Hidradenitis suppurativa

Common Name(s)

Hidradenitis suppurativa, Hidradenitis suppurativa familial

Hidradenitis suppurativa (HS) is a rare condition that causes abscesses and cysts to form on a person’s skin. The most commonly affected areas are the underarms, under the breasts, inner thighs, groin, and buttocks. Though this disease is not contagious, it can be extremely painful for that affected person. Cysts that form from HS can go through periods of inflammation, swelling to the size of golf and even tennis balls. In certain cases, a small incision can be made to drain the cyst. In more severe cases sinus tracts can form between cysts, which can lead to open wounds that take a long time to heal. Certain factors such as hot and humid weather, as well as wearing clothes that do not breathe and rub the cysts, can cause inflammation.

HS is not a rare condition. It is estimated that it affects between 1/100 to 1/1000 in Western populations. Females are more likely to be affected, with a female to male ratio of 4 or 5 to 1. Symptoms of HS normally begin after puberty but rarely after menopause with the mean age of onset being 20-23 years old. The specific cause of HS is unknown, although it probably results from a combination of genetic and environmental factors. Talk to your doctor to decide on the best treatment if you or a family member has been diagnosed with HS. Support groups are also a good source of information and a way to connect with others affected with HS.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hidradenitis suppurativa" for support, advocacy or research.

European Hidradenitis Suppurativa Foundation eV

The purpose of the Foundation is the promotion of science and research in the field of disease hidradenitis suppurativa / acne inversa. The purpose of the Foundation is to be achieved by raising funds for the promotion of research projects in the field of disease hidradenitis suppurativa / acne inversa by other entities or persons. Purpose of the Foundation is also the training of doctors, patients and laypersons. The Foundation pursues exclusively charitable purposes within the meaning of the "tax-privileged purposes" of the tax code.

Last Updated: 1 Apr 2013

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Hidradenitis Suppurativa Foundation, Inc.

The mission of the Hidradentitis Suppurativa Foundation, Inc. (HSF) is to foster and encourage worldwide research by developing and supporting an interdisciplinary family of scientists and physicians devoted to studying the molecular and cellular basis of Hidradentitis Suppurativa (HS), in order to develop and deliver more effective forms of treatment and preventative measures for those with this common, debilitating, and eminently chronic disease.

Last Updated: 10 May 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hidradenitis suppurativa" for support, advocacy or research.

European Hidradenitis Suppurativa Foundation eV

The purpose of the Foundation is the promotion of science and research in the field of disease hidradenitis suppurativa / acne inversa. The purpose of the Foundation is to be achieved by raising funds for the promotion of research projects in the field of disease hidradenitis suppurativa / acne inversa by other entities or persons. Purpose of the Foundation is also the training of doctors, patients and laypersons. The Foundation pursues exclusively charitable purposes within the meaning of the "tax-privileged purposes" of the tax code.

http://www.klinikum-dessau.de/klinikenundinstitute/hautklinikundimmuno ...

Last Updated: 1 Apr 2013

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Hidradenitis Suppurativa Foundation, Inc.

The mission of the Hidradentitis Suppurativa Foundation, Inc. (HSF) is to foster and encourage worldwide research by developing and supporting an interdisciplinary family of scientists and physicians devoted to studying the molecular and cellular basis of Hidradentitis Suppurativa (HS), in order to develop and deliver more effective forms of treatment and preventative measures for those with this common, debilitating, and eminently chronic disease.

http://www.hs-foundation.org/

Last Updated: 10 May 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hidradenitis suppurativa" returned 68 free, full-text research articles on human participants. First 3 results:

A 3D ultrasound study of sinus tract formation in hidradenitis suppurativa.
 

Author(s): Ximena Wortsman, Gregor Jemec

Journal:

 

Imaging of hidradenitis suppurativa allows the study of both the lesion morphology and evolution. Hidradenitis lesions of different stages were studied using 3D ultrasound in a cross sectional pilot study. A total of 25 HS patients (18 female/ 7 male, aged 18-46 year-old) and 10 healthy ...

Last Updated: 9 Sep 2013

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Hidradenitis suppurativa: retrospective study of 20 cases.
 

Author(s): Nurimar Conceição Fernandes, Camilla Pimentel A Franco, Cíntia Maria O Lima

Journal: An Bras Dermatol. ;88(3):480-1.

 

In this study, twenty cases of severe hidradenitis suppurativa are reported, mainly in non-white people and in axillary areas. Wide surgical excision has offered good results, although relapses have occurred at variable intervals in the follow-up period.

Last Updated: 24 Jun 2013

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Phenotypic heterogeneity in hidradenitis suppurativa (acne inversa): classification is an essential step toward personalized therapy.
 

Author(s): John R Ingram, Vincent Piguet

Journal: J. Invest. Dermatol.. 2013 Jun;133(6):1453-6.

 

Awareness is increasing that there is phenotypic heterogeneity within the hidradenitis suppurativa (HS) disease spectrum. However, the few randomized HS trials that are available have not distinguished between the subtypes of the disease. In this issue, Canoui-Poitrine et al. used ...

Last Updated: 15 May 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hidradenitis suppurativa" returned 12 free, full-text review articles on human participants. First 3 results:

Hidradenitis suppurativa: A practical review of possible medical treatments based on over 350 hidradenitis patients.
 

Author(s): Noah Scheinfeld

Journal:

 

Hidradenitis suppurativa (HS), a pathological follicular disease, impacts patients' lives profoundly. HS most commonly involves cutaneous intertriginous areas, such as the axilla, inner thighs, groin and buttocks, and pendulous breasts, but can appear on any follicular skin. Protean, ...

Last Updated: 11 Sep 2013

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γ-Secretase mutations in hidradenitis suppurativa: new insights into disease pathogenesis.
 

Author(s): Andrew E Pink, Michael A Simpson, Nemesha Desai, Richard C Trembath, Jonathan N W Barker

Journal: J. Invest. Dermatol.. 2013 Mar;133(3):601-7.

 

Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin condition of unclear etiology. It may segregate as an autosomal dominant trait, and heterozygous mutations in the γ-secretase genes NCSTN, PSENEN, and PSEN1 have recently been reported in a small number of ...

Last Updated: 12 Feb 2013

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Hidradenitis suppurativa: viewpoint on clinical phenotyping, pathogenesis and novel treatments.
 

Author(s): Hessel H van der Zee, Jon D Laman, Jurr Boer, Errol P Prens

Journal: Exp. Dermatol.. 2012 Oct;21(10):735-9.

 

Hidradenitis suppurativa (HS) is an inflammatory, debilitating follicular skin disease with recurring flare-ups. The painful, deep-seated, inflamed lesions in the inverse areas of the body cause severe discomfort, and hence, serious psycho-social and economic costs. HS is common, ...

Last Updated: 19 Oct 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 13 Jun 2014

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