke Reis, Rogério de Melo Costa Pinto, Gustavo B F Oliveira, Álvaro Avezum, Mansueto Neto, André Rodrigues Durães, Rose Mary Ferreira Lisboa da Silva, Antonio José Grande, Celise Denardi, Renato Delascio Lopes, Nitesh Nerlekar, Shahab Alizadeh, Adrian V Hernandez, Maria Inês da Rosa, Giuseppe Biondi-Zoccai,

Journal: Medicine (Baltimore). 2018 Jun;97(24):e11094.

 

The prevalence of metabolic syndrome (MetS) and MetS-related stroke is set to increase dramatically in coming decades. MetS is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia and an increased risk ...

Last Updated: 31 Dec 1969

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High-density lipoprotein cholesterol efflux capacity is inversely associated with cardiovascular risk: a systematic review and meta-analysis.
 

Author(s): Chengfeng Qiu, Xiang Zhao, Quan Zhou, Zhen Zhang

Journal:

 

A low plasma level of high-density lipoprotein (HDL) cholesterol (HDL-C) is associated with cardiovascular risk. A key cardioprotective property of HDL is cholesterol efflux capacity (CEC), the ability of HDL to accept cholesterol from macrophages. In this study, we aimed to identify ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Spanish Familial Hypercholesterolaemia Cohort Study
 

Status: Recruiting

Condition Summary: Familial Hypercholesterolaemia

 

Last Updated: 20 Aug 2018

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Study of Awareness and Detection of Familial Hypercholesterolemia
 

Status: Recruiting

Condition Summary: Hypercholesterolemia

 

Last Updated: 1 Aug 2017

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Effect of Indian Gooseberry Extract (AMX160) in Hypercholesterolemia
 

Status: Recruiting

Condition Summary: Hypercholesterolemia

 

Last Updated: 21 Jul 2018

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