Hydrocephalus

Common Name(s)

Hydrocephalus

Hydrocephalus is a condition characterized by excessive accumulation of fluid in the brain. Although it was once known as "water on the brain," the "water" is actually cerebrospinal fluid (CSF) - clear fluid that surrounds the brain and spinal cord. Excess CSF builds up when it cannot drain from the brain due to a blockage in a passage through which the fluid normally flows.  This excess fluid causes an abnormal widening of spaces in the brain called ventricles; this can create harmful pressure on brain tissue. Symptoms vary with age, disease progression, and individual differences in tolerance to the condition. Hydrocephalus may be congenital (present at birth) or acquired. The causes are not fully understood; it may result from inherited genetic abnormalities or developmental disorders; complications of premature birth; diseases such as meningitis; tumors; traumatic head injury; or other causes. It is most often treated by surgically inserting a shunt system.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hydrocephalus" for support, advocacy or research.

Chiari & Syringomyelia Foundation

Our mission is to advance knowledge through research and to educate the medical, allied sciences, and lay community about Chiari malformation, syringomyelia and related CSF (cerebrospinal fluid) disorders.

Last Updated: 18 Mar 2013

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CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

Last Updated: 12 Oct 2013

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Hydrocephalus Association

The Hydrocephalus Association’s goal is to eliminate the challenges of hydrocephalus by stimulating innovative research and providing support, education and advocacy for individuals, families and professionals dealing with the complex issues of the condition.

Last Updated: 19 Nov 2012

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Missouri Family to Family

Missouri Family to Family provides customized information that allows families and individuals about needed resources and supports, navigating the maze of systems and services, as well as options to make their vision for their life possible. MOF2F also offers Sharing Our Strengths, which connects individuals with disabilities and/or their caregivers to a person who is available to listen with an open heart and open mind, offering emotional support, practical information, and/or shared experiences.

Last Updated: 15 Apr 2014

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Spina Bifida Resource

Spina Bifida Resource's mission is to promote the prevention of spina bifida and its secondary conditions and to enhance the health and well-being of those affected.

Last Updated: 15 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hydrocephalus" for support, advocacy or research.

Chiari & Syringomyelia Foundation

Our mission is to advance knowledge through research and to educate the medical, allied sciences, and lay community about Chiari malformation, syringomyelia and related CSF (cerebrospinal fluid) disorders.

http://www.CSFinfo.org

Last Updated: 18 Mar 2013

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CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

http://www.cnsfoundation.org

Last Updated: 12 Oct 2013

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Hydrocephalus Association

The Hydrocephalus Association’s goal is to eliminate the challenges of hydrocephalus by stimulating innovative research and providing support, education and advocacy for individuals, families and professionals dealing with the complex issues of the condition.

http://www.hydroassoc.org

Last Updated: 19 Nov 2012

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Missouri Family to Family

Missouri Family to Family provides customized information that allows families and individuals about needed resources and supports, navigating the maze of systems and services, as well as options to make their vision for their life possible. MOF2F also offers Sharing Our Strengths, which connects individuals with disabilities and/or their caregivers to a person who is available to listen with an open heart and open mind, offering emotional support, practical information, and/or shared experiences.

http://www.mofamilytofamily.org

Last Updated: 15 Apr 2014

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Spina Bifida Resource

Spina Bifida Resource's mission is to promote the prevention of spina bifida and its secondary conditions and to enhance the health and well-being of those affected.

http://spinabifidaresource.weebly.com/

Last Updated: 15 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hydrocephalus" returned 634 free, full-text research articles on human participants. First 3 results:

Effect of sevoflurane on cerebral perfusion pressure in patients with internal hydrocephalus.
 

Author(s): Zbigniew Karwacki, Małgorzata Witkowska, Seweryn Niewiadomski, Andrzej Wiatr, Jarosław Dzierżanowski, Paweł Słoniewski

Journal: Anaesthesiol Intensive Ther. ;45(4):211-4.

 

Due to its confirmed neuroprotective properties, sevoflurane is one of a few anaesthetics used for neuroanaesthesia. Its effects on the cerebral and systemic circulations may be of particular importance in patientswith intracranial pathology. This study aimed to evaluate the effect ...

Last Updated: 10 Jan 2014

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Normal pressure hydrocephalus: a qualitative study on outcome.
 

Author(s): Paulo Bugalho, Luísa Alves, Olga Ribeiro

Journal: Arq Neuropsiquiatr. 2013 Nov;71(11):890-5.

 

To describe the natural history and shunt outcome in patients with normal pressure hydrocephalus (NPH) and the variables that influence both.

Last Updated: 7 Jan 2014

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Exploring the efficacy of endoscopic ventriculostomy for hydrocephalus treatment via a multicompartmental poroelastic model of CSF transport: a computational perspective.
 

Author(s): John C Vardakis, Brett J Tully, Yiannis Ventikos

Journal:

 

This study proposes the implementation of a Multiple-Network Poroelastic Theory (MPET) model coupled with finite-volume computational fluid dynamics for the purpose of studying, in detail, the effects of obstructing CSF transport within an anatomically accurate cerebral environment. ...

Last Updated: 6 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hydrocephalus" returned 36 free, full-text review articles on human participants. First 3 results:

A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus.
 

Author(s): Esteban M Rodríguez, María M Guerra, Karin Vío, César González, Alexander Ortloff, Luis F Bátiz, Sara Rodríguez, María C Jara, Rosa I Muñoz, Eduardo Ortega, Jaime Jaque, Francisco Guerra, Deborah A Sival, Wilfred F A den Dunnen, Antonio J Jiménez, María D Domínguez-Pinos, José M Pérez-Fígares, James P McAllister, Conrad Johanson

Journal: Biol. Res.. 2012 ;45(3):231-42.

 

Most cells of the developing mammalian brain derive from the ventricular (VZ) and the subventricular (SVZ) zones. The VZ is formed by the multipotent radial glia/neural stem cells (NSCs) while the SVZ harbors the rapidly proliferative neural precursor cells (NPCs). Evidence from human ...

Last Updated: 3 Jan 2013

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Armored brain in patients with hydrocephalus after shunt surgery: review of the literatures.
 

Author(s): Mahmoud M Taha

Journal: Turk Neurosurg. 2012 ;22(4):407-10.

 

Armored brain or chronic calcified subdural hematoma is a rare complication of cerebrospinal fluid diversion with few cases reported in the literature. Seventeen patients with this pathology have been published. A complete review of the literatures regarding this topic has been collected ...

Last Updated: 30 Jul 2012

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Neonatal posthemorrhagic hydrocephalus from prematurity: pathophysiology and current treatment concepts.
 

Author(s): Shenandoah Robinson

Journal: J Neurosurg Pediatr. 2012 Mar;9(3):242-58.

 

Preterm infants are at risk for perinatal complications, including germinal matrix-intraventricular hemorrhage (IVH) and subsequent posthemorrhagic hydrocephalus (PHH). This review summarizes the current understanding of the epidemiology, pathophysiology, management, and outcomes ...

Last Updated: 2 Mar 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Magnetic Resonance Elastography in Hydrocephalus
 

Status: Recruiting

Condition Summary: Hydrocephalus

 

Last Updated: 2 Sep 2014

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Cerebrospinal Fluid Proteome in Hydrocephalus
 

Status: Recruiting

Condition Summary: Normal Pressure Hydrocephalus

 

Last Updated: 22 Jul 2014

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A Study Comparing Two Treatments for Infants With Hydrocephalus
 

Status: Recruiting

Condition Summary: Hydrocephalus

 

Last Updated: 6 Sep 2013

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