Hemoglobinuria

Common Name(s)

Hemoglobinuria

Hemoglobinuria is symptom of different blood conditions or problems with the kidney (an organ in the abdomen which filters blood and produces urine). Hemoglobin is a chemical found in the blood cells and its function is to carry oxygen from the lungs to the rest of the body. Hemoglobinuria is when this chemical is inappropriately found in the urine (usually, there is no hemoglobin present in urine). This may occur due to the destruction of red blood cells and leaking of hemoglobin into the bloodstream, which then passes into urine. Other causes include severe skin burns, kidney cancer, malaria, and reactions to blood transfusions. Symptoms and treatment vary depending upon the condition and symptoms of patient.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobinuria" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobinuria" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemoglobinuria" returned 322 free, full-text research articles on human participants. First 3 results:

Paroxysmal nocturnal hemoglobinuria diagnosed after influenza vaccine: coincidence or consequence?
 

Author(s): Hefziba Green, Noa Eliakim-Raz, Yael Zimra, Anat Gafter-Gvili

Journal: Isr. Med. Assoc. J.. 2014 Feb;16(2):122-4.

 

Last Updated: 20 Mar 2014

Go To URL
Effects of immunosuppressive therapy in a patient with aplastic anemia-paroxysmal nocturnal hemoglobinuria (AA-PNH) syndrome during ongoing eculizumab treatment.
 

Author(s): Jin Asano, Ryosuke Ueda, Yasuhiro Tanaka, Isaku Shinzato, Toshiro Takafuta

Journal: Intern. Med.. 2014 ;53(2):125-8.

 

A 65-year-old woman experienced a hemolytic attack triggered by sepsis. She presented with markedly increased CD55(-) CD59(-) erythrocytes and the signs of bone marrow failure, which led to a diagnosis of aplastic anemia-paroxysmal nocturnal hemoglobinuria (AA-PNH) syndrome. There ...

Last Updated: 16 Jan 2014

Go To URL
Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria.
 

Author(s): Tommaso Rondelli, Antonio M Risitano, Régis Peffault de Latour, Michela Sica, Benedetta Peruzzi, Patrizia Ricci, Wilma Barcellini, Anna Paola Iori, Carla Boschetti, Veronica Valle, Veronique Frémeaux-Bacchi, Maria De Angioletti, Gerard Socie, Lucio Luzzatto, Rosario Notaro

Journal: Haematologica. 2014 Feb;99(2):262-6.

 

Complement blockade by eculizumab is clinically effective in hemolytic paroxysmal nocturnal hemoglobinuria. However, the response is variable and some patients remain dependent on red blood cell transfusions. In 72 patients with hemolytic paroxysmal nocturnal hemoglobinuria on eculizumab ...

Last Updated: 5 Feb 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemoglobinuria" returned 26 free, full-text review articles on human participants. First 3 results:

[Targeting therapy strategy for paroxysmal nocturnal hemoglobinuria].
 

Author(s): Xiang-yan Feng, Mei-li Ge, Yi-zhou Zheng

Journal: Zhonghua Xue Ye Xue Za Zhi. 2011 Sep;32(9):638-41.

 

Last Updated: 16 Feb 2012

Go To URL
Management of paroxysmal nocturnal hemoglobinuria in the era of complement inhibitory therapy.
 

Author(s): Charles J Parker

Journal: Hematology Am Soc Hematol Educ Program. 2011 ;2011():21-9.

 

Despite the availability of safe, effective targeted therapy that controls intravascular hemolysis, the management of paroxysmal nocturnal hemoglobinuria (PNH) remains complicated because of disease heterogeneity and close association with BM failure syndromes. The purpose of this ...

Last Updated: 14 Dec 2011

Go To URL
Thrombolytic therapy is effective in paroxysmal nocturnal hemoglobinuria: a series of nine patients and a review of the literature.
 

Author(s): David J Araten, Rosario Notaro, Howard T Thaler, Nancy Kernan, Farid Boulad, Hugo Castro-Malaspina, Trudy Small, Andromachi Scaradavou, Heather Magnan, Susan Prockop, Sara Chaffee, Jason Gonsky, Raymond Thertulien, Roberto Tarquini, Lucio Luzzatto

Journal: Haematologica. 2012 Mar;97(3):344-52.

 

Thrombosis is the major risk factor for death in patients with paroxysmal nocturnal hemoglobinuria. Previous case reports indicate that venous thrombosis in patients with paroxysmal nocturnal hemoglobinuria is amenable to thrombolysis.

Last Updated: 2 Mar 2012

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry
 

Status: Recruiting

Condition Summary: Paroxysmal Nocturnal Hemoglobinuria

 

Last Updated: 9 Sep 2014

Go to URL
Microvascular and Cardiac Dysfunction in Paroxysmal Nocturnal Hemoglobinuria and Sickle Cell Disease
 

Status: Recruiting

Condition Summary: Rheologic Disease; Sickle Cell Disease; Paroxysmal Nocturnal Hemoglobinuria

 

Last Updated: 11 Feb 2011

Go to URL

Last Updated: 19 Oct 2010

Go to URL