Hepatic encephalopathy

Common Name(s)

Hepatic encephalopathy

Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.  Signs and symptoms may be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may include personality or mood changes, intellectual impairment, abnormal movements, a depressed level of consciousness, and other symptoms.  There are several theories regarding the exact cause, but development of the condition is probably at least partially due to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatic encephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatic encephalopathy" returned 219 free, full-text research articles on human participants. First 3 results:

Candida albicans in peritoneal fluid in a patient with hepatic encephalopathy.
 

Author(s): Eilon Krashin, Michael Lishner, Michal Chowers, Sharon Reisfeld

Journal: Isr. Med. Assoc. J.. 2014 Dec;16(12):801-2.

 

Last Updated: 29 Jan 2015

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Effect of rifaximin, probiotics, and l-ornithine l-aspartate on minimal hepatic encephalopathy: a randomized controlled trial.
 

Author(s): Kapil Sharma, Sanjay Pant, Sriprakash Misra, Manisha Dwivedi, Alok Misra, Sushil Narang, Reshu Tewari, Ajeet S Bhadoria

Journal: Saudi J Gastroenterol. ;20(4):225-32.

 

Minimal hepatic encephalopathy (MHE) implies subtle impairment of cognitive functions in the absence of features of overt encephalopathy. We aimed to determine the prevalence of MHE in patients with liver cirrhosis and to find out the effect of rifaximin, probiotics, and l-ornithine ...

Last Updated: 19 Jul 2014

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Utility values for specific hepatic encephalopathy health states elicited from the general public in the United Kingdom.
 

Author(s): Julian F Guest, Kam Nanuwa, Rob Barden

Journal:

 

To elicit utility values for five health states corresponding to increasing severity of hepatic encephalopathy, from members of the general public in the UK. The health states studied were Conn grades 0, 1, 2, 3 and 4.

Last Updated: 26 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatic encephalopathy" returned 43 free, full-text review articles on human participants. First 3 results:

Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure.
 

Author(s): Manuel Romero-Gómez, Sara Montagnese, Rajiv Jalan

Journal: J. Hepatol.. 2015 Feb;62(2):437-47.

 

Hepatic encephalopathy in a hospitalized cirrhotic patient is associated with a high mortality rate and its presence adds further to the mortality of patients with acute-on-chronic liver failure (ACLF). The exact pathophysiological mechanisms of HE in this group of patients are unclear ...

Last Updated: 19 Jan 2015

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Effects of probiotic therapy on hepatic encephalopathy in patients with liver cirrhosis: an updated meta-analysis of six randomized controlled trials.
 

Author(s): Jun Xu, Rui Ma, Li-Feng Chen, Li-Jun Zhao, Kan Chen, Ren-Bing Zhang

Journal: HBPD INT. 2014 Aug;13(4):354-60.

 

Liver cirrhotic patients with hepatic encephalopathy have poor prognosis. Probiotics alter the intestinal microbiota and reduce the production of ammonia. We conducted a meta-analysis about the role of probiotics on liver cirrhotic patients with hepatic encephalopathy.

Last Updated: 7 Aug 2014

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Management of hepatic encephalopathy in the hospital.
 

Author(s): Michael D Leise, John J Poterucha, Patrick S Kamath, W Ray Kim

Journal: Mayo Clin. Proc.. 2014 Feb;89(2):241-53.

 

Hepatic encephalopathy (HE) develops in up to 50% of patients with cirrhosis and is a feature of decompensated cirrhosis. With the goal of reviewing the evidence for treatment and prevention of overt hepatic encephalopathy, pubmed was searched using search terms hepatic encephalopathy ...

Last Updated: 3 Feb 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate
 

Status: Not yet recruiting

Condition Summary: Hepatic Encephalopathy; Minimal Hepatic Encephalopathy; Cirrhosis

 

Last Updated: 6 May 2013

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Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE)
 

Status: Recruiting

Condition Summary: Acute Episode of Overt Hepatic Encephalopathy; Hepatic Encephalopathy

 

Last Updated: 31 Mar 2015

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Hepatic Encephalopathy: Lactulose or Polyethylene Glycol (H.E.L.P.)
 

Status: Recruiting

Condition Summary: Hepatic Encephalopathy; HE; Cirrhosis; Altered Mental Status; AMS

 

Last Updated: 13 Aug 2013

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