Hemoglobin SC disease

Common Name(s)

Hemoglobin SC disease

Hemoglobin SC disease is a common type of hemoglobinopathy, or hemoglobin disorder. Hemoglobin is a chemical found in the blood and its function is to carry oxygen from the lungs to the rest of the body. Hemoglobinopathies occur when there is a problem with this chemical and it is not able to function correctly. More specifically, hemoglobin SC disease is also a form of sickle cell disease, which is where the blood cells can change shape, or “sickle”, causing injury to the blood cells or clogging blood vessels. Hemoglobin SC disease may cause anemia (low blood cell counts), jaundice (yellowing of the skin), and enlargement of the spleen (an organ in the belly which works to filter blood). In infants, symptoms such as low energy, yellow eyes, orange-colored skin, and swollen hand and feet may be observed. This is a genetic disorder, meaning that it may be transferred from parents to their children. This condition often requires lifelong management, including frequent check-ups, different vitamins, and often medication.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobin SC disease" for support, advocacy or research.

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American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

Last Updated: 1 Jun 2015

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Sickle Cell Disease Foundation of California

To provide education and life-enhancing programs and services to individuals with sickle cell disease, to broaden public awareness about sickle cell disease and to promote medical research and education to ultimately find a cure.

Last Updated: 27 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobin SC disease" for support, advocacy or research.

Logo
American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

http://www.ascaa.org

Last Updated: 1 Jun 2015

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Sickle Cell Disease Foundation of California

To provide education and life-enhancing programs and services to individuals with sickle cell disease, to broaden public awareness about sickle cell disease and to promote medical research and education to ultimately find a cure.

http://www.scdfc.org/

Last Updated: 27 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemoglobin SC disease" returned 21 free, full-text research articles on human participants. First 3 results:

Elevated hypercoagulability markers in hemoglobin SC disease.
 

Author(s): Marina P Colella, Erich V de Paula, João A Machado-Neto, Nicola Conran, Joyce M Annichino-Bizzacchi, Fernando F Costa, Sara T Olalla Saad, Fabiola Traina

Journal: Haematologica. 2015 Apr;100(4):466-71.

 

Hemoglobin SC disease is a very prevalent hemoglobinopathy; however, very little is known about this condition specifically. There appears to be an increased risk of thromboembolic events in hemoglobin SC disease, but studies evaluating the hemostatic alterations are lacking. We describe ...

Last Updated: 1 Apr 2015

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Higher-than-expected prevalence of silent cerebral infarcts in children with hemoglobin SC disease.
 

Author(s): Kristin P Guilliams, Melanie E Fields, Monica L Hulbert

Journal: Blood. 2015 Jan;125(2):416-7.

 

Last Updated: 9 Jan 2015

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Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease.
 

Author(s): Justin Wanek, Bruce Gaynes, Jennifer I Lim, Robert Molokie, Mahnaz Shahidi

Journal: Am. J. Hematol.. 2013 Aug;88(8):661-4.

 

The known biophysical variations of hemoglobin (Hb) S and Hb C may result in hemodynamic differences between subjects with SS and SC disease. The purpose of this study was to measure and compare conjunctival hemodynamics between subjects with Hb SS and SC hemoglobinopathies. Image ...

Last Updated: 24 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemoglobin SC disease" returned 1 free, full-text review articles on human participants. First 3 results:

Role of phlebotomy in the management of hemoglobin SC disease: case report and review of the literature.
 

Author(s): Merry Jennifer Markham, Richard Lottenberg, Marc Zumberg

Journal: Am. J. Hematol.. 2003 Jun;73(2):121-5.

 

Marked variability is a keynote in the disease course of patients with hemoglobin SC (Hb SC) and hemoglobin S/beta(+)-thalassemia (Hb S/beta(+)-thal), with some patients having a frequency of complications and painful episodes similar to patients with homozygous sickle cell (Hb SS) ...

Last Updated: 15 May 2003

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE)
 

Status: Recruiting

Condition Summary: Hemoglobin SC Disease

 

Last Updated: 23 Dec 2015

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Treatment of Hemoglobin SC Disease
 

Status: Recruiting

Condition Summary: Hemoglobin SC Disease

 

Last Updated: 11 Jan 2016

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Natural History of Sickle Cell Disease and Other Hemolytic Disorders
 

Status: Recruiting

Condition Summary: Hemoglobin SC Disease; Hematologic Diseases; Sickle Cell Anemia; Hemolytic Anemia

 

Last Updated: 26 May 2016

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