Hemoglobinuria

Common Name(s)

Hemoglobinuria

Hemoglobinuria is symptom of different blood conditions or problems with the kidney (an organ in the abdomen which filters blood and produces urine). Hemoglobin is a chemical found in the blood cells and its function is to carry oxygen from the lungs to the rest of the body. Hemoglobinuria is when this chemical is inappropriately found in the urine (usually, there is no hemoglobin present in urine). This may occur due to the destruction of red blood cells and leaking of hemoglobin into the bloodstream, which then passes into urine. Other causes include severe skin burns, kidney cancer, malaria, and reactions to blood transfusions. Symptoms and treatment vary depending upon the condition and symptoms of patient.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobinuria" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobinuria" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemoglobinuria" returned 403 free, full-text research articles on human participants. First 3 results:

Development of a disease-specific quality of life questionnaire for patients with aplastic anemia and/or paroxysmal nocturnal hemoglobinuria (QLQ-AA/PNH)-report on phases I and II.
 

Author(s): Martha Groth, Susanne Singer, Cathrin Niedeggen, Andrea Petermann-Meyer, Alexander Röth, Hubert Schrezenmeier, Britta Höchsmann, Tim H Brümmendorf, Jens Panse

Journal: Ann. Hematol.. 2017 Feb;96(2):171-181.

 

Acquired aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH) are interrelated ultra-rare diseases. Quality of life (QoL) evaluation tools used in studies for AA and PNH are unspecific and designed for cancer patients (e.g., the European Organization for Research and ...

Last Updated: 12 Nov 2016

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Successful Treatment of Ascites using a Denver(®) Peritoneovenous Shunt in a Patient with Paroxysmal Nocturnal Hemoglobinuria and Budd-Chiari syndrome.
 

Author(s): Tomomi Kogiso, Etsuko Hashimoto, Taito Ito, Toshifumi Hara, Yuichi Ikarashi, Kazuhisa Kodama, Makiko Taniai, Nobuyuki Torii, Kentaro Yoshinaga, Satoru Morita, Yutaka Takahashi, Junji Tanaka, Shuji Sakai, Masakazu Yamamoto, Katsutoshi Tokushige

Journal: Intern. Med.. ;55(20):2957-2963.

 

A 56-year-old man was diagnosed with aplastic anemia and paroxysmal nocturnal hemoglobinuria at 43 years of age and treatment with cyclosporin A was started. Liver cirrhosis, ascites, and thrombus in the hepatic veins were found at 56 years of age and Budd-Chiari syndrome (BCS) was ...

Last Updated: 17 Oct 2016

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AOHE: manuscript AOHE-D-16-00564 paroxysmal nocturnal hemoglobinuria with autoimmune hemolytic anemia following eculizumab therapy-with large granular lymphocytic leukemia.
 

Author(s): Nathan Visweshwar, Michael Jaglal, Cassie Booth, Patrick Griffin, Damian Laber

Journal: Ann. Hematol.. 2016 Oct;95(10):1747-9.

 

Last Updated: 13 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemoglobinuria" returned 35 free, full-text review articles on human participants. First 3 results:

Paroxysmal nocturnal hemoglobinuria: a complement-mediated hemolytic anemia.
 

Author(s): Amy E DeZern, Robert A Brodsky

Journal: Hematol. Oncol. Clin. North Am.. 2015 Jun;29(3):479-94.

 

Paroxysmal nocturnal hemoglobinuria is manifests with a chronic hemolytic anemia from uncontrolled complement activation, a propensity for thrombosis and marrow failure. The hemolysis is largely mediated by the alternative pathway of complement. Clinical manifestations result from ...

Last Updated: 5 Jun 2015

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Cerebral venous thrombosis in paroxysmal nocturnal hemoglobinuria: a series of 15 cases and review of the literature.
 

Author(s): Elodie Meppiel, Isabelle Crassard, Régis Peffault de Latour, Sophie de Guibert, Louis Terriou, Hugues Chabriat, Gérard Socié, Marie-Germaine Bousser

Journal: Medicine (Baltimore). 2015 Jan;94(1):e362.

 

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder of hematopoietic stem cells characterized by hemolytic anemia, marrow failure, and a high incidence of life-threatening venous thrombosis. Cerebral venous system is the second most frequent location of thrombosis ...

Last Updated: 9 Jan 2015

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Paroxysmal nocturnal hemoglobinuria.
 

Author(s): Robert A Brodsky

Journal: Blood. 2014 Oct;124(18):2804-11.

 

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare bone marrow failure disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias. The absence of two glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59, leads to uncontrolled complement ...

Last Updated: 31 Oct 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Treatment Study of ACH-0144471 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
 

Status: Not yet recruiting

Condition Summary: Paroxysmal Nocturnal Hemoglobinuria (PNH)

 

Last Updated: 10 Feb 2017

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Coversin in Paroxysmal Nocturnal Haemoglobinuria (PNH)
 

Status: Recruiting

Condition Summary: Paroxysmal Nocturnal Haemoglobinuria (PNH)

 

Last Updated: 23 Jan 2017

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ALXN1210 Versus Eculizumab in Complement Inhibitor Treatment-Naïve Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
 

Status: Recruiting

Condition Summary: Paroxysmal Nocturnal Hemoglobinuria (PNH)

 

Last Updated: 27 Jan 2017

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