Human T-cell leukemia virus type 1

Common Name(s)

Human T-cell leukemia virus type 1

Human T-cell leukemia virus, type 1 (HTLV-1) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no signs or symptoms, some affected people may later develop adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or other medical conditions. HTLV-1 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-1 and it is considered a lifelong condition; however, most (95%) infected people remain asymptomatic (show no symptoms) throughout life.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Human T-cell leukemia virus type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Human T-cell leukemia virus type 1" returned 425 free, full-text research articles on human participants. First 3 results:

IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways.
 

Author(s): Leila Sawada, Yoshiko Nagano, Atsuhiko Hasegawa, Hikari Kanai, Kai Nogami, Sayaka Ito, Tomoo Sato, Yoshihisa Yamano, Yuetsu Tanaka, Takao Masuda, Mari Kannagi

Journal:

 

Human T-cell leukemia virus type-1 (HTLV-1) causes two distinct diseases, adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Since there are no disease-specific differences among HTLV-1 strains, the etiological mechanisms ...

Last Updated: 14 Sep 2017

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Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice.
 

Author(s): Takeo Ohsugi

Journal: J. Vet. Med. Sci.. 2017 May;79(5):935-938.

 

Transgenic mice expressing the tax gene from human T-cell leukemia virus type 1 (HTLV-I) genome developed T-cell leukemia or histiocytic sarcoma after at least 12 months. The transgenic mice showed low expression of the downstream of tyrosine kinase (DOK) family members, DOK1, DOK2 ...

Last Updated: 17 Mar 2017

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The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1).
 

Author(s): Christine Gross, Veit Wiesmann, Sebastian Millen, Martina Kalmer, Thomas Wittenberg, Jan Gettemans, Andrea K Thoma-Kress

Journal:

 

The delta-retrovirus Human T-cell leukemia virus type 1 (HTLV-1) preferentially infects CD4+ T-cells via cell-to-cell transmission. Viruses are transmitted by polarized budding and by transfer of viral biofilms at the virological synapse (VS). Formation of the VS requires the viral ...

Last Updated: 24 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Human T-cell leukemia virus type 1" returned 8 free, full-text review articles on human participants. First 3 results:

Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence.
 

Author(s): Alexandre Carpentier, Pierre-Yves Barez, Malik Hamaidia, Hélène Gazon, Alix de Brogniez, Srikanth Perike, Nicolas Gillet, Luc Willems

Journal:

 

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy-tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission ...

Last Updated: 22 Jul 2015

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Double control systems for human T-cell leukemia virus type 1 by innate and acquired immunity.
 

Author(s): Mari Kannagi, Atsuhiko Hasegawa, Shuichi Kinpara, Yukiko Shimizu, Ayako Takamori, Atae Utsunomiya

Journal: Cancer Sci.. 2011 Apr;102(4):670-6.

 

Human T-cell leukemia virus type 1 (HTLV-1) is the causative retrovirus of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-specific T-cell responses elicit antitumor and antiviral effects in experimental models, and are considered ...

Last Updated: 18 Mar 2011

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Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy.
 

Author(s): M Matsuoka, K-T Jeang

Journal: Oncogene. 2011 Mar;30(12):1379-89.

 

The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic ...

Last Updated: 24 Mar 2011

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Raltegravir for HAM/TSP
 

Status: Recruiting

Condition Summary: HTLV-I Infection

 

Last Updated: 3 Nov 2017

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A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM)
 

Status: Recruiting

Condition Summary: HTLV-1 Associated Myelopathy

 

Last Updated: 25 Jun 2017

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Evaluation of Patients With HAM/TSP
 

Status: Recruiting

Condition Summary: HTLV-I Infection; Tropical Spastic Paraparesis

 

Last Updated: 18 Oct 2017

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