Hodgkin lymphoma

Common Name(s)

Hodgkin lymphoma, Hodgkin's disease

Hodgkin lymphoma is a cancer of the lymph tissue, which can be found in the lymph nodes, spleen and other organs of the immune system. There are two types of Hodgkin lymphoma, which are known as nodular and classical Hodgkin’s. The classical form is further divided into four subtypes and is characterized by the presence of what are known as "Reed–Sternberg cells" (overgrown B-cells). Although Hodgkin lymphoma starts in the bone marrow, it may also spread to other tissues of the body, depending on the stage and how aggressive the type is. Anyone can get Hodgkin lymphoma, but there are some factors that increase one’s risks. People who have or have had the Epstein-Barr virus (also known as mono or mononucleosis) or HIV are at an increased risk, as well as those with a family history of the condition. Additionally, males, young adults and the elderly, and people from the U.S., Canada, or Europe are more likely to develop Hodgkin lymphoma than women, children, or people from other geographic locations.

The most common symptom is one or more enlarged lymph node(s), but enlargement of the spleen or liver may also be a sign. Other symptoms include night sweats, unexplained weight loss, itching, back pain, and red colored patched on the skin. The most effective and commonly used method for diagnosis is a lymph node biopsy, in which the lymph node is cut open and examined. Scans such as the PET or CT scans may be used as well to determine where the cancer is or how far it has spread and the appropriate treatment options. Treatment varies depending on the individual's weight, age, and size as well as the severity of the cancer. Treatment generally involves chemotherapy, radiation, or a combination of the two. Talk to your doctor if you are experiencing any symptoms or think you have Hodgkin lymphoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hodgkin lymphoma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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The Kimberly D. Holland Hodgkins Disease Foundation

Research and Cure... One Cell At A Time. Finding a cure for Hodgkins Disease by Funding Clinical Trial Research at Memorial Sloan-Kettering Cancer Center through Fundraising efforts.

Last Updated: 15 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hodgkin lymphoma" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

View Details
The Kimberly D. Holland Hodgkins Disease Foundation

Research and Cure... One Cell At A Time. Finding a cure for Hodgkins Disease by Funding Clinical Trial Research at Memorial Sloan-Kettering Cancer Center through Fundraising efforts.

http://www.hodgkinsfoundation.org

Last Updated: 15 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hodgkin lymphoma" returned 1638 free, full-text research articles on human participants. First 3 results:

A roadmap of constitutive NF-κB activity in Hodgkin lymphoma: Dominant roles of p50 and p52 revealed by genome-wide analyses.
 

Author(s): Kivia A P de Oliveira, Eva Kaergel, Matthias Heinig, Jean-Fred Fontaine, Giannino Patone, Enrique M Muro, Stephan Mathas, Michael Hummel, Miguel A Andrade-Navarro, Norbert Hübner, Claus Scheidereit

Journal:

 

NF-κB is widely involved in lymphoid malignancies; however, the functional roles and specific transcriptomes of NF-κB dimers with distinct subunit compositions have been unclear.

Last Updated: 18 Mar 2016

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Ileocecal Obstruction Due to B-cell Non-Hodgkin Lymphoma.
 

Author(s): Vasile Negrean, Florin Graur, Emil Moiş, Nadim Al-Hajjar,

Journal: Chirurgia (Bucur). ;111(1):71-3.

 

We report a rare case of non-Hodgkin lymphoma presented as an ileocecal mass. The patient was a 77-year-old man with history of symptoms of partial bowel obstruction, intermittent right iliac fossa pain, loss of weight, vomiting and fatigue. Clinical signs included moderate abdominal ...

Last Updated: 18 Mar 2016

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Human Cytokine Genetic Variants Associated With HBsAg Reverse Seroconversion in Rituximab-Treated Non-Hodgkin Lymphoma Patients.
 

Author(s): Liang-Tsai Hsiao, Hao-Yuan Wang, Ching-Fen Yang, Tzeon-Jye Chiou, Jyh-Pyng Gau, Yuan-Bin Yu, Hsiao-Ling Liu, Wen-Chun Chang, Po-Min Chen, Cheng-Hwai Tzeng, Yu-Jiun Chan, Muh-Hwa Yang, Jin-Hwang Liu, Yi-Hsiang Huang

Journal: Medicine (Baltimore). 2016 Mar;95(11):e3064.

 

Hepatitis B virus (HBV) reactivation has been noted in HBV surface antigen (HBsAg)-seronegative patients with CD20 B-cell non-Hodgkin lymphoma (NHL) undergoing rituximab treatment. Clinically, hepatitis flares are usually associated with the reappearance of HBsAg (reverse seroconversion ...

Last Updated: 18 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hodgkin lymphoma" returned 133 free, full-text review articles on human participants. First 3 results:

Prognostic value of pretransplant FDG-PET in refractory/relapsed Hodgkin lymphoma treated with autologous stem cell transplantation: systematic review and meta-analysis.
 

Author(s): Hugo J A Adams, Thomas C Kwee

Journal: Ann. Hematol.. 2016 Apr;95(5):695-706.

 

This study aimed to systematically review the prognostic value of pretransplant (18)F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in refractory/relapsed Hodgkin lymphoma treated with autologous stem cell transplantation (SCT). MEDLINE was systematically searched ...

Last Updated: 31 Mar 2016

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Clinical Options in Relapsed or Refractory Hodgkin Lymphoma: An Updated Review.
 

Author(s): Roberta Fedele, Massimo Martino, Anna Grazia Recchia, Giuseppe Irrera, Massimo Gentile, Fortunato Morabito

Journal: J Immunol Res. 2015 ;2015():968212.

 

Hodgkin lymphoma (HL) is a potentially curable lymphoma, and modern therapy is expected to successfully cure more than 80% of the patients. Second-line salvage high-dose chemotherapy and autologous stem cell transplantation (auto-SCT) have an established role in the management of ...

Last Updated: 20 Jan 2016

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Discordant lymphoma consisting of mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes: a case report.
 

Author(s): Chun Zhang, Yuanxue Yi, Chunyan Chen, Jianrong Wang, Zhu Liu

Journal:

 

Discordant lymphoma is defined by the simultaneous presence of two or more distinct types of lymphomas at different anatomic sites. With fewer than 20 studies reporting cases of discordant lymphoma to date, the incidence of this condition is believed to be very low.

Last Updated: 30 Dec 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 17 Aug 2016

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Brazilian Prospective Hodgkin Lymphoma Registry
 

Status: Recruiting

Condition Summary: Hodgkin Lymphoma; Hodgkin Disease

 

Last Updated: 10 May 2016

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