High cholesterol

Common Name(s)

High cholesterol, Hypercholesterolemia

High cholesterol, or hypercholesterolemia, is a condition in which there are high levels of cholesterol in the blood. Cholesterol is a thick, fat-like substance made by our body, mainly in the liver. We also get cholesterol from some of the foods we eat, such as egg yolks, meat, poultry, fish, and dairy products. Our bodies needs cholesterol, but too much may cause health problems. Too much cholesterol may stick to the sides of arteries (the blood vessels which carry oxygen rich blood to every part of our body). As more cholesterol builds up, a mass of cholesterol and other substances that circulate in our blood form plaques or clumps on the wall of the artery. As the plaque builds, the arteries become narrow and stiff (also known as atherosclerosis). Decreased flow of oxygen to the heart may cause angina (chest pain) or a heart attack. Decreased oxygen flow to the legs may cause leg pain or peripheral artery disease. Sometimes a plaque ruptures, and the blood clot that forms to stop the bleeding blocks the artery completely leading to a heart attack or stroke, depending on the artery affected.

There are often no symptoms in the early stages of high cholesterol. The best way to find out if you have high cholesterol is to have a lipid panel/lipid profile blood test. Risk factors associated with high cholesterol include: family history of high cholesterol or heart disease, smoking, diabetes, high blood pressure, obesity, poor diet, and lack of exercise. Certain types of high cholesterol may run in families. Treatment to lower cholesterol levels may include exercise, eating food low in cholesterol, and medication. Sometimes surgery may be needed. Early diagnosis and treatment have been shown to improve the health of individuals affected by high cholesterol. Talk with your doctor about the latest treatments to decide which options are the best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "High cholesterol" for support, advocacy or research.

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Familial Hypercholesterolemia (FH) Foundation

The FH Foundation is a patient-centered nonprofit organization dedicated to education, advocacy, and research of Familial Hypercholesterolemia (FH). Our mission is to raise awareness and save lives by increasing the rate of early diagnosis and encouraging proactive treatment. If left untreated, FH leads to aggressive and premature heart disease in women, men and children of all racial and ethnic backgrounds.

Last Updated: 1 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "High cholesterol" for support, advocacy or research.

Logo
Familial Hypercholesterolemia (FH) Foundation

The FH Foundation is a patient-centered nonprofit organization dedicated to education, advocacy, and research of Familial Hypercholesterolemia (FH). Our mission is to raise awareness and save lives by increasing the rate of early diagnosis and encouraging proactive treatment. If left untreated, FH leads to aggressive and premature heart disease in women, men and children of all racial and ethnic backgrounds.

http://www.thefhfoundation.org

Last Updated: 1 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "High cholesterol" returned 955 free, full-text research articles on human participants. First 3 results:

[Variation tendency in serum high density lipoprotein cholesterol and apolipoprotein A-I in different thyroid function status during pregnancy].
 

Author(s): Jia Cai, Man Zhang

Journal: Beijing Da Xue Xue Bao. 2015 Dec;47(6):910-3.

 

To study the metabolism of high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) in different thyroid function status during pregnancy.

Last Updated: 18 Dec 2015

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Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism.
 

Author(s): Ruwanthi N Gunawardane, Preston Fordstrom, Derek E Piper, Stephanie Masterman, Sophia Siu, Dongming Liu, Mike Brown, Mei Lu, Jie Tang, Richard Zhang, Janet Cheng, Andrew Gates, David Meininger, Joyce Chan, Tim Carlson, Nigel Walker, Margrit Schwarz, John Delaney, Mingyue Zhou

Journal: J. Biol. Chem.. 2016 Feb;291(6):2799-811.

 

Drug discovery opportunities where loss-of-function alleles of a target gene link to a disease-relevant phenotype often require an agonism approach to up-regulate or re-establish the activity of the target gene. Antibody therapy is increasingly recognized as a favored drug modality ...

Last Updated: 6 Feb 2016

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Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol.
 

Author(s): Tamara S Roman, Amanda F Marvelle, Marie P Fogarty, Swarooparani Vadlamudi, Arlene J Gonzalez, Martin L Buchkovich, Jeroen R Huyghe, Christian Fuchsberger, Anne U Jackson, Ying Wu, Mete Civelek, Aldons J Lusis, Kyle J Gaulton, Praveen Sethupathy, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Johanna Kuusisto, Francis S Collins, Markku Laakso, Michael Boehnke, Karen L Mohlke

Journal: Am. J. Hum. Genet.. 2015 Dec;97(6):801-15.

 

Genome-wide association studies (GWASs) have identified more than 150 loci associated with blood lipid and cholesterol levels; however, the functional and molecular mechanisms for many associations are unknown. We examined the functional regulatory effects of candidate variants at ...

Last Updated: 7 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "High cholesterol" returned 59 free, full-text review articles on human participants. First 3 results:

High systemic levels of low-density lipoprotein cholesterol: fuel to the flames in inflammatory osteoarthritis?
 

Author(s): Wouter de Munter, Peter M van der Kraan, Wim B van den Berg, Peter L E M van Lent

Journal: Rheumatology (Oxford). 2016 Jan;55(1):16-24.

 

There is increasing evidence that low-density lipoprotein (LDL) cholesterol plays a role in the pathology of OA. Specifically, oxidized LDL (oxLDL), which has been shown to play an essential role during development of atherosclerosis, could be involved in processes such as synovial ...

Last Updated: 15 Dec 2015

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MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism.
 

Author(s): Koh Ono, Takahiro Horie, Tomohiro Nishino, Osamu Baba, Yasuhide Kuwabara, Takeshi Kimura

Journal: Int Heart J. 2015 ;56(4):365-71.

 

MicroRNAs (miRNAs) are small non-protein-coding RNAs that negatively regulate gene expression. They bind to the 3'-untranslated region of specific mRNAs and inhibit translation or promote mRNA degradation. Dyslipidemia/hyperlipidemia is a well-accepted risk factor for the development ...

Last Updated: 13 Jul 2015

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Genes associated with low serum high-density lipoprotein cholesterol.
 

Author(s): Alireza Ahmadzadeh, Fereidoun Azizi

Journal: Arch Iran Med. 2014 Jun;17(6):444-50.

 

Atherosclerosis is the main cause of death in the world through causing ischemic heart disease (IHD). Altered serum lipid level is the most important risk factor for coronary artery disease (CAD). Many studies reveal a strong inverse association between low levels of high density ...

Last Updated: 11 Jun 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study in Subjects With Type 2 Diabetes Mellitus With Hypercholesterolemia/Mixed Dyslipidemia
 

Status: Recruiting

Condition Summary: Hypercholesterolemia; Mixed Dyslipidemia; Type 2 Diabetes

 

Last Updated: 15 Jun 2016

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A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-833)
 

Status: Recruiting

Condition Summary: Hypercholesterolemia; Familial Hypercholesterolemia

 

Last Updated: 26 May 2016

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