Human T-cell leukemia virus type 1

Common Name(s)

Human T-cell leukemia virus type 1

Human T-cell leukemia virus, type 1 (HTLV-1) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no signs or symptoms, some affected people may later develop adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or other medical conditions. HTLV-1 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-1 and it is considered a lifelong condition; however, most (95%) infected people remain asymptomatic (show no symptoms) throughout life.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Human T-cell leukemia virus type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Human T-cell leukemia virus type 1" returned 424 free, full-text research articles on human participants. First 3 results:

Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax.
 

Author(s): Mariko Mizuguchi, Yuka Sasaki, Toshifumi Hara, Masaya Higuchi, Yuetsu Tanaka, Noriko Funato, Nobuyuki Tanaka, Masahiro Fujii, Masataka Nakamura

Journal:

 

Tax1 encoded by the human T-cell leukemia virus type 1 (HTLV-1) has been believed to dysregulate the expression of cellular genes involved in cell survival and mortality, leading to the development of adult T-cell leukemia (ATL). The function of Tax1 in ATL development however is ...

Last Updated: 2 Feb 2016

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Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation.
 

Author(s): Chun-Kit Yuen, Ching-Ping Chan, Sin-Yee Fung, Pei-Hui Wang, Wan-Man Wong, Hei-Man Vincent Tang, Kit-San Yuen, Chi-Ping Chan, Dong-Yan Jin, Kin-Hang Kok

Journal:

 

Infection with human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and tropical spastic paraparesis. Type I interferons (IFNs) are key effectors of the innate antiviral response, and IFN-α combined with the nucleoside reverse transcriptase inhibitor ...

Last Updated: 29 Mar 2016

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Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis.
 

Author(s): Amanda R Panfil, Nathan J Dissinger, Cory M Howard, Brandon M Murphy, Kristina Landes, Soledad A Fernandez, Patrick L Green

Journal:

 

Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are highly related retroviruses that transform T cells in vitro but have distinct pathological outcomes in vivo. HTLV-1 encodes a protein from the antisense strand of its proviral genome, the HTLV-1 basic leucine zipper ...

Last Updated: 12 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Human T-cell leukemia virus type 1" returned 10 free, full-text review articles on human participants. First 3 results:

Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence.
 

Author(s): Alexandre Carpentier, Pierre-Yves Barez, Malik Hamaidia, Hélène Gazon, Alix de Brogniez, Srikanth Perike, Nicolas Gillet, Luc Willems

Journal:

 

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy-tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission ...

Last Updated: 22 Jul 2015

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Human T-cell leukemia virus type 1 and Foxp3 expression: viral strategy in vivo.
 

Author(s): Paola Miyazato, Masao Matsuoka

Journal: Int. Immunol.. 2014 Aug;26(8):419-25.

 

Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of adult T-cell leukemia (ATL) and inflammatory diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis, uveitis and infective dermatitis. However, it remains to be elucidated how HTLV-1 induces ...

Last Updated: 29 Jul 2014

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Double control systems for human T-cell leukemia virus type 1 by innate and acquired immunity.
 

Author(s): Mari Kannagi, Atsuhiko Hasegawa, Shuichi Kinpara, Yukiko Shimizu, Ayako Takamori, Atae Utsunomiya

Journal: Cancer Sci.. 2011 Apr;102(4):670-6.

 

Human T-cell leukemia virus type 1 (HTLV-1) is the causative retrovirus of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-specific T-cell responses elicit antitumor and antiviral effects in experimental models, and are considered ...

Last Updated: 18 Mar 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1
 

Status: Not yet recruiting

Condition Summary: HTLV-I Infections

 

Last Updated: 18 Dec 2012

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Evaluation of Patients With HAM/TSP
 

Status: Recruiting

Condition Summary: HTLV-I Infection; Tropical Spastic Paraparesis

 

Last Updated: 31 Aug 2016

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Last Updated: 31 Aug 2016

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