Hemolytic uremic syndrome

Common Name(s)

Hemolytic uremic syndrome

Hemolytic uremic syndrome (HUS) is a condition in which red blood cells are abnormally destroyed, leading to a decreased red blood cell count (anemia) and destruction of the platelets (thrombocytopenia). Platelets are found circulating in the blood and are involved in clot formation to stop bleeding. HUS is most often caused by an infection of a certain strain of E. coli. An individual is likely to ingest E. coli, a bacterium, when eating undercooked, spoiled, or contaminated food or drinking contaminated water. Children ages 2 to 14 are most commonly affected. In adults, other causes of HUS are medications, other infections, and genetic inheritance (atypical hemolytic uremic syndrome).

HUS is often found after symptoms of bloody diarrhea and abdominal pain. Symptoms of HUS include paleness, fatigue, passing only small amounts of urine, bloody urine, stomach pain, swelling, vomiting, easy bruising, small amounts of bleeding from the mouth and nose, and fever. The debris from destroyed red blood cells in HUS can clog or damage the tiny blood vessels in the kidney, which is the organ that filters blood and produces urine. Kidney failure may occur and is a feared complication of this condition.

Diagnosis of HUS is usually made using a blood test to look at potential red blood cell damage, a urine test, and a stool test for bacteria. HUS is treated in a hospital and may involve fluid replacement, an injection of more red blood cells and/or platelets, injection of plasma (the liquid part of blood), and possibly kidney dialysis if the kidney can no longer filter blood. If you or a loved one has been diagnosed with HUS, talk to your doctor about the most current treatment options. Support groups are available for resources and more information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemolytic uremic syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemolytic uremic syndrome" returned 483 free, full-text research articles on human participants. First 3 results:

Low Serum Fetuin-A as a Biomarker to Predict Pneumococcal Necrotizing Pneumonia and Hemolytic Uremic Syndrome in Children.
 

Author(s): Rajendra Prasad Janapatla, Mei-Hua Hsu, Wan-Ting Liao, Kun-Yi Chien, Hao-Yuan Lee, Cheng-Hsun Chiu

Journal: Medicine (Baltimore). 2016 Mar;95(13):e3221.

 

Streptococcus pneumoniae, a neuraminidase-producing pathogen, can cause invasive pneumococcal disease (IPD) with or without hemolytic uremic syndrome (HUS) in humans. We aimed to identify serum sialoglycoproteins that are targeted by neuraminidases in severe pneumococcal infection. ...

Last Updated: 5 Apr 2016

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Thrombotic Microangiopathic Hemolytic Anemia without Evidence of Hemolytic Uremic Syndrome.
 

Author(s): Şinasi Özsoylu

Journal: Turk J Haematol. 2016 Mar;33(1):83.

 

Last Updated: 29 Mar 2016

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[Hemolytic uremic syndrome in urban areas].
 

Author(s): Adriana Bentancor

Journal: Rev. Argent. Microbiol.. ;48(1):1-4.

 

Last Updated: 28 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemolytic uremic syndrome" returned 54 free, full-text review articles on human participants. First 3 results:

Prophylactic Eculizumab Use in Kidney Transplantation: A Review of the Literature and Report of a Case with Atypical Hemolytic Uremic Syndrome.
 

Author(s): Umut Kasapoğlu, Çaglar Ruhi, Murat Tuğcu, Başak Boynueğri, İzzet Titiz, Veysel Sabri Hançer, Süheyla Apaydın

Journal:

 

Atypical hemolytic uremic syndrome (aHUS) is a very rare disease, which presents with microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Progression to end-stage renal disease (ESRD) from acute kidney injury is observed in 60% of aHUS cases. The prognosis ...

Last Updated: 1 Dec 2015

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Atypical hemolytic uremic syndrome: from diagnosis to treatment.
 

Author(s): Massimo Franchini

Journal: Clin. Chem. Lab. Med.. 2015 Oct;53(11):1679-88.

 

Thrombotic microangiopathy (TMA) is a relatively rare condition but a medical urgency requiring immediate intervention to avoid irreversible organ damage or death. Symptoms on presentation include microangiopathic haemolytic anaemia, thrombocytopenia and organ damage. The most frequent ...

Last Updated: 7 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Atypcial Hemolytic-Uremic Syndrome (aHUS) Registry
 

Status: Recruiting

Condition Summary: Atypical Hemolytic-Uremic Syndrome

 

Last Updated: 22 Jul 2015

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Study Assessing an Algorithm-based Strategy of Eculizumab Discontinuation in Children and Adults With aHUS
 

Status: Recruiting

Condition Summary: Atypical Hemolytic Uremic Syndrome

 

Last Updated: 20 Sep 2016

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Last Updated: 13 Sep 2016

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