Hereditary spastic paraplegia

Common Name(s)

Hereditary spastic paraplegia, Hereditary Spastic Paraparesis, Familial Spastic Paraparesis

Hereditary spastic paraplegia is a group of hereditary, degenerative, neurological disorders that primarily affect the upper motor neurons. Upper motor neurons in the brain and spinal cord deliver signals to the lower motor neurons which in turn, carry messages to the muscles. In hereditary spastic paraplegia, upper motor neurons slowly degenerate so the muscles do not receive the correct messages causing progressive spasticity (increased muscle tone/stiffness) and weakness of the legs leading to difficulty walking.  As degeneration continues, symptoms worsen.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary spastic paraplegia" for support, advocacy or research.

Logo
Spastic Paraplegia Foundation, Inc.

We are committed to discovering the cures for HSP and PLS by promoting research, providing accurate information about these disorders, and creating opportunities for mutual support and sharing.

Last Updated: 29 Oct 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary spastic paraplegia" for support, advocacy or research.

Logo
Spastic Paraplegia Foundation, Inc.

We are committed to discovering the cures for HSP and PLS by promoting research, providing accurate information about these disorders, and creating opportunities for mutual support and sharing.

http://www.sp-foundation.org

Last Updated: 29 Oct 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary spastic paraplegia" returned 119 free, full-text research articles on human participants. First 3 results:

Truncating mutation in intracellular phospholipase A₁ gene (DDHD2) in hereditary spastic paraplegia with intellectual disability (SPG54).
 

Author(s): Nuha Alrayes, Hussein Sheikh Ali Mohamoud, Musharraf Jelani, Saleem Ahmad, Nirmal Vadgama, Khadijah Bakur, Michael Simpson, Jumana Yousuf Al-Aama, Jamal Nasir

Journal:

 

Hereditary spastic paraplegias (HSP), a group of genetically heterogeneous neurological disorders with more than 56 documented loci (SPG1-56), are described either as uncomplicated (or pure), or complicated where in addition to spasticity and weakness of lower extremeties, additional ...

Last Updated: 26 Jun 2015

Go To URL
High frequency of SPG4 in Taiwanese families with autosomal dominant hereditary spastic paraplegia.
 

Author(s): Min-Yu Lan, Yung-Yee Chang, Tu-Hseuh Yeh, Szu-Chia Lai, Chia-Wei Liou, Hung-Chou Kuo, Yih-Ru Wu, Rong-Kuo Lyu, Jen-Wen Hung, Ying-Chao Chang, Chin-Song Lu

Journal:

 

Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative diseases characterized by progressive spasticity and weakness of the lower limbs. SPG4, SPG3A and SPG31 are the three leading causes of autosomal dominant (AD) HSPs.

Last Updated: 11 Mar 2015

Go To URL
Hereditary spastic paraplegia: a novel mutation and expansion of the phenotype variability in SPG10.
 

Author(s): Laura Carosi, Temistocle Lo Giudice, Martina Di Lullo, Federica Lombardi, Carla Babalini, Fabrizio Gaudiello, Girolama Alessandra Marfia, Roberto Massa, Toshitaka Kawarai, Antonio Orlacchio

Journal: J. Neurol. Neurosurg. Psychiatr.. 2015 Jun;86(6):702-4.

 

Last Updated: 15 May 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary spastic paraplegia" returned 11 free, full-text review articles on human participants. First 3 results:

Hereditary spastic paraplegia: clinical-genetic characteristics and evolving molecular mechanisms.
 

Author(s): Temistocle Lo Giudice, Federica Lombardi, Filippo Maria Santorelli, Toshitaka Kawarai, Antonio Orlacchio

Journal: Exp. Neurol.. 2014 Nov;261():518-39.

 

Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurological disorders characterized by pathophysiologic hallmark of length-dependent distal axonal degeneration of the corticospinal tracts. The prominent features of this pathological condition ...

Last Updated: 11 Oct 2014

Go To URL
Clinical features and management of hereditary spastic paraplegia.
 

Author(s): Ingrid Faber, Katiane R Servelhere, Alberto R M Martinez, Anelyssa D'Abreu, Iscia Lopes-Cendes, Marcondes C França-Jr

Journal: Arq Neuropsiquiatr. 2014 Mar;72(3):219-26.

 

Hereditary spastic paraplegia (HSP) is a group of genetically-determined disorders characterized by progressive spasticity and weakness of lower limbs. An apparently sporadic case of adult-onset spastic paraplegia is a frequent clinical problem and a significant proportion of cases ...

Last Updated: 28 Mar 2014

Go To URL
The global epidemiology of hereditary ataxia and spastic paraplegia: a systematic review of prevalence studies.
 

Author(s): Luis Ruano, Claudia Melo, M Carolina Silva, Paula Coutinho

Journal: Neuroepidemiology. 2014 ;42(3):174-83.

 

Hereditary cerebellar ataxias (HCA) and hereditary spastic paraplegias (HSP) are two groups of neurodegenerative disorders that usually present with progressive gait impairment, often leading to permanent disability. Advances in genetic research in the last decades have improved their ...

Last Updated: 1 Apr 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia
 

Status: Not yet recruiting

Condition Summary: Hereditary Spastic Paraplegia

 

Last Updated: 1 Jun 2016

Go to URL
Genetic and Physical Study of Childhood Nerve and Muscle Disorders
 

Status: Recruiting

Condition Summary: Muscular Dystrophies; Muscle Myopathies; Hereditary Spastic Paraplegias; Inherited Neuropathies; Inherited Neuromuscular Conditions

 

Last Updated: 11 May 2016

Go to URL
Phenotype, Genotype & Biomarkers in ALS and Related Disorders
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Primary Lateral Sclerosis; Hereditary Spastic Paraplegia; Progressive Muscular Atrophy; Multisystem Proteinopathy

 

Last Updated: 10 Dec 2015

Go to URL