Human T-cell leukemia virus type 1

Common Name(s)

Human T-cell leukemia virus type 1

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Human T-cell leukemia virus type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Human T-cell leukemia virus type 1" returned 387 free, full-text research articles on human participants. First 3 results:

Human T-cell leukemia/lymphoma virus type 1 p30, but not p12/p8, counteracts toll-like receptor 3 (TLR3) and TLR4 signaling in human monocytes and dendritic cells.
 

Author(s): Claudio Fenizia, Martina Fiocchi, Kathryn Jones, Robyn Washington Parks, Michele Ceribelli, Sebastien A Chevalier, Dustin Edwards, Francis Ruscetti, Cynthia A Pise-Masison, Genoveffa Franchini

Journal: J. Virol.. 2014 Jan;88(1):393-402.

 

The human T-cell leukemia/lymphoma virus type 1 (HTLV-1) p30 protein, essential for virus infectivity in vivo, is required for efficient infection of human dendritic cells (DCs) but not B and T cells in vitro. We used a human monocytic cell line, THP-1, and dendritic cells to study ...

Last Updated: 19 Dec 2013

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HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-κB activation and HTLV-1 replication.
 

Author(s): Linlin Gao, Edward William Harhaj

Journal: J. Virol.. 2013 Dec;87(24):13640-54.

 

Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 genome encodes the Tax protein that plays essential regulatory roles in HTLV-1 replication and oncogenic ...

Last Updated: 22 Nov 2013

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Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats.
 

Author(s): Ching-Ping Chan, Yeung-Tung Siu, Kin-Hang Kok, Yick-Pang Ching, Hei-Man Vincent Tang, Dong-Yan Jin

Journal:

 

Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia and tropical spastic paraparesis. HTLV-1 encodes transactivator protein Tax that interacts with various cellular factors to modulate transcription and other biological functions. Additional ...

Last Updated: 13 May 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Human T-cell leukemia virus type 1" returned 7 free, full-text review articles on human participants. First 3 results:

Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy.
 

Author(s): M Matsuoka, K-T Jeang

Journal: Oncogene. 2011 Mar;30(12):1379-89.

 

The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic ...

Last Updated: 24 Mar 2011

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Hijacking the T-cell communication network by the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) p12 and p8 proteins.
 

Author(s): Nancy Van Prooyen, Vibeke Andresen, Heather Gold, Izabela Bialuk, Cynthia Pise-Masison, Genoveffa Franchini

Journal: Mol. Aspects Med.. 2010 Oct;31(5):333-43.

 

The non-structural proteins encoded by the orf-I, II, III, and IV genes of the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) genome, are critical for the modulation of cellular gene expression and T-cell proliferation, the escape from cytotoxic T-cells and natural killer cells, ...

Last Updated: 1 Nov 2010

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Epidemiology, treatment, and prevention of human T-cell leukemia virus type 1-associated diseases.
 

Author(s): Denise Utsch Gonçalves, Fernando Augusto Proietti, João Gabriel Ramos Ribas, Marcelo Grossi Araújo, Sônia Regina Pinheiro, Antônio Carlos Guedes, Anna Bárbara F Carneiro-Proietti

Journal: Clin. Microbiol. Rev.. 2010 Jul;23(3):577-89.

 

Human T-cell leukemia virus type 1 (HTLV-1), the first human retrovirus to be discovered, is present in diverse regions of the world, where its infection is usually neglected in health care settings and by public health authorities. Since it is usually asymptomatic in the beginning ...

Last Updated: 8 Jul 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Patients With HAM/TSP
 

Status: Recruiting

Condition Summary: HTLV-I Infection; Tropical Spastic Paraparesis

 

Last Updated: 14 Mar 2014

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Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1
 

Status: Not yet recruiting

Condition Summary: HTLV-I Infections

 

Last Updated: 18 Dec 2012

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Raltegravir for HAM/TSP
 

Status: Recruiting

Condition Summary: HAM/TSP; HTLV-1

 

Last Updated: 19 Mar 2014

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