Lynch syndrome

Common Name(s)

Lynch syndrome, Hereditary Non-Polyposis Colorectal Cancer (HNPCC)

Lynch syndrome (LS) is a result of a defective mismatch repair gene. The defect subjects family members to a high lifetime risk of contracting aggressive cancers, which often present at a younger than avg age, of 82% colorectal, 60% endometrial, 20% urothelial tract, 15% gastric tract, 13% ovarian & a higher than avg risk for cancers of the hepatobiliary tract, pancreas, prostate, skin and brain. Genetic testing and regular cancer screenings are essential for these families to insure survival.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lynch syndrome" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

Last Updated: 5 Aug 2013

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

Last Updated: 4 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lynch syndrome" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 4 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lynch syndrome" returned 217 free, full-text research articles on human participants. First 3 results:

Systematic study on genetic and epimutational profile of a cohort of Amsterdam criteria-defined Lynch Syndrome in Singapore.
 

Author(s): Yanqun Liu, Min Hoe Chew, Xue Wei Goh, Soo Yong Tan, Carol Tien Tau Loi, Yuen Ming Tan, Hai Yang Law, Poh Koon Koh, Choong Leong Tang

Journal:

 

Germline defects of mismatch repair (MMR) genes underlie Lynch Syndrome (LS). We aimed to gain comprehensive genetic and epigenetic profiles of LS families in Singapore, which will facilitate efficient molecular diagnosis of LS in Singapore and the region.

Last Updated: 8 Apr 2014

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Lynch syndrome from a surgeon perspective: retrospective study of clinical impact of mismatch repair protein expression analysis in colorectal cancer patients less than 50 years old.
 

Author(s): Gian Luca Baiocchi, Nazario Portolani, William Vermi, Carla Baronchelli, Federico Gheza, Claudio Zogno, Alessandro Scaglia, Eleonora Marchina, Guido A M Tiberio, Stefano Maria Giulini

Journal:

 

In clinical practice, unexpected diagnosis of colorectal cancer in young patients requires prompt surgery, thus genetic testing for Lynch Syndrome is frequently missed, and clinical management may result incorrect.

Last Updated: 19 Mar 2014

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Pyloric gland adenoma in Lynch syndrome.
 

Author(s): Seung Eun Lee, So Young Kang, Junhun Cho, Boram Lee, Dong Kyung Chang, Hyein Woo, Jong Won Kim, Ha Young Park, In Gu Do, Young Eun Kim, Ryoji Kushima, Gregory Y Lauwers, Cheol Keun Park, Kyoung M Kim

Journal: Am. J. Surg. Pathol.. 2014 Jun;38(6):784-92.

 

The prevalence of gastric cancer associated with Lynch syndrome (LS) is highly variable, and the underlying histologic pathway or molecular mechanisms remain unclear. From 1995 to 2012, 15 patients had been treated for both gastric and colonic adenocarcinomas and diagnosed as LS. ...

Last Updated: 13 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lynch syndrome" returned 25 free, full-text review articles on human participants. First 3 results:

Endometrial and ovarian cancer in women with Lynch syndrome: update in screening and prevention.
 

Author(s): Karen H Lu, Molly Daniels

Journal: Fam. Cancer. 2013 Jun;12(2):273-7.

 

Women with Lynch syndrome have an additional need to address the substantial increased lifetime risk of endometrial and ovarian cancer. Endometrial or ovarian cancer can be the presenting cancer in individuals with Lynch syndrome, or can be a second cancer. Lifetime risk of endometrial ...

Last Updated: 22 Jul 2013

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The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome.
 

Author(s): Juana V Martín-López, Richard Fishel

Journal: Fam. Cancer. 2013 Jun;12(2):159-68.

 

The majority of Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer (HNPCC), has been linked to heterozygous defects in DNA mismatch repair (MMR). MMR is a highly conserved pathway that recognizes and repairs polymerase misincorporation errors and nucleotide ...

Last Updated: 22 Jul 2013

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Prediction models in Lynch syndrome.
 

Author(s): Fay Kastrinos, Judith Balmaña, Sapna Syngal

Journal: Fam. Cancer. 2013 Jun;12(2):217-28.

 

Prediction models for the identification of Lynch syndrome have been developed to quantify an individual's risk of carrying a mismatch repair gene mutation and help clinicians decide for whom further risk assessment and genetic testing is necessary. There are diverse clinical settings ...

Last Updated: 22 Jul 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Women Who Are At Risk Or May Have Lynch Syndrome
 

Status: Recruiting

Condition Summary: Hereditary Nonpolyposis Colorectal Cancer; Lynch Syndrome

 

Last Updated: 13 Nov 2014

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I-Scan For Colon Polyp Detection In HNPCC
 

Status: Recruiting

Condition Summary: Hereditary Non-polyposis Colon Carcinoma; HNPCC; Lynch Syndrome

 

Last Updated: 29 Mar 2013

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Molecular Screening for Lynch Syndrome in Denmark
 

Status: Recruiting

Condition Summary: Colorectal Cancer; Lynch Syndrome; HNPCC

 

Last Updated: 3 Dec 2014

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