Hypercholesterolemia

Common Name(s)

Hypercholesterolemia

Description for this condition is not yet available.
 

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypercholesterolemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypercholesterolemia" returned 912 free, full-text research articles on human participants. First 3 results:

A genetic variant in the LDLR promoter is responsible for part of the LDL-cholesterol variability in primary hypercholesterolemia.
 

Author(s): Isabel De Castro-Orós, Javier Pérez-López, Rocio Mateo-Gallego, Soraya Rebollar, Marta Ledesma, Montserrat León, Montserrat Cofán, Jose A Casasnovas, Emilio Ros, Jose C Rodríguez-Rey, Fernando Civeira, Miguel Pocoví

Journal:

 

GWAS have consistently revealed that LDLR locus variability influences LDL-cholesterol in general population. Severe LDLR mutations are responsible for familial hypercholesterolemia (FH). However, most primary hypercholesterolemias are polygenic diseases. Although Cis-regulatory regions ...

Last Updated: 18 Apr 2014

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Hypercholesterolemia and risk of incident psoriasis and psoriatic arthritis in US women.
 

Author(s): Shaowei Wu, Wen-Qing Li, Jiali Han, Qi Sun, Abrar A Qureshi

Journal: Arthritis Rheumatol. 2014 Feb;66(2):304-10.

 

Psoriasis is a systemic inflammatory disorder associated with an increased risk of cardiovascular disease. Hypercholesterolemia is a major risk factor for cardiovascular disease, and patients with psoriasis or psoriatic arthritis (PsA) have been shown to have elevated cholesterol ...

Last Updated: 7 Feb 2014

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Familial hypercholesterolemia mutations in Petrozavodsk: no similarity to St. Petersburg mutation spectrum.
 

Author(s): Tatiana Yu Komarova, Victoria A Korneva, Tatiana Yu Kuznetsova, Alexandra S Golovina, Vadim B Vasilyev, Michail Yu Mandelshtam

Journal:

 

Familial hypercholesterolemia (FH) is a human monogenic disease induced by a variety of mutations with striking genetic diversity. Despite this variability recurrent mutations occur in each population studied, which allows both elucidating prevalent mutations and developing DNA diagnostic ...

Last Updated: 2 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypercholesterolemia" returned 57 free, full-text review articles on human participants. First 3 results:

Inhibition of hepatic microsomal triglyceride transfer protein - a novel therapeutic option for treatment of homozygous familial hypercholesterolemia.
 

Author(s): Alpo Vuorio, Matti J Tikkanen, Petri T Kovanen

Journal:

 

Familial hypercholesterolemia (FH) is an autosomal dominant disease caused by mutations in the low-density lipoprotein (LDL)-receptor gene (LDLR). Patients with homozygous FH (hoFH) have inherited a mutated LDLR gene from both parents, and therefore all their LDL-receptors are incapable ...

Last Updated: 22 May 2014

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The efficacy of colesevelam HCl in the treatment of heterozygous familial hypercholesterolemia in pediatric and adult patients.
 

Author(s): Michael Davidson

Journal: Clin Ther. 2013 Aug;35(8):1247-52.

 

Familial hypercholesterolemia (FH) is a common autosomal co-dominant genetic disorder that results in severely increased levels of LDL-C. Patients with FH are at an increased risk for premature coronary artery disease. Expert panels therefore recommend initiation of lipid-lowering ...

Last Updated: 26 Aug 2013

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Management of familial hypercholesterolemia: a review of the recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia.
 

Author(s): Jennifer G Robinson

Journal: J Manag Care Pharm. 2013 Mar;19(2):139-49.

 

Familial hypercholesterolemia (FH) is a genetic disorder of lipid metabolism that is characterized by a significant elevation in levels of low-density lipoprotein cholesterol (LDL-C), and patients are at very high risk for premature coronary heart disease (CHD). The etiology of FH ...

Last Updated: 6 Mar 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Awareness and Detection of Familial Hypercholesterolemia
 

Status: Recruiting

Condition Summary: Hypercholesterolemia

 

Last Updated: 8 Oct 2013

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Familial Hypercholesterolemia Canada / Hypercholesterolemie Familiale Canada
 

Status: Recruiting

Condition Summary: Familial Hypercholesterolemia; Lipid Disorder

 

Last Updated: 20 Jun 2014

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Safety Study of AEM-28 to Treat Refractory Hypercholesterolemia
 

Status: Recruiting

Condition Summary: Hypercholesterolemia; Hyperlipoproteinemia Type II

 

Last Updated: 1 Apr 2014

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