Human T-cell leukemia virus type 1

Common Name(s)

Human T-cell leukemia virus type 1

Human T-cell leukemia virus, type 1 (HTLV-1) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no signs or symptoms, some affected people may later develop adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or other medical conditions. HTLV-1 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-1 and it is considered a lifelong condition; however, most (95%) infected people remain asymptomatic (show no symptoms) throughout life.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Human T-cell leukemia virus type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Human T-cell leukemia virus type 1" returned 421 free, full-text research articles on human participants. First 3 results:

Endemic impact of human T cell leukemia virus type 1 screening in bone allografts.
 

Author(s): Yasuhiro Ishidou, Kanehiro Matsuyama, Eiji Matsuura, Takao Setoguchi, Satoshi Nagano, Hironori Kakoi, Masataka Hirotsu, Ichiro Kawamura, Takuya Yamamoto, Setsuro Komiya

Journal: Cell Tissue Bank. 2016 Dec;17(4):555-560.

 

Allograft bone is a widely used as a convenient tool for reconstructing massive bone defects in orthopedic surgery. However, allografts are associated with the risk of viral disease transmission. One of the viruses transmitted in this manner is human T-lymphotropic virus type 1 (HTLV-1), ...

Last Updated: 28 Sep 2016

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Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax.
 

Author(s): Mariko Mizuguchi, Yuka Sasaki, Toshifumi Hara, Masaya Higuchi, Yuetsu Tanaka, Noriko Funato, Nobuyuki Tanaka, Masahiro Fujii, Masataka Nakamura

Journal:

 

Tax1 encoded by the human T-cell leukemia virus type 1 (HTLV-1) has been believed to dysregulate the expression of cellular genes involved in cell survival and mortality, leading to the development of adult T-cell leukemia (ATL). The function of Tax1 in ATL development however is ...

Last Updated: 2 Feb 2016

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Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation.
 

Author(s): Chun-Kit Yuen, Ching-Ping Chan, Sin-Yee Fung, Pei-Hui Wang, Wan-Man Wong, Hei-Man Vincent Tang, Kit-San Yuen, Chi-Ping Chan, Dong-Yan Jin, Kin-Hang Kok

Journal:

 

Infection with human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and tropical spastic paraparesis. Type I interferons (IFNs) are key effectors of the innate antiviral response, and IFN-α combined with the nucleoside reverse transcriptase inhibitor ...

Last Updated: 29 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Human T-cell leukemia virus type 1" returned 8 free, full-text review articles on human participants. First 3 results:

Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence.
 

Author(s): Alexandre Carpentier, Pierre-Yves Barez, Malik Hamaidia, Hélène Gazon, Alix de Brogniez, Srikanth Perike, Nicolas Gillet, Luc Willems

Journal:

 

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy-tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission ...

Last Updated: 22 Jul 2015

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Double control systems for human T-cell leukemia virus type 1 by innate and acquired immunity.
 

Author(s): Mari Kannagi, Atsuhiko Hasegawa, Shuichi Kinpara, Yukiko Shimizu, Ayako Takamori, Atae Utsunomiya

Journal: Cancer Sci.. 2011 Apr;102(4):670-6.

 

Human T-cell leukemia virus type 1 (HTLV-1) is the causative retrovirus of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-specific T-cell responses elicit antitumor and antiviral effects in experimental models, and are considered ...

Last Updated: 18 Mar 2011

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Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy.
 

Author(s): M Matsuoka, K-T Jeang

Journal: Oncogene. 2011 Mar;30(12):1379-89.

 

The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic ...

Last Updated: 24 Mar 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Raltegravir for HAM/TSP
 

Status: Recruiting

Condition Summary: HTLV-I Infection

 

Last Updated: 20 Apr 2017

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Last Updated: 20 Apr 2017

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Evaluation of Patients With HAM/TSP
 

Status: Recruiting

Condition Summary: HTLV-I Infection; Tropical Spastic Paraparesis

 

Last Updated: 20 Apr 2017

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