Hepatic encephalopathy

Common Name(s)

Hepatic encephalopathy

Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.  Signs and symptoms may be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may include personality or mood changes, intellectual impairment, abnormal movements, a depressed level of consciousness, and other symptoms.  There are several theories regarding the exact cause, but development of the condition is probably at least partially due to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hepatic encephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hepatic encephalopathy" returned 292 free, full-text research articles on human participants. First 3 results:

Early diet intervention to reduce the incidence of hepatic encephalopathy in cirrhosis patients: post-Transjugular Intrahepatic Portosystemic Shunt (TIPS) findings.
 

Author(s): Ling Luo, Shiying Fu, Yunzhi Zhang, Jingxiang Wang

Journal: Asia Pac J Clin Nutr. 2016 ;25(3):497-503.

 

Hepatic encephalopathy is a common complication in patients who have received transjugular intrahepatic portosystemic shunt (TIPS) as treatment for cirrhosis. The objective of this study was to reduce the incidence of post-TIPS hepatic encephalopathy for these patients via positive ...

Last Updated: 21 Jul 2016

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Clostridium difficile Infection in Hospitalized Cirrhotic Patients with Hepatic Encephalopathy.
 

Author(s): Florin Alexandru Căruntu, Valeriu Gheorghiță

Journal: J Gastrointestin Liver Dis. 2016 Mar;25(1):120-1.

 

Last Updated: 25 Mar 2016

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Machine Learning Classification of Cirrhotic Patients with and without Minimal Hepatic Encephalopathy Based on Regional Homogeneity of Intrinsic Brain Activity.
 

Author(s): Qiu-Feng Chen, Hua-Jun Chen, Jun Liu, Tao Sun, Qun-Tai Shen

Journal:

 

Machine learning-based approaches play an important role in examining functional magnetic resonance imaging (fMRI) data in a multivariate manner and extracting features predictive of group membership. This study was performed to assess the potential for measuring brain intrinsic activity ...

Last Updated: 16 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hepatic encephalopathy" returned 61 free, full-text review articles on human participants. First 3 results:

How to diagnose and manage hepatic encephalopathy: a consensus statement on roles and responsibilities beyond the liver specialist.
 

Author(s): Debbie L Shawcross, Arthur A Dunk, Rajiv Jalan, Gerald Kircheis, Robert J de Knegt, Wim Laleman, John K Ramage, Heiner Wedemeyer, Ian E J Morgan,

Journal: Eur J Gastroenterol Hepatol. 2016 Feb;28(2):146-52.

 

Hepatic encephalopathy is defined as brain dysfunction caused by liver insufficiency and/or portosystemic shunting. Symptoms include nonspecific cognitive impairment, personality changes and changes in consciousness. Overt (symptomatic) hepatic encephalopathy is a common complication ...

Last Updated: 23 Dec 2015

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Inflammation: A novel target of current therapies for hepatic encephalopathy in liver cirrhosis.
 

Author(s): Ming Luo, Jian-Yang Guo, Wu-Kui Cao

Journal: World J. Gastroenterol.. 2015 Nov;21(41):11815-24.

 

Hepatic encephalopathy (HE) is a severe neuropsychiatric syndrome that most commonly occurs in decompensated liver cirrhosis and incorporates a spectrum of manifestations that ranges from mild cognitive impairment to coma. Although the etiology of HE is not completely understood, ...

Last Updated: 11 Nov 2015

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Covert and Overt Hepatic Encephalopathy: Diagnosis and Management.
 

Author(s): Kavish R Patidar, Jasmohan S Bajaj

Journal: Clin. Gastroenterol. Hepatol.. 2015 Nov;13(12):2048-61.

 

Hepatic encephalopathy (HE) is part of a spectrum of neurocognitive changes in cirrhosis. HE is divided into 2 broad categories based on severity: covert hepatic encephalopathy (CHE) and overt hepatic encephalopathy (OHE). CHE has a significant impact on a patient's quality of life, ...

Last Updated: 20 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effects of Nitazoxanide in Hepatic Encephalopathy
 

Status: Recruiting

Condition Summary: Hepatic Encephalopathy

 

Last Updated: 7 Jan 2015

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Real World Outcomes Study of Hepatic Encephalopathy Patients' Experience on Rifaximin (PROSPER)
 

Status: Recruiting

Condition Summary: Hepatic Encephalopathy

 

Last Updated: 10 Dec 2015

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Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE)
 

Status: Recruiting

Condition Summary: Acute Episode of Overt Hepatic Encephalopathy; Hepatic Encephalopathy

 

Last Updated: 21 Oct 2016

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