Heparin induced thrombocytopenia

Common Name(s)

Heparin induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). HIT is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. This condition occurs in up to 5% of those who are exposed to heparin. Characteristic signs of HIT are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  The first step of treatment is to discontinue and avoid all heparin products immediately. Often, affected individuals require another medicine to prevent blood clotting (anticoagulants).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heparin induced thrombocytopenia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Heparin induced thrombocytopenia" returned 317 free, full-text research articles on human participants. First 3 results:

Optical Coherence Tomography Findings in Early Stent Thrombosis by Heparin-Induced Thrombocytopenia.
 

Author(s): Hiroshi Okamoto, Teruyoshi Kume, Kenzo Fukuhara, Yusuke Kobayashi, Ai Kawamura, Yutaka Goryo, Terumasa Koyama, Tomoko Tamada, Ryotaro Yamada, Koichiro Imai, Yoji Neishi, Shiro Uemura

Journal: Int Heart J. 2016 Dec;57(6):763-765.

 

A 62-year-old man with a family history of coronary artery disease and a history of smoking, diabetes and dyslipidemia was admitted to our hospital with chest pain from acute myocardial infarction. Emergent coronary angiography was performed with intervention to a mid-right coronary ...

Last Updated: 7 Nov 2016

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Heparin-Induced-Thrombocytopenia Causing Massive Aortic Thrombosis after Ascending Aortic Replacement for Type A Acute Aortic Dissection.
 

Author(s): Yusuke Matsuki, Kiyotaka Imoto, Keiji Uchida, Susumu Isoda, Norihisa Karube, Shota Yasuda, Munetaka Masuda

Journal: Ann Thorac Cardiovasc Surg. 2016 Oct;22(5):318-321.

 

A 77-year-old woman underwent emergency ascending aortic replacement for type A acute aortic dissection. Fifteen days after the operation, she had motor and sensory disturbances in the lower limbs. Computed tomography revealed multiple aortic thrombi and disrupted blood flow in the ...

Last Updated: 19 Jan 2016

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Bivalirudin Anticoagulation for a Pediatric Patient with Heparin-Induced Thrombocytopenia and Thrombosis Requiring Cardiopulmonary Bypass for Ventricular Assist Device Placement.
 

Author(s): Katie H Faella, David Whiting, Francis Fynn-Thompson, Gregory S Matte

Journal: J Extra Corpor Technol. 2016 Mar;48(1):39-42.

 

The direct thrombin inhibitor bivalirudin is an option for anticoagulation in patients with heparin induced thrombocytopenia (HIT) requiring cardiopulmonary bypass (CPB). There are a limited number of reports of pediatric patients in which bivalirudin has been used for anticoagulation ...

Last Updated: 2 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Heparin induced thrombocytopenia" returned 48 free, full-text review articles on human participants. First 3 results:

[Heparin-induced thrombocytopenia. New therapeutical options].
 

Author(s): Carina E Seculini Patiño, Aldo H Tabares

Journal: Medicina (B Aires). ;76(4):230-4.

 

Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse reaction due to antibodies to a multimolecular complex of heparin and platelet factor 4 (PF4) characterized by moderate thrombocytopenia and paradoxical arterial or venous thrombosis. It is a relatively infrequent ...

Last Updated: 31 Aug 2016

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Diagnostic value of immunoassays for heparin-induced thrombocytopenia: a systematic review and meta-analysis.
 

Author(s): Michael Nagler, Lucas M Bachmann, Hugo ten Cate, Arina ten Cate-Hoek

Journal: Blood. 2016 Feb;127(5):546-57.

 

Immunoassays are essential in the workup of patients with suspected heparin-induced thrombocytopenia. However, the diagnostic accuracy is uncertain with regard to different classes of assays, antibody specificities, thresholds, test variations, and manufacturers. We aimed to assess ...

Last Updated: 5 Feb 2016

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Heparin-induced thrombocytopenia.
 

Author(s): Łukasz J Krzych, Elżbieta Nowacka, Piotr Knapik

Journal: Anaesthesiol Intensive Ther. 2015 ;47(1):63-76.

 

Heparin-induced thrombocytopenia (HIT) is a clinical immune-mediated syndrome; symptoms of HIT result from the development of arterial and venous thrombosis and are correlated with the severity of the thrombocytopenia. In all patients receiving heparin preparations in intensive care ...

Last Updated: 10 Mar 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pharmacogenomics of Heparin-Induced Thrombocytopenia
 

Status: Recruiting

Condition Summary: Heparin-induced Thrombocytopenia

 

Last Updated: 27 Oct 2016

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Immunogenetics of Heparin-Induced Thrombocytopenia: Aim 2
 

Status: Recruiting

Condition Summary: Heparin-induced Thrombocytopenia

 

Last Updated: 2 May 2016

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Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin
 

Status: Recruiting

Condition Summary: Aneurysmal Subarachnoid Hemorrhage; Neurobehavioral Manifestations; Vasospasm, Intracranial; Intracranial Aneurysm; Heparin-induced Thrombocytopenia Type II

 

Last Updated: 15 Apr 2016

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