Henoch-Schonlein purpura

Common Name(s)

Henoch-Schonlein purpura

Henoch-Schonlein purpura (HSP) is the most common form of blood vessel inflammation (vasculitis) in children. The disease affects the small blood vessels in the skin, joints, intestines, and kidneys. It is typically seen in children between the ages of 2 and 6 years. The cause of HSP is not known, but it is believed to be the result of an overreaction by the body’s immune system. Experts believe bacteria, viruses, medications, food, and immunizations may all be triggers for HSP. About 50% of cases occur after a child has an upper respiratory infection (cold).

The hallmark sign of HSP is a red or purple rash (purpura) that typically shows up on the legs or buttocks. The rash is the result of inflammation of the blood vessels under the skin. Other signs and symptoms of HSP may include joint pain, abdominal pain, or blood in the urine due to inflammation in the kidneys. In rare cases, serious complications can occur. These may include permanent kidney damage or folding of the intestines. Diagnosis of HSP is based on the combination of symptoms identified by the physician through a physical exam as well as a blood test to look for immune markers. A collection of affected tissue (biopsy) may be needed to confirm the diagnosis. HSP usually resolves in a few weeks with only minor treatment, including bed rest and fluids. Joint or abdominal pain can be treated with pain medications. Additional treatment options may be provided to those with serious complications of HSP. If your child has been diagnosed with HSP, talk with your doctor to discuss current treatment recommendations. Support groups are a good resource for additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Henoch-Schonlein purpura" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Henoch-Schonlein purpura" returned 244 free, full-text research articles on human participants. First 3 results:

[Clinical effect of gamma globulin pulse therapy for abdominal Henoch-Schönlein purpura in children].
 

Author(s): Li-Ping Xia, Xu Chen, Yi Jiang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Oct;18(10):988-990.

 

To study the clinical effect of high-dose gamma globulin pulse therapy for abdominal Henoch-Schönlein purpura (HSP).

Last Updated: 18 Oct 2016

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Henoch-Schönlein Purpura: A Rare Cause of Recurrent Acute Pancreatitis.
 

Author(s): Dong-Ya Huang, Qiang Li, Kui-Rong Jiang, Bin Xiao, Guo-Sheng Chen, Yi Miao

Journal: Chin. Med. J.. 2016 10;129(20):2510-2511.

 

Last Updated: 17 Oct 2016

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Henoch Schonlein purpura and Clostridium difficile infection: a hematologist's point of view.
 

Author(s): Delia Dima, Ciprian Tomuleasa, Mihnea Zdrenghea

Journal: J Gastrointestin Liver Dis. 2016 Sep;25(3):411.

 

Last Updated: 30 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Henoch-Schonlein purpura" returned 31 free, full-text review articles on human participants. First 3 results:

A Case of Henoch-Schonlein Purpura Associated with Rotavirus Infection in an Elderly Asian Male and Review of the Literature.
 

Author(s): Chen Tang, Daphne Scaramangas-Plumley, Cynthia C Nast, Zab Mosenifar, Marc A Edelstein, Michael Weisman

Journal:

 

BACKGROUND Henoch-Schönlein purpura (HSP), a small vessel vasculitis mediated by deposition of immune-complexes containing IgA in the skin, gut, and glomeruli, often presents with abdominal pain, purpuric rash in the lower extremities and buttocks, joint pain, and hematuria. The ...

Last Updated: 8 Feb 2017

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Factor XIII deficiency in Henoch-Schönlein purpura - report on two cases and literature review.
 

Author(s): Anna Hogendorf, Wojciech Młynarski

Journal: Dev Period Med. ;18(3):318-22.

 

Factor XIII (FXIII) deficiency is a rare, inherited or acquired coagulation disorder that potentially precipitates fatal haemorrhage. We report two consecutive pediatric patients with Henoch-Schönlein purpura (HSP) and symptomatic decrease in FXIII. The possible FXIII deficiency ...

Last Updated: 3 Sep 2014

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Henoch-Schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment.
 

Author(s): Yukihiko Kawasaki, Atsushi Ono, Shinichiro Ohara, Yuichi Suzuki, Kazuhide Suyama, Junzo Suzuki, Mitsuaki Hosoya

Journal: Fukushima J Med Sci. 2013 ;59(1):15-26.

 

Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and the deposition of IgA immune complexes. Renal involvement is the principal cause of morbidity and mortality in children with HSP. Thus, it is important ...

Last Updated: 11 Jul 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura
 

Status: Recruiting

Condition Summary: Henoch Schönlein Purpura

 

Last Updated: 24 Oct 2016

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The Research of Standard Diagnosis and Treatment for Severe HSP in Children
 

Status: Recruiting

Condition Summary: Henoch-Schoenlein Purpura

 

Last Updated: 29 Oct 2016

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The Research of Standard Diagnosis and Treatment for HSPN in Children
 

Status: Recruiting

Condition Summary: Henoch-Schoenlein Purpura Nephritis

 

Last Updated: 29 Oct 2016

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