Hereditary Cancer

Common Name(s)

Hereditary Cancer, Cancer predisposition, Cancer, Hereditary

Hereditary cancer refers to changes in specific genes passed down from one blood relative to another, which increase the likelihood of developing cancer for the individuals who inherit these gene changes. Approximately 5-10% of all cancers are hereditary. Symptoms of hereditary cancer will vary depending on the type of cancer. Some of the tests used to diagnose cancer include: blood tests, imaging studies, urine tests, and biopsy, where a needle is used to take out tissue to look at under a microscope. To identify the cancer as hereditary a physician will order a genetic test and take into account family history. Treatment for cancer may include chemotherapy, radiation, and/or surgery.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary Cancer" for support, advocacy or research.

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Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

Last Updated: 31 Jan 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

Last Updated: 5 Aug 2013

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

Last Updated: 4 May 2014

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary Cancer" for support, advocacy or research.

Logo
Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

http://mensociety.ca/

Last Updated: 31 Jan 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

View Details
Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

View Details
FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 4 May 2014

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary Cancer" returned 539 free, full-text research articles on human participants. First 3 results:

Survey on knowledge, attitudes, and training needs of Italian residents on genetic tests for hereditary breast and colorectal cancer.
 

Author(s): Nikola Panic, Emanuele Leoncini, Paolo Di Giannantonio, Benedetto Simone, Andrea Silenzi, Anna Maria Ferriero, Roberto Falvo, Giulia Silvestrini, Chiara Cadeddu, Carolina Marzuillo, Corrado De Vito, Walter Ricciardi, Paolo Villari, Stefania Boccia

Journal: Biomed Res Int. 2014 ;2014():418416.

 

The aim of the study was to assess knowledge and attitudes of medical residents working in Università Cattolica del Sacro Cuore, Rome, Italy, on genetic tests for breast and colorectal cancer.

Last Updated: 22 Jul 2014

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Oral manifestations of hereditary nonpolyposis colorectal cancer syndrome: a family case series.
 

Author(s): Fabiana Tolentino Almeida, Raquel Ribeiro Gomes, André Ferreira Leite, João Batista Sousa, Ana Carolina Acevedo, Eliete Neves Silva Guerra

Journal:

 

Hereditary nonpolyposis colorectal cancer is a colorectal cancer syndrome characterized by the development of colorectal cancer and extracolonic tumors, and this syndrome has an autosomal dominant mode of inheritance. To our knowledge, our study was the first to find dento-osseous ...

Last Updated: 23 Jul 2014

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First evidence of a large CHEK2 duplication involved in cancer predisposition in an Italian family with hereditary breast cancer.
 

Author(s): Gianluca Tedaldi, Rita Danesi, Valentina Zampiga, Michela Tebaldi, Lucia Bedei, Wainer Zoli, Dino Amadori, Fabio Falcini, Daniele Calistri

Journal:

 

CHEK2 is a multi-cancer susceptibility gene whose common germline mutations are known to contribute to the risk of developing breast and prostate cancer.

Last Updated: 11 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary Cancer" returned 88 free, full-text review articles on human participants. First 3 results:

NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations.
 

Author(s): Rebecca Dunbar Schroeder, Laura S Angelo, Razelle Kurzrock

Journal: Oncotarget. 2014 Jan;5(1):67-77.

 

Inactivating germline mutations in the tumor suppressor gene NF2 cause the hereditary syndrome neurofibromatosis 2, which is characterized by the development of neoplasms of the nervous system, most notably bilateral vestibular schwannoma. Somatic NF2 mutations have also been reported ...

Last Updated: 17 Mar 2014

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Hereditary kidney cancer syndromes.
 

Author(s): Naomi B Haas, Katherine L Nathanson

Journal: Adv Chronic Kidney Dis. 2014 Jan;21(1):81-90.

 

Inherited susceptibility to kidney cancer is a fascinating and complex topic. Our knowledge about types of genetic syndromes associated with an increased risk of disease is continually expanding. Currently, there are 10 syndromes associated with an increased risk of all types of kidney ...

Last Updated: 23 Dec 2013

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Genes and SNPs associated with non-hereditary and hereditary colorectal cancer.
 

Author(s): Mohammadreza Nassiri, Mohammad Mahdi Kooshyar, Zahra Roudbar, Morteza Mahdavi, Mohammad Doosti

Journal: Asian Pac. J. Cancer Prev.. 2013 ;14(10):5609-14.

 

Colorectal cancer is the third most common cancer in both men and women in the world and the second leading cause of cancer-related deaths. The incidence of colorectal cancer has increased in Iran in the past three decades and is now considered as a serious problem for our society. ...

Last Updated: 2 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cancer Genetics Hereditary Cancer Panel Testing
 

Status: Recruiting

Condition Summary: Hereditary Breast and Ovarian Cancer

 

Last Updated: 27 Jan 2015

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Familial Cancer Registry and DNA Bank
 

Status: Recruiting

Condition Summary: Cancer

 

Last Updated: 6 Mar 2014

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Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Sertoli-Leydig Cell Tumor of Ovary; Medulloepithelioma; Embryonal Rhabdomyosarcoma of Cervix

 

Last Updated: 9 Sep 2014

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