Herpes simplex encephalitis

Common Name(s)

Herpes simplex encephalitis

Herpes simplex is a viral infection of two types, herpes simplex 1 (HS1) and 2 (HS2). HS1 is received through contact with oral secretions (saliva) or skin sores containing the virus. This can be done through kissing and sharing toothbrushes or eating utensils with an individual who has HS1. HS1 causes sores around the mouth and lips. HS2 is received through sexual contact with an individual infected with HS2. HS2 may also be transmitted to a newborn baby during childbirth if the mother is infected with the virus. HS2 can cause genital warts in men and women. Although symptoms can be treated for with medication, there is no cure for herpes. The virus can become dormant in its host for different amounts of time causing outbreaks of symptoms triggered by stress, trauma to the affected area, illness, fatigue, weakening of the immune system.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Herpes simplex encephalitis" for support, advocacy or research.

Encephalitis Global Inc.

Encephalitis Global (E Global) is a U.S.A. 501(c)(3) public charity formed in 2005 as an alliance connecting encephalitis survivors and caregivers around the world. E Global strives to raise awareness, aiming to promote swift diagnosis, to alleviate unnecessary suffering and to prevent untimely death.

Last Updated: 19 Feb 2013

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ProjectAccept.org

To gather together all individuals and groups affected by HSV(herpes) & HPV into one social movement; to organize and empower the community in order to fund ProjectAccept.org which will combat HSV & HPV on the following fronts: Awareness: To raise public awareness of both the present and the potential impact of viruses on the uninfected and their loved ones Acceptance: To combat the stigma surrounding HSV & HPV; to make life for the affected easier, while fighting the spread of the viruses through more open communication Virus Research: To combat the disease(s) medically

Last Updated: 15 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Herpes simplex encephalitis" for support, advocacy or research.

Encephalitis Global Inc.

Encephalitis Global (E Global) is a U.S.A. 501(c)(3) public charity formed in 2005 as an alliance connecting encephalitis survivors and caregivers around the world. E Global strives to raise awareness, aiming to promote swift diagnosis, to alleviate unnecessary suffering and to prevent untimely death.

http://www.encephalitisglobal.org

Last Updated: 19 Feb 2013

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ProjectAccept.org

To gather together all individuals and groups affected by HSV(herpes) & HPV into one social movement; to organize and empower the community in order to fund ProjectAccept.org which will combat HSV & HPV on the following fronts: Awareness: To raise public awareness of both the present and the potential impact of viruses on the uninfected and their loved ones Acceptance: To combat the stigma surrounding HSV & HPV; to make life for the affected easier, while fighting the spread of the viruses through more open communication Virus Research: To combat the disease(s) medically

http://www.projectaccept.org

Last Updated: 15 Apr 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Herpes simplex encephalitis" returned 162 free, full-text research articles on human participants. First 3 results:

Clinical Neuropathology practice guide 4-2013: post-herpes simplex encephalitis: N-methyl-Daspartate receptor antibodies are part of the problem.
 

Author(s): Romana Höftberger, Thaís Armangue, Frank Leypoldt, Francesc Graus, Josep Dalmau

Journal: Clin. Neuropathol.. ;32(4):251-4.

 

Classic herpes simplex virus encephalitis (HSVE) is an acute viral infection that usually follows a monophasic disease course; however some patients, mainly children, experience a relapse within weeks or months after the initial event. In a subset of these patients a viral reactivation ...

Last Updated: 28 Jun 2013

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The proteome of Toll-like receptor 3-stimulated human immortalized fibroblasts: implications for susceptibility to herpes simplex virus encephalitis.
 

Author(s): Rebeca Pérez de Diego, Claire Mulvey, Mark Crawford, Matthew W B Trotter, Lazaro Lorenzo, Vanessa Sancho-Shimizu, Laurent Abel, Shen-Ying Zhang, Jean-Laurent Casanova, Jasminka Godovac-Zimmermann

Journal: J. Allergy Clin. Immunol.. 2013 Apr;131(4):1157-66.

 

Inborn errors in Toll-like receptor 3 (TLR3)-IFN type I and III pathways have been implicated in susceptibility to herpes simplex virus encephalitis (HSE) in children, but most patients studied do not carry mutations in any of the genes presently associated with HSE susceptibility. ...

Last Updated: 1 Apr 2013

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N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis.
 

Author(s): Harald Prüss, Carsten Finke, Markus Höltje, Joerg Hofmann, Christine Klingbeil, Christian Probst, Kathrin Borowski, Gudrun Ahnert-Hilger, Lutz Harms, Jan M Schwab, Christoph J Ploner, Lars Komorowski, Winfried Stoecker, Josep Dalmau, Klaus-Peter Wandinger

Journal: Ann. Neurol.. 2012 Dec;72(6):902-11.

 

To determine the presence and kinetics of antibodies against synaptic proteins in patients with herpes simplex virus encephalitis (HSE).

Last Updated: 2 Jan 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Herpes simplex encephalitis" returned 8 free, full-text review articles on human participants. First 3 results:

Herpes simplex virus encephalitis complicated by intracerebral hematoma.
 

Author(s): Satoru Takeuchi, Yoshio Takasato

Journal: Neurol India. ;59(4):594-6.

 

Herpes simplex virus (HSV) encephalitis complicated by cerebral hematoma is extremely rare. We report a 54-year-old man with hepes simplex encephalitis complicated by intracerebral hematoma and review the literature and describe the characteristics of HSV encephalitis complicated ...

Last Updated: 5 Sep 2011

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Antiviral therapy for herpesvirus central nervous system infections: neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infection.
 

Author(s): Scott H James, David W Kimberlin, Richard J Whitley

Journal: Antiviral Res.. 2009 Sep;83(3):207-13.

 

Herpesvirus infections of the central nervous system (CNS) are a significant cause of morbidity and mortality, including long-term neurologic sequelae. Among the family of herpesviruses, the most significant CNS infections are due to herpes simplex virus (HSV) and cytomegalovirus ...

Last Updated: 14 Aug 2009

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Choreoathetosis after herpes simplex encephalitis with basal ganglia involvement on MRI.
 

Author(s): Megan Wills Kullnat, Richard P Morse

Journal: Pediatrics. 2008 Apr;121(4):e1003-7.

 

Children with herpes simplex virus encephalitis have a relapse in approximately 25% of cases, which rarely may present as a movement disorder, most often choreoathetosis. The anatomic basis for herpes simplex virus encephalitis-associated movement disorders has been poorly understood, ...

Last Updated: 2 Apr 2008

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.