Alveolar Soft Part Sarcoma

Common Name(s)

Alveolar Soft Part Sarcoma

Alveolar soft part sarcoma is an unusual tumor with highly characteristic histopathology and ultrastructure, controversial histogenesis, and enigmatic clinical behavior ({3:Lieberman et al., 1989}; {4:Ordonez, 1999}). The typical histology of ASPS shows well-defined nests of cells with abundant pink cytoplasm. The loss of central cohesion produces a pseudoalveolar appearance ({2:Ladanyi et al., 2001}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alveolar Soft Part Sarcoma" for support, advocacy or research.

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alveolar Soft Part Sarcoma" for support, advocacy or research.

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Alveolar Soft Part Sarcoma" returned 82 free, full-text research articles on human participants. First 3 results:

Alveolar soft part sarcoma presenting as a breast metastasis in a patient with a history of thyroid cancer: a case report.
 

Author(s): Andrey Bychkov, Pichet Sampatanukul

Journal:

 

Metastases to the breast are uncommon, accounting for 0.5% of breast tumors, and most of them are originated from lymphoma, melanoma and carcinomas of various organs. Alveolar soft part sarcoma (ASPS) is a very rare neoplasm that is usually found in the lower extremities. Lungs are ...

Last Updated: 14 Oct 2015

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Validation and utilization of a TFE3 break-apart FISH assay for Xp11.2 translocation renal cell carcinoma and alveolar soft part sarcoma.
 

Author(s): Dinesh Pradhan, Somak Roy, Gabriela Quiroga-Garza, Kathleen Cieply, Alyssa L Mahaffey, Sheldon Bastacky, Rajiv Dhir, Anil V Parwani

Journal:

 

Xp11.2 or TFE3 translocation renal cell carcinomas (RCC) and alveolar soft part sarcoma (ASPS) are characterized by chromosome translocations involving the Xp11.2 breakpoint resulting in transcription factor TFE3 gene fusions. The most common translocations documented in TFE3 RCCs ...

Last Updated: 29 Sep 2015

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Alveolar soft part sarcoma of lung: report of a unique case with emphasis on diagnostic utility of molecular genetic analysis for TFE3 gene rearrangement and immunohistochemistry for TFE3 antigen expression.
 

Author(s): Ming Zhao, Qiu Rao, Cuiyun Wu, Zhongsheng Zhao, Xianglei He, Guoqing Ru

Journal:

 

Alveolar soft part sarcoma (ASPS) is a rare, malignant mesenchymal tumor of distinctive clinical, morphologic, ultrastructural, and cytogenetical characteristics. It typically arises in the extremities of adolescents and young adults, but has also been documented in a number of unusual ...

Last Updated: 15 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Alveolar Soft Part Sarcoma" returned 9 free, full-text review articles on human participants. First 3 results:

Primary alveolar soft part sarcoma of the uterine cervix: a case report and literature review.
 

Author(s): Min Feng, Wei Jiang, Yanmei He, Lei Li

Journal:

 

Alveolar soft part sarcoma (ASPS) is a tumor of unknown histogenesis, composed of large, epithelioid cells with eosinophilic cytoplasm, having an alveolar pattern. Primary ASPS of uterine cervix is very rare. In this report, we present a 21-aged-old female with primary ASPS in the ...

Last Updated: 31 Dec 2014

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Alveolar soft part sarcoma of the uterine corpus with pelvic lymph node metastasis: case report and literature review.
 

Author(s): Lei-lei Zhang, Qian Tang, Zhen Wang, Xiang-sheng Zhang

Journal: Int J Clin Exp Pathol. 2012 ;5(7):715-9.

 

Alveolar soft part sarcoma (ASPS) is a rare malignant soft tissue tumor, mainly localized in the extremities, occurring principally in adolescents and young adults. ASPS is uncommon in the female genital tract , and only 37 cases have been reported so far, including 9 cases in the ...

Last Updated: 14 Sep 2012

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Oral alveolar soft part sarcoma in childhood and adolescence: report of two cases and review of literature.
 

Author(s): Prokopios P Argyris, Robyn C Reed, J Carlos Manivel, Dolores Lopez-Terrada, Jared Jakacky, Zuzan Cayci, Konstantinos I Tosios, Stefan E Pambuccian, Lester D R Thompson, Ioannis G Koutlas

Journal: Head Neck Pathol. 2013 Mar;7(1):40-9.

 

Alveolar soft part sarcoma (ASPS) constitutes a rare soft tissue malignant neoplasm comprising less than 1 % of all soft tissue sarcomas. ASPS demonstrates a strong predilection for adolescents and young adults, with a female predominance reported. The head and neck region is the ...

Last Updated: 15 Mar 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Axitinib and Pembrolizumab in Subjects With Advanced Alveolar Soft Part Sarcoma and Other Soft Tissue Sarcomas
 

Status: Recruiting

Condition Summary: Alveolar Soft Part Sarcoma; Soft Tissue Sarcomas

 

Last Updated: 1 Sep 2016

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Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors
 

Status: Not yet recruiting

Condition Summary: Adrenal Cortex Carcinoma; Adult Alveolar Soft Part Sarcoma; Adult Clear Cell Sarcoma of Soft Parts; Adult Hepatocellular Carcinoma; Adult Rhabdomyosarcoma; Adult Soft Tissue Sarcoma; Childhood Alveolar Soft Part Sarcoma; Childhood Central Nervous System Neoplasm; Childhood Clear Cell Sarcoma of Soft Parts; Childhood Hepatocellular Carcinoma; Childhood Rhabdomyosarcoma; Childhood Soft Tissue Sarcoma; Childhood Solid Neoplasm; Ewing Sarcoma; Hepatoblastoma; Hepatocellular Carcinoma; Recurrent Adrenal Cortex Carcinoma; Recurrent Adult Hepatocellular Carcinoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Alveolar Soft Part Sarcoma; Recurrent Childhood Central Nervous System Neoplasm; Recurrent Childhood Hepatocellular Carcinoma; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Ewing Sarcoma; Recurrent Hepatoblastoma; Recurrent Renal Cell Carcinoma; Recurrent Rhabdomyosarcoma; Relapsed Solid Neoplasm; Renal Cell Carcinoma; Thyroid Gland Medullary Carcinoma; Wilms Tumor

 

Last Updated: 15 Aug 2016

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Phase II Study of Cediranib (AZD2171) in Patients With Alveolar Soft Part Sarcoma
 

Status: Recruiting

Condition Summary: Sarcoma, Alveolar Soft Part

 

Last Updated: 31 Aug 2016

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