Hepatic encephalopathy

Common Name(s)

Hepatic encephalopathy

Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.  Signs and symptoms may be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may include personality or mood changes, intellectual impairment, abnormal movements, a depressed level of consciousness, and other symptoms.  There are several theories regarding the exact cause, but development of the condition is probably at least partially due to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatic encephalopathy" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatic encephalopathy" returned 288 free, full-text research articles on human participants. First 3 results:

Early diet intervention to reduce the incidence of hepatic encephalopathy in cirrhosis patients: post-Transjugular Intrahepatic Portosystemic Shunt (TIPS) findings.
 

Author(s): Ling Luo, Shiying Fu, Yunzhi Zhang, Jingxiang Wang

Journal: Asia Pac J Clin Nutr. 2016 ;25(3):497-503.

 

Hepatic encephalopathy is a common complication in patients who have received transjugular intrahepatic portosystemic shunt (TIPS) as treatment for cirrhosis. The objective of this study was to reduce the incidence of post-TIPS hepatic encephalopathy for these patients via positive ...

Last Updated: 21 Jul 2016

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Clostridium difficile Infection in Hospitalized Cirrhotic Patients with Hepatic Encephalopathy.
 

Author(s): Florin Alexandru Căruntu, Valeriu Gheorghiță

Journal: J Gastrointestin Liver Dis. 2016 Mar;25(1):120-1.

 

Last Updated: 25 Mar 2016

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Machine Learning Classification of Cirrhotic Patients with and without Minimal Hepatic Encephalopathy Based on Regional Homogeneity of Intrinsic Brain Activity.
 

Author(s): Qiu-Feng Chen, Hua-Jun Chen, Jun Liu, Tao Sun, Qun-Tai Shen

Journal:

 

Machine learning-based approaches play an important role in examining functional magnetic resonance imaging (fMRI) data in a multivariate manner and extracting features predictive of group membership. This study was performed to assess the potential for measuring brain intrinsic activity ...

Last Updated: 16 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatic encephalopathy" returned 58 free, full-text review articles on human participants. First 3 results:

Systematic review with network meta-analysis: the comparative effectiveness and safety of interventions in patients with overt hepatic encephalopathy.
 

Author(s): G-Q Zhu, K-Q Shi, S Huang, L-R Wang, Y-Q Lin, G-Q Huang, Y-P Chen, M Braddock, M-H Zheng

Journal: Aliment. Pharmacol. Ther.. 2015 Apr;41(7):624-35.

 

Interventional treatment for overt hepatic encephalopathy (OHE), includes non-absorbable disaccharides, neomycin, rifaximin, L-ornithine-L-aspartate and branched chain amino acids (BCAA). However, the optimum regimen remains inconclusive.

Last Updated: 4 Mar 2015

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Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure.
 

Author(s): Manuel Romero-Gómez, Sara Montagnese, Rajiv Jalan

Journal: J. Hepatol.. 2015 Feb;62(2):437-47.

 

Hepatic encephalopathy in a hospitalized cirrhotic patient is associated with a high mortality rate and its presence adds further to the mortality of patients with acute-on-chronic liver failure (ACLF). The exact pathophysiological mechanisms of HE in this group of patients are unclear ...

Last Updated: 19 Jan 2015

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Concise review of current concepts on nomenclature and pathophysiology of hepatic encephalopathy.
 

Author(s): Ilona Savlan, Valentina Liakina, Jonas Valantinas

Journal: Medicina (Kaunas). 2014 ;50(2):75-81.

 

Hepatic encephalopathy is a neuropsychiatric complication of liver cirrhosis the symptoms of which may vary from imperceptible to severe, invaliding, and even lethal. Minimal hepatic encephalopathy is also important because of its tendency to impair patients' cognitive functions and ...

Last Updated: 30 Aug 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE)
 

Status: Recruiting

Condition Summary: Acute Episode of Overt Hepatic Encephalopathy; Hepatic Encephalopathy

 

Last Updated: 25 Aug 2016

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The Role of Bacterial Overgrowth and Delayed Intestinal Transit in Hepatic Encephalopathy
 

Status: Recruiting

Condition Summary: Hepatic Encephalopathy; Hepatitis C; Liver Cirrhosis

 

Last Updated: 4 Nov 2010

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Metformin Experience on Minimal Hepatic Encephalopathy
 

Status: Recruiting

Condition Summary: Liver Cirrhosis; Hepatic Encephalopathy

 

Last Updated: 9 Jun 2015

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