Hemiplegia

Common Name(s)

Hemiplegia

Hemiplegia refers to a state in which there is a complete or near-complete loss of movement on one entire side of the body. Hemiplegia is caused by damage to the brain in regions that control body movements, and it is similar but more severe than hemiparesis. The side of the body that is paralyzed is opposite to the damaged side of the brain. Hemiplegia may be present at birth or may develop later in life from stroke or damage to the brain from injury, infection, or tumors.

The major symptoms of hemiplegia include stiffness, weakness, or lack of control on either the left or right side of the body. Other early symptoms include the use of only one hand, keeping one hand in a fist, difficulty walking and balancing, and difficulty performing actions requiring fine motor skills, such as using scissors or writing. In general, affected children may experience delayed milestones compared to their peers and are more likely to develop scoliosis, or curvature of the spine, as they grow. Once present, hemiplegia does not progress, but limitations may become more obvious with age. Damage to the brain may lead to related disorders in affected individuals. These include learning difficulties, such as dyslexia, difficulty with sight and speech, psychiatric illnesses, epilepsy, and behavioral problems.

While there is currently no cure for hemiplegia, there are treatments available to help reduce symptoms. Physical therapy can help prevent a decrease in muscle mass (atrophy). Braces and other devices may be used to increase mobility. Medications can be used to decrease seizures and help with psychiatric or behavioral issues. Surgery may be required if the condition affects other body functions. If you or your child has been diagnosed with a hemiplegia, talk to your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemiplegia" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemiplegia" returned 280 free, full-text research articles on human participants. First 3 results:

Faulty cardiac repolarization reserve in alternating hemiplegia of childhood broadens the phenotype.
 

Author(s): Fatima Jaffer, Andreja Avbersek, Rosaria Vavassori, Carmen Fons, Jaume Campistol, Michela Stagnaro, Elisa De Grandis, Edvige Veneselli, Hendrik Rosewich, Melania Gianotta, Claudio Zucca, Francesca Ragona, Tiziana Granata, Nardo Nardocci, Mohamed Mikati, Ashley R Helseth, Cyrus Boelman, Berge A Minassian, Sophia Johns, Sarah I Garry, Ingrid E Scheffer, Isabelle Gourfinkel-An, Ines Carrilho, Sarah E Aylett, Matthew Parton, Michael G Hanna, Henry Houlden, Brian Neville, Manju A Kurian, Jan Novy, Josemir W Sander, Pier D Lambiase, Elijah R Behr, Tsveta Schyns, Alexis Arzimanoglou, J Helen Cross, Juan P Kaski, Sanjay M Sisodiya

Journal: Brain. 2015 Oct;138(Pt 10):2859-74.

 

Alternating hemiplegia of childhood is a rare disorder caused by de novo mutations in the ATP1A3 gene, expressed in neurons and cardiomyocytes. As affected individuals may survive into adulthood, we use the term 'alternating hemiplegia'. The disorder is characterized by early-onset, ...

Last Updated: 26 Sep 2015

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[Neuropsychological deficits in alternating hemiplegia of childhood: a case study].
 

Author(s): Vega Muriel, Alberto Garcia-Molina, Celeste Aparicio-Lopez, Antònia Ensenat, Teresa Roig-Rovira

Journal: Rev Neurol. 2015 Jul;61(1):25-8.

 

Alternating hemiplegic of childhood is a predominantly sporadic neurodevelopmental syndrome of uncertain etiology, characterized by alternating transient attacks of hemiplegia. Additional features include tonic fits, dystonic posturing, ocular motor abnormalities and deficits in cognitive ...

Last Updated: 25 Jun 2015

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Alternating Hemiplegia of Childhood: Retrospective Genetic Study and Genotype-Phenotype Correlations in 187 Subjects from the US AHCF Registry.
 

Author(s): Louis Viollet, Gustavo Glusman, Kelley J Murphy, Tara M Newcomb, Sandra P Reyna, Matthew Sweney, Benjamin Nelson, Frederick Andermann, Eva Andermann, Gyula Acsadi, Richard L Barbano, Candida Brown, Mary E Brunkow, Harry T Chugani, Sarah R Cheyette, Abigail Collins, Suzanne D DeBrosse, David Galas, Jennifer Friedman, Lee Hood, Chad Huff, Lynn B Jorde, Mary D King, Bernie LaSalle, Richard J Leventer, Aga J Lewelt, Mylynda B Massart, Mario R Mérida, Louis J Ptáček, Jared C Roach, Robert S Rust, Francis Renault, Terry D Sanger, Marcio A Sotero de Menezes, Rachel Tennyson, Peter Uldall, Yue Zhang, Mary Zupanc, Winnie Xin, Kenneth Silver, Kathryn J Swoboda

Journal:

 

Mutations in ATP1A3 cause Alternating Hemiplegia of Childhood (AHC) by disrupting function of the neuronal Na+/K+ ATPase. Published studies to date indicate 2 recurrent mutations, D801N and E815K, and a more severe phenotype in the E815K cohort. We performed mutation analysis and ...

Last Updated: 22 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemiplegia" returned 13 free, full-text review articles on human participants. First 3 results:

The virtual bodily self: Mentalisation of the body as revealed in anosognosia for hemiplegia.
 

Author(s): Aikaterini Fotopoulou

Journal: Conscious Cogn. 2015 May;33():500-10.

 

Despite the coherence and seeming directness of our bodily experience, our perception of the world, including that of our own body, may constitute an inference based on ambiguous sensory data and prior expectations. In this article, I apply a 'psychologised' version of the recently ...

Last Updated: 6 Apr 2015

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The expanding spectrum of neurological phenotypes in children with ATP1A3 mutations, Alternating Hemiplegia of Childhood, Rapid-onset Dystonia-Parkinsonism, CAPOS and beyond.
 

Author(s): Matthew T Sweney, Tara M Newcomb, Kathryn J Swoboda

Journal: Pediatr. Neurol.. 2015 Jan;52(1):56-64.

 

ATP1A3 mutations have now been recognized in infants and children presenting with a diverse group of neurological phenotypes, including Rapid-onset Dystonia-Parkinsonism (RDP), Alternating Hemiplegia of Childhood (AHC), and most recently, Cerebellar ataxia, Areflexia, Pes cavus, Optic ...

Last Updated: 23 Dec 2014

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Brain reorganization following intervention in children with congenital hemiplegia: a systematic review.
 

Author(s): E Inguaggiato, G Sgandurra, S Perazza, A Guzzetta, G Cioni

Journal: Neural Plast.. 2013 ;2013():356275.

 

Noninvasive rehabilitation strategies for children with unilateral cerebral palsy are routinely used to improve hand motor function, activity, and participation. Nevertheless, the studies exploring their effects on brain structure and function are very scarce. Recently, structural ...

Last Updated: 24 Dec 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Bimanual Training in Children With Hemiplegia
 

Status: Recruiting

Condition Summary: Hemiplegia; Cerebral Palsy; Children

 

Last Updated: 8 Sep 2011

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Contralaterally Controlled FES of Arm & Hand for Subacute Stroke Rehabilitation
 

Status: Recruiting

Condition Summary: Stroke; Hemiparesis; Hemiplegia

 

Last Updated: 21 Mar 2016

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