Hemolytic uremic syndrome

Common Name(s)

Hemolytic uremic syndrome

Hemolytic uremic syndrome (HUS) is a condition in which red blood cells are abnormally destroyed, leading to a decreased red blood cell count (anemia) and destruction of the platelets (thrombocytopenia). Platelets are found circulating in the blood and are involved in clot formation to stop bleeding. HUS is most often caused by an infection of a certain strain of E. coli. An individual is likely to ingest E. coli, a bacterium, when eating undercooked, spoiled, or contaminated food or drinking contaminated water. Children ages 2 to 14 are most commonly affected. In adults, other causes of HUS are medications, other infections, and genetic inheritance (atypical hemolytic uremic syndrome).

HUS is often found after symptoms of bloody diarrhea and abdominal pain. Symptoms of HUS include paleness, fatigue, passing only small amounts of urine, bloody urine, stomach pain, swelling, vomiting, easy bruising, small amounts of bleeding from the mouth and nose, and fever. The debris from destroyed red blood cells in HUS can clog or damage the tiny blood vessels in the kidney, which is the organ that filters blood and produces urine. Kidney failure may occur and is a feared complication of this condition.

Diagnosis of HUS is usually made using a blood test to look at potential red blood cell damage, a urine test, and a stool test for bacteria. HUS is treated in a hospital and may involve fluid replacement, an injection of more red blood cells and/or platelets, injection of plasma (the liquid part of blood), and possibly kidney dialysis if the kidney can no longer filter blood. If you or a loved one has been diagnosed with HUS, talk to your doctor about the most current treatment options. Support groups are available for resources and more information.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemolytic uremic syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemolytic uremic syndrome" returned 480 free, full-text research articles on human participants. First 3 results:

Association among Complement Factor H Autoantibodies, Deletions of CFHR, and the Risk of Atypical Hemolytic Uremic Syndrome.
 

Author(s): Hong Jiang, Meng-Nan Fan, Min Yang, Chao Lu, Ming Zhang, Xiao-Hong Liu, Le Ma

Journal:

 

To evaluate the association among complement factor H-related (CFHRs) gene deficiency, complement factor H (CFH) autoantibodies, and atypical hemolytic uremic syndrome (aHUS) susceptibility. EMBASE, PubMed, and the ISI Web of Science databases were searched for all eligible studies ...

Last Updated: 8 Dec 2016

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Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.
 

Author(s): Xuan Yuan, Eleni Gavriilaki, Jane A Thanassi, Guangwei Yang, Andrea C Baines, Steven D Podos, Yongqing Huang, Mingjun Huang, Robert A Brodsky

Journal: Haematologica. 2017 Mar;102(3):466-475.

 

Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are treated with eculizumab, a humanized monoclonal antibody against the terminal complement component C5. Eculizumab must be ...

Last Updated: 4 Nov 2016

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Cerebral Hemodynamics in Patients with Hemolytic Uremic Syndrome Assessed by Susceptibility Weighted Imaging and Four-Dimensional Non-Contrast MR Angiography.
 

Author(s): Ulrike Löbel, Nils Daniel Forkert, Peter Schmitt, Thorsten Dohrmann, Maria Schroeder, Tim Magnus, Stefan Kluge, Christina Weiler-Normann, Xiaoming Bi, Jens Fiehler, Jan Sedlacik

Journal:

 

Conventional magnetic resonance imaging (MRI) of patients with hemolytic uremic syndrome (HUS) and neurological symptoms performed during an epidemic outbreak of Escherichia coli O104:H4 in Northern Europe has previously shown pathological changes in only approximately 50% of patients. ...

Last Updated: 1 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemolytic uremic syndrome" returned 56 free, full-text review articles on human participants. First 3 results:

Expert Statements on the Standard of Care in Critically Ill Adult Patients With Atypical Hemolytic Uremic Syndrome.
 

Author(s): Elie Azoulay, Paul Knoebl, José Garnacho-Montero, Katerina Rusinova, Gennadii Galstian, Philippe Eggimann, Fekri Abroug, Dominique Benoit, Michael von Bergwelt-Baildon, Julia Wendon, Marie Scully

Journal: Chest. 2017 Aug;152(2):424-434.

 

A typical hemolytic uremic syndrome (aHUS) presents similarly to thrombotic thrombocytopenic purpura (TTP) and other causes or conditions with thrombotic microangiopathy (TMA), such as disseminated intravascular coagulation or sepsis. Similarity in clinical presentation may hinder ...

Last Updated: 26 Apr 2017

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A Case Report and Literature Review of Eculizumab Withdrawal in Atypical Hemolytic-Uremic Syndrome.
 

Author(s): Borja Quiroga, Alberto de Lorenzo, Cristina Vega, Fernando de Alvaro

Journal:

 

BACKGROUND Recent advances in the treatment of atypical hemolytic-uremic syndrome (aHUS) have resulted to better long-term survival rates for patients with this life-threatening disease. However, many questions remain such as whether or not long-term treatment is necessary in some ...

Last Updated: 15 Dec 2016

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Efficacy of rituximab and plasmapharesis in an adult patient with antifactor H autoantibody-associated hemolytic uremic syndrome: A case report and literature review.
 

Author(s): Clemence Deville, Cyril Garrouste, Paul Coppo, Bertrand Evrard, Alexandre Lautrette, Anne Elisabeth Heng

Journal: Medicine (Baltimore). 2016 Sep;95(39):e5007.

 

Antifactor H antibody (anti-CFHAb) is found in 6% to 25% cases of atypical hemolytic uremic syndrome (aHUS) in children, but has been only exceptionally reported in adults. There is no consensus about the best treatment for this type of aHUS. We report the case of an adult patient ...

Last Updated: 30 Sep 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Atypcial Hemolytic-Uremic Syndrome (aHUS) Registry
 

Status: Recruiting

Condition Summary: Atypical Hemolytic-Uremic Syndrome

 

Last Updated: 23 Aug 2017

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Study of ALXN1210 in Children and Adolescents With Atypical Hemolytic Uremic Syndrome (aHUS)
 

Status: Recruiting

Condition Summary: Atypical Hemolytic Uremic Syndrome (aHUS)

 

Last Updated: 6 Sep 2017

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Study Assessing an Algorithm-based Strategy of Eculizumab Discontinuation in Children and Adults With aHUS
 

Status: Recruiting

Condition Summary: Atypical Hemolytic Uremic Syndrome

 

Last Updated: 20 Sep 2016

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