Hemoglobinuria

Common Name(s)

Hemoglobinuria

Hemoglobinuria is symptom of different blood conditions or problems with the kidney (an organ in the abdomen which filters blood and produces urine). Hemoglobin is a chemical found in the blood cells and its function is to carry oxygen from the lungs to the rest of the body. Hemoglobinuria is when this chemical is inappropriately found in the urine (usually, there is no hemoglobin present in urine). This may occur due to the destruction of red blood cells and leaking of hemoglobin into the bloodstream, which then passes into urine. Other causes include severe skin burns, kidney cancer, malaria, and reactions to blood transfusions. Symptoms and treatment vary depending upon the condition and symptoms of patient.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobinuria" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemoglobinuria" returned 328 free, full-text research articles on human participants. First 3 results:

Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria.
 

Author(s): Wenyi Shen, Michael J Clemente, Naoko Hosono, Kenichi Yoshida, Bartlomiej Przychodzen, Tetsuichi Yoshizato, Yuichi Shiraishi, Satoru Miyano, Seishi Ogawa, Jaroslaw P Maciejewski, Hideki Makishima

Journal: J. Clin. Invest.. 2014 Oct;124(10):4529-38.

 

Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal disease of hematopoietic stem cells that is associated with hemolysis, marrow failure, and thrombophilia. PNH has been considered a monogenic disease that results from somatic mutations in the gene encoding PIGA, which ...

Last Updated: 2 Oct 2014

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[Abnormal WT1 gene expression in paroxysmal nocturnal hemoglobinuria].
 

Author(s): Yuanyuan Zhang, Rong Fu, Yihao Wang, Lijuan Li, Hui Liu, Chunyan Liu, Tian Zhang, Shaoxue Ding, Liyan Li, Erbao Ruan, Wen Qu, Huaquan Wang, Xiaoming Wang, Guojin Wang, Yuhong Wu, Jia Song, Hong Liu, Limin Xing, Jing Guan, Zonghong Shao

Journal: Zhonghua Xue Ye Xue Za Zhi. 2014 Jul;35(7):596-600.

 

To explore the pathogenesis of abnormal WT1 expression in paroxysmal nocturnal hemoglobinuria (PNH).

Last Updated: 23 Jul 2014

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Complement blockade with a C1 esterase inhibitor in paroxysmal nocturnal hemoglobinuria.
 

Author(s): Amy E DeZern, Marc Uknis, Xuan Yuan, Galina L Mukhina, Juan Varela, JoAnne Saye, Jeffrey Pu, Robert A Brodsky

Journal: Exp. Hematol.. 2014 Oct;42(10):857-61.e1.

 

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, clonal, hematopoietic stem cell disorder that manifests with a complement-mediated hemolytic anemia, bone marrow failure, and a propensity for thrombosis. These patients experience both intra- and extravascular hemolysis in the ...

Last Updated: 2 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemoglobinuria" returned 28 free, full-text review articles on human participants. First 3 results:

Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape.
 

Author(s): Dimitrios C Mastellos, Daniel Ricklin, Despina Yancopoulou, Antonio Risitano, John D Lambris

Journal: Expert Rev Hematol. 2014 Oct;7(5):583-98.

 

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder associated with an acquired deficiency in glycophosphatidylinositol-anchor biosynthesis that renders erythrocytes susceptible to complement attack. Intravascular hemolysis via the membrane attack complex is ...

Last Updated: 12 Sep 2014

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[Targeting therapy strategy for paroxysmal nocturnal hemoglobinuria].
 

Author(s): Xiang-yan Feng, Mei-li Ge, Yi-zhou Zheng

Journal: Zhonghua Xue Ye Xue Za Zhi. 2011 Sep;32(9):638-41.

 

Last Updated: 16 Feb 2012

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Management of paroxysmal nocturnal hemoglobinuria in the era of complement inhibitory therapy.
 

Author(s): Charles J Parker

Journal: Hematology Am Soc Hematol Educ Program. 2011 ;2011():21-9.

 

Despite the availability of safe, effective targeted therapy that controls intravascular hemolysis, the management of paroxysmal nocturnal hemoglobinuria (PNH) remains complicated because of disease heterogeneity and close association with BM failure syndromes. The purpose of this ...

Last Updated: 14 Dec 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry
 

Status: Recruiting

Condition Summary: Paroxysmal Nocturnal Hemoglobinuria

 

Last Updated: 1 Apr 2015

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Last Updated: 19 Oct 2010

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Study of Global Coagulation Tests in Patients With Paroxysmal Nocturnal Haemoglobinuria
 

Status: Recruiting

Condition Summary: Paroxysmal Nocturnal Haemoglobinuria

 

Last Updated: 25 May 2010

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