Alveolar Soft Part Sarcoma

Common Name(s)

Alveolar Soft Part Sarcoma

Alveolar soft part sarcoma is an unusual tumor with highly characteristic histopathology and ultrastructure, controversial histogenesis, and enigmatic clinical behavior ({3:Lieberman et al., 1989}; {4:Ordonez, 1999}). The typical histology of ASPS shows well-defined nests of cells with abundant pink cytoplasm. The loss of central cohesion produces a pseudoalveolar appearance ({2:Ladanyi et al., 2001}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alveolar Soft Part Sarcoma" for support, advocacy or research.

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alveolar Soft Part Sarcoma" for support, advocacy or research.

Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Alveolar Soft Part Sarcoma" returned 75 free, full-text research articles on human participants. First 3 results:

Imaging features of alveolar soft-part sarcoma: a report from Children's Oncology Group Study ARST0332.
 

Author(s): M Beth McCarville, Sofia Muzzafar, Simon C Kao, Cheryl M Coffin, David M Parham, James R Anderson, Sheri L Spunt

Journal: AJR Am J Roentgenol. 2014 Dec;203(6):1345-52.

 

There are few studies in the literature regarding the imaging features of alveolar soft-part sarcoma (ASPS). We performed a comprehensive assessment of the imaging characteristics of this rare tumor to determine whether there are features that suggest the diagnosis.

Last Updated: 22 Nov 2014

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Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: ultrastructural features and differential diagnosis.
 

Author(s): Matthew D Cykowski, John Hicks, David I Sandberg, Adriana Olar, Julia A Bridge, Patricia T Greipp, Patricia Navarro, Steven Kolodziej, Meenakshi B Bhattacharjee

Journal: Ultrastruct Pathol. 2015 Feb;39(1):69-77.

 

We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic ...

Last Updated: 28 Jan 2015

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Orbital alveolar soft-part sarcoma: clinico-pathological profiles, management and outcomes.
 

Author(s): Kaustubh Mulay, Mohammad Javed Ali, Santosh G Honavar, Vijay Anand P Reddy

Journal: J Cancer Res Ther. ;10(2):294-8.

 

To study the clinico-radiological and clinic-pathological features of orbital alveolar soft-part sarcomas (ASPS).

Last Updated: 15 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Alveolar Soft Part Sarcoma" returned 9 free, full-text review articles on human participants. First 3 results:

Primary alveolar soft part sarcoma of the uterine cervix: a case report and literature review.
 

Author(s): Min Feng, Wei Jiang, Yanmei He, Lei Li

Journal:

 

Alveolar soft part sarcoma (ASPS) is a tumor of unknown histogenesis, composed of large, epithelioid cells with eosinophilic cytoplasm, having an alveolar pattern. Primary ASPS of uterine cervix is very rare. In this report, we present a 21-aged-old female with primary ASPS in the ...

Last Updated: 31 Dec 2014

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Alveolar soft part sarcoma of the uterine corpus with pelvic lymph node metastasis: case report and literature review.
 

Author(s): Lei-lei Zhang, Qian Tang, Zhen Wang, Xiang-sheng Zhang

Journal: Int J Clin Exp Pathol. 2012 ;5(7):715-9.

 

Alveolar soft part sarcoma (ASPS) is a rare malignant soft tissue tumor, mainly localized in the extremities, occurring principally in adolescents and young adults. ASPS is uncommon in the female genital tract , and only 37 cases have been reported so far, including 9 cases in the ...

Last Updated: 14 Sep 2012

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Oral alveolar soft part sarcoma in childhood and adolescence: report of two cases and review of literature.
 

Author(s): Prokopios P Argyris, Robyn C Reed, J Carlos Manivel, Dolores Lopez-Terrada, Jared Jakacky, Zuzan Cayci, Konstantinos I Tosios, Stefan E Pambuccian, Lester D R Thompson, Ioannis G Koutlas

Journal: Head Neck Pathol. 2013 Mar;7(1):40-9.

 

Alveolar soft part sarcoma (ASPS) constitutes a rare soft tissue malignant neoplasm comprising less than 1 % of all soft tissue sarcomas. ASPS demonstrates a strong predilection for adolescents and young adults, with a female predominance reported. The head and neck region is the ...

Last Updated: 15 Mar 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Axitinib and Pembrolizumab in Subjects With Advanced Alveolar Soft Part Sarcoma and Other Soft Tissue Sarcomas
 

Status: Not yet recruiting

Condition Summary: Alveolar Soft Part Sarcoma; Soft Tissue Sarcomas

 

Last Updated: 17 Dec 2015

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Pazopanib for Metastatic Alveolar Soft Part Sarcoma
 

Status: Recruiting

Condition Summary: Metastatic Alveolar Soft Part Sarcoma

 

Last Updated: 7 Mar 2015

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A Trial of Cediranib in the Treatment of Patients With Alveolar Soft Part Sarcoma (CASPS)
 

Status: Recruiting

Condition Summary: Alveolar Soft-part Sarcoma

 

Last Updated: 12 Nov 2014

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