Hereditary angioedema

Common Name(s)

Hereditary angioedema, HAE

Hereditary angioedema (HAE) is a rare, debilitating, and potentially fatal genetic disorder that is characterized by episodes of swelling in various body parts including the hands, feet, face and airway. In addition, patients often have bouts of excruciating abdominal pain, nausea, and vomiting that is caused by swelling in the intestinal wall. Airway swelling is particularly dangerous and can lead to death by asphyxiation.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary angioedema" for support, advocacy or research.

Logo
US Hereditary Angioedema Association

Helping HAE patients and their families to achieve lifelong health.

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary angioedema" for support, advocacy or research.

Logo
US Hereditary Angioedema Association

Helping HAE patients and their families to achieve lifelong health.

http://www.haea.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

HAE Essentials - A Patient's Guide

Video series of HAE disease information for patients and family and caregivers

Updated 20 Nov 2012

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary angioedema" returned 82 free, full-text research articles on human participants. First 3 results:

Bradykinin-mediated hereditary angioedema (non-estrogen-dependent) without C1 inhibitor deficiency.
 

Author(s): C Vela Vizcaino, L Sola Enrique, S Chugo Gordillo, M T Lizaso Bacaicoa, T Caballero Molina, B E García Figueroa

Journal: J Investig Allergol Clin Immunol. 2014 ;24(4):280-1.

 

Last Updated: 15 Sep 2014

Go To URL
Long-term prophylaxis with C1-inhibitor concentrate in patients with hereditary angioedema.
 

Author(s): M Pedrosa, T Lobera, C Panizo, J Jurado, T Caballero

Journal: J Investig Allergol Clin Immunol. 2014 ;24(4):271-3.

 

Last Updated: 15 Sep 2014

Go To URL
The influence of trigger factors on hereditary angioedema due to C1-inhibitor deficiency.
 

Author(s): Zsuzsanna Zotter, Dorottya Csuka, Erika Szabó, Ibolya Czaller, Zsuzsanna Nébenführer, György Temesszentandrási, George Fust, Lilian Varga, Henriette Farkas

Journal:

 

Hereditary angioedema (HAE) resulting from C1-inhibitor deficiency is characterized by attacks of subcutaneous and submucosal edema. Many factors have been presumed to induce edema. Our study analyzed these factors in a fairly large patient population.

Last Updated: 8 Apr 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary angioedema" returned 19 free, full-text review articles on human participants. First 3 results:

[Algorithm for diagnosis and treatment of hereditary angioedema as a tool for management].
 

Author(s): María Luisa Baeza, Teresa Caballero Molina, Carlos Crespo Diz, González-Quevedo, Mar Guilarte Clavero, Dolores Hernández Fernández de Rojas, Teófilo Lobera Labairu, Carmen Marcos Bravo, Andrés Navarro Ruiz, A Navarro Ruiz, José Luis Poveda Andrés, J L Poveda Andrés, María Antonia Cebollero, A Cebollero de Torre

Journal: Farm Hosp. ;37(6):521-9.

 

Hereditary angioedema is a disease with low prevalence and high heterogeneity with regards to the severity of the clinical picture, which makes the diagnosis difficult and requires the need for early start of specific treatment in order to prevent complications.

Last Updated: 22 Nov 2013

Go To URL
Hereditary angioedema type III (estrogen-dependent) report of three cases and literature review.
 

Author(s): Amanda Rodrigues Miranda, Ana Paula Fusel de Ue, Dominique Vilarinho Sabbag, Wellington de Jesus Furlani, Patrícia Karla de Souza, Osmar Rotta

Journal: An Bras Dermatol. ;88(4):578-84.

 

In this article, three cases of hereditary angioedema (HAE) type III (estrogen-dependent or with normal C1 inhibitor) are reported. The HAE was initially described in women of the same family in association with high-leveled estrogenic conditions such as the use of oral contraceptives ...

Last Updated: 26 Sep 2013

Go To URL
Recent advances in the management of hereditary angioedema.
 

Author(s): Stephen E Hemperly, Niti Sardana Agarwal, Ying-Yang Xu, Yu-Xiang Zhi, Timothy J Craig

Journal: J Am Osteopath Assoc. 2013 Jul;113(7):546-55.

 

Hereditary angioedema (HAE) is a rare genetic condition that manifests as painful and potentially life-threatening episodic attacks of cutaneous and submucosal swelling. It results from functional deficiency of C1 inhibitor (C1 INH), which is a regulator of the complement, fibrinolytic, ...

Last Updated: 11 Jul 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents With Hereditary Angioedema
 

Status: Recruiting

Condition Summary: Hereditary Angioedema Types I and II

 

Last Updated: 23 Sep 2014

Go to URL

Last Updated: 6 Oct 2014

Go to URL
Safety of Ruconest in 2-13 Year Old Hereditary Angioedema (HAE) Patients
 

Status: Recruiting

Condition Summary: Hereditary Angioedema

 

Last Updated: 10 Nov 2014

Go to URL