Hepatitis E

Common Name(s)

Hepatitis E

Hepatitis E is a viral hepatitis that affects the liver and is caused by the hepatitis E virus, or HEV. The liver is an organ found on the right side of our belly (abdomen) under the rib cage. It cleans our blood of toxins, poisons, and bacteria. It produces bile which helps our body breakdown food. It stores vitamins, minerals and sugars. And it helps control cholesterol levels. Hepatitis E occurs when the hepatitis E virus causes the liver to swell, scar, and become inflamed, which stops it from working properly or completely Symptoms may include nausea, diarrhea, fatigue, and jaundice (yellowing of the skin). Hepatitis E symptoms usually go away after 4-6 weeks. It is rare for HEV to become chronic, but it can be very serious for pregnant women. HEV is spread through food or water that is contaminated with the feces (bowel movement) of people infected with HEV. There is some concern that it may also be passed through pigs in areas where HEV is common. There is no evidence that HEV is passed through sexual intercourse. It is very rarely passed from person to person. HEV is rare in developed nations. However, people who travel to the developing countries where HEV is common may be at risk. Outbreaks of hepatitis E have been reported in Central and South-East Asia, North and West Africa, and in Mexico, especially where fecal contamination of drinking water occurs. Physicians can diagnose hepatitis E through blood tests and stool tests that detect the presence of HEV. Physicians and hospitals can provide supportive care for individuals affected by HEV until they recover if needed. If HEV does become chronic, medications are available to help treat the condition. Talk with your doctor if you or a family member has been diagnosed with hepatitis to decide on the best treatment plan. Support groups are also good resources of support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatitis E" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

Last Updated: 23 Feb 2015

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World Hepatitis Alliance

The World Hepatitis Alliance is a not-for-profit international umbrella NGO. Our membership is composed of over 170 organisations who work in the field of viral hepatitis, representing every region of the world. We are patient-led and patient-driven, and in this way, we are the global voice for the 500 million people worldwide living with viral hepatitis. Through better awareness, prevention, care, support and access to treatment, our ultimate goal is to work with governments to eradicate these diseases from the planet.

Last Updated: 15 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatitis E" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

http://www.HepatitisFoundation.org

Last Updated: 23 Feb 2015

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World Hepatitis Alliance

The World Hepatitis Alliance is a not-for-profit international umbrella NGO. Our membership is composed of over 170 organisations who work in the field of viral hepatitis, representing every region of the world. We are patient-led and patient-driven, and in this way, we are the global voice for the 500 million people worldwide living with viral hepatitis. Through better awareness, prevention, care, support and access to treatment, our ultimate goal is to work with governments to eradicate these diseases from the planet.

http://www.worldhepatitisalliance.org/en/

Last Updated: 15 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatitis E" returned 725 free, full-text research articles on human participants. First 3 results:

Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia.
 

Author(s): Claudia Lamarca Vitral, Mônica da Silva-Nunes, Marcelo Alves Pinto, Jaqueline Mendes de Oliveira, Ana Maria Coimbra Gaspar, Rebeca Cristina Costa Pereira, Marcelo Urbano Ferreira

Journal:

 

Hepatitis A virus (HAV) and hepatitis E virus (HEV) are both transmitted by the faecal-oral route, and represent common causes of acute hepatitis in developing countries. The endemicity of HAV infection has shifted from high to moderate in Brazil. Human cases of HEV infection seem ...

Last Updated: 1 Sep 2014

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Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins.
 

Author(s): Ji-Young Lee, Eliana G Acosta, Ina Karen Stoeck, Gang Long, Marie-Sophie Hiet, Birthe Mueller, Oliver T Fackler, Stephanie Kallis, Ralf Bartenschlager

Journal: J. Virol.. 2014 Nov;88(21):12422-37.

 

The assembly of infectious hepatitis C virus (HCV) particles is tightly linked to components of the very-low-density lipoprotein (VLDL) pathway. We and others have shown that apolipoprotein E (ApoE) plays a major role in production of infectious HCV particles. However, the mechanism ...

Last Updated: 7 Oct 2014

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Hepatitis E virus inhibits type I interferon induction by ORF1 products.
 

Author(s): Yuchen Nan, Ying Yu, Zexu Ma, Sunil K Khattar, Brenda Fredericksen, Yan-Jin Zhang

Journal: J. Virol.. 2014 Oct;88(20):11924-32.

 

Hepatitis E virus (HEV) causes both endemic and epidemic human hepatitis by fecal-oral transmission in many parts of the world. Zoonotic transmission of HEV from animals to humans has been reported. Due to the lack of an efficient cell culture system, the molecular mechanisms of HEV ...

Last Updated: 23 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatitis E" returned 44 free, full-text review articles on human participants. First 3 results:

Naturally occurring animal models of human hepatitis E virus infection.
 

Author(s): Danielle M Yugo, Caitlin M Cossaboom, Xiang-Jin Meng

Journal: ILAR J. 2014 ;55(1):187-99.

 

Hepatitis E virus (HEV) is a single-stranded, positive-sense RNA virus in the family Hepeviridae. Hepatitis E caused by HEV is a clinically important global disease. There are currently four well-characterized genotypes of HEV in mammalian species, although numerous novel strains ...

Last Updated: 17 Jun 2014

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An update on hepatitis B, D, and E viruses.
 

Author(s): Jennifer Price

Journal: Top Antivir Med. 2014 Jan;21(5):157-63.

 

Although newer and more effective treatments are now available for hepatitis C virus (HCV) infection, non-HCV viral hepatitis remains an important cause of liver disease, especially among HIV-infected individuals. Hepatitis B virus (HBV) is the leading cause of cirrhosis worldwide, ...

Last Updated: 17 Feb 2014

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Fetal and neonatal health consequences of vertically transmitted hepatitis E virus infection.
 

Author(s): Lisa J Krain, Jessica E Atwell, Kenrad E Nelson, Alain B Labrique

Journal: Am. J. Trop. Med. Hyg.. 2014 Feb;90(2):365-70.

 

Hepatitis E virus (HEV) infections lead to tens of thousands of deaths annually, mostly in developing countries. Hepatitis E poses a significant threat to the health of expectant mothers, a well-noted epidemiologic feature of the disease, but the contribution of vertically transmitted ...

Last Updated: 6 Feb 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Seroprevalence of Hepatitis E in People With an Organ Transplant
 

Status: Recruiting

Condition Summary: Hepatitis E

 

Last Updated: 17 Jan 2015

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Phase Ⅳ Clinical Trial of Recombinant Hepatitis E Vaccine(Hecolin®)
 

Status: Recruiting

Condition Summary: Hepatitis E

 

Last Updated: 10 Jul 2014

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A Phase Ⅳ Clinical Trial of the Recombinant Hepatitis E Vaccine (Escherichia Coli)
 

Status: Recruiting

Condition Summary: Hepatitis E

 

Last Updated: 5 May 2015

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