Hemoglobinuria

Common Name(s)

Hemoglobinuria

Hemoglobinuria is symptom of different blood conditions or problems with the kidney (an organ in the abdomen which filters blood and produces urine). Hemoglobin is a chemical found in the blood cells and its function is to carry oxygen from the lungs to the rest of the body. Hemoglobinuria is when this chemical is inappropriately found in the urine (usually, there is no hemoglobin present in urine). This may occur due to the destruction of red blood cells and leaking of hemoglobin into the bloodstream, which then passes into urine. Other causes include severe skin burns, kidney cancer, malaria, and reactions to blood transfusions. Symptoms and treatment vary depending upon the condition and symptoms of patient.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobinuria" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemoglobinuria" returned 403 free, full-text research articles on human participants. First 3 results:

New Insights in Abdominal Pain in Paroxysmal Nocturnal Hemoglobinuria (PNH): A MRI Study.
 

Author(s): Francesco De Cobelli, Giulio Pezzetti, Sergio Margari, Antonio Esposito, Francesco Giganti, Giulia Agostini, Alessandro Del Maschio

Journal:

 

Abdominal pain in PNH has never been investigated by in-vivo imaging studies. With MRI, we aimed to assess mesenteric vessels flow and small bowel wall perfusion to investigate the ischemic origin of abdominal pain.

Last Updated: 22 Apr 2015

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Natural killer (NK) cell function in paroxysmal nocturnal hemoglobinuria: a deficiency of NK cells, but not an NK cell deficiency.
 

Author(s): Yasser M El-Sherbiny, Gina M Doody, Richard J Kelly, Anita Hill, Peter Hillmen, Graham P Cook

Journal: Blood. 2015 Feb;125(8):1351-2.

 

Last Updated: 21 Feb 2015

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Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab.
 

Author(s): Régis Peffault de Latour, Véronique Fremeaux-Bacchi, Raphaël Porcher, Aliénor Xhaard, Jérémie Rosain, Diana Cadena Castaneda, Paula Vieira-Martins, Stéphane Roncelin, Paula Rodriguez-Otero, Aurélie Plessier, Flore Sicre de Fontbrune, Sarah Abbes, Marie Robin, Gérard Socié

Journal: Blood. 2015 Jan;125(5):775-83.

 

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by intravascular hemolysis, which is effectively controlled with eculizumab, a humanized monoclonal antibody that binds complement protein 5 (C5). The residual functional activity of C5 can be screened using a 50% hemolytic ...

Last Updated: 30 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemoglobinuria" returned 37 free, full-text review articles on human participants. First 3 results:

Paroxysmal nocturnal hemoglobinuria: a complement-mediated hemolytic anemia.
 

Author(s): Amy E DeZern, Robert A Brodsky

Journal: Hematol. Oncol. Clin. North Am.. 2015 Jun;29(3):479-94.

 

Paroxysmal nocturnal hemoglobinuria is manifests with a chronic hemolytic anemia from uncontrolled complement activation, a propensity for thrombosis and marrow failure. The hemolysis is largely mediated by the alternative pathway of complement. Clinical manifestations result from ...

Last Updated: 5 Jun 2015

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Cerebral venous thrombosis in paroxysmal nocturnal hemoglobinuria: a series of 15 cases and review of the literature.
 

Author(s): Elodie Meppiel, Isabelle Crassard, Régis Peffault de Latour, Sophie de Guibert, Louis Terriou, Hugues Chabriat, Gérard Socié, Marie-Germaine Bousser

Journal: Medicine (Baltimore). 2015 Jan;94(1):e362.

 

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder of hematopoietic stem cells characterized by hemolytic anemia, marrow failure, and a high incidence of life-threatening venous thrombosis. Cerebral venous system is the second most frequent location of thrombosis ...

Last Updated: 9 Jan 2015

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Paroxysmal nocturnal hemoglobinuria.
 

Author(s): Robert A Brodsky

Journal: Blood. 2014 Oct;124(18):2804-11.

 

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare bone marrow failure disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias. The absence of two glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59, leads to uncontrolled complement ...

Last Updated: 31 Oct 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry
 

Status: Recruiting

Condition Summary: Paroxysmal Nocturnal Hemoglobinuria

 

Last Updated: 1 Apr 2015

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Coversin in Paroxysmal Nocturnal Haemoglobinuria (PNH)
 

Status: Recruiting

Condition Summary: Paroxysmal Nocturnal Haemoglobinuria (PNH)

 

Last Updated: 4 May 2016

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