Herpetic keratitis

Common Name(s)

Herpetic keratitis, Herpes zoster ophthalmicus

Herpetic keratitis is a herpes simplex virus infection of the eye. There are two types of herpes viruses, herpes simplex 1 (HS1) and 2 (HS2). HS2 herpetic keratitis is more rare since HS2 is sexually transmitted. HS1, however can spread to the eye by touching an infected mouth sore and then touching the eye. Symptoms of herpetic keratitis include redness, photophobia (light sensitivity), blurred vision, tearing, and pain. Herpetic keratitis is also the most common form of infectious blindness in the world. Most infections, however, are healed on their own within three weeks. Oral and topical antiviral therapies are also effective treatments for herpetic keratitis.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Herpetic keratitis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Herpetic keratitis" returned 50 free, full-text research articles on human participants. First 3 results:

Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice.
 

Author(s): Xiao-Tang Yin, Tammie L Keadle, Jessicah Hard, John Herndon, Chloe A Potter, Chelsea R Del Rosso, Thomas A Ferguson, Patrick M Stuart

Journal: J Immunol Res. 2015 ;2015():435140.

 

Herpes simplex virus-1 (HSV-1) infection of the cornea leads to a potentially blinding condition termed herpetic stromal keratitis (HSK). Clinical studies have indicated that disease is primarily associated with recurrent HSK following reactivation of a latent viral infection of the ...

Last Updated: 27 Oct 2015

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Herpetic Keratitis after Corneal Collagen Cross-Linking with Riboflavin and Ultraviolet-A for Keratoconus.
 

Author(s): Awad Al-Qarni, Mosa AlHarbi

Journal: Middle East Afr J Ophthalmol. ;22(3):389-92.

 

To describe two cases of herpetic keratitis after corneal collagen cross-linking (CXL) for progressive keratoconus. An 18-year-old male and a 21-year-old male with rapidly progressive keratoconus were treated with CXL. Postoperatively, on the 6(th) and 9(th) days respectively, a dendritic ...

Last Updated: 16 Jul 2015

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Role of miR-155 in the pathogenesis of herpetic stromal keratitis.
 

Author(s): Siddheshvar Bhela, Sachin Mulik, Fernanda Gimenez, Pradeep B J Reddy, Raphael L Richardson, Siva Karthik Varanasi, Ujjaldeep Jaggi, John Xu, Patrick Y Lu, Barry T Rouse

Journal: Am. J. Pathol.. 2015 Apr;185(4):1073-84.

 

Ocular infection with herpes simplex virus 1 can result in a chronic immunoinflammatory stromal keratitis (SK) lesion that is a significant cause of human blindness. A key to controlling SK lesion severity is to identify cellular and molecular events responsible for tissue damage ...

Last Updated: 21 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Herpetic keratitis" returned 5 free, full-text review articles on human participants. First 3 results:

A systematic review and meta-analysis to compare the efficacy of acyclovir 3% ophthalmic ointment to idoxuridine in curing herpetic keratitis by Day 7 of treatment.
 

Author(s): Diane E Balderson, Gengqian Cai, Michael A Fries, David M Kleinman, Megan M McLaughlin, Trupti M Trivedi, John I Wurzelmann, Sheila B Young

Journal:

 

This objective of the review and analysis is to demonstrate that acyclovir (ACV) 3% ophthalmic ointment is superior to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geographic ulcer sub-types.

Last Updated: 3 Jun 2015

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Corneal lymphangiogenesis in herpetic stromal keratitis.
 

Author(s): Paul J Park, Michael Chang, Nitin Garg, Jimmy Zhu, Jin-Hong Chang, Deepak Shukla

Journal: Surv Ophthalmol. ;60(1):60-71.

 

Corneal lymphangiogenesis is the extension of lymphatic vessels into the normally alymphatic cornea, a process that compromises the cornea's immune-privileged state and facilitates herpetic stromal keratitis (HSK). HSK results most commonly from infection by herpes simplex virus-1 ...

Last Updated: 10 Dec 2014

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Potential function of miRNAs in herpetic stromal keratitis.
 

Author(s): Sachin Mulik, Siddheshvar Bhela, Barry T Rouse

Journal:

 

MicroRNAs (miRNAs), the newly discovered regulators of gene expression, act by promoting degradation of mRNA and/or by inhibiting protein expression. Dysregulation of miRNA expression has been noted in an expanding number of diseases; and in some instances, manipulating miRNA expression ...

Last Updated: 18 Jan 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP
 

Status: Recruiting

Condition Summary: Corneal Opacity; Keratitis, Herpetic; Corneal Ulcer; Corneal Dystrophies, Hereditary

 

Last Updated: 4 Jul 2016

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