Hepatitis E

Common Name(s)

Hepatitis E

Hepatitis E is a viral hepatitis that affects the liver and is caused by the hepatitis E virus, or HEV. The liver is an organ found on the right side of our belly (abdomen) under the rib cage. It cleans our blood of toxins, poisons, and bacteria. It produces bile which helps our body breakdown food. It stores vitamins, minerals and sugars. And it helps control cholesterol levels. Hepatitis E occurs when the hepatitis E virus causes the liver to swell, scar, and become inflamed, which stops it from working properly or completely Symptoms may include nausea, diarrhea, fatigue, and jaundice (yellowing of the skin). Hepatitis E symptoms usually go away after 4-6 weeks. It is rare for HEV to become chronic, but it can be very serious for pregnant women. HEV is spread through food or water that is contaminated with the feces (bowel movement) of people infected with HEV. There is some concern that it may also be passed through pigs in areas where HEV is common. There is no evidence that HEV is passed through sexual intercourse. It is very rarely passed from person to person. HEV is rare in developed nations. However, people who travel to the developing countries where HEV is common may be at risk. Outbreaks of hepatitis E have been reported in Central and South-East Asia, North and West Africa, and in Mexico, especially where fecal contamination of drinking water occurs. Physicians can diagnose hepatitis E through blood tests and stool tests that detect the presence of HEV. Physicians and hospitals can provide supportive care for individuals affected by HEV until they recover if needed. If HEV does become chronic, medications are available to help treat the condition. Talk with your doctor if you or a family member has been diagnosed with hepatitis to decide on the best treatment plan. Support groups are also good resources of support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatitis E" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

Last Updated: 23 Feb 2015

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World Hepatitis Alliance

The World Hepatitis Alliance is a not-for-profit international umbrella NGO. Our membership is composed of over 170 organisations who work in the field of viral hepatitis, representing every region of the world. We are patient-led and patient-driven, and in this way, we are the global voice for the 500 million people worldwide living with viral hepatitis. Through better awareness, prevention, care, support and access to treatment, our ultimate goal is to work with governments to eradicate these diseases from the planet.

Last Updated: 15 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatitis E" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

http://www.HepatitisFoundation.org

Last Updated: 23 Feb 2015

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World Hepatitis Alliance

The World Hepatitis Alliance is a not-for-profit international umbrella NGO. Our membership is composed of over 170 organisations who work in the field of viral hepatitis, representing every region of the world. We are patient-led and patient-driven, and in this way, we are the global voice for the 500 million people worldwide living with viral hepatitis. Through better awareness, prevention, care, support and access to treatment, our ultimate goal is to work with governments to eradicate these diseases from the planet.

http://www.worldhepatitisalliance.org/en/

Last Updated: 15 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatitis E" returned 812 free, full-text research articles on human participants. First 3 results:

Prediction of Clinical Outcomes in Hepatitis B E Antigen Negative Chronic Hepatitis B Patients with Elevated Hepatitis B Virus DNA Levels.
 

Author(s): Jem Ma Ahn, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik

Journal:

 

We investigated whether long-term clinical outcomes such as disease progression or inactive hepatitis B virus (HBV) carrier state can be predicted by baseline factors in hepatitis B e antigen (HBeAg)-negative HBV infected patients with an elevated viral load.

Last Updated: 23 Dec 2015

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Acute Hepatitis E Virus infection with coincident reactivation of Epstein-Barr virus infection in an immunosuppressed patient with rheumatoid arthritis: a case report.
 

Author(s): Detlev Schultze, Bernhard Mani, Günter Dollenmaier, Roland Sahli, Andrea Zbinden, Pierre Alexandre Krayenbühl

Journal:

 

Hepatitis E virus (HEV) is the most recently discovered of the hepatotropic viruses, and is considered an emerging pathogen in developed countries with the possibility of fulminant hepatitis in immunocompromised patients. Especially in the latter elevated transaminases should be taken ...

Last Updated: 29 Oct 2015

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Hepatitis E virus antibody prevalence in hunters from a district in Central Germany, 2013: a cross-sectional study providing evidence for the benefit of protective gloves during disembowelling of wild boars.
 

Author(s): A Schielke, V Ibrahim, I Czogiel, M Faber, C Schrader, P Dremsek, R G Ulrich, R Johne

Journal:

 

In Germany, 17% of the general human population have antibodies to hepatitis E virus (HEV) (recomLine HEV-IgG/IgM immunoassay [Mikrogen GmbH]). Wild boars represent an animal reservoir for HEV genotype 3, which is the common genotype in Germany. We estimated the seroprevalence among ...

Last Updated: 23 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatitis E" returned 56 free, full-text review articles on human participants. First 3 results:

Therapeutic targets for the treatment of hepatitis E virus infection.
 

Author(s): Scott P Kenney, Xiang-Jin Meng

Journal: Expert Opin. Ther. Targets. 2015 ;19(9):1245-60.

 

Hepatitis E virus (HEV) is one of the most common causes of acute viral hepatitis in the world with an estimated 20 million infections per year. Although the mortality rate is < 1% among the general population, pregnant women can have a fatality rate of up to 30%. Additionally, chronic ...

Last Updated: 12 Aug 2015

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Dysgeusia in a Patient with Guillain-Barré Syndrome Associated with Acute Hepatitis E: A Case Report and Literature Review.
 

Author(s): Masa-Aki Higuchi, Jiro Fukae, Jun Tsugawa, Shinji Ouma, Kazuaki Takahashi, Shunji Mishiro, Yoshio Tsuboi

Journal: Intern. Med.. 2015 ;54(12):1543-6.

 

Guillain-Barré syndrome (GBS) is usually triggered by viral or bacterial infection. In addition, it was recently reported that infection with hepatitis E virus (HEV) also causes GBS. A 49-year-old man presented with acute-onset paralysis in all extremities and dysgeusia during an ...

Last Updated: 15 Jun 2015

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The development of a recombinant hepatitis E vaccine HEV 239.
 

Author(s): Shao-Wei Li, Qinjian Zhao, Ting Wu, Shu Chen, Jun Zhang, Ning-Shao Xia

Journal: Hum Vaccin Immunother. 2015 ;11(4):908-14.

 

Hepatitis E virus (HEV) infection is one of the main causes of acute hepatitis worldwide. A recombinant hepatitis E vaccine, HEV 239, has been licensed in China for immunizing adults of 16 y old and above. The vaccine antigen contains pORF2 aa 368 - 606 of the HEV genotype 1 expressed ...

Last Updated: 2 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Seroprevalence of Hepatitis E in People With an Organ Transplant
 

Status: Recruiting

Condition Summary: Hepatitis E

 

Last Updated: 12 Feb 2016

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Phase Ⅳ Clinical Trial of Recombinant Hepatitis E Vaccine(Hecolin®)
 

Status: Recruiting

Condition Summary: Hepatitis E

 

Last Updated: 10 Jul 2014

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A Clinical Trial to Evaluate a Recombinant Hepatitis E Vaccine in Healthy Adults
 

Status: Recruiting

Condition Summary: Hepatitis E

 

Last Updated: 10 Nov 2015

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