Henoch-Schonlein purpura

Common Name(s)

Henoch-Schonlein purpura

Henoch-Schonlein purpura (HSP) is the most common form of blood vessel inflammation (vasculitis) in children. The disease affects the small blood vessels in the skin, joints, intestines, and kidneys. It is typically seen in children between the ages of 2 and 6 years. The cause of HSP is not known, but it is believed to be the result of an overreaction by the body’s immune system. Experts believe bacteria, viruses, medications, food, and immunizations may all be triggers for HSP. About 50% of cases occur after a child has an upper respiratory infection (cold).

The hallmark sign of HSP is a red or purple rash (purpura) that typically shows up on the legs or buttocks. The rash is the result of inflammation of the blood vessels under the skin. Other signs and symptoms of HSP may include joint pain, abdominal pain, or blood in the urine due to inflammation in the kidneys. In rare cases, serious complications can occur. These may include permanent kidney damage or folding of the intestines. Diagnosis of HSP is based on the combination of symptoms identified by the physician through a physical exam as well as a blood test to look for immune markers. A collection of affected tissue (biopsy) may be needed to confirm the diagnosis. HSP usually resolves in a few weeks with only minor treatment, including bed rest and fluids. Joint or abdominal pain can be treated with pain medications. Additional treatment options may be provided to those with serious complications of HSP. If your child has been diagnosed with HSP, talk with your doctor to discuss current treatment recommendations. Support groups are a good resource for additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Henoch-Schonlein purpura" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Henoch-Schonlein purpura" returned 263 free, full-text research articles on human participants. First 3 results:

[Significance of detection of biomarker fecal bile acids in the diagnosis and treatment of childhood Henoch-Schönlein purpura].
 

Author(s): Hong-Wei Hu, Jiang Duan, Bo Zhao, Jing-Jing Xiong, Mei Liu, Jing-Jing Cui, Xiao-Fei Ji, Ting-Ting Zhang, Li-Zhi Zhang, Yong-Kun Huang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Jun;18(6):517-21.

 

To investigate the changes and clinical significance of biomarker fecal bile acids (BA) in children with Henoch-Schönlein purpura (HSP).

Last Updated: 21 Jun 2016

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The Optimal Cut-Off Value of Neutrophil-to-Lymphocyte Ratio for Predicting Prognosis in Adult Patients with Henoch-Schönlein Purpura.
 

Author(s): Chan Hyuk Park, Dong Soo Han, Jae Yoon Jeong, Chang Soo Eun, Kyo-Sang Yoo, Yong Cheol Jeon, Joo Hyun Sohn

Journal:

 

The development of gastrointestinal (GI) bleeding and end-stage renal disease (ESRD) can be a concern in the management of Henoch-Schönlein purpura (HSP). We aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR) is associated with the prognosis of adult patients with HSP.

Last Updated: 14 Apr 2016

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Henoch-Schönlein purpura with joint involvement: Analysis of 71 cases.
 

Author(s): Xuehong Wang, Yongmei Zhu, Laiqiang Gao, Shuyue Wei, Youyou Zhen, Qiang Ma

Journal:

 

Although joint involvement is the second most common clinical manifestation after skin involvement in patients with Henoch-Schönlein purpura (HSP), it has not been well characterized. The aim of this study was to profile the clinical characteristics and identify the potential risk ...

Last Updated: 31 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Henoch-Schonlein purpura" returned 29 free, full-text review articles on human participants. First 3 results:

Factor XIII deficiency in Henoch-Schönlein purpura - report on two cases and literature review.
 

Author(s): Anna Hogendorf, Wojciech Młynarski

Journal: Dev Period Med. ;18(3):318-22.

 

Factor XIII (FXIII) deficiency is a rare, inherited or acquired coagulation disorder that potentially precipitates fatal haemorrhage. We report two consecutive pediatric patients with Henoch-Schönlein purpura (HSP) and symptomatic decrease in FXIII. The possible FXIII deficiency ...

Last Updated: 3 Sep 2014

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Henoch-Schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment.
 

Author(s): Yukihiko Kawasaki, Atsushi Ono, Shinichiro Ohara, Yuichi Suzuki, Kazuhide Suyama, Junzo Suzuki, Mitsuaki Hosoya

Journal: Fukushima J Med Sci. 2013 ;59(1):15-26.

 

Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and the deposition of IgA immune complexes. Renal involvement is the principal cause of morbidity and mortality in children with HSP. Thus, it is important ...

Last Updated: 11 Jul 2013

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Fatal Henoch-Schonlein purpura in an adult related to bowel perforation: report and review of the literature.
 

Author(s): Una Miniter, Yoon-Soo Cindy Bae-Harboe, Jennifer G Powers, Shannon M Campbell, Lynne J Goldberg

Journal:

 

Henoch-Schonlein purpura is an idiopathic, IgA associated, systemic small-vessel vasculitis characterized by the clinical tetrad of palpable purpura, arthralgias, renal dysfunction, and abdominal pain. Whereas Henoch-Schonlein is an overwhelmingly pediatric disease, its rare diagnosis ...

Last Updated: 5 Nov 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura
 

Status: Recruiting

Condition Summary: Henoch Schönlein Purpura

 

Last Updated: 24 Oct 2016

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The Research of Standard Diagnosis and Treatment for Severe HSP in Children
 

Status: Recruiting

Condition Summary: Henoch-Schoenlein Purpura

 

Last Updated: 29 Oct 2016

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The Research of Standard Diagnosis and Treatment for HSPN in Children
 

Status: Recruiting

Condition Summary: Henoch-Schoenlein Purpura Nephritis

 

Last Updated: 29 Oct 2016

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