Hereditary cancer

Common Name(s)

Hereditary cancer, Cancer predisposition, Cancer, Hereditary

Hereditary cancer, or inherited cancer, is cancer that occurs as a result of a genetic change (mutation) that a person is born with. All cancer is a result of genetic changes that cause a cell to divide faster than it should. These changes can occur in a gene that slows down cell division, in a gene that speeds up cell division, or in a gene that is in charge of repairing genetic changes. These are collectively known as cancer susceptibility genes. People have two copies of these genes in all of their cells.

As a person ages and gets exposed to different things in the environment, such as smoking or the sun, their genes are changed (acquired mutations). Most cancer occurs because both copies of a person’s cancer susceptibility gene get changed over time (sporadic cancer). In hereditary cancer, a person is born with a change in one copy of a cancer susceptibility gene. This significantly increases their lifetime risk of cancer because it is more likely, and takes less time, to get a change in the one remaining unchanged gene copy.

About 10% of all cancer is hereditary and there are many types, depending on the gene that is affected. The most common forms of hereditary cancer are breast cancer, ovarian cancer, and colorectal cancer. Factors that increase the risk of cancer being hereditary include multiple family members affected with similar types of cancer, cancer at a young age (less than 50 years) in the family, rare forms of cancer in the family (such as kidney cancer or breast cancer in a man), and more than one type of primary cancer in a person (a woman with both breast and ovarian cancer). If you have signs of hereditary cancer in your family, talk with a genetic counselor about the likelihood of it being hereditary as well as genetic testing options. Diagnosing hereditary cancer in a family can help to determine a person’s cancer risk as well as determine cancer surveillance recommendations.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary cancer" for support, advocacy or research.

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Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

Last Updated: 31 Jan 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

Last Updated: 5 Aug 2013

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

Last Updated: 16 Jun 2015

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary cancer" for support, advocacy or research.

Logo
Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

http://mensociety.ca/

Last Updated: 31 Jan 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

View Details
FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 16 Jun 2015

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary cancer" returned 679 free, full-text research articles on human participants. First 3 results:

Risk-Reducing Surgery in Hereditary Breast and Ovarian Cancer.
 

Author(s): Lynn C Hartmann, Noralane M Lindor

Journal: N. Engl. J. Med.. 2016 Jun;374(24):2404.

 

Last Updated: 16 Jun 2016

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Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility.
 

Author(s): Tuomo Mantere, Robert Winqvist, Saila Kauppila, Mervi Grip, Arja Jukkola-Vuorinen, Anna Tervasmäki, Katrin Rapakko, Katri Pylkäs

Journal:

 

Breast cancer is strongly influenced by hereditary risk factors, a majority of which still remain unknown. Here, we performed a targeted next-generation sequencing of 796 genes implicated in DNA repair in 189 Finnish breast cancer cases with indication of hereditary disease susceptibility ...

Last Updated: 29 Jan 2016

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Breast Cancer Survivors' Knowledge of Hereditary Breast and Ovarian Cancer following Genetic Counseling: An Exploration of General and Survivor-Specific Knowledge Items.
 

Author(s): Courtney L Scherr, Juliette Christie, Susan T Vadaparampil

Journal: Public Health Genomics. 2016 ;19(1):1-10.

 

Previous studies found genetic counseling increased participants' knowledge about hereditary breast and ovarian cancer (HBOC). However, most explored knowledge gain in unaffected women and the scale most commonly used does not include items that may be more pertinent to breast cancer (BC) survivors.

Last Updated: 9 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary cancer" returned 114 free, full-text review articles on human participants. First 3 results:

Hereditary ovarian cancer: not only BRCA 1 and 2 genes.
 

Author(s): Angela Toss, Chiara Tomasello, Elisabetta Razzaboni, Giannina Contu, Giovanni Grandi, Angelo Cagnacci, Russell J Schilder, Laura Cortesi

Journal: Biomed Res Int. 2015 ;2015():341723.

 

More than one-fifth of ovarian tumors have hereditary susceptibility and, in about 65-85% of these cases, the genetic abnormality is a germline mutation in BRCA genes. Nevertheless, several other suppressor genes and oncogenes have been associated with hereditary ovarian cancers, ...

Last Updated: 15 Jun 2015

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Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.
 

Author(s): Rachel S van der Post, Ingrid P Vogelaar, Fátima Carneiro, Parry Guilford, David Huntsman, Nicoline Hoogerbrugge, Carlos Caldas, Karen E Chelcun Schreiber, Richard H Hardwick, Margreet G E M Ausems, Linda Bardram, Patrick R Benusiglio, Tanya M Bisseling, Vanessa Blair, Eveline Bleiker, Alex Boussioutas, Annemieke Cats, Daniel Coit, Lynn DeGregorio, Joana Figueiredo, James M Ford, Esther Heijkoop, Rosella Hermens, Bostjan Humar, Pardeep Kaurah, Gisella Keller, Jennifer Lai, Marjolijn J L Ligtenberg, Maria O'Donovan, Carla Oliveira, Hugo Pinheiro, Krish Ragunath, Esther Rasenberg, Susan Richardson, Franco Roviello, Hans Schackert, Raquel Seruca, Amy Taylor, Anouk Ter Huurne, Marc Tischkowitz, Sheena Tjon A Joe, Benjamin van Dijck, Nicole C T van Grieken, Richard van Hillegersberg, Johanna W van Sandick, Rianne Vehof, J Han van Krieken, Rebecca C Fitzgerald

Journal: J. Med. Genet.. 2015 Jun;52(6):361-74.

 

Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies, pathology reporting and the patient's perspective on multiple ...

Last Updated: 24 May 2015

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Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy.
 

Author(s): Christine S Walsh

Journal: Gynecol. Oncol.. 2015 May;137(2):343-50.

 

Almost exactly 20 years after their discovery, the BRCA1 and BRCA2 genes have become the target of the first "personalized" therapy available for patients with ovarian cancer. In December 2014, a poly(ADP-ribose) polymerase (PARP) inhibitor was granted expedited approved by the United ...

Last Updated: 8 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cancer Genetics Hereditary Cancer Panel Testing
 

Status: Recruiting

Condition Summary: Hereditary Breast and Ovarian Cancer

 

Last Updated: 31 Jan 2016

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Familial Cancer Registry and DNA Bank
 

Status: Recruiting

Condition Summary: Cancer

 

Last Updated: 6 Mar 2014

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Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Sertoli-Leydig Cell Tumor of Ovary; Medulloepithelioma; Embryonal Rhabdomyosarcoma of Cervix; Goiter; Sarcoma; Pineoblastoma; Pituitary Tumors; Wilms Tumor

 

Last Updated: 28 Jul 2016

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