Hereditary Ataxias

Common Name(s)

Hereditary Ataxias, Hereditary ataxia

Hereditary Ataxias are a group of genetic disorders that affect muscle control during voluntary movements, such as walking and hand, speech, and eye movements. Usually ataxia means that there is damage to the part of the brain that controls muscle coordination. Hereditary ataxias can develop over time or come on suddenly. The typical symptoms of ataxia are: poor coordination, unsteady walking, difficulty with fine motor tasks, change in speech, involuntary eye movements, and difficulty swallowing. To diagnose ataxia a physician will conduct a physical and neurological exam. Genetic tests may be used to further identify ataxia as hereditary ataxia. There is no treatment specifically for hereditary ataxia, although adaptive devices like canes or walkers may be beneficial. Physical therapy, occupational therapy and speech therapy can also help manage the symptoms of ataxia.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary Ataxias" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary Ataxias" returned 4 free, full-text research articles on human participants. First 3 results:

Multimodal neurophysiological study of SCA2 and SCA3 autosomal dominant hereditary spinocerebellar ataxias.
 

Author(s): S Álvarez-Paradelo, A García, J Infante, J Berciano

Journal: Neurologia. 2011 Apr;26(3):157-65.

 

The spinocerebellar ataxias (SCA) are a group of genetic neurodegenerative diseases, clinically and pathologically heterogeneous, characterized by slowly progressive cerebellar ataxia.

Last Updated: 22 Mar 2011

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Hereditary spinocerebellar ataxias: number, prevalence, and treatment prospects.
 

Author(s): B W Soong

Journal: Hong Kong Med J. 2004 Aug;10(4):229-30.

 

Last Updated: 9 Aug 2004

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Paradoxical absence of nuclear inclusion in cerebellar Purkinje cells of hereditary ataxias linked to CAG expansion.
 

Author(s): S Koyano, K Iwabuchi, S Yagishita, Y Kuroiwa, T Uchihara

Journal: J. Neurol. Neurosurg. Psychiatr.. 2002 Oct;73(4):450-2.

 

Degeneration of cerebellar cortex is one of the principal features of hereditary ataxias linked to expansion of CAG repeat. In an attempt to clarify possible correlation between neuronal depletion and neuronal intranuclear inclusions, both triggered by the pathological expansion of ...

Last Updated: 17 Sep 2002

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary Ataxias" returned 2 free, full-text review articles on human participants. First 3 results:

Cardiac involvement in hereditary ataxias.
 

Author(s): Sean Moore, Subha V Raman

Journal: J. Child Neurol.. 2012 Sep;27(9):1174-8.

 

Although much attention has been focused on the neurological sequelae of the hereditary ataxias, patients with these conditions also may develop cardiac complications that represent a significant cause of disability and even death. In this article, the authors describe the hereditary ...

Last Updated: 28 Aug 2012

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[Hereditary ataxias].
 

Author(s): Chantal M E Tallaksen

Journal: Tidsskr. Nor. Laegeforen.. 2008 Sep;128(17):1977-80.

 

Hereditary ataxias constitute a heterogeneous group of rare neurodegenerative diseases with an increasingly unsteady gait as the most common symptom. The three main groups: hereditary, sporadic and acquired ataxias, are difficult to distinguish from one another clinically. This overview ...

Last Updated: 12 Sep 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 26 Nov 2012

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Phenotype/Genotype Correlations in Movement Disorders
 

Status: Recruiting

Condition Summary: Movement Disorder

 

Last Updated: 4 Oct 2014

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Efficacy of Riluzole in Hereditary Cerebellar Ataxia
 

Status: Recruiting

Condition Summary: Cerebellar Ataxia

 

Last Updated: 19 Jul 2011

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