Lynch syndrome

Common Name(s)

Lynch syndrome, Hereditary Non-Polyposis Colorectal Cancer (HNPCC)

Lynch syndrome (LS) is a result of a defective mismatch repair gene. The defect subjects family members to a high lifetime risk of contracting aggressive cancers, which often present at a younger than avg age, of 82% colorectal, 60% endometrial, 20% urothelial tract, 15% gastric tract, 13% ovarian & a higher than avg risk for cancers of the hepatobiliary tract, pancreas, prostate, skin and brain. Genetic testing and regular cancer screenings are essential for these families to insure survival.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lynch syndrome" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

View Details
Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

Last Updated: 5 Aug 2013

View Details
Logo
Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

Last Updated: 4 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lynch syndrome" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

View Details
Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

View Details
Logo
Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 4 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lynch syndrome" returned 208 free, full-text research articles on human participants. First 3 results:

Pyloric gland adenoma in Lynch syndrome.
 

Author(s): Seung Eun Lee, So Young Kang, Junhun Cho, Boram Lee, Dong Kyung Chang, Hyein Woo, Jong Won Kim, Ha Young Park, In Gu Do, Young Eun Kim, Ryoji Kushima, Gregory Y Lauwers, Cheol Keun Park, Kyoung M Kim

Journal: Am. J. Surg. Pathol.. 2014 Jun;38(6):784-92.

 

The prevalence of gastric cancer associated with Lynch syndrome (LS) is highly variable, and the underlying histologic pathway or molecular mechanisms remain unclear. From 1995 to 2012, 15 patients had been treated for both gastric and colonic adenocarcinomas and diagnosed as LS. ...

Last Updated: 13 May 2014

Go To URL
Epithelial-mesenchymal transition in colorectal cancer tissue of patients with Lynch syndrome.
 

Author(s): Guo-Li Gu, Xiao-Quan Zhu, Xue-Ming Wei, Li Ren, De-Chang Li, Shi-Lin Wang

Journal: World J. Gastroenterol.. 2014 Jan;20(1):250-7.

 

To explore the epithelial-mesenchymal transition (EMT) in tissue from patients with Lynch syndrome, and to interpret biological behaviour of Lynch syndrome.

Last Updated: 13 Jan 2014

Go To URL
Early-onset colorectal cancer patients without family history are "at very low risk" for lynch syndrome.
 

Author(s): Vittoria Stigliano, Lupe Sanchez-Mete, Aline Martayan, Maria Diodoro, Beatrice Casini, Isabella Sperduti, Marcello Anti

Journal:

 

Several studies evaluated the prevalence of Lynch Syndrome (LS) in young onset colorectal cancer (CRC) patients and the results were extremely variable (5%-20%). Immunohistochemistry (IHC) for MMR proteins and/or MSI analysis are screening tests that are done, either by themselves ...

Last Updated: 14 Jan 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lynch syndrome" returned 25 free, full-text review articles on human participants. First 3 results:

Endometrial and ovarian cancer in women with Lynch syndrome: update in screening and prevention.
 

Author(s): Karen H Lu, Molly Daniels

Journal: Fam. Cancer. 2013 Jun;12(2):273-7.

 

Women with Lynch syndrome have an additional need to address the substantial increased lifetime risk of endometrial and ovarian cancer. Endometrial or ovarian cancer can be the presenting cancer in individuals with Lynch syndrome, or can be a second cancer. Lifetime risk of endometrial ...

Last Updated: 22 Jul 2013

Go To URL
Prediction models in Lynch syndrome.
 

Author(s): Fay Kastrinos, Judith BalmaƱa, Sapna Syngal

Journal: Fam. Cancer. 2013 Jun;12(2):217-28.

 

Prediction models for the identification of Lynch syndrome have been developed to quantify an individual's risk of carrying a mismatch repair gene mutation and help clinicians decide for whom further risk assessment and genetic testing is necessary. There are diverse clinical settings ...

Last Updated: 22 Jul 2013

Go To URL
Genetic modifiers of cancer risk in Lynch syndrome: a review.
 

Author(s): Bente A Talseth-Palmer, Juul T Wijnen, Desma M Grice, Rodney J Scott

Journal: Fam. Cancer. 2013 Jun;12(2):207-16.

 

The report by Aldred Scott Warthin in 1913 of a cancer family history and expanded on by Henry T. Lynch demonstrated one of the most enduring traits observed in patients with Lynch syndrome. The recognition of a variety of malignancies occurring at differing ages within a single family ...

Last Updated: 22 Jul 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Women Who Are At Risk Or May Have Lynch Syndrome
 

Status: Recruiting

Condition Summary: Hereditary Nonpolyposis Colorectal Cancer; Lynch Syndrome

 

Last Updated: 12 May 2014

Go to URL
I-Scan For Colon Polyp Detection In HNPCC
 

Status: Recruiting

Condition Summary: Hereditary Non-polyposis Colon Carcinoma; HNPCC; Lynch Syndrome

 

Last Updated: 29 Mar 2013

Go to URL
Molecular Screening for Lynch Syndrome in Denmark
 

Status: Recruiting

Condition Summary: Colorectal Cancer; Lynch Syndrome; HNPCC

 

Last Updated: 28 Mar 2014

Go to URL