Hodgkin lymphoma

Common Name(s)

Hodgkin lymphoma, Hodgkin's disease

Hodgkin lymphoma is a cancer of the lymph tissue, which can be found in the lymph nodes, spleen and other organs of the immune system. There are two types of Hodgkin lymphoma, which are known as nodular and classical Hodgkin’s. The classical form is further divided into four subtypes and is characterized by the presence of what are known as "Reed–Sternberg cells" (overgrown B-cells). Although Hodgkin lymphoma starts in the bone marrow, it may also spread to other tissues of the body, depending on the stage and how aggressive the type is. Anyone can get Hodgkin lymphoma, but there are some factors that increase one’s risks. People who have or have had the Epstein-Barr virus (also known as mono or mononucleosis) or HIV are at an increased risk, as well as those with a family history of the condition. Additionally, males, young adults and the elderly, and people from the U.S., Canada, or Europe are more likely to develop Hodgkin lymphoma than women, children, or people from other geographic locations.

The most common symptom is one or more enlarged lymph node(s), but enlargement of the spleen or liver may also be a sign. Other symptoms include night sweats, unexplained weight loss, itching, back pain, and red colored patched on the skin. The most effective and commonly used method for diagnosis is a lymph node biopsy, in which the lymph node is cut open and examined. Scans such as the PET or CT scans may be used as well to determine where the cancer is or how far it has spread and the appropriate treatment options. Treatment varies depending on the individual's weight, age, and size as well as the severity of the cancer. Treatment generally involves chemotherapy, radiation, or a combination of the two. Talk to your doctor if you are experiencing any symptoms or think you have Hodgkin lymphoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hodgkin lymphoma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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The Kimberly D. Holland Hodgkins Disease Foundation

Research and Cure... One Cell At A Time. Finding a cure for Hodgkins Disease by Funding Clinical Trial Research at Memorial Sloan-Kettering Cancer Center through Fundraising efforts.

Last Updated: 15 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hodgkin lymphoma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

View Details
The Kimberly D. Holland Hodgkins Disease Foundation

Research and Cure... One Cell At A Time. Finding a cure for Hodgkins Disease by Funding Clinical Trial Research at Memorial Sloan-Kettering Cancer Center through Fundraising efforts.

http://www.hodgkinsfoundation.org

Last Updated: 15 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hodgkin lymphoma" returned 1172 free, full-text research articles on human participants. First 3 results:

microRNA levels in paraffin-embedded indolent B-cell non-Hodgkin lymphoma tissues from patients chronically infected with hepatitis B or C virus.
 

Author(s): Roberto Bruni, Cinzia Marcantonio, Alessandro Pulsoni, Paola Tataseo, Federico De Angelis, Enea Spada, Fabrizio Marcucci, Sara Panfilio, Paolo Bianco, Mara Riminucci, Umbertina Villano, Maria Tosti, Anna Ciccaglione, Alfonso Mele

Journal: BMC Infect. Dis.. 2014 ;14 Suppl 5():S6.

 

Epidemiological evidence links Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) to B-cell non-Hodgkin lymphoma (B-NHL). These B-NHLs, particularly those associated with HCV, may represent a distinct sub-group with peculiar molecular features, including peculiar expression of microRNAs (miRs).

Last Updated: 19 Sep 2014

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Involved-node proton therapy in combined modality therapy for Hodgkin lymphoma: results of a phase 2 study.
 

Author(s): Bradford S Hoppe, Stella Flampouri, Robert Zaiden, William Slayton, Eric Sandler, Savas Ozdemir, Nam H Dang, James W Lynch, Zuofeng Li, Christopher G Morris, Nancy P Mendenhall

Journal: Int. J. Radiat. Oncol. Biol. Phys.. 2014 Aug;89(5):1053-9.

 

This study describes the early clinical outcomes of a prospective phase 2 study of consolidative involved-node proton therapy (INPT) as a component of combined-mode therapy in patients with stages I to III Hodgkin lymphoma (HL) with mediastinal involvement.

Last Updated: 18 Jul 2014

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[ZO-1 gene methylation status and its clinical significance in children with non-Hodgkin lymphoma].
 

Author(s): Yu-Qiao Diao, Fan Qu, Ming-Juan Yang, Jian-Hui Meng, Xiu-Li Zhu, Jian Chen

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Jun;16(6):619-23.

 

To investigate the methylation status of zonula occludens-1 (ZO-1) gene promoter and its clinical significance in children with stage IV non-Hodgkin lymphoma (NHL) and to provide a basis for further etiological study and early diagnosis of this disease.

Last Updated: 14 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hodgkin lymphoma" returned 89 free, full-text review articles on human participants. First 3 results:

Bulky mediastinal classical Hodgkin lymphoma in young women.
 

Author(s): Mary-Elizabeth M Percival, Richard T Hoppe, Ranjana H Advani

Journal: Oncology (Williston Park, N.Y.). 2014 Mar;28(3):253-6, 258-60, C3.

 

Last Updated: 26 May 2014

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Non-Hodgkin lymphoma and occupational exposure to agricultural pesticide chemical groups and active ingredients: a systematic review and meta-analysis.
 

Author(s): Leah Schinasi, Maria E Leon

Journal:

 

This paper describes results from a systematic review and a series of meta-analyses of nearly three decades worth of epidemiologic research on the relationship between non-Hodgkin lymphoma (NHL) and occupational exposure to agricultural pesticide active ingredients and chemical groups. ...

Last Updated: 25 Apr 2014

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Nodular lymphocyte predominant Hodgkin lymphoma and diphenylhydantoin: report of a case and review of the literature.
 

Author(s): Shobhna Sharma, Hari Menon, Manju Sengar, Sumeet Gujral

Journal: Indian J Pathol Microbiol. ;56(4):440-2.

 

A variety of lymphoma types have been reported in patients being treated with anticonvulsant therapy. Non-Hodgkin lymphomas have been reported twice as frequently as Hodgkin lymphomas. Association of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) with dilantin therapy is ...

Last Updated: 20 Jan 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gemcitabine and Bendamustine in Patients With Relapsed or Refractory Hodgkin's Lymphoma
 

Status: Recruiting

Condition Summary: Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

 

Last Updated: 8 Aug 2014

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A Phase II Trial of Panobinostat and Lenalidomide in Patients With Relapsed or Refractory Hodgkin's Lymphoma
 

Status: Recruiting

Condition Summary: Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

 

Last Updated: 15 Jul 2013

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Adcetris (Brentuximab Vedotin), Combination Chemotherapy, and Radiation Therapy in Treating Younger Patients With Stage IIB, IIIB and IV Hodgkin Lymphoma
 

Status: Recruiting

Condition Summary: Stage II Childhood Hodgkin Lymphoma; Stage III Childhood Hodgkin Lymphoma; Stage IV Childhood Hodgkin Lymphoma

 

Last Updated: 11 Nov 2014

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