Hepatic encephalopathy

Common Name(s)

Hepatic encephalopathy

Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.  Signs and symptoms may be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may include personality or mood changes, intellectual impairment, abnormal movements, a depressed level of consciousness, and other symptoms.  There are several theories regarding the exact cause, but development of the condition is probably at least partially due to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatic encephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatic encephalopathy" returned 333 free, full-text research articles on human participants. First 3 results:

JianPi HuaZhuo XingNao formula (Chinese herbal medicine) for the treatment of minimal hepatic encephalopathy: a protocol for a randomized, placebo-controlled pilot trial.
 

Author(s): XiaoKe Li, DaNan Gan, Ying Li, Peng Zhang, ZhiGuo Li, HongBo Du, LuDan Zhang, Yuan Cheng, YaQiang Zhang, YiJun Liang, YongAn Ye

Journal: Medicine (Baltimore). 2018 Apr;97(17):e0526.

 

Minimal hepatic encephalopathy (MHE) is a subclinical state of hepatic encephalopathy with the possibility of developing into overt hepatic encephalopathy (OHE) and having adverse outcomes. However, no preventative medicine for MHE has been recommended so far. The aim is to evaluate ...

Last Updated: 31 Dec 1969

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Alpha-1 antichymotrypsin is involved in astrocyte injury in concert with arginine-vasopressin during the development of acute hepatic encephalopathy.
 

Author(s): Jonghyuk Park, Takahiro Masaki, Yoshihiro Mezaki, Hiroshi Yokoyama, Mariko Nakamura, Haruka Maehashi, Takahiko J Fujimi, Sabine S Gouraud, Keisuke Nagatsuma, Madoka Nakagomi, Naofumi Kimura, Tomokazu Matsuura

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We developed a bio-artificial liver (BAL) using a radial-flow bioreactor and rescued mini-pig models with lethal acute liver failure (ALF). The point of the rescue is the recovery from hepatic encephalopathy (HE). HE on ALF has sometimes resulted in brain death following brain edema ...

Last Updated: 31 Dec 1969

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Reduced resting state connectivity and gray matter volume correlate with cognitive impairment in minimal hepatic encephalopathy.
 

Author(s): Raquel García-García, Álvaro Javier Cruz-Gómez, Alba Mangas-Losada, Amparo Urios, Cristina Forn, Desamparados Escudero-García, Elena Kosenko, Juan Fermín Ordoño, Joan Tosca, Remedios Giner-Durán, Miguel Angel Serra, César Avila, Vicente Belloch, Vicente Felipo, Carmina Montoliu

Journal:

 

Minimal hepatic encephalopathy (MHE) is associated with cognitive alterations and changes in connectivity. We assessed the relationship of the abnormalities of resting-state functional connectivity (rs-FC) and gray matter (GM) volume with different cognitive alterations and biochemical ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatic encephalopathy" returned 67 free, full-text review articles on human participants. First 3 results:

Association between proton pump inhibitors and hepatic encephalopathy: A meta-analysis.
 

Author(s): Jin Bian, Anqiang Wang, Jianzhen Lin, Liangcai Wu, Hanchun Huang, Shanshan Wang, Xiaobo Yang, Xin Lu, Yiyao Xu, Haitao Zhao

Journal: Medicine (Baltimore). 2017 Apr;96(17):e6723.

 

Several studies have shown that proton pump inhibitors (PPIs) use can increase the risk of developing hepatic encephalopathy (HE) in patients with liver dysfunction. However, no definite conclusion is drawn because of study design limitations. Therefore, we conducted a meta-analysis ...

Last Updated: 31 Dec 1969

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Hyperammonemic coma after craniotomy: Hepatic encephalopathy from upper gastrointestinal hemorrhage or valproate side effect?: Case report and literature review.
 

Author(s): Xiaopeng Guo, Junji Wei, Lu Gao, Bing Xing, Zhiqin Xu

Journal: Medicine (Baltimore). 2017 Apr;96(15):e6588.

 

Postoperative coma is not uncommon in patients after craniotomy. It generally presents as mental state changes and is usually caused by intracranial hematoma, brain edema, or swelling. Hyperammonemia can also result in postoperative coma; however, it is rarely recognized as a potential ...

Last Updated: 31 Dec 1969

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Covert Hepatic Encephalopathy: Can My Patient Drive?
 

Author(s): Jawaid Shaw, Jasmohan S Bajaj

Journal: J. Clin. Gastroenterol.. 2017 Feb;51(2):118-126.

 

Liver cirrhosis is a public health problem and hepatic encephalopathy is one of its main complications, which can be either overt meaning thereby evident and readily diagnosed, or covert/minimal (covert hepatic encephalopathy-CHE) needing psychometric testing for diagnosis. Patients ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fecal Transplant for Hepatic Encephalopathy
 

Status: Recruiting

Condition Summary: Hepatic Encephalopathy

 

Last Updated: 13 Feb 2018

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Last Updated: 8 Dec 2017

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Low-dose Rifaximin in the Treatment of Covert Hepatic Encephalopathy
 

Status: Not yet recruiting

Condition Summary: Covert Hepatic Encephalopathy

 

Last Updated: 6 Mar 2017

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