Hydrops fetalis

Common Name(s)

Hydrops fetalis

Hydrops fetalis is a serious condition in which abnormal amounts of fluid build up in two or more body areas of a fetus or newborn. There are two types of hydrops fetalis: immune and nonimmune. Immune hydrops fetalis is a complication of a severe form of Rh incompatibility. Rh compatibility causes massive red blood cell destruction, which leads to several problems, including total body swelling. Severe swelling can interfere with how the body organs work. Nonimmune hydrops fetalis occurs when a disease or medical condition disrupts the body's ability to manage fluid. There are three main causes for this type: heart or lung problems, severe anemia (thalassemia), and genetic defects, including Turner syndrome. The exact cause depends on which form a baby has.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hydrops fetalis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hydrops fetalis" returned 93 free, full-text research articles on human participants. First 3 results:

Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise.
 

Author(s): Manoel Sarno, Gielson A Sacramento, Ricardo Khouri, Mateus S do Rosário, Federico Costa, Gracinda Archanjo, Luciane A Santos, Nivison Nery, Nikos Vasilakis, Albert I Ko, Antonio R P de Almeida

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The rapid spread of Zika virus in the Americas and current outbreak of microcephaly in Brazil has raised attention to the possible deleterious effects that the virus may have on fetuses.

Last Updated: 26 Feb 2016

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Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis.
 

Author(s): Elisavet Fotiou, Silvia Martin-Almedina, Michael A Simpson, Shin Lin, Kristiana Gordon, Glen Brice, Giles Atton, Iona Jeffery, David C Rees, Cyril Mignot, Julie Vogt, Tessa Homfray, Michael P Snyder, Stanley G Rockson, Steve Jeffery, Peter S Mortimer, Sahar Mansour, Pia Ostergaard

Journal:

 

Generalized lymphatic dysplasia (GLD) is a rare form of primary lymphoedema characterized by a uniform, widespread lymphoedema affecting all segments of the body, with systemic involvement such as intestinal and/or pulmonary lymphangiectasia, pleural effusions, chylothoraces and/or ...

Last Updated: 3 Sep 2015

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Perinatal-lethal Gaucher disease presenting as hydrops fetalis.
 

Author(s): Emira BenHamida, Imene Ayadi, Ines Ouertani, Maroua Chammem, Ahlem Bezzine, Riadh BenTmime, Leila Attia, Ridha Mrad, Zahra Marrakchi

Journal:

 

Perinatal-lethal Gaucher disease is very rare and is considered a variant of type 2 Gaucher disease that occurs in the neonatal period. The most distinct features of perinatal-lethal Gaucher disease are non-immune hydrops fetalis. Less common signs of the disease are hepatosplenomegaly, ...

Last Updated: 2 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hydrops fetalis" returned 4 free, full-text review articles on human participants. First 3 results:

Lysosomal storage disorder in non-immunological hydrops fetalis (NIHF): more common than assumed? Report of four cases with transient NIHF and a review of the literature.
 

Author(s): Catharina Whybra, Eugen Mengel, Alexandra Russo, Franz Bahlmann, Christoph Kampmann, Michael Beck, Elke Eich, Eva Mildenberger

Journal:

 

Lysosomal storage disorders (LSD) are a rare cause of non immunological hydrops fetalis (NIHF) and congenital ascites. The reported incidence is about 1%. The incidence of idiopathic NIHF is estimated to be about 18%.

Last Updated: 24 Jan 2013

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Hydrops fetalis caused by homozygous alpha-thalassemia and Rh antigen alloimmunization: report of a survivor and literature review.
 

Author(s): Divya-Devi Joshi, H James Nickerson, Michael J McManus

Journal: Clin Med Res. 2004 Nov;2(4):228-32.

 

Hematologic causes of hydrops fetalis include homozygous alpha-thalassemia and immune hemolytic anemias. We report the case of a boy with hydrops fetalis who had homozygous alpha-thalassemia and alloimmune hemolytic anemia due to anti-E and anti-C blood group antibodies. He received ...

Last Updated: 3 Oct 2005

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Pathogenesis of nonimmune hydrops fetalis caused by intrauterine B19 infection.
 

Author(s): N Yaegashi

Journal: Tohoku J. Exp. Med.. 2000 Feb;190(2):65-82.

 

Intrauterine human parvovirus B19 infection is related to non-immune hydrops fetalis and fetal death. First, we performed epidemiological studies to determine the critical period during which maternal infection led to hydrops fetalis. The studies showed that the hepatic period of ...

Last Updated: 19 May 2000

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 3 Nov 2016

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In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)
 

Status: Not yet recruiting

Condition Summary: Alpha Thalassemia Major; Hemoglobinopathy; With Thalassemia; Hemoglobinopathies; Fetal Anemia; Fetal Hydrops; Alpha; Thalassemia; Thalassemia Major; Thalassemia Alpha; A-Thalassemia

 

Last Updated: 7 Dec 2016

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