Hepatic encephalopathy

Common Name(s)

Hepatic encephalopathy

Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.  Signs and symptoms may be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may include personality or mood changes, intellectual impairment, abnormal movements, a depressed level of consciousness, and other symptoms.  There are several theories regarding the exact cause, but development of the condition is probably at least partially due to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatic encephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatic encephalopathy" returned 270 free, full-text research articles on human participants. First 3 results:

Hepatic encephalopathy coexists with acquired chronic hepatocerebral degeneration.
 

Author(s): Feng-Zhen Huang, Xuan Hou, Tie-Qiao Zhou, Si Chen

Journal: Neurosciences (Riyadh). 2015 Jul;20(3):277-9.

 

Hyperkinetic extrapyramidal syndrome is the typical clinical characteristic of acquired hepatocerebral degeneration (AHD), but is usually not observed with hepatic encephalopathy (HE). We present a case of AHD coexisting with HE. Both conditions were secondary to liver cirrhosis and ...

Last Updated: 13 Jul 2015

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GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy.
 

Author(s): Maja Johansson, Ana Agusti, Marta Llansola, Carmina Montoliu, Jessica Strömberg, Evgenya Malinina, Gianna Ragagnin, Magnus Doverskog, Torbjörn Bäckström, Vicente Felipo

Journal: Am. J. Physiol. Gastrointest. Liver Physiol.. 2015 Sep;309(5):G400-9.

 

Hepatic encephalopathy (HE) is one of the primary complications of liver cirrhosis. Current treatments for HE, mainly directed to reduction of ammonia levels, are not effective enough because they cannot completely eliminate hyperammonemia and inflammation, which induce the neurological ...

Last Updated: 2 Sep 2015

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Candida albicans in peritoneal fluid in a patient with hepatic encephalopathy.
 

Author(s): Eilon Krashin, Michael Lishner, Michal Chowers, Sharon Reisfeld

Journal: Isr. Med. Assoc. J.. 2015 Mar;17(3):193-4.

 

Last Updated: 7 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatic encephalopathy" returned 56 free, full-text review articles on human participants. First 3 results:

Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure.
 

Author(s): Manuel Romero-Gómez, Sara Montagnese, Rajiv Jalan

Journal: J. Hepatol.. 2015 Feb;62(2):437-47.

 

Hepatic encephalopathy in a hospitalized cirrhotic patient is associated with a high mortality rate and its presence adds further to the mortality of patients with acute-on-chronic liver failure (ACLF). The exact pathophysiological mechanisms of HE in this group of patients are unclear ...

Last Updated: 19 Jan 2015

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Multimodality magnetic resonance imaging in hepatic encephalopathy: an update.
 

Author(s): Xiao-Dong Zhang, Long-Jiang Zhang, Sheng-Yong Wu, Guang-Ming Lu

Journal: World J. Gastroenterol.. 2014 Aug;20(32):11262-72.

 

Hepatic encephalopathy (HE) is a neuropsychiatric complication of cirrhosis or acute liver failure. Currently, HE is regarded as a continuous cognitive impairment ranging from the mildest stage, minimal HE to overt HE. Hyperammonaemia and neuroinflammation are two main underlying ...

Last Updated: 29 Aug 2014

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Effects of probiotic therapy on hepatic encephalopathy in patients with liver cirrhosis: an updated meta-analysis of six randomized controlled trials.
 

Author(s): Jun Xu, Rui Ma, Li-Feng Chen, Li-Jun Zhao, Kan Chen, Ren-Bing Zhang

Journal: HBPD INT. 2014 Aug;13(4):354-60.

 

Liver cirrhotic patients with hepatic encephalopathy have poor prognosis. Probiotics alter the intestinal microbiota and reduce the production of ammonia. We conducted a meta-analysis about the role of probiotics on liver cirrhotic patients with hepatic encephalopathy.

Last Updated: 7 Aug 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE)
 

Status: Recruiting

Condition Summary: Acute Episode of Overt Hepatic Encephalopathy; Hepatic Encephalopathy

 

Last Updated: 8 Feb 2016

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The Role of Bacterial Overgrowth and Delayed Intestinal Transit in Hepatic Encephalopathy
 

Status: Recruiting

Condition Summary: Hepatic Encephalopathy; Hepatitis C; Liver Cirrhosis

 

Last Updated: 4 Nov 2010

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Metformin Experience on Minimal Hepatic Encephalopathy
 

Status: Recruiting

Condition Summary: Liver Cirrhosis; Hepatic Encephalopathy

 

Last Updated: 9 Jun 2015

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