Histiocytosis

Common Name(s)

Histiocytosis

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Histiocytosis" for support, advocacy or research.

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Histiocytosis Association

The Histiocytosis Association is dedicated to raising awareness about histiocytic disorders, providing educational and emotional support, and funding research leading to better treatments and a cure.

Last Updated: 30 Oct 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Histiocytosis" for support, advocacy or research.

Logo
Histiocytosis Association

The Histiocytosis Association is dedicated to raising awareness about histiocytic disorders, providing educational and emotional support, and funding research leading to better treatments and a cure.

http://www.histio.org

Last Updated: 30 Oct 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Histiocytosis" returned 600 free, full-text research articles on human participants. First 3 results:

Pseudo-Peritoneal Carcinomatosis Presentation of a Crystal-Storing Histiocytosis With an Unmutated Monoclonal κ Light Chain.
 

Author(s): Aude Aline-Fardin, Sebastien Bender, Bettina Fabiani, David Buob, Said Brahimi, Marie Christine Verpont, Mohamad Mothy, Pierre Ronco, Jean Jacques Boffa, Pierre Aucouturier, Laurent Garderet

Journal: Medicine (Baltimore). 2015 Aug;94(32):e1247.

 

Crystal-storing histiocytosis (CSH) is a rare complication of monoclonal gammopathies caused by accumulation of crystalline material inside macrophages, and it may result in a variety of clinical manifestations depending on the involved organs. Although immunoglobulin κ light chains ...

Last Updated: 13 Aug 2015

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Cladribine and cytarabine in refractory multisystem Langerhans cell histiocytosis: results of an international phase 2 study.
 

Author(s): Jean Donadieu, Frederic Bernard, Max van Noesel, Mohamed Barkaoui, Odile Bardet, Rosella Mura, Maurizio Arico, Christophe Piguet, Virginie Gandemer, Corinne Armari Alla, Niels Clausen, Eric Jeziorski, Anne Lambilliote, Sheila Weitzman, Jan Inge Henter, Cor Van Den Bos,

Journal: Blood. 2015 Sep;126(12):1415-23.

 

An international phase 2 study combining cladribine and cytarabine (Ara-C) was initiated for patients with refractory, risk-organ-positive Langerhans cell histiocytosis (LCH) in 2005. The protocol, comprising at least two 5-day courses of Ara-C (1 g/m(2) per day) plus cladribine (9 ...

Last Updated: 19 Sep 2015

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Pulmonary Langerhans Cell Histiocytosis in an Adult Diagnosed with Solitary Inguinal Lymphadenopathy.
 

Author(s): Wei Luo, Ya-lun Li, Lian Jia, Chun-tao Liu

Journal: Intern. Med.. 2015 ;54(13):1643-6.

 

We herein report an extremely rare case of pulmonary Langerhans cell histiocytosis with a solitary enlarged inguinal lymph node. A 19-year-old man presented with a non-productive cough lasting for over a five-month period and an enlarged left inguinal lymph node that had persisted ...

Last Updated: 3 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Histiocytosis" returned 65 free, full-text review articles on human participants. First 3 results:

Co-occurrence of intracranial Rosai-Dorfman disease and Langerhans histiocytosis of the skull: case report and review of literature.
 

Author(s): Shankar Ayyappan Kutty, Sreekala Sreehari

Journal: Turk Neurosurg. 2015 ;25(3):496-9.

 

Rosai-Dorfman Disease involves histiocytic proliferation of the lymphatic system. Extranodal disease involving the central nervous system is uncommon. Furthermore, the combination of this disease entity with Langerhans cell histiocytosis is an even rarer phenomenon that has only recently ...

Last Updated: 3 Jun 2015

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Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis.
 

Author(s): Ichiro Murakami, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Masako Kato, Keiko Nagata, Yasushi Horie, Kazuhiko Hayashi, Toshihiko Imamura, Akira Morimoto, Shinsaku Imashuku, Jean Gogusev, Francis Jaubert, Katsuyoshi Takata, Takashi Oka, Tadashi Yoshino

Journal:

 

We propose Langerhans cell histiocytosis (LCH) is an inflammatory process that is prolonged by mutations. We hypothesize that Merkel cell polyomavirus (MCPyV) infection triggers an interleukin-1 (IL-1) activation loop that underlies the pathogenesis of LCH. Langerhans cells (LCs) ...

Last Updated: 19 Apr 2015

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[Specific locations of Langerhans cell histiocytosis in the child, scapula and pubis: report of two cases].
 

Author(s): Karima Atarraf, Lamiae Chater, Mounir Arroud, My Abderrahman Afifi

Journal:

 

Last Updated: 5 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 19 Nov 2015

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Evaluation of Exercise Capacity and Exercise Limitation in Patients With Pulmonary Langerhans Cell Histiocytosis
 

Status: Not yet recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 26 Jan 2016

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Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 10 Mar 2015

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