Heparin induced thrombocytopenia

Common Name(s)

Heparin induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). HIT is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. This condition occurs in up to 5% of those who are exposed to heparin. Characteristic signs of HIT are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  The first step of treatment is to discontinue and avoid all heparin products immediately. Often, affected individuals require another medicine to prevent blood clotting (anticoagulants).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heparin induced thrombocytopenia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Heparin induced thrombocytopenia" returned 206 free, full-text research articles on human participants. First 3 results:

Heparin-induced thrombocytopenia presenting as bilateral adrenal hemorrhages.
 

Author(s): Theodore E Warkentin, Eric L Safyan, Lori-Ann Linkins

Journal: N. Engl. J. Med.. 2015 Jan;372(5):492-4.

 

Last Updated: 29 Jan 2015

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[Anti PF4/heparin antibodies detection by immunoturbidimetry in the diagnosis of heparin-induced thrombocytopenia].
 

Author(s): Marta E Martinuzzo, Luis H Barrera, MarĂ­a A D'Adamo, Juan C Otaso, Ricardo R Forastiero

Journal: Medicina (B Aires). 2014 ;74(6):507-8.

 

Last Updated: 5 Jan 2015

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Heparin-induced thrombocytopenia testing is over-utilized in cirrhosis & correlates with poor clinical outcomes.
 

Author(s): Karlyn Martin, Leila Kia, Neehar D Parikh, Laura Kulik, Brandon McMahon

Journal: Ann Hepatol. ;13(5):548-54.

 

Heparin-induced thrombocytopenia (HIT) is a serious complication seen in hospitalized, medically-ill patients. Evaluation for HIT using a commercially-available ELISA-based test has become increasingly common; however, it does have a high false positive rate. Implications of HIT testing ...

Last Updated: 26 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Heparin induced thrombocytopenia" returned 37 free, full-text review articles on human participants. First 3 results:

Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia.
 

Author(s): Steven E McKenzie, Bruce S Sachais

Journal: Curr. Opin. Hematol.. 2014 Sep;21(5):380-7.

 

To review the recent developments in understanding the pathophysiology of heparin-induced thrombocytopenia (HIT) and in applying this knowledge to the treatment of patients with suspected and proven HIT.

Last Updated: 6 Aug 2014

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Heparin-induced thrombocytopenia.
 

Author(s): Grace M Lee, Gowthami M Arepally

Journal: Hematology Am Soc Hematol Educ Program. 2013 ;2013():668-74.

 

Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by antibodies that recognize complexes of platelet factor 4 (PF4) and heparin. HIT is frequently considered in the differential diagnosis of thrombocytopenia occurring in patients on heparin therapy. HIT is ...

Last Updated: 9 Dec 2013

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Diagnosis and management of heparin-induced thrombocytopenia.
 

Author(s): Grace M Lee, Gowthami M Arepally

Journal: Hematol. Oncol. Clin. North Am.. 2013 Jun;27(3):541-63.

 

Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by antibodies to platelet factor 4/heparin (PF4/H) complexes. It presents with declining platelet counts 5 to 14 days after heparin administration and results in a predisposition to arterial and venous thrombosis. ...

Last Updated: 29 May 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Validating 4Ts for Heparin Induced Thrombocytopenia (HIT)
 

Status: Not yet recruiting

Condition Summary: Heparin-Induced Thrombocytopenia

 

Last Updated: 24 Jul 2009

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Rivaroxaban for Treatment of Patients With Suspected or Confirmed Heparin-Induced Thrombocytopenia
 

Status: Recruiting

Condition Summary: Heparin-induced Thrombocytopenia

 

Last Updated: 27 Apr 2015

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Immunogenetics of Heparin-Induced Thrombocytopenia: Aim 2
 

Status: Recruiting

Condition Summary: Heparin-induced Thrombocytopenia

 

Last Updated: 16 Aug 2015

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