Human T-cell leukemia virus type 2

Common Name(s)

Human T-cell leukemia virus type 2

Human T-cell leukemia virus, type 2 (HTLV-2) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no signs or symptoms, scientists suspect that some affected people may later develop neurological problems and/or chronic lung infections. HTLV-2 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-2 and it is considered a lifelong condition; however, most infected people remain asymptomatic (show no symptoms) throughout life
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Human T-cell leukemia virus type 2" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Human T-cell leukemia virus type 2" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Human T-cell leukemia virus type 2" returned 64 free, full-text research articles on human participants. First 3 results:

Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis.
 

Author(s): Amanda R Panfil, Nathan J Dissinger, Cory M Howard, Brandon M Murphy, Kristina Landes, Soledad A Fernandez, Patrick L Green

Journal:

 

Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are highly related retroviruses that transform T cells in vitro but have distinct pathological outcomes in vivo. HTLV-1 encodes a protein from the antisense strand of its proviral genome, the HTLV-1 basic leucine zipper ...

Last Updated: 12 Mar 2016

Go To URL
Downregulation of proapoptotic Bim augments IL-2-independent T-cell transformation by human T-cell leukemia virus type-1 Tax.
 

Author(s): Masaya Higuchi, Masahiko Takahashi, Yuetsu Tanaka, Masahiro Fujii

Journal: Cancer Med. 2014 Dec;3(6):1605-14.

 

Human T-cell leukemia virus type 1 (HTLV-1), an etiological agent of adult T-cell leukemia, immortalizes and transforms primary human T cells in vitro in both an interleukin (IL)-2-dependent and IL-2-independent manner. Expression of the HTLV-1 oncoprotein Tax transforms the growth ...

Last Updated: 5 Jan 2015

Go To URL
Human T cell leukemia virus type 2 tax-mediated NF-κB activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO.
 

Author(s): Chloé Journo, Amandine Bonnet, Arnaud Favre-Bonvin, Jocelyn Turpin, Jennifer Vinera, Emilie Côté, Sébastien Alain Chevalier, Youmna Kfoury, Ali Bazarbachi, Claudine Pique, Renaud Mahieux

Journal: J. Virol.. 2013 Jan;87(2):1123-36.

 

Permanent activation of the NF-κB pathway by the human T cell leukemia virus type 1 (HTLV-1) Tax (Tax1) viral transactivator is a key event in the process of HTLV-1-induced T lymphocyte immortalization and leukemogenesis. Although encoding a Tax transactivator (Tax2) that activates ...

Last Updated: 28 Dec 2012

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Human T-cell leukemia virus type 2" returned 0 free, full-text review articles on human participants.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.