Hepatic encephalopathy

Common Name(s)

Hepatic encephalopathy

Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.  Signs and symptoms may be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may include personality or mood changes, intellectual impairment, abnormal movements, a depressed level of consciousness, and other symptoms.  There are several theories regarding the exact cause, but development of the condition is probably at least partially due to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatic encephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatic encephalopathy" returned 201 free, full-text research articles on human participants. First 3 results:

Utility values for specific hepatic encephalopathy health states elicited from the general public in the United Kingdom.
 

Author(s): Julian F Guest, Kam Nanuwa, Rob Barden

Journal:

 

To elicit utility values for five health states corresponding to increasing severity of hepatic encephalopathy, from members of the general public in the UK. The health states studied were Conn grades 0, 1, 2, 3 and 4.

Last Updated: 26 Jun 2014

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Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China.
 

Author(s): Su-Wen Li, Kai Wang, Yong-Qiang Yu, Hai-Bao Wang, Yuan-Hai Li, Jian-Ming Xu

Journal: World J. Gastroenterol.. 2013 Dec;19(46):8745-51.

 

To construct normal values for the tests of the psychometric hepatic encephalopathy score (PHES) and to evaluate its usefulness in the diagnosis of minimal hepatic encephalopathy (MHE) among Chinese individuals with cirrhosis.

Last Updated: 31 Dec 2013

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Minimal hepatic encephalopathy diagnosis by magnetic resonance spectroscopy. A case report.
 

Author(s): Cristian Scheau, Anca Ioana Bădărău, Andreea Elena Gherguş, Gelu Adrian Popa, Ioana Gabriela Lupescu

Journal: J Gastrointestin Liver Dis. 2013 Dec;22(4):455-9.

 

Minimal Hepatic Encephalopathy (MHE) is a potentially reversible spectrum of neuro-psychiatric alterations in patients with acute or chronic liver disease, in the presence of a normal neurological examination. Studies demonstrated that early diagnosis and treatment of this complication ...

Last Updated: 26 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatic encephalopathy" returned 37 free, full-text review articles on human participants. First 3 results:

Management of hepatic encephalopathy in the hospital.
 

Author(s): Michael D Leise, John J Poterucha, Patrick S Kamath, W Ray Kim

Journal: Mayo Clin. Proc.. 2014 Feb;89(2):241-53.

 

Hepatic encephalopathy (HE) develops in up to 50% of patients with cirrhosis and is a feature of decompensated cirrhosis. With the goal of reviewing the evidence for treatment and prevention of overt hepatic encephalopathy, pubmed was searched using search terms hepatic encephalopathy ...

Last Updated: 3 Feb 2014

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Contributions of microdialysis to new alternative therapeutics for hepatic encephalopathy.
 

Author(s): Liliana Rivera-Espinosa, Esaú Floriano-Sánchez, José Pedraza-Chaverrí, Elvia Coballase-Urrutia, Aristides Iii Sampieri, Daniel Ortega-Cuellar, Noemí Cárdenas-Rodríguez, Liliana Carmona-Aparicio

Journal:

 

Hepatic encephalopathy (HE) is a common complication of cirrhosis, of largely reversible impairment of brain function occurring in patients with acute or chronic liver failure or when the liver is bypassed by portosystemic shunts. The mechanisms causing this brain dysfunction are ...

Last Updated: 7 Aug 2013

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A systematic review and meta-analysis of the use of oral zinc in the treatment of hepatic encephalopathy.
 

Author(s): Norberto C Chavez-Tapia, Asunción Cesar-Arce, Tonatiuh Barrientos-Gutiérrez, Francisco A Villegas-López, Nahum Méndez-Sanchez, Misael Uribe

Journal:

 

Because low serum zinc levels precipitate hepatic encephalopathy, zinc supplementation is considered a potential therapeutic option. The aim of this study was to assess the effects of oral zinc supplementation in the treatment of hepatic encephalopathy.

Last Updated: 21 Jun 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate
 

Status: Not yet recruiting

Condition Summary: Hepatic Encephalopathy; Minimal Hepatic Encephalopathy; Cirrhosis

 

Last Updated: 6 May 2013

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Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE)
 

Status: Recruiting

Condition Summary: Acute Episode of Overt Hepatic Encephalopathy; Hepatic Encephalopathy

 

Last Updated: 8 Jul 2014

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Hepatic Encephalopathy: Lactulose or Polyethylene Glycol (H.E.L.P.)
 

Status: Recruiting

Condition Summary: Hepatic Encephalopathy; HE; Cirrhosis; Altered Mental Status; AMS

 

Last Updated: 13 Aug 2013

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