Hydrocephalus

Common Name(s)

Hydrocephalus

Hydrocephalus is a condition characterized by excessive accumulation of fluid in the brain. Although it was once known as "water on the brain," the "water" is actually cerebrospinal fluid (CSF) - clear fluid that surrounds the brain and spinal cord. Excess CSF builds up when it cannot drain from the brain due to a blockage in a passage through which the fluid normally flows.  This excess fluid causes an abnormal widening of spaces in the brain called ventricles; this can create harmful pressure on brain tissue. Symptoms vary with age, disease progression, and individual differences in tolerance to the condition. Hydrocephalus may be congenital (present at birth) or acquired. The causes are not fully understood; it may result from inherited genetic abnormalities or developmental disorders; complications of premature birth; diseases such as meningitis; tumors; traumatic head injury; or other causes. It is most often treated by surgically inserting a shunt system.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hydrocephalus" for support, advocacy or research.

Chiari & Syringomyelia Foundation

Our mission is to advance knowledge through research and to educate the medical, allied sciences, and lay community about Chiari malformation, syringomyelia and related CSF (cerebrospinal fluid) disorders.

Last Updated: 18 Mar 2013

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Hydrocephalus Association

The Hydrocephalus Association’s goal is to eliminate the challenges of hydrocephalus by stimulating innovative research and providing support, education and advocacy for individuals, families and professionals dealing with the complex issues of the condition.

Last Updated: 19 Nov 2012

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Missouri Family to Family

Missouri Family to Family provides customized information that allows families and individuals about needed resources and supports, navigating the maze of systems and services, as well as options to make their vision for their life possible. MOF2F also offers Sharing Our Strengths, which connects individuals with disabilities and/or their caregivers to a person who is available to listen with an open heart and open mind, offering emotional support, practical information, and/or shared experiences.

Last Updated: 15 Apr 2014

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Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

Last Updated: 22 Apr 2015

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Spina Bifida Resource

Spina Bifida Resource's mission is to promote the prevention of spina bifida and its secondary conditions and to enhance the health and well-being of those affected.

Last Updated: 15 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hydrocephalus" for support, advocacy or research.

Chiari & Syringomyelia Foundation

Our mission is to advance knowledge through research and to educate the medical, allied sciences, and lay community about Chiari malformation, syringomyelia and related CSF (cerebrospinal fluid) disorders.

http://www.CSFinfo.org

Last Updated: 18 Mar 2013

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Hydrocephalus Association

The Hydrocephalus Association’s goal is to eliminate the challenges of hydrocephalus by stimulating innovative research and providing support, education and advocacy for individuals, families and professionals dealing with the complex issues of the condition.

http://www.hydroassoc.org

Last Updated: 19 Nov 2012

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Missouri Family to Family

Missouri Family to Family provides customized information that allows families and individuals about needed resources and supports, navigating the maze of systems and services, as well as options to make their vision for their life possible. MOF2F also offers Sharing Our Strengths, which connects individuals with disabilities and/or their caregivers to a person who is available to listen with an open heart and open mind, offering emotional support, practical information, and/or shared experiences.

http://www.mofamilytofamily.org

Last Updated: 15 Apr 2014

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Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

http://www.pediatricbrainfoundation.org

Last Updated: 22 Apr 2015

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Spina Bifida Resource

Spina Bifida Resource's mission is to promote the prevention of spina bifida and its secondary conditions and to enhance the health and well-being of those affected.

http://spinabifidaresource.weebly.com/

Last Updated: 15 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hydrocephalus" returned 807 free, full-text research articles on human participants. First 3 results:

The value of early and comprehensive diagnoses in a human fetus with hydrocephalus and progressive obliteration of the aqueduct of Sylvius: Case Report.
 

Author(s): Eduardo Ortega, Rosa I Muñoz, Nelly Luza, Francisco Guerra, Monserrat Guerra, Karin Vio, Roberto Henzi, Jaime Jaque, Sara Rodriguez, James P McAllister, Esteban Rodriguez

Journal:

 

Mutant rodent models have highlighted the importance of the ventricular ependymal cells and the subcommissural organ (a brain gland secreting glycoproteins into the cerebrospinal fluid) in the development of fetal onset hydrocephalus. Evidence indicates that communicating and non-communicating ...

Last Updated: 12 Apr 2016

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Disappearance of the Hummingbird Sign after Shunt Surgery in a Case of Idiopathic Normal Pressure Hydrocephalus.
 

Author(s): Zen Kobayashi, Shin Tsuruoka, Yoshiyuki Numasawa, Hiroyuki Tomimitsu, Shuzo Shintani

Journal: Intern. Med.. 2016 ;55(7):815-7.

 

A 79-year-old man presented with a slowly progressive gait disturbance. Brain MRI demonstrated ventriculomegaly and the hummingbird sign. A lumbar puncture showed no abnormalities of the cerebrospinal fluid. The improvement of the gait disturbance after the ventriculoperitoneal shunt ...

Last Updated: 4 Apr 2016

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Cerebral microbleeds in idiopathic normal pressure hydrocephalus.
 

Author(s): Elias Johansson, Khalid Ambarki, Richard Birgander, Nazila Bahrami, Anders Eklund, Jan Malm

Journal:

 

A vascular disease could be involved in pathophysiology of normal pressure hydrocephalus (INPH). If so, there should be an association between INPH and cerebral microbleeds (CMB). This study aims to analyze if CMB are associated with INPH.

Last Updated: 10 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hydrocephalus" returned 51 free, full-text review articles on human participants. First 3 results:

Nonsurgical therapy for hydrocephalus: a comprehensive and critical review.
 

Author(s): Marc R Del Bigio, Domenico L Di Curzio

Journal:

 

Pharmacological interventions have been tested experimentally and clinically to prevent hydrocephalus and avoid the need for shunting beginning in the 1950s. Clinical trials of varied quality have not demonstrated lasting and convincing protective effects through manipulation of cerebrospinal ...

Last Updated: 5 Feb 2016

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A review of cognitive impairment and differential diagnosis in idiopathic normal pressure hydrocephalus.
 

Author(s): Marta Picascia, Roberta Zangaglia, Sara Bernini, Brigida Minafra, Elena Sinforiani, Claudio Pacchetti

Journal: Funct. Neurol.. ;30(4):217-28.

 

Idiopathic normal pressure hydrocephalus (iNPH) is a complex and still underestimated pathology. In the early stages, the cognitive profile is characterized mainly by impairments of attention, psychomotor speed and memory, suggesting frontal involvement; patients with more advanced ...

Last Updated: 5 Jan 2016

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The impact of selected cytokines in the follow-up of normal pressure hydrocephalus.
 

Author(s): L Sosvorova, M Mohapl, J Vcelak, M Hill, J Vitku, R Hampl

Journal: Physiol Res. 2015 ;64 Suppl 2():S283-90.

 

Cytokines are widely known mediators of inflammation accompanying many neurodegenerative disorders including normal pressure hydrocephalus (NPH). NPH is caused by impaired cerebrospinal fluid (CSF) reabsorption and treated by surgical shunt insertion. The diagnostics is still complicated ...

Last Updated: 18 Dec 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 18 Nov 2016

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A Randomized Cross-over Study for Normal Pressure Hydrocephalus
 

Status: Recruiting

Condition Summary: Normal Pressure Hydrocephalus

 

Last Updated: 17 Mar 2015

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Study of Choroid Plexus Cauderization in Patients With Hydrocephalus
 

Status: Not yet recruiting

Condition Summary: Hydrocephalus

 

Last Updated: 26 Sep 2016

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