High cholesterol

Common Name(s)

High cholesterol, Hypercholesterolemia

High cholesterol, or hypercholesterolemia, is a condition in which there are high levels of cholesterol in the blood. Cholesterol is a thick, fat-like substance made by our body, mainly in the liver. We also get cholesterol from some of the foods we eat, such as egg yolks, meat, poultry, fish, and dairy products. Our bodies needs cholesterol, but too much may cause health problems. Too much cholesterol may stick to the sides of arteries (the blood vessels which carry oxygen rich blood to every part of our body). As more cholesterol builds up, a mass of cholesterol and other substances that circulate in our blood form plaques or clumps on the wall of the artery. As the plaque builds, the arteries become narrow and stiff (also known as atherosclerosis). Decreased flow of oxygen to the heart may cause angina (chest pain) or a heart attack. Decreased oxygen flow to the legs may cause leg pain or peripheral artery disease. Sometimes a plaque ruptures, and the blood clot that forms to stop the bleeding blocks the artery completely leading to a heart attack or stroke, depending on the artery affected.

There are often no symptoms in the early stages of high cholesterol. The best way to find out if you have high cholesterol is to have a lipid panel/lipid profile blood test. Risk factors associated with high cholesterol include: family history of high cholesterol or heart disease, smoking, diabetes, high blood pressure, obesity, poor diet, and lack of exercise. Certain types of high cholesterol may run in families. Treatment to lower cholesterol levels may include exercise, eating food low in cholesterol, and medication. Sometimes surgery may be needed. Early diagnosis and treatment have been shown to improve the health of individuals affected by high cholesterol. Talk with your doctor about the latest treatments to decide which options are the best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "High cholesterol" for support, advocacy or research.

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Familial Hypercholesterolemia (FH) Foundation

The FH Foundation is a patient-centered nonprofit organization dedicated to education, advocacy, and research of Familial Hypercholesterolemia (FH). Our mission is to raise awareness and save lives by increasing the rate of early diagnosis and encouraging proactive treatment. If left untreated, FH leads to aggressive and premature heart disease in women, men and children of all racial and ethnic backgrounds.

Last Updated: 1 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "High cholesterol" for support, advocacy or research.

Logo
Familial Hypercholesterolemia (FH) Foundation

The FH Foundation is a patient-centered nonprofit organization dedicated to education, advocacy, and research of Familial Hypercholesterolemia (FH). Our mission is to raise awareness and save lives by increasing the rate of early diagnosis and encouraging proactive treatment. If left untreated, FH leads to aggressive and premature heart disease in women, men and children of all racial and ethnic backgrounds.

http://www.thefhfoundation.org

Last Updated: 1 Jun 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "High cholesterol" returned 976 free, full-text research articles on human participants. First 3 results:

Patterns of statin use and cholesterol goal attainment in a high-risk cardiovascular population: A retrospective study of primary care electronic medical records.
 

Author(s): Maria García-Gil, Jordi Blanch, Marc Comas-Cufí, Josep Daunis-i-Estadella, Bonaventura Bolíbar, Ruth Martí, Anna Ponjoan, Lia Alves-Cabratosa, Rafel Ramos

Journal: J Clin Lipidol. ;10(1):134-42.

 

To describe real-life patterns of statin use and cholesterol goal attainment in a retrospective cohort of patients with high cardiovascular risk.

Last Updated: 19 Feb 2016

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Optimal Management Target for Non-High-Density Lipoprotein Cholesterol.
 

Author(s): Hayato Tada, Junji Kobayashi

Journal: J. Atheroscler. Thromb.. 2016 ;23(4):399-401.

 

Last Updated: 4 Apr 2016

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Why high cholesterol levels help hematological malignancies: role of nuclear lipid microdomains.
 

Author(s): Michela Codini, Samuela Cataldi, Andrea Lazzarini, Anna Tasegian, Maria Rachele Ceccarini, Alessandro Floridi, Remo Lazzarini, Francesco Saverio Ambesi-Impiombato, Francesco Curcio, Tommaso Beccari, Elisabetta Albi

Journal:

 

Diet and obesity are recognized in the scientific literature as important risk factors for cancer development and progression. Hypercholesterolemia facilitates lymphoma lymphoblastic cell growth and in time turns in hypocholesterolemia that is a sign of tumour progression. The present ...

Last Updated: 12 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "High cholesterol" returned 60 free, full-text review articles on human participants. First 3 results:

High systemic levels of low-density lipoprotein cholesterol: fuel to the flames in inflammatory osteoarthritis?
 

Author(s): Wouter de Munter, Peter M van der Kraan, Wim B van den Berg, Peter L E M van Lent

Journal: Rheumatology (Oxford). 2016 Jan;55(1):16-24.

 

There is increasing evidence that low-density lipoprotein (LDL) cholesterol plays a role in the pathology of OA. Specifically, oxidized LDL (oxLDL), which has been shown to play an essential role during development of atherosclerosis, could be involved in processes such as synovial ...

Last Updated: 15 Dec 2015

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MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism.
 

Author(s): Koh Ono, Takahiro Horie, Tomohiro Nishino, Osamu Baba, Yasuhide Kuwabara, Takeshi Kimura

Journal: Int Heart J. 2015 ;56(4):365-71.

 

MicroRNAs (miRNAs) are small non-protein-coding RNAs that negatively regulate gene expression. They bind to the 3'-untranslated region of specific mRNAs and inhibit translation or promote mRNA degradation. Dyslipidemia/hyperlipidemia is a well-accepted risk factor for the development ...

Last Updated: 13 Jul 2015

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High-Density Lipoprotein Function Measurement in Human Studies: Focus on Cholesterol Efflux Capacity.
 

Author(s): Anand Rohatgi

Journal: Prog Cardiovasc Dis. ;58(1):32-40.

 

A low plasma level of high-density lipoprotein (HDL) cholesterol (HDL-C) is a major risk factor for the development of atherosclerotic cardiovascular disease (ASCVD). However, several observations have highlighted the shortcomings of using cholesterol content as the sole reflection ...

Last Updated: 29 Jun 2015

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Symptoms, Diagnosis, and Treatment

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There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

French Observatory of Familial Hypercholesterolemia in Cardiology
 

Status: Recruiting

Condition Summary: Familial Hypercholesterolemia

 

Last Updated: 12 Feb 2015

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Last Updated: 12 Sep 2016

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The Rogosin Institute Homozygous Familial Hypercholesterolemia Repository
 

Status: Recruiting

Condition Summary: Homozygous Familial Hypercholesterolemia

 

Last Updated: 9 Aug 2016

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