Hydrocephalus

Common Name(s)

Hydrocephalus

Hydrocephalus is a condition characterized by excessive accumulation of fluid in the brain. Although it was once known as "water on the brain," the "water" is actually cerebrospinal fluid (CSF) - clear fluid that surrounds the brain and spinal cord. Excess CSF builds up when it cannot drain from the brain due to a blockage in a passage through which the fluid normally flows.  This excess fluid causes an abnormal widening of spaces in the brain called ventricles; this can create harmful pressure on brain tissue. Symptoms vary with age, disease progression, and individual differences in tolerance to the condition. Hydrocephalus may be congenital (present at birth) or acquired. The causes are not fully understood; it may result from inherited genetic abnormalities or developmental disorders; complications of premature birth; diseases such as meningitis; tumors; traumatic head injury; or other causes. It is most often treated by surgically inserting a shunt system.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hydrocephalus" for support, advocacy or research.

Chiari & Syringomyelia Foundation

Our mission is to advance knowledge through research and to educate the medical, allied sciences, and lay community about Chiari malformation, syringomyelia and related CSF (cerebrospinal fluid) disorders.

Last Updated: 18 Mar 2013

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Hydrocephalus Association

The Hydrocephalus Association’s goal is to eliminate the challenges of hydrocephalus by stimulating innovative research and providing support, education and advocacy for individuals, families and professionals dealing with the complex issues of the condition.

Last Updated: 19 Nov 2012

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Missouri Family to Family

Missouri Family to Family provides customized information that allows families and individuals about needed resources and supports, navigating the maze of systems and services, as well as options to make their vision for their life possible. MOF2F also offers Sharing Our Strengths, which connects individuals with disabilities and/or their caregivers to a person who is available to listen with an open heart and open mind, offering emotional support, practical information, and/or shared experiences.

Last Updated: 15 Apr 2014

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Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

Last Updated: 22 Apr 2015

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Spina Bifida Resource

Spina Bifida Resource's mission is to promote the prevention of spina bifida and its secondary conditions and to enhance the health and well-being of those affected.

Last Updated: 15 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hydrocephalus" for support, advocacy or research.

Chiari & Syringomyelia Foundation

Our mission is to advance knowledge through research and to educate the medical, allied sciences, and lay community about Chiari malformation, syringomyelia and related CSF (cerebrospinal fluid) disorders.

http://www.CSFinfo.org

Last Updated: 18 Mar 2013

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Hydrocephalus Association

The Hydrocephalus Association’s goal is to eliminate the challenges of hydrocephalus by stimulating innovative research and providing support, education and advocacy for individuals, families and professionals dealing with the complex issues of the condition.

http://www.hydroassoc.org

Last Updated: 19 Nov 2012

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Missouri Family to Family

Missouri Family to Family provides customized information that allows families and individuals about needed resources and supports, navigating the maze of systems and services, as well as options to make their vision for their life possible. MOF2F also offers Sharing Our Strengths, which connects individuals with disabilities and/or their caregivers to a person who is available to listen with an open heart and open mind, offering emotional support, practical information, and/or shared experiences.

http://www.mofamilytofamily.org

Last Updated: 15 Apr 2014

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Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

http://www.pediatricbrainfoundation.org

Last Updated: 22 Apr 2015

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Spina Bifida Resource

Spina Bifida Resource's mission is to promote the prevention of spina bifida and its secondary conditions and to enhance the health and well-being of those affected.

http://spinabifidaresource.weebly.com/

Last Updated: 15 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hydrocephalus" returned 651 free, full-text research articles on human participants. First 3 results:

Yolk sac tumor of the temporal bone: an unusual presentation as hydrocephalus.
 

Author(s): Mukund Sable, Aanchal Kakkar, Richa Ranjan, Ajay Garg, Sameer Bakhshi, Mehar Chand Sharma

Journal: Neurol India. ;62(6):679-81.

