Hyperammonemia

Common Name(s)

Hyperammonemia

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hyperammonemia" for support, advocacy or research.

National Urea Cycle Disorders Foundation

The National Urea Cycle Disorders Foundation is the only organization solely dedicated to saving the lives of children and adults with urea cycle disorders and leading the search for a cure. NUCDF serves as a lifeline to families and medical professionals around the world seeking life saving information. NUCDF focuses on educating UCD patients, families and medical professionals on diagnosis and treatment, stimulating and supporting critical research, as well as providing guidance, information and support to all those affected by urea cycle disorders. The UCD International Patient Registry (www.ucdregistry.org), an IRB-approved research study, empowers UCD patients and caregivers to self-report their own unique experiences with UCD and compare them to others with UCD. Participants in the UCD Registry can help improve the understanding of UCDs, improve care, and accelerate research and development of new treatments.

Last Updated: 18 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hyperammonemia" for support, advocacy or research.

National Urea Cycle Disorders Foundation

The National Urea Cycle Disorders Foundation is the only organization solely dedicated to saving the lives of children and adults with urea cycle disorders and leading the search for a cure. NUCDF serves as a lifeline to families and medical professionals around the world seeking life saving information. NUCDF focuses on educating UCD patients, families and medical professionals on diagnosis and treatment, stimulating and supporting critical research, as well as providing guidance, information and support to all those affected by urea cycle disorders. The UCD International Patient Registry (www.ucdregistry.org), an IRB-approved research study, empowers UCD patients and caregivers to self-report their own unique experiences with UCD and compare them to others with UCD. Participants in the UCD Registry can help improve the understanding of UCDs, improve care, and accelerate research and development of new treatments.

http://www.nucdf.org

Last Updated: 18 Mar 2013

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General Support Organizations

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General Resources

UCD International Patient Registry

Join other UCD families in the only registry in existence designed to accelerate new research specifically for UCDs. Patients & caregivers self-report their own unique experiences with UCD to help improve care and find new treatments.

Updated 18 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hyperammonemia" returned 58 free, full-text research articles on human participants. First 3 results:

Low dose of carglumic acid for treatment of hyperammonemia due to N-acetylglutamate synthase deficiency.
 

Author(s): Ertugrul Kiykim, Tanyel Zubarioglu

Journal: Indian Pediatr. 2014 Sep;51(9):755-6.

 

Last Updated: 17 Sep 2014

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Novel therapy for non-cirrhotic hyperammonemia due to a spontaneous splenorenal shunt.
 

Author(s): Shari S Rogal, Angela Hu, Rupal Bandi, Obaid Shaikh

Journal: World J. Gastroenterol.. 2014 Jul;20(25):8288-91.

 

Spontaneous splenorenal shunts in the absence of cirrhosis have rarely been reported as a cause hyperammonemia with encephalopathy. Several closure techniques of such lesions have been described. Here we report a case of a patient with no history of liver disease who developed significant ...

Last Updated: 10 Jul 2014

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Differential ammonia decay kinetics indicates more than one concurrent etiological mechanism for symptomatic hyperammonemia caused by valproate overdose.
 

Author(s): Deb Kumar Mojumder, Radhames Ramos De Oleo

Journal: Indian J Pharmacol. ;46(3):345-7.

 

Valproic acid (VPA) has successfully been used in the therapy of a number of conditions including absence seizures, partial seizures, tonic-clonic seizures, bipolar disorder, schizoaffective disorder, social phobias, neuropathic pain and migraine headaches. There is a high rise in ...

Last Updated: 2 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hyperammonemia" returned 2 free, full-text review articles on human participants. First 3 results:

Alterations of blood brain barrier function in hyperammonemia: an overview.
 

Author(s): Marta SkowroĊ„ska, Jan Albrecht

Journal: Neurotox Res. 2012 Feb;21(2):236-44.

 

Ammonia is a neurotoxin involved in the pathogenesis of neurological conditions associated with hyperammonemia, including hepatic encephalopathy, a condition associated with acute--(ALF) or chronic liver failure. This article reviews evidence that apart from directly affecting the ...

Last Updated: 28 Dec 2011

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Hyperammonemia and neonatal cardiac failure.
 

Author(s): T Adamovic, P Jouvet, S Vobecky, L Garel, A L Rougemont, F Alvarez

Journal: Minerva Anestesiol. 2011 May;77(5):554-7.

 

Severe hyperammonemia (hyperNH3) in neonatal cardiac failure after cardiac surgery is rare. We report a case of a 2470-g female infant born at the week 37 of gestation with complex congenital heart disease (truncus arteriosus type III, interrupted aortic arch and tricuspid valve insufficiency) ...

Last Updated: 4 May 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Blood Sugars in Children With Idiopathic Seizures.
 

Status: Recruiting

Condition Summary: Seizures; Hypoglycemia; Hyperammonemia

 

Last Updated: 6 Sep 2006

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N-Carbamylglutamate (Carbaglu) In The Treatment Of Hyperammonemia
 

Status: Recruiting

Condition Summary: Inborn Errors of Metabolism

 

Last Updated: 14 Apr 2015

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Short-term Outcome of N-Carbamylglutamate in the Treatment of Acute Hyperammonemia
 

Status: Recruiting

Condition Summary: Propionic Acidemia (PA); Methylmalonic Acidemia (MMA); Late-onset CPS1 Deficiency (CPSD); Late-onset Ornithine Transcarbamylase Deficiency (OTCD)

 

Last Updated: 24 Nov 2014

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