Henoch-Schonlein purpura

Common Name(s)

Henoch-Schonlein purpura

Henoch-Schonlein purpura (HSP) is the most common form of blood vessel inflammation (vasculitis) in children. The disease affects the small blood vessels in the skin, joints, intestines, and kidneys. It is typically seen in children between the ages of 2 and 6 years. The cause of HSP is not known, but it is believed to be the result of an overreaction by the body’s immune system. Experts believe bacteria, viruses, medications, food, and immunizations may all be triggers for HSP. About 50% of cases occur after a child has an upper respiratory infection (cold).

The hallmark sign of HSP is a red or purple rash (purpura) that typically shows up on the legs or buttocks. The rash is the result of inflammation of the blood vessels under the skin. Other signs and symptoms of HSP may include joint pain, abdominal pain, or blood in the urine due to inflammation in the kidneys. In rare cases, serious complications can occur. These may include permanent kidney damage or folding of the intestines. Diagnosis of HSP is based on the combination of symptoms identified by the physician through a physical exam as well as a blood test to look for immune markers. A collection of affected tissue (biopsy) may be needed to confirm the diagnosis. HSP usually resolves in a few weeks with only minor treatment, including bed rest and fluids. Joint or abdominal pain can be treated with pain medications. Additional treatment options may be provided to those with serious complications of HSP. If your child has been diagnosed with HSP, talk with your doctor to discuss current treatment recommendations. Support groups are a good resource for additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Henoch-Schonlein purpura" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Henoch-Schonlein purpura" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Henoch-Schonlein purpura" returned 270 free, full-text research articles on human participants. First 3 results:

Encephalopathy in Henoch-Schönlein Purpura.
 

Author(s): Huijun Shen, Jianhua Mao, Qiang Shu, Lizhong Du

Journal: Indian Pediatr. 2017 Aug;54(8):675-677.

 

Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood. Severe central nervous system (CNS) involvement is rare in HSP.

Last Updated: 31 Dec 1969

Go To URL
Henoch-Schonlein purpura associated with primary active Epstein-Barr virus infection: a case report.
 

Author(s): Burcu Karakayali, Sila Yilmaz, Deniz Çakir, Pembe Gül Günes, Sirin Güven, Ismail Islek

Journal:

 

Henoch-Schönlein purpura (HSP) is the most common form of childhood vasculitis. Various viral and bacterial infections, drugs, vaccines, food allergy and even insect bites have been considered as triggering factors in pathogenesis of HSP. Epstein-Barr virus (EBV) infection, which ...

Last Updated: 31 Dec 1969

Go To URL
[Association of serum vitamin D level with severity and treatment in children with Henoch-Schönlein purpura].
 

Author(s): Li Fan, Heng Liu, Yu-Chuan Wang, Li Chen, Jing-Jing Zhou, Yu-Xia Cui

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jul;19(7):796-799.

 

To investigate the association of serum vitamin D [25-(OH)D3] level with the severity and treatment in children with Henoch-Schönlein purpura (HSP).

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Henoch-Schonlein purpura" returned 32 free, full-text review articles on human participants. First 3 results:

A Case of Henoch-Schonlein Purpura Associated with Rotavirus Infection in an Elderly Asian Male and Review of the Literature.
 

Author(s): Chen Tang, Daphne Scaramangas-Plumley, Cynthia C Nast, Zab Mosenifar, Marc A Edelstein, Michael Weisman

Journal:

 

BACKGROUND Henoch-Schönlein purpura (HSP), a small vessel vasculitis mediated by deposition of immune-complexes containing IgA in the skin, gut, and glomeruli, often presents with abdominal pain, purpuric rash in the lower extremities and buttocks, joint pain, and hematuria. The ...

Last Updated: 31 Dec 1969

Go To URL
Henoch-Schönlein purpura from vasculitis to intestinal perforation: A case report and literature review.
 

Author(s): Butsabong Lerkvaleekul, Suporn Treepongkaruna, Pawaree Saisawat, Pornsri Thanachatchairattana, Napat Angkathunyakul, Nichanan Ruangwattanapaisarn, Soamarat Vilaiyuk

Journal: World J. Gastroenterol.. 2016 Jul;22(26):6089-94.

 

Henoch-Schönlein purpura (HSP) is generally a self-limited vasculitis disease and has a good prognosis. We report a 4-year-old Thai boy who presented with palpable purpura, abdominal colicky pain, seizure, and eventually developed intestinal ischemia and perforation despite adequate ...

Last Updated: 31 Dec 1969

Go To URL
Gallbladder and Pancreas in Henoch-Schönlein Purpura: Review of the Literature.
 

Author(s): Rossana Helbling, Sebastiano A G Lava, Giacomo D Simonetti, Pietro Camozzi, Mario G Bianchetti, Gregorio P Milani

Journal: J. Pediatr. Gastroenterol. Nutr.. 2016 Mar;62(3):457-61.

 

Involvement of the pancreato-biliary system has been occasionally noted in Henoch-Schönlein purpura. Furthermore, cases of this vasculitis syndrome sometimes develop in the context of a viral hepatitis or after hepatitis vaccination.

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura
 

Status: Recruiting

Condition Summary: Henoch Schönlein Purpura

 

Last Updated: 16 Jun 2017

Go to URL
The Research of Standard Diagnosis and Treatment for Severe HSP in Children
 

Status: Recruiting

Condition Summary: Henoch-Schoenlein Purpura

 

Last Updated: 29 Oct 2016

Go to URL
The Research of Standard Diagnosis and Treatment for HSPN in Children
 

Status: Recruiting

Condition Summary: Henoch-Schoenlein Purpura Nephritis

 

Last Updated: 29 Oct 2016

Go to URL