 

Last Updated: 16 Jan 2015

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Study of the association between the incidences of congenital anomalies and hydrocephalus in Sudanese fetuses.
 

Author(s): Mustafa Z Mahmoud, Hussien A Dinar, Alsafi A Abdulla, Esameldeen Babikir, Abdelmoneim Sulieman

Journal:

 

This study was designed with an aim to detect the congenital anomalies appear to be linked to and in conjunction with hydrocephalus fetuses in Sudan, when ultrasound is used to exam fetuses in the second and third trimesters of pregnancy. This prospective cohort study was performed ...

Last Updated: 29 Aug 2014

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Axon diameter and intra-axonal volume fraction of the corticospinal tract in idiopathic normal pressure hydrocephalus measured by q-space imaging.
 

Author(s): Kouhei Kamiya, Masaaki Hori, Masakazu Miyajima, Madoka Nakajima, Yuriko Suzuki, Koji Kamagata, Michimasa Suzuki, Hajime Arai, Kuni Ohtomo, Shigeki Aoki

Journal:

 

Previous studies suggest that compression and stretching of the corticospinal tract (CST) potentially cause treatable gait disturbance in patients with idiopathic normal pressure hydrocephalus (iNPH). Measurement of axon diameter with diffusion MRI has recently been used to investigate ...

Last Updated: 6 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hydrocephalus" returned 36 free, full-text review articles on human participants. First 3 results:

The influence of decompressive craniectomy on the development of hydrocephalus: a review.
 

Author(s): Jun Ding, Yan Guo, Hengli Tian

Journal: Arq Neuropsiquiatr. 2014 Sep;72(9):715-20.

 

Decompressive craniectomy (DC) is widely used to treat intracranial hypertension following traumatic brain injury (TBI) or cerebral vascular disease. Many studies have discussed complications of this procedure, and hydrocephalus is a common complication of DC. To further evaluate ...

Last Updated: 25 Sep 2014

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Benign external hydrocephalus in infants. A single centre experience and literature review.
 

Author(s): Maria Adele Marino, Rosa Morabito, Sergio Vinci, Antonino Germanò, Marilena Briguglio, Concetta Alafaci, Enricomaria Mormina, Marcello Longo, Francesca Granata

Journal: Neuroradiol J. 2014 Apr;27(2):245-50.

 

External hydrocephalus (EH) is a benign clinical entity in which macrocephaly is associated with an increase in volume of the subarachnoid space, especially overlying both frontal lobes, and a normal or only slight increase in volume of the lateral ventricles. Several pathogenic hypotheses ...

Last Updated: 22 Apr 2014

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A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus.
 

Author(s): Esteban M Rodríguez, María M Guerra, Karin Vío, César González, Alexander Ortloff, Luis F Bátiz, Sara Rodríguez, María C Jara, Rosa I Muñoz, Eduardo Ortega, Jaime Jaque, Francisco Guerra, Deborah A Sival, Wilfred F A den Dunnen, Antonio J Jiménez, María D Domínguez-Pinos, José M Pérez-Fígares, James P McAllister, Conrad Johanson

Journal: Biol. Res.. 2012 ;45(3):231-42.

 

Most cells of the developing mammalian brain derive from the ventricular (VZ) and the subventricular (SVZ) zones. The VZ is formed by the multipotent radial glia/neural stem cells (NSCs) while the SVZ harbors the rapidly proliferative neural precursor cells (NPCs). Evidence from human ...

Last Updated: 3 Jan 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cerebrospinal Fluid Proteome in Hydrocephalus
 

Status: Recruiting

Condition Summary: Normal Pressure Hydrocephalus

 

Last Updated: 2 Dec 2014

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A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of Hydrocephalus
 

Status: Recruiting

Condition Summary: Hydrocephalus, Normal Pressure

 

Last Updated: 3 May 2010

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Magnetic Resonance Elastography in Hydrocephalus
 

Status: Recruiting

Condition Summary: Hydrocephalus

 

Last Updated: 2 Sep 2014

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