Hemolytic uremic syndrome

Common Name(s)

Hemolytic uremic syndrome

Hemolytic uremic syndrome (HUS) is a complex disorder that may affect children after different infections, particularly bacterial infections that cause bloody diarrhea. HUS causes damage to the blood cells and the kidneys, which are organs in the abdomen responsible for filtering blood and creating urine. Symptoms of HUS commonly include bloody diarrhea, vomiting, pale skin tone, extreme tiredness, fever, blood in the urine, decreased urination, swelling, and confusion. A physician can diagnose HUS using blood, urine, and other lab tests. HUS usually requires treatment in the hospital to manage symptoms and prevent further organ damage.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemolytic uremic syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemolytic uremic syndrome" returned 423 free, full-text research articles on human participants. First 3 results:

Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome.
 

Author(s): Elena B Volokhina, Nicole C A J van de Kar, Grethe Bergseth, Thea J A M van der Velden, Dineke Westra, Jack F M Wetzels, Lambertus P van den Heuvel, Tom Eirik Mollnes

Journal: Clin. Immunol.. 2015 Oct;160(2):237-43.

 

Complement C5 inhibitor eculizumab treatment in atypical hemolytic uremic syndrome is effective, but associated with high costs. Complement inhibition monitoring in these patients has not been standardized. In this study we evaluated novel functional assays for application in routine ...

Last Updated: 24 Sep 2015

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Eculizumab in Typical Hemolytic Uremic Syndrome (HUS) With Neurological Involvement.
 

Author(s): Lars Pape, Hans Hartmann, Franz Christoph Bange, Sebastian Suerbaum, Eva Bueltmann, Thurid Ahlenstiel-Grunow

Journal: Medicine (Baltimore). 2015 Jun;94(24):e1000.

 

In typical hemolytic uremic syndrome (HUS) approximately 25% of patients show central nervous system (CNS) involvement often leading to serious long-term disabilities. We used the C5-complement inhibitor Eculizumab as rescue therapy. From 2011 to 2014, 11 children (median age 22 months, ...

Last Updated: 20 Jun 2015

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Acute encephalopathy associated with hemolytic uremic syndrome caused by Escherichia coli O157: H7 and rotavirus infection.
 

Author(s): G Imataka, K Wake, M Suzuki, H Yamanouchi, O Arisaka

Journal: Eur Rev Med Pharmacol Sci. 2015 May;19(10):1842-4.

 

We reported a case of a 22-months child with hemolytic uremic syndrome associated with encephalopathy. As the cause of this case, the involvements of verotoxin 1 and 2 caused by O157: the H7 strain of the enterohemorrhagic Escherichia coli and rotavirus were presumed. We administered ...

Last Updated: 5 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemolytic uremic syndrome" returned 51 free, full-text review articles on human participants. First 3 results:

Atypical hemolytic-uremic syndrome: a case report and literature review.
 

Author(s): Arsalan Rafiq, Hassan Tariq, Naeem Abbas, Roopalekha Shenoy

Journal:

 

Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by hemolysis, thrombocytopenia, and renal dysfunction. It is a disease related to genetic mutations in the alternative complement pathway and has a distinct pathophysiology but is difficult to differentiate ...

Last Updated: 24 Feb 2015

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Gemcitabine-induced hemolytic uremic syndrome in pancreatic cancer: a case report and review of the literature.
 

Author(s): Hye Won Lee, Moon Jae Chung, Huapyong Kang, Heun Choi, Youn Jeong Choi, Kyung Joo Lee, Seung Woo Lee, Seung Hyuk Han, Jin Seok Kim, Si Young Song

Journal: Gut Liver. 2014 Jan;8(1):109-12.

 

Hemolytic uremic syndrome (HUS) is a rare thrombotic complication characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS may be caused by several different conditions, including infection, malignancy, and chemotherapeutic agents, ...

Last Updated: 11 Feb 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Atypcial Hemolytic-Uremic Syndrome (aHUS) Registry
 

Status: Recruiting

Condition Summary: Atypical Hemolytic-Uremic Syndrome

 

Last Updated: 22 Jul 2015

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Complement Activation During Hemodialysis in Atypical Hemolytic Uraemic Syndrome as Underlying Kidney Disease
 

Status: Recruiting

Condition Summary: Atypical Hemolytic Uraemic Syndrome.

 

Last Updated: 4 Dec 2014

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Rituximab in Patients With Relapsed or Refractory TTP-HUS
 

Status: Recruiting

Condition Summary: Thrombotic Thrombocytopenic Purpura; Hemolytic Uremic Syndrome

 

Last Updated: 18 May 2010

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