Human T-cell leukemia virus type 1

Common Name(s)

Human T-cell leukemia virus type 1

Human T-cell leukemia virus, type 1 (HTLV-1) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no signs or symptoms, some affected people may later develop adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or other medical conditions. HTLV-1 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-1 and it is considered a lifelong condition; however, most (95%) infected people remain asymptomatic (show no symptoms) throughout life.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Human T-cell leukemia virus type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Human T-cell leukemia virus type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Human T-cell leukemia virus type 1" returned 421 free, full-text research articles on human participants. First 3 results:

Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax.
 

Author(s): Mariko Mizuguchi, Yuka Sasaki, Toshifumi Hara, Masaya Higuchi, Yuetsu Tanaka, Noriko Funato, Nobuyuki Tanaka, Masahiro Fujii, Masataka Nakamura

Journal:

 

Tax1 encoded by the human T-cell leukemia virus type 1 (HTLV-1) has been believed to dysregulate the expression of cellular genes involved in cell survival and mortality, leading to the development of adult T-cell leukemia (ATL). The function of Tax1 in ATL development however is ...

Last Updated: 2 Feb 2016

Go To URL
Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans.
 

Author(s): Maria Fernanda de Castro-Amarante, Cynthia A Pise-Masison, Katherine McKinnon, Robyn Washington Parks, Veronica Galli, Maria Omsland, Vibeke Andresen, Raya Massoud, Giovanna Brunetto, Breanna Caruso, David Venzon, Steven Jacobson, Genoveffa Franchini

Journal:

 

Because the viral DNA burden correlates with disease development, we investigated the contribution of monocyte subsets (classical, intermediate, and nonclassical monocytes) to the total viral burden in 22 human T cell leukemia virus type 1 (HTLV-1)-infected individuals by assessing ...

Last Updated: 12 Feb 2016

Go To URL
Expression of Alternatively Spliced Human T-Cell Leukemia Virus Type 1 mRNAs Is Influenced by Mitosis and by a Novel cis-Acting Regulatory Sequence.
 

Author(s): Ilaria Cavallari, Francesca Rende, Marion K Bona, Joanna Sztuba-Solinska, Micol Silic-Benussi, Martina Tognon, Stuart F J LeGrice, Genoveffa Franchini, Donna M D'Agostino, Vincenzo Ciminale

Journal:

 

Human T-cell leukemia virus type 1 (HTLV-1) expression depends on the concerted action of Tax, which drives transcription of the viral genome, and Rex, which favors expression of incompletely spliced mRNAs and determines a 2-phase temporal pattern of viral expression. In the present ...

Last Updated: 16 Jan 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Human T-cell leukemia virus type 1" returned 9 free, full-text review articles on human participants. First 3 results:

Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence.
 

Author(s): Alexandre Carpentier, Pierre-Yves Barez, Malik Hamaidia, Hélène Gazon, Alix de Brogniez, Srikanth Perike, Nicolas Gillet, Luc Willems

Journal:

 

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy-tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission ...

Last Updated: 22 Jul 2015

Go To URL
Double control systems for human T-cell leukemia virus type 1 by innate and acquired immunity.
 

Author(s): Mari Kannagi, Atsuhiko Hasegawa, Shuichi Kinpara, Yukiko Shimizu, Ayako Takamori, Atae Utsunomiya

Journal: Cancer Sci.. 2011 Apr;102(4):670-6.

 

Human T-cell leukemia virus type 1 (HTLV-1) is the causative retrovirus of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-specific T-cell responses elicit antitumor and antiviral effects in experimental models, and are considered ...

Last Updated: 18 Mar 2011

Go To URL
Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy.
 

Author(s): M Matsuoka, K-T Jeang

Journal: Oncogene. 2011 Mar;30(12):1379-89.

 

The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic ...

Last Updated: 24 Mar 2011

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1
 

Status: Not yet recruiting

Condition Summary: HTLV-I Infections

 

Last Updated: 18 Dec 2012

Go to URL
Evaluation of Patients With HAM/TSP
 

Status: Recruiting

Condition Summary: HTLV-I Infection; Tropical Spastic Paraparesis

 

Last Updated: 21 Jul 2016

Go to URL

Last Updated: 6 Jul 2016

Go to URL