Hereditary cancer

Common Name(s)

Hereditary cancer, Cancer predisposition, Cancer, Hereditary

Hereditary cancer, or inherited cancer, is cancer that occurs as a result of a genetic change (mutation) that a person is born with. All cancer is a result of genetic changes that cause a cell to divide faster than it should. These changes can occur in a gene that slows down cell division, in a gene that speeds up cell division, or in a gene that is in charge of repairing genetic changes. These are collectively known as cancer susceptibility genes. People have two copies of these genes in all of their cells.

As a person ages and gets exposed to different things in the environment, such as smoking or the sun, their genes are changed (acquired mutations). Most cancer occurs because both copies of a person’s cancer susceptibility gene get changed over time (sporadic cancer). In hereditary cancer, a person is born with a change in one copy of a cancer susceptibility gene. This significantly increases their lifetime risk of cancer because it is more likely, and takes less time, to get a change in the one remaining unchanged gene copy.

About 10% of all cancer is hereditary and there are many types, depending on the gene that is affected. The most common forms of hereditary cancer are breast cancer, ovarian cancer, and colorectal cancer. Factors that increase the risk of cancer being hereditary include multiple family members affected with similar types of cancer, cancer at a young age (less than 50 years) in the family, rare forms of cancer in the family (such as kidney cancer or breast cancer in a man), and more than one type of primary cancer in a person (a woman with both breast and ovarian cancer). If you have signs of hereditary cancer in your family, talk with a genetic counselor about the likelihood of it being hereditary as well as genetic testing options. Diagnosing hereditary cancer in a family can help to determine a person’s cancer risk as well as determine cancer surveillance recommendations.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary cancer" for support, advocacy or research.

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Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

Last Updated: 31 Jan 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

Last Updated: 5 Aug 2013

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

Last Updated: 16 Jun 2015

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary cancer" for support, advocacy or research.

Logo
Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

http://mensociety.ca/

Last Updated: 31 Jan 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

View Details
FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 16 Jun 2015

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary cancer" returned 656 free, full-text research articles on human participants. First 3 results:

Patients Tested at a Laboratory for Hereditary Cancer Syndromes Show an Overlap for Multiple Syndromes in Their Personal and Familial Cancer Histories.
 

Author(s): Jennifer Saam, Christopher Arnell, Aaron Theisen, Kelsey Moyes, Ingrid Marino, Kirstin M Roundy, Richard J Wenstrup

Journal: Oncology. 2015 ;89(5):288-93.

 

Hereditary cancer testing guidelines are based on the premise that the common hereditary cancer syndromes have distinct, recognizable phenotypes. However, many syndromes present with overlapping cancers. The aim of this analysis was to identify the proportion of patients tested for ...

Last Updated: 21 Oct 2015

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Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair.
 

Author(s): Nuria Seguí, Leonardo B Mina, Conxi Lázaro, Rebeca Sanz-Pamplona, Tirso Pons, Matilde Navarro, Fernando Bellido, Adriana López-Doriga, Rafael Valdés-Mas, Marta Pineda, Elisabet Guinó, August Vidal, José Luís Soto, Trinidad Caldés, Mercedes Durán, Miguel Urioste, Daniel Rueda, Joan Brunet, Milagros Balbín, Pilar Blay, Silvia Iglesias, Pilar Garré, Enrique Lastra, Ana Beatriz Sánchez-Heras, Alfonso Valencia, Victor Moreno, Miguel Ángel Pujana, Alberto Villanueva, Ignacio Blanco, Gabriel Capellá, Jordi Surrallés, Xose S Puente, Laura Valle

Journal: Gastroenterology. 2015 Sep;149(3):563-6.

 

Identification of genes associated with hereditary cancers facilitates management of patients with family histories of cancer. We performed exome sequencing of DNA from 3 individuals from a family with colorectal cancer who met the Amsterdam criteria for risk of hereditary nonpolyposis ...

Last Updated: 25 Aug 2015

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Identification of a comprehensive spectrum of genetic factors for hereditary breast cancer in a Chinese population by next-generation sequencing.
 

Author(s): Xiaochen Yang, Jiong Wu, Jingsong Lu, Guangyu Liu, Genhong Di, Canming Chen, Yifeng Hou, Menghong Sun, Wentao Yang, Xiaojing Xu, Ying Zhao, Xin Hu, Daqiang Li, Zhigang Cao, Xiaoyan Zhou, Xiaoyan Huang, Zhebin Liu, Huan Chen, Yanzi Gu, Yayun Chi, Xia Yan, Qixia Han, Zhenzhou Shen, Zhimin Shao, Zhen Hu

Journal:

 

The genetic etiology of hereditary breast cancer has not been fully elucidated. Although germline mutations of high-penetrance genes such as BRCA1/2 are implicated in development of hereditary breast cancers, at least half of all breast cancer families are not linked to these genes. ...

Last Updated: 1 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary cancer" returned 110 free, full-text review articles on human participants. First 3 results:

Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy.
 

Author(s): Christine S Walsh

Journal: Gynecol. Oncol.. 2015 May;137(2):343-50.

 

Almost exactly 20 years after their discovery, the BRCA1 and BRCA2 genes have become the target of the first "personalized" therapy available for patients with ovarian cancer. In December 2014, a poly(ADP-ribose) polymerase (PARP) inhibitor was granted expedited approved by the United ...

Last Updated: 8 May 2015

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ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
 

Author(s): Sapna Syngal, Randall E Brand, James M Church, Francis M Giardiello, Heather L Hampel, Randall W Burt,

Journal: Am. J. Gastroenterol.. 2015 Feb;110(2):223-62; quiz 263.

 

This guideline presents recommendations for the management of patients with hereditary gastrointestinal cancer syndromes. The initial assessment is the collection of a family history of cancers and premalignant gastrointestinal conditions and should provide enough information to develop ...

Last Updated: 4 Feb 2015

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Genetic counseling for hereditary breast and ovarian cancer among Puerto Rican women living in the United States.
 

Author(s): Courtney L Scherr, Elsa Vasquez, Gwendolyn P Quinn, Susan T Vadaparampil

Journal: Rev Recent Clin Trials. 2014 ;9(4):245-53.

 

Little is known about barriers to Hereditary Breast and Ovarian Cancer (HBOC) genetic counseling among Puerto Rican women.

Last Updated: 13 Mar 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cancer Genetics Hereditary Cancer Panel Testing
 

Status: Recruiting

Condition Summary: Hereditary Breast and Ovarian Cancer

 

Last Updated: 31 Jan 2016

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Familial Cancer Registry and DNA Bank
 

Status: Recruiting

Condition Summary: Cancer

 

Last Updated: 6 Mar 2014

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Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Sertoli-Leydig Cell Tumor of Ovary; Medulloepithelioma; Embryonal Rhabdomyosarcoma of Cervix; Goiter; Sarcoma; Pineoblastoma; Pituitary Tumors; Wilms Tumor

 

Last Updated: 11 Dec 2015

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