Gilbert syndrome

Common Name(s)

Gilbert syndrome, Hyperbilirubinemia type 1

Gilbert syndrome is an inherited condition in which the liver does not correctly process bilirubin, a yellow-ish substance produced during the normal breakdown of old red blood cells. Bilirubin travels through the bloodstream to the liver where it is processed and removed from the blood. The symptom of cholemia or hyperbilirubinemia (high bilirubin levels) is jaundice or yellowing of the skin and whites of the eyes. It is generally a mild condition and does not usually require treatment. Times of jaundice are sometimes induced in children and adults during infections and illness, lack of sleep, fasting (stretches of not eating), menstruation cycles, and stress and may be accompanied by mild abdominal pain or nausea. The jaundice during these times goes away on its own after the person recovers. In the newborn period, jaundice can be longer-lasting and more severe. Diagnosis often occurs by accident when blood is drawn for another reason unless a person or newborn has a severe bout of jaundice and the yellow in the skin or eyes is noted. Treatment is only necessary if bilirubin levels are very high.

More males than females have been diagnosed with Gilbert syndrome. This condition is caused by mutations in the UGT1A1 gene. Gilbert syndrome is inherited or passed through families in an autosomal recessive manner. This means that to be affected, an individual must have two copies of the changed gene that causes the condition. An affected person has then inherited one changed gene from each of his or her parents. Each child of two carrier parents has a 25% chance of inheriting both changed genes and therefore the condition. A genetic counselor can provide an understanding of the underlying cause as well as recurrence risks.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gilbert syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gilbert syndrome" returned 30 free, full-text research articles on human participants. First 3 results:

Gilbert Syndrome with Concomitant Hereditary Spherocytosis Presenting with Moderate Unconjugated Hyperbilirubinemia.
 

Author(s): Mitsuhiko Aiso, Minami Yagi, Atsushi Tanaka, Kotaro Miura, Ryo Miura, Toshihiko Arizumi, Yoriyuki Takamori, Sayuri Nakahara, Yoshihiro Maruo, Hajime Takikawa

Journal: Intern. Med.. 2017 ;56(6):661-664.

 

We experienced a case of a 19-year-old man with Gilbert syndrome with concomitant hereditary spherocytosis. The patient presented with moderate unconjugated hyperbilirubinemia, and inherited etiology was strongly suspected. The diagnosis of Gilbert syndrome was confirmed by the genetic ...

Last Updated: 21 Mar 2017

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Effectiveness of switching from oral ziprasidone to risperidone in a patient with comorbid autistic disorder, profound intellectual disability, Gilbert syndrome, and exacerbation of psychosis.
 

Author(s): Antonio Del Casale, Georgios D Kotzalidis, Michele Sacco, Chiara Rapinesi, Riccardo De Giorgi, Marco Giardini, Michele D'Andreagiovanni, Nicola Carlino, Roberto Brugnoli, Paolo Girardi

Journal: Psychiatr Danub. 2016 Mar;28(1):91-4.

 

Last Updated: 4 Mar 2016

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Scoliosis in a Patient With Gilbert Syndrome: A Case Report and Review of the Literature.
 

Author(s): Zheng Li, Jianxiong Shen, Jinqian Liang

Journal: Medicine (Baltimore). 2015 Nov;94(47):e2147.

 

Gilbert syndrome (GS) is mainly characterized by intermittent unconjugated hyperbilirubinemia in the absence of hepatocellular disease or hemolysis. Little data are available on operative outcomes in GS patients with spinal deformity surgery.This study has presented a case of GS occurring ...

Last Updated: 4 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gilbert syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biomarker for Patients With Gilbert Disease
 

Status: Recruiting

Condition Summary: Gilbert Syndrome; Gilbert-Lereboullet Syndrome; Meulengracht Syndrome

 

Last Updated: 19 Sep 2016

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