Henoch-Schonlein purpura

Common Name(s)

Henoch-Schonlein purpura

Henoch-Schonlein purpura (HSP) is the most common form of blood vessel inflammation (vasculitis) in children. The disease affects the small blood vessels in the skin, joints, intestines, and kidneys. It is typically seen in children between the ages of 2 and 6 years. The cause of HSP is not known, but it is believed to be the result of an overreaction by the body’s immune system. Experts believe bacteria, viruses, medications, food, and immunizations may all be triggers for HSP. About 50% of cases occur after a child has an upper respiratory infection (cold).

The hallmark sign of HSP is a red or purple rash (purpura) that typically shows up on the legs or buttocks. The rash is the result of inflammation of the blood vessels under the skin. Other signs and symptoms of HSP may include joint pain, abdominal pain, or blood in the urine due to inflammation in the kidneys. In rare cases, serious complications can occur. These may include permanent kidney damage or folding of the intestines. Diagnosis of HSP is based on the combination of symptoms identified by the physician through a physical exam as well as a blood test to look for immune markers. A collection of affected tissue (biopsy) may be needed to confirm the diagnosis. HSP usually resolves in a few weeks with only minor treatment, including bed rest and fluids. Joint or abdominal pain can be treated with pain medications. Additional treatment options may be provided to those with serious complications of HSP. If your child has been diagnosed with HSP, talk with your doctor to discuss current treatment recommendations. Support groups are a good resource for additional information.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Henoch-Schonlein purpura" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Henoch-Schonlein purpura" returned 213 free, full-text research articles on human participants. First 3 results:

[Clinical analysis of childhood Henoch-Schonlein purpura on the Tibetan Plateau, China].
 

Author(s): Zhen Yang, Lin Guo, Hao Xiong, Zhu Gang, Jian-Xin Li, Yu-Ping Deng, Qu-Zhen Dawa, Zha-Xi Pubu, Hui Li

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Dec;16(12):1231-5.

 

To study the clinical characteristics of childhood Henoch-Schonlein purpura (HSP) on the Tibetan Plateau, China.

Last Updated: 19 Dec 2014

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MEFV gene mutations in Egyptian children with Henoch-Schonlein purpura.
 

Author(s): Samia Salah, Samia Rizk, Hala M Lotfy, Salma El Houchi, Huda Marzouk, Yomna Farag

Journal:

 

Due to an increased frequency of vasculitis in FMF patients, many investigators have studied MEFV mutations in patients with HSP. The aim of the study is to investigate the frequency and clinical significance of MEFV mutations in Egyptian children with Henoch-Schonlein purpura (HSP). ...

Last Updated: 18 Sep 2014

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Effects of Chinese herbs in children with Henoch-Schonlein purpura nephritis: a randomized controlled trial.
 

Author(s): Dandan Ding, Huimin Yan, Xiaofang Zhen

Journal: J Tradit Chin Med. 2014 Feb;34(1):15-22.

 

To research the curative effect of Chinese herbs for clearing away heat, promoting diuresis, nourishing the kidney, and consolidating essence in children with Henoch-Schonlein purpura nephritis (HSPN) with internal accumulation of damp-toxin using randomized controlled observations ...

Last Updated: 8 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Henoch-Schonlein purpura" returned 26 free, full-text review articles on human participants. First 3 results:

Factor XIII deficiency in Henoch-Schönlein purpura - report on two cases and literature review.
 

Author(s): Anna Hogendorf, Wojciech Młynarski

Journal: Dev Period Med. ;18(3):318-22.

 

Factor XIII (FXIII) deficiency is a rare, inherited or acquired coagulation disorder that potentially precipitates fatal haemorrhage. We report two consecutive pediatric patients with Henoch-Schönlein purpura (HSP) and symptomatic decrease in FXIII. The possible FXIII deficiency ...

Last Updated: 3 Sep 2014

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Henoch-Schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment.
 

Author(s): Yukihiko Kawasaki, Atsushi Ono, Shinichiro Ohara, Yuichi Suzuki, Kazuhide Suyama, Junzo Suzuki, Mitsuaki Hosoya

Journal: Fukushima J Med Sci. 2013 ;59(1):15-26.

 

Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and the deposition of IgA immune complexes. Renal involvement is the principal cause of morbidity and mortality in children with HSP. Thus, it is important ...

Last Updated: 11 Jul 2013

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Fatal Henoch-Schonlein purpura in an adult related to bowel perforation: report and review of the literature.
 

Author(s): Una Miniter, Yoon-Soo Cindy Bae-Harboe, Jennifer G Powers, Shannon M Campbell, Lynne J Goldberg

Journal:

 

Henoch-Schonlein purpura is an idiopathic, IgA associated, systemic small-vessel vasculitis characterized by the clinical tetrad of palpable purpura, arthralgias, renal dysfunction, and abdominal pain. Whereas Henoch-Schonlein is an overwhelmingly pediatric disease, its rare diagnosis ...

Last Updated: 5 Nov 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura
 

Status: Recruiting

Condition Summary: Henoch Schönlein Purpura

 

Last Updated: 22 Apr 2015

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Identification of Biomarkers Predictive of Worse Prognosis in Henoch Schonlein Purpura
 

Status: Recruiting

Condition Summary: Purpura, Schoenlein-Henoch

 

Last Updated: 22 Apr 2014

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Impact of Vasculitis on Employment and Income
 

Status: Recruiting

Condition Summary: Vasculitis; Systemic Vasculitis; Behcet's Disease; CNS Vasculitis; Cryoglobulinemic Vasculitis; Eosinophilic Granulomatosis; Temporal Arteritis; Wegener Granulomatosis; Henoch-Schoenlein Purpura; Microscopic Polyangiitis; Polyarteritis Nodosa (PAN); Takayasu's Arteritis; Urticarial Vasculitis

 

Last Updated: 18 Jun 2015

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