Hemolytic uremic syndrome, atypical

Common Name(s)

Hemolytic uremic syndrome, atypical, Atypical Hemolytic Uremic Syndrome

Atypical hemolytic-uremic syndrome (aHUS) is a disease that causes abnormal blood clots to form in small blood vessels in the kidneys. These clots can cause serious medical problems if they restrict or block blood flow, including hemolytic anemia, thrombocytopenia, and kidney failure. It can occur at any age and is often caused by a combination of environmental and genetic factors. Genetic factors involve genes that code for proteins that help control the complement system (part of your bodyƕs immune system). Environmental factors include certain medications (such as anticancer drugs), chronic diseases (e.g., systemic sclerosis and malignant hypertension), viral or bacterial infections, cancers, organ transplantation, and pregnancy.  Most cases are sporadic. Less than 20 percent of all cases have been reported to run in families. When the disorder is familial, it can have an autosomal dominant or an autosomal recessive pattern of inheritance.

Atypical hemolytic-uremic syndrome differs from a more common condition called typical hemolytic-uremic syndrome. The two disorders have different causes and different signs and symptoms.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemolytic uremic syndrome, atypical" for support, advocacy or research.

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Foundation for Children with Atypical HUS

The Foundation for Children with Atypical HUS is a not-for-profit 501 (c)(3) organization that provides information to those affected by this rare disease, offers support for patients and families, collaborates with national and international rare disease organizations, offers aHUS meetings, and raises funds for research. The Foundation for Children with Atypical HUS encourages patients and investigators to share information and explore options/resources as we work together to gain insight into this rare complement disorder.

Last Updated: 18 Sep 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemolytic uremic syndrome, atypical" for support, advocacy or research.

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Foundation for Children with Atypical HUS

The Foundation for Children with Atypical HUS is a not-for-profit 501 (c)(3) organization that provides information to those affected by this rare disease, offers support for patients and families, collaborates with national and international rare disease organizations, offers aHUS meetings, and raises funds for research. The Foundation for Children with Atypical HUS encourages patients and investigators to share information and explore options/resources as we work together to gain insight into this rare complement disorder.

http://www.atypicalhus.org

Last Updated: 18 Sep 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemolytic uremic syndrome, atypical" returned 0 free, full-text research articles on human participants.

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemolytic uremic syndrome, atypical" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Complement Activation During Hemodialysis in Atypical Hemolytic Uraemic Syndrome as Underlying Kidney Disease
 

Status: Recruiting

Condition Summary: Atypical Hemolytic Uraemic Syndrome.

 

Last Updated: 4 Dec 2014

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Atypcial Hemolytic-Uremic Syndrome (aHUS) Registry
 

Status: Recruiting

Condition Summary: Atypical Hemolytic-Uremic Syndrome

 

Last Updated: 8 Sep 2014

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The Safety and Efficacy of Eculizumab in Japanese Patients With Atypical Hemolytic Uremic Syndrome (aHUS)
 

Status: Recruiting

Condition Summary: Atypical Hemolytic Uremic Syndrome (aHUS)

 

Last Updated: 21 Dec 2012

